[go: up one dir, main page]

AR064760A1 - Derivados de diazol como inhibidores de la eg-5 - Google Patents

Derivados de diazol como inhibidores de la eg-5

Info

Publication number
AR064760A1
AR064760A1 ARP080100042A ARP080100042A AR064760A1 AR 064760 A1 AR064760 A1 AR 064760A1 AR P080100042 A ARP080100042 A AR P080100042A AR P080100042 A ARP080100042 A AR P080100042A AR 064760 A1 AR064760 A1 AR 064760A1
Authority
AR
Argentina
Prior art keywords
alkyl
group
pharmaceutically acceptable
substituted alkyl
substituted
Prior art date
Application number
ARP080100042A
Other languages
English (en)
Inventor
Weibo Wang
Hong Yang
Rustum Boyce
Paul A Barsanti
Eric Martin
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR064760A1 publication Critical patent/AR064760A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

La presente se refiere a compuestos imidazol substituidos con la siguiente formula (1) y a las sales farmacéuticamente aceptables, ésteres o prodrogas de los mismos, a las composiciones de los compuestos conjuntamente con los portadores farmacéuticamente aceptables, y a los usos de los compuestos. Reivindicacion 1: Un compuesto o una sal farmacéuticamente aceptable, éster o prodroga del mismo con la formula (1), en donde: R1 se selecciona del grupo compuesto de alquilo y alquilo substituido; R2 se selecciona de un grupo compuesto de hidrogeno, alquilo y alquilo substituido; L se selecciona de un grupo compuesto de a) -O-; b) -OCH2-, -CH2O-, -C(O)NR7-; c) -CH2OCH2-, -CH2NR7CH2-, -CH2CH2O-, -C(O)NR7CH2-, y -CH2CH2NR7-; R3 y R4 se seleccionan independientemente de un grupo compuesto de halo, alquilo, y alquilo substituido; R5 y R6 se seleccionan independientemente de un grupo compuesto de ciano, alquilo, alquilo substituido, alcoxi, alcoxi, halo, e hidroxi; R7 se selecciona de un grupo compuesto de hidrogeno, alquilo, y -SO2alquilo; m es 0, 1, 2, o 3; n es 0, 1, 2, o 3; y p es 0 o 1.
ARP080100042A 2007-01-05 2008-01-04 Derivados de diazol como inhibidores de la eg-5 AR064760A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88374007P 2007-01-05 2007-01-05

Publications (1)

Publication Number Publication Date
AR064760A1 true AR064760A1 (es) 2009-04-22

Family

ID=39577804

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080100042A AR064760A1 (es) 2007-01-05 2008-01-04 Derivados de diazol como inhibidores de la eg-5

Country Status (30)

Country Link
US (3) US7820646B2 (es)
EP (1) EP2106399A2 (es)
JP (1) JP2010515687A (es)
KR (1) KR20090097210A (es)
CN (1) CN101622247A (es)
AR (1) AR064760A1 (es)
AU (1) AU2008205169B2 (es)
BR (1) BRPI0806264A2 (es)
CA (1) CA2674318A1 (es)
CL (1) CL2008000029A1 (es)
CO (1) CO6561828A2 (es)
CR (1) CR10879A (es)
DO (1) DOP2009000169A (es)
EA (1) EA200900924A1 (es)
EC (1) ECSP099485A (es)
GE (1) GEP20125415B (es)
GT (1) GT200900192A (es)
HN (1) HN2009001262A (es)
MA (1) MA31080B1 (es)
MX (1) MX2009007260A (es)
NI (1) NI200900134A (es)
NZ (1) NZ577727A (es)
PE (1) PE20081850A1 (es)
SM (1) SMP200900065B (es)
SV (1) SV2009003325A (es)
TN (1) TN2009000287A1 (es)
TW (1) TW200836722A (es)
UA (1) UA97821C2 (es)
WO (1) WO2008086122A2 (es)
ZA (1) ZA200904175B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8252832B2 (en) 2007-12-14 2012-08-28 Novartis Ag Kinesin inhibitors as cancer therapeutics
EP2558450A1 (en) 2010-04-15 2013-02-20 Novartis AG Triazole compounds as ksp inhibitors
US8748626B2 (en) * 2010-04-15 2014-06-10 Novartis Ag Oxazole and thiazole compounds as KSP inhibitors
EP2390247A1 (en) 2010-05-26 2011-11-30 Netherlands Organisation for Scientific Research (Advanced Chemical Technologies for Sustainability) Preparation of caprolactone, caprolactam, 2,5-tetrahydrofuran dimethanol, 1,6-hexanediol or 1,2,6-hexanetriol from 5-hydroxymethyl-2-furfuraldehyde
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
US9498540B2 (en) 2013-03-15 2016-11-22 Novartis Ag Cell proliferation inhibitors and conjugates thereof
CN105451773A (zh) * 2013-03-15 2016-03-30 诺华股份有限公司 细胞增殖抑制剂及其缀合物
KR102329024B1 (ko) * 2013-12-23 2021-11-19 바이엘 파마 악티엔게젤샤프트 키네신 스핀들 단백질(ksp)과의 항체 약물 접합체 (adcs)
WO2016207089A1 (de) 2015-06-22 2016-12-29 Bayer Pharma Aktiengesellschaft Binder-wirkstoff-konjugate (adcs) und binder-prodrug-konjugate (apdcs) mit enzymatisch spaltbaren gruppen
CN105330657B (zh) * 2015-12-08 2019-05-21 华润双鹤药业股份有限公司 5-氯-2-[5-(r)-甲基-1,4-二氮杂环庚烷-1-]苯并恶唑的制备方法
CN105367506B (zh) * 2015-12-08 2021-02-05 华润双鹤药业股份有限公司 手性高哌嗪环的制备方法
WO2017216028A1 (en) 2016-06-15 2017-12-21 Bayer Pharma Aktiengesellschaft Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies
WO2018114578A1 (de) 2016-12-21 2018-06-28 Bayer Pharma Aktiengesellschaft Binder-wirkstoff-konjugate (adcs) mit enzymatisch spaltbaren gruppen
CA3047522A1 (en) 2016-12-21 2018-06-28 Bayer Pharma Aktiengesellschaft Specific antibody drug conjugates (adcs) having ksp inhibitors
WO2019243159A1 (de) 2018-06-18 2019-12-26 Bayer Aktiengesellschaft Gegen cxcr5 gerichtete binder-wirkstoff-konjugate mit enzymatisch spaltbaren linkern und verbessertem wirkungsprofil
CN119859151A (zh) * 2023-10-19 2025-04-22 北京振东光明药物研究院有限公司 从白土苓中分离得到的生物碱类化合物及其制备方法和应用

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2550959C3 (de) * 1975-11-13 1980-12-04 Hoechst Ag, 6000 Frankfurt Tetrazolyl-imidazole und Tetrazolyl--benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) * 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
GB2157285B (en) 1984-04-11 1987-10-28 Erba Farmitalia 1h, 7h-pyrazolo1, 5-a pyrimidine-7-one derivatives and process for their preparation
US5023252A (en) * 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US4837028A (en) * 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5011472A (en) * 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
US5859012A (en) * 1996-04-03 1999-01-12 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JP2001505585A (ja) 1996-12-16 2001-04-24 藤沢薬品工業株式会社 新規アミド化合物およびそれらの一酸化窒素シンターゼ阻害剤としての用途
US6117940A (en) 1997-10-17 2000-09-12 Mjalli; Adnan M. M. Amino-ketone solid support templates
US6172087B1 (en) * 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
CA2369549A1 (en) 1999-04-02 2000-10-12 Robert W. Desimone Aryl and heteroaryl fused aminoalkyl-imidazole derivatives and their use as antidiabetics
US6271241B1 (en) * 1999-04-02 2001-08-07 Neurogen Corporation Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors
US20040132788A1 (en) * 1999-10-11 2004-07-08 Chabrier De Lassauniere Pierre-Etienne Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
US7291641B2 (en) * 1999-10-11 2007-11-06 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
TWI292316B (en) 1999-10-11 2008-01-11 Sod Conseils Rech Applic Pharmaceutical composition of thiazole derivatives intended to inhibit mao and/or lipidic peroxidation and/or to act as modulators of sodium channels and the use thereof
NZ518480A (en) 1999-10-27 2004-02-27 Cytokinetics Inc Methods and compositions utilizing quinazolinones
US6545004B1 (en) * 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US6620882B1 (en) 2000-05-02 2003-09-16 Advanced Syntech, Llc Solid support template for preparation of highly functionalized heterocycle compounds
US6683191B2 (en) 2000-06-05 2004-01-27 Ortho-Mcneil Pharmaceuticals, Inc. Method for synthesis of substituted azole libraries
AU2001264872A1 (en) 2000-06-05 2001-12-17 Ortho-Mcneil Pharmaceutical, Inc. Method for synthesis of substituted azole libraries
ES2282275T3 (es) 2000-08-01 2007-10-16 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Derivados de imidazolilo.
US20030055037A1 (en) 2000-10-06 2003-03-20 Delombaert Stephane Benzimidazole and indole derivatives as CRF receptor modulators
EP1341768A1 (en) 2000-12-07 2003-09-10 AstraZeneca AB Therapeutic benzimidazole compounds
CN1575177A (zh) 2000-12-11 2005-02-02 图拉里克公司 Cxcr3拮抗剂
WO2002057244A1 (en) 2001-01-19 2002-07-25 Cytokinetics, Inc. Phenothiazine kinesin inhibitors
US20040132830A1 (en) 2001-01-19 2004-07-08 Finer Jeffrey T Triphenylmethane kinesin inhibitors
JP2005511581A (ja) 2001-11-07 2005-04-28 メルク　エンド　カムパニー　インコーポレーテッド 有糸分裂キネシン阻害剤
WO2003043995A1 (en) 2001-11-20 2003-05-30 Cytokinetics, Inc. Process for the racemization of chiral quinazolinones
US7244723B2 (en) 2001-12-06 2007-07-17 Merck & Co., Inc. Substituted furopyrimidinones as a mitotic kinesin inhibitors
ATE424388T1 (de) 2001-12-06 2009-03-15 Merck & Co Inc Mitotische kinesinhemmer
ATE447577T1 (de) 2001-12-06 2009-11-15 Merck & Co Inc Mitotische kinesin-hemmer
EP1463733B1 (en) 2001-12-06 2007-09-05 Merck & Co., Inc. Mitotic kinesin inhibitors
DE60232994D1 (de) 2001-12-06 2009-08-27 Merck & Co Inc Inhibitoren von mitotischem kinesin
EP1465888A2 (en) 2002-01-10 2004-10-13 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted benzoimidazole analogues
WO2003105855A1 (en) 2002-01-11 2003-12-24 Merck & Co., Inc. Mitotic kinesin inhibitors
JP2005529076A (ja) 2002-02-15 2005-09-29 サイトキネティクス・インコーポレーテッド キナゾリノンの合成
ATE448207T1 (de) 2002-03-08 2009-11-15 Merck & Co Inc Mitotische kinesin-hemmer
DE10211770A1 (de) 2002-03-14 2003-10-02 Boehringer Ingelheim Pharma Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US7026312B2 (en) * 2002-03-14 2006-04-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof
CN100381437C (zh) 2002-04-17 2008-04-16 赛特凯恩蒂克公司 化合物、组合物和方法
GB0209995D0 (en) 2002-05-01 2002-06-12 Merck Sharp & Dohme Therapeutic agents
AU2003245259A1 (en) 2002-05-02 2003-11-17 Neurogen Corporation Substituted imidazole derivatives: gabaa receptor ligands
AU2003301864A1 (en) 2002-05-08 2004-06-07 Neurogen Corporation Substituted imidazolylmethyl pyridine and pyrazine derivatives and their use as gabaa receptor ligands
WO2003097053A1 (en) 2002-05-09 2003-11-27 Cytokinetics, Inc. Compounds, compositions, and methods
AU2003223786A1 (en) 2002-05-09 2003-11-11 Cytokinetics, Inc. Compounds, methods and compositions
EP1507534A4 (en) 2002-05-10 2006-11-08 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
ATE333455T1 (de) 2002-05-17 2006-08-15 Neurogen Corp Substituierte, ringkondensierte imidazolderivate: gabaa-rezeptorliganden
CA2483627A1 (en) 2002-05-23 2003-12-04 Merck & Co., Inc. Mitotic kinesin inhibitors
AU2003265242A1 (en) 2002-05-23 2003-12-22 Cytokinetics, Inc. Compounds, compositions, and methods
US7041676B2 (en) 2002-06-14 2006-05-09 Cytokinetics, Inc. Compounds, compositions, and methods
JP4463679B2 (ja) 2002-06-14 2010-05-19 メルク エンド カムパニー インコーポレーテッド 有糸分裂キネシン阻害剤
US20060134767A1 (en) 2002-07-08 2006-06-22 Buser-Doepner Carolyn A Mitotic kinesin binding site
WO2004006865A2 (en) 2002-07-17 2004-01-22 Cytokinetics, Inc. Compounds, compositions, and methods
AU2003256805A1 (en) 2002-07-23 2004-02-09 Cytokinetics, Inc. Compounds compositions and methods
JP2005536553A (ja) 2002-08-21 2005-12-02 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
JP2005539062A (ja) 2002-09-13 2005-12-22 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
CN100579579C (zh) 2002-10-01 2010-01-13 诺华疫苗和诊断公司 抗癌及抗感染性疾病组合物及其使用方法
WO2004041808A1 (en) 2002-11-08 2004-05-21 Neurogen Corporation 4-imidazol-1-ylmethyl-pyrimidine derivatives_as ligands for gabaa receptors
AU2003299612A1 (en) * 2002-12-13 2004-07-09 Cytokinetics Compounds, compositions and methods
WO2004064741A2 (en) 2003-01-17 2004-08-05 Cytokinetics Inc. Compounds, compositions, and methods
US20040186151A1 (en) 2003-02-12 2004-09-23 Mjalli Adnan M.M. Substituted azole derivatives as therapeutic agents
WO2004100873A2 (en) 2003-05-07 2004-11-25 Cytokinetics, Inc. Compounds, compositions, and methods
US20070032536A1 (en) 2003-05-15 2007-02-08 Xianping Qian Compounds, compositions and methods
JP2007520435A (ja) 2003-06-20 2007-07-26 カイロン コーポレイション 抗癌剤としてのピリジノ［１，２−ａ］ピリミジン−４−オン化合物
JP2007510652A (ja) * 2003-11-03 2007-04-26 サイトキネティクス・インコーポレーテッド ピリミジン−４−オン化合物、組成物、および方法
AU2005214349B2 (en) * 2004-02-12 2011-11-03 Transtech Pharma, Inc. Substituted azole derivatives, compositions, and methods of use
PT1732926E (pt) * 2004-04-06 2009-04-03 Novartis Vaccines & Diagnostic Inibidores de cinesinas mitóticas
US20080132549A1 (en) 2004-04-14 2008-06-05 Pfizer Inc. Sulphur-Linked Imidazone Compounds for the Treatment of Hiv/Aids
US7618981B2 (en) 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
PL1753723T3 (pl) * 2004-05-21 2009-01-30 Novartis Vaccines & Diagnostics Inc Podstawione pochodne chinoliny jako inhibitory kinezyn mitotycznych
KR101170925B1 (ko) * 2004-06-18 2012-08-07 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 암 치료용 키네신 방추 단백질 (ｋｓｐ) 억제제로서의ｎ-(1-(1-벤질-4-페닐-1ｈ-이미다졸-2-일)-2,2-디메틸프로필)벤자미드 유도체 및 관련 화합물
KR20070072598A (ko) * 2004-10-19 2007-07-04 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 인돌 및 벤지미다졸 유도체
TW200800951A (en) * 2005-08-09 2008-01-01 Novartis Ag Substituted imidazole compounds as KSP inhibitors
MX2009005071A (es) * 2006-11-13 2009-05-25 Novartis Ag Compuestos de pirazol y triazol sustituidos como inhibidores de ksp.

Also Published As

Publication number Publication date
GEP20125415B (en) 2012-03-12
WO2008086122A3 (en) 2008-10-16
US20120189623A1 (en) 2012-07-26
EA200900924A1 (ru) 2009-12-30
CL2008000029A1 (es) 2008-04-04
US20080207589A1 (en) 2008-08-28
NZ577727A (en) 2012-03-30
MX2009007260A (es) 2009-07-10
JP2010515687A (ja) 2010-05-13
GT200900192A (es) 2010-06-24
CO6561828A2 (es) 2012-11-15
NI200900134A (es) 2010-07-05
SV2009003325A (es) 2011-08-09
EP2106399A2 (en) 2009-10-07
CR10879A (es) 2009-08-05
US7820646B2 (en) 2010-10-26
KR20090097210A (ko) 2009-09-15
DOP2009000169A (es) 2009-08-31
US20110003791A1 (en) 2011-01-06
CA2674318A1 (en) 2008-07-17
TN2009000287A1 (en) 2010-12-31
UA97821C2 (en) 2012-03-26
BRPI0806264A2 (pt) 2011-08-30
ECSP099485A (es) 2009-08-28
HN2009001262A (es) 2012-01-09
WO2008086122A2 (en) 2008-07-17
AU2008205169B2 (en) 2012-02-02
CN101622247A (zh) 2010-01-06
PE20081850A1 (es) 2009-02-05
ZA200904175B (en) 2010-04-28
TW200836722A (en) 2008-09-16
MA31080B1 (fr) 2010-01-04
SMAP200900065A (it) 2009-09-07
SMP200900065B (it) 2010-09-10
AU2008205169A1 (en) 2008-07-17

Similar Documents

Publication Publication Date Title
AR064760A1 (es) Derivados de diazol como inhibidores de la eg-5
CU20110217A7 (es) Derivados amino-propiónicos sustituidos como inhibidores de neprilisina
SV2011004077A (es) Derivados aminobutiricos sustituidos como inhibidores de neprilisina
EA200801828A2 (ru) Соединения 1,2,4,5-тетрагидро-3h-бензазепина, способ их получения и фармацевтические композиции, содержащие эти соединения
AR107377A2 (es) Compuestos derivados de tetrahidroquinolina
CU24039B1 (es) Derivados de imidazolidin-2-ona 1,3-disustituida como inhibidores de cyp17
AR074481A1 (es) Derivados de tienopiridina como inhibidores de quinasa
AR085004A1 (es) Inhibidores selectivos de glicosidasas y usos de los mismos
UY32490A (es) Inhibidores de beta-secretasa
MX343264B (es) Ciertas amino-piridazinas, composiciones de las mismas y metodos de uso de los mismos.
AR094314A1 (es) Inhibidores de fosfatidilinositol 3-cinasa
ECSP12011645A (es) Compuestos y métodos inhibidores de jak de pirazolopirimidina
AR086474A1 (es) Compuestos de pirazol pesticidas
AR087919A1 (es) Heterociclos biciclicos como inhibidores de irak4
ECSP088965A (es) Derivados de 2-tioxantina que actúan como inhibidores de la mpo
MX2015007883A (es) Compuestos para protección de células.
AR066153A1 (es) Derivados de piperidina / piperazina
AR101815A1 (es) Compuestos y composiciones como inhibidores de quinasa
AR062797A1 (es) Derivados de piperidina como inhibidores de renina, composiciones farmaceuticas.
PE20142081A1 (es) Inhibidores de quinurenina-3-monooxigenasa, composiciones farmaceuticas y metodo de uso de los mismos
CO6230986A2 (es) Compuesto de 4-piridinona y su uso para cancer
CU20210023A7 (es) Inhibidores fenil sustituidos de la piridinil 1,2-oxaborolan-2-ol fosfodiesterasa 4
NI201000049A (es) Método para producir 2'-desoxi-5-azacitidina (decitabina)
CR10671A (es) Compuestos azabiciclicos como inhibidores de la recaptacion de monoaminas
AR061806A1 (es) Derivados de alquilpiridazina como inhibidores de 11b-hsd1 (t2d)

Legal Events

Date Code Title Description
FA Abandonment or withdrawal