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BRPI0806264A2 - derivados ciclizados como inibidores de eg-5 - Google Patents

derivados ciclizados como inibidores de eg-5 Download PDF

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Publication number
BRPI0806264A2
BRPI0806264A2 BRPI0806264-1A BRPI0806264A BRPI0806264A2 BR PI0806264 A2 BRPI0806264 A2 BR PI0806264A2 BR PI0806264 A BRPI0806264 A BR PI0806264A BR PI0806264 A2 BRPI0806264 A2 BR PI0806264A2
Authority
BR
Brazil
Prior art keywords
inhibitors
cyclized derivatives
compounds
pharmaceutically acceptable
cyclized
Prior art date
Application number
BRPI0806264-1A
Other languages
English (en)
Inventor
Rustum Boyce
Eric Martin
Weibo Wang
Hong Yang
Paul A Barsanti
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0806264A2 publication Critical patent/BRPI0806264A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

DERIVADOS CICLIZADOS COMO INIBIDORES DE EG-5. A presente invenção refere-se a novos compostos de imidazol substituidos que possuem a seguinte Fórmula (I) e aos sais farmaceuticamente aceitáveis, ésteres, ou pró-fármacos dos mesmos, às composições dos compostos juntamente com os veículos farmaceuticamente aceitáveis, e aos usos dos compostos.
BRPI0806264-1A 2007-01-05 2008-01-03 derivados ciclizados como inibidores de eg-5 BRPI0806264A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88374007P 2007-01-05 2007-01-05
PCT/US2008/050149 WO2008086122A2 (en) 2007-01-05 2008-01-03 Imidazole derivatives as kinesin spindle protein inhibitors (eg-5)

Publications (1)

Publication Number Publication Date
BRPI0806264A2 true BRPI0806264A2 (pt) 2011-08-30

Family

ID=39577804

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0806264-1A BRPI0806264A2 (pt) 2007-01-05 2008-01-03 derivados ciclizados como inibidores de eg-5

Country Status (30)

Country Link
US (3) US7820646B2 (pt)
EP (1) EP2106399A2 (pt)
JP (1) JP2010515687A (pt)
KR (1) KR20090097210A (pt)
CN (1) CN101622247A (pt)
AR (1) AR064760A1 (pt)
AU (1) AU2008205169B2 (pt)
BR (1) BRPI0806264A2 (pt)
CA (1) CA2674318A1 (pt)
CL (1) CL2008000029A1 (pt)
CO (1) CO6561828A2 (pt)
CR (1) CR10879A (pt)
DO (1) DOP2009000169A (pt)
EA (1) EA200900924A1 (pt)
EC (1) ECSP099485A (pt)
GE (1) GEP20125415B (pt)
GT (1) GT200900192A (pt)
HN (1) HN2009001262A (pt)
MA (1) MA31080B1 (pt)
MX (1) MX2009007260A (pt)
NI (1) NI200900134A (pt)
NZ (1) NZ577727A (pt)
PE (1) PE20081850A1 (pt)
SM (1) SMP200900065B (pt)
SV (1) SV2009003325A (pt)
TN (1) TN2009000287A1 (pt)
TW (1) TW200836722A (pt)
UA (1) UA97821C2 (pt)
WO (1) WO2008086122A2 (pt)
ZA (1) ZA200904175B (pt)

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US8252832B2 (en) 2007-12-14 2012-08-28 Novartis Ag Kinesin inhibitors as cancer therapeutics
EP2558450A1 (en) 2010-04-15 2013-02-20 Novartis AG Triazole compounds as ksp inhibitors
US8748626B2 (en) * 2010-04-15 2014-06-10 Novartis Ag Oxazole and thiazole compounds as KSP inhibitors
EP2390247A1 (en) 2010-05-26 2011-11-30 Netherlands Organisation for Scientific Research (Advanced Chemical Technologies for Sustainability) Preparation of caprolactone, caprolactam, 2,5-tetrahydrofuran dimethanol, 1,6-hexanediol or 1,2,6-hexanetriol from 5-hydroxymethyl-2-furfuraldehyde
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
US9498540B2 (en) 2013-03-15 2016-11-22 Novartis Ag Cell proliferation inhibitors and conjugates thereof
CN105451773A (zh) * 2013-03-15 2016-03-30 诺华股份有限公司 细胞增殖抑制剂及其缀合物
KR102329024B1 (ko) * 2013-12-23 2021-11-19 바이엘 파마 악티엔게젤샤프트 키네신 스핀들 단백질(ksp)과의 항체 약물 접합체 (adcs)
WO2016207089A1 (de) 2015-06-22 2016-12-29 Bayer Pharma Aktiengesellschaft Binder-wirkstoff-konjugate (adcs) und binder-prodrug-konjugate (apdcs) mit enzymatisch spaltbaren gruppen
CN105330657B (zh) * 2015-12-08 2019-05-21 华润双鹤药业股份有限公司 5-氯-2-[5-(r)-甲基-1,4-二氮杂环庚烷-1-]苯并恶唑的制备方法
CN105367506B (zh) * 2015-12-08 2021-02-05 华润双鹤药业股份有限公司 手性高哌嗪环的制备方法
WO2017216028A1 (en) 2016-06-15 2017-12-21 Bayer Pharma Aktiengesellschaft Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies
WO2018114578A1 (de) 2016-12-21 2018-06-28 Bayer Pharma Aktiengesellschaft Binder-wirkstoff-konjugate (adcs) mit enzymatisch spaltbaren gruppen
CA3047522A1 (en) 2016-12-21 2018-06-28 Bayer Pharma Aktiengesellschaft Specific antibody drug conjugates (adcs) having ksp inhibitors
WO2019243159A1 (de) 2018-06-18 2019-12-26 Bayer Aktiengesellschaft Gegen cxcr5 gerichtete binder-wirkstoff-konjugate mit enzymatisch spaltbaren linkern und verbessertem wirkungsprofil
CN119859151A (zh) * 2023-10-19 2025-04-22 北京振东光明药物研究院有限公司 从白土苓中分离得到的生物碱类化合物及其制备方法和应用

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Also Published As

Publication number Publication date
GEP20125415B (en) 2012-03-12
WO2008086122A3 (en) 2008-10-16
US20120189623A1 (en) 2012-07-26
EA200900924A1 (ru) 2009-12-30
CL2008000029A1 (es) 2008-04-04
US20080207589A1 (en) 2008-08-28
NZ577727A (en) 2012-03-30
MX2009007260A (es) 2009-07-10
JP2010515687A (ja) 2010-05-13
GT200900192A (es) 2010-06-24
CO6561828A2 (es) 2012-11-15
NI200900134A (es) 2010-07-05
SV2009003325A (es) 2011-08-09
EP2106399A2 (en) 2009-10-07
CR10879A (es) 2009-08-05
US7820646B2 (en) 2010-10-26
KR20090097210A (ko) 2009-09-15
DOP2009000169A (es) 2009-08-31
US20110003791A1 (en) 2011-01-06
CA2674318A1 (en) 2008-07-17
TN2009000287A1 (en) 2010-12-31
UA97821C2 (en) 2012-03-26
ECSP099485A (es) 2009-08-28
HN2009001262A (es) 2012-01-09
WO2008086122A2 (en) 2008-07-17
AU2008205169B2 (en) 2012-02-02
CN101622247A (zh) 2010-01-06
PE20081850A1 (es) 2009-02-05
ZA200904175B (en) 2010-04-28
TW200836722A (en) 2008-09-16
MA31080B1 (fr) 2010-01-04
SMAP200900065A (it) 2009-09-07
SMP200900065B (it) 2010-09-10
AR064760A1 (es) 2009-04-22
AU2008205169A1 (en) 2008-07-17

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