SK288050B6 - Octahydro-6,10-dioxo-6H-pyridazino[1,2-a] [1,2]diazepin-1- carboxylic acid derivatives, preparation method, intermediates and use for preparing therapeutically active compounds - Google Patents

Octahydro-6,10-dioxo-6H-pyridazino[1,2-a] [1,2]diazepin-1- carboxylic acid derivatives, preparation method, intermediates and use for preparing therapeutically active compounds Download PDF

Info

Publication number: SK288050B6
Authority: SK; Slovakia
Prior art keywords: formula; compound; dioxo; carbon atoms; group containing
Prior art date: 1998-04-27

Application number

SK1600-2000A

Other languages

English (en)

Slovak (sk)

Other versions

SK16002000A3 (sk

Inventor

Colette Colladant

Veronique Crocq

John Patrick Larkin

Patrick Roussel

Original Assignee

Aventis Pharma S. A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-27

Filing date

1999-04-26

Publication date

2013-03-01

1999-04-26 Application filed by Aventis Pharma S. A. filed Critical Aventis Pharma S. A.

2001-09-11 Publication of SK16002000A3 publication Critical patent/SK16002000A3/sk

2013-03-01 Publication of SK288050B6 publication Critical patent/SK288050B6/sk

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)

SK1600-2000A 1998-04-27 1999-04-26 Octahydro-6,10-dioxo-6H-pyridazino[1,2-a] [1,2]diazepin-1- carboxylic acid derivatives, preparation method, intermediates and use for preparing therapeutically active compounds SK288050B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9805243A FR2777889B1 (fr)	1998-04-27	1998-04-27	Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs
PCT/FR1999/000981 WO1999055724A1 (fr)	1998-04-27	1999-04-26	NOUVEAUX DERIVES DE L'ACIDE OCTAHYDRO-6,10-DIOXO-6H-PYRIDAZINO[1,2-a] [1,2] DIAZEPINE-1-CARBOXYLIQUE, LEUR PROCEDE DE PREPARATION ET LEUR APPLICATION A LA PREPARATION DE COMPOSES THERAPEUTIQUEMENT ACTIFS

Publications (2)

Publication Number	Publication Date
SK16002000A3 SK16002000A3 (sk)	2001-09-11
SK288050B6 true SK288050B6 (sk)	2013-03-01

Family

ID=9525705

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1600-2000A SK288050B6 (sk)	1998-04-27	1999-04-26	Octahydro-6,10-dioxo-6H-pyridazino[1,2-a] [1,2]diazepin-1- carboxylic acid derivatives, preparation method, intermediates and use for preparing therapeutically active compounds

Country Status (37)

Country	Link
US (3)	US6548664B1 (es)
EP (1)	EP1073673B1 (es)
JP (2)	JP4332298B2 (es)
KR (1)	KR100561582B1 (es)
CN (1)	CN1167711C (es)
AP (1)	AP1518A (es)
AR (1)	AR016466A1 (es)
AU (1)	AU755286B2 (es)
BG (1)	BG65282B1 (es)
BR (1)	BR9910020A (es)
CA (1)	CA2330492C (es)
CU (1)	CU23155A3 (es)
CY (1)	CY1107599T1 (es)
DE (1)	DE69934790T2 (es)
DK (1)	DK1073673T3 (es)
EA (1)	EA003280B1 (es)
EE (1)	EE04682B1 (es)
ES (1)	ES2279617T3 (es)
FR (1)	FR2777889B1 (es)
GE (1)	GEP20033119B (es)
HR (1)	HRP20000733B1 (es)
HU (1)	HU230060B1 (es)
ID (1)	ID26292A (es)
IL (3)	IL139102A0 (es)
ME (2)	ME00300B (es)
NO (1)	NO328864B1 (es)
NZ (1)	NZ507618A (es)
PL (1)	PL203762B1 (es)
PT (1)	PT1073673E (es)
RS (1)	RS50423B (es)
SI (1)	SI1073673T1 (es)
SK (1)	SK288050B6 (es)
TR (1)	TR200003142T2 (es)
TW (1)	TWI249537B (es)
UA (1)	UA71913C2 (es)
WO (1)	WO1999055724A1 (es)
ZA (1)	ZA200006081B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6177565B1 (en)	1998-08-19	2001-01-23	Vertex Pharmaceuticals Inc.	Process for synthesizing piperazic acid
US6201118B1 (en)	1998-08-19	2001-03-13	Vertex Pharmaceuticals Inc.	Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor
FR2853901B1 (fr) *	2003-04-16	2005-06-17	Isochem Sa	Procede de preparation de derives de l'acide hexahydropyridazine-3-carboxylique
WO2005028449A1 (en) *	2003-06-26	2005-03-31	Honeywell Specialty Chemicals Seelze Gmbh	Improved process for the manufacture of 1,2-disubstituted hexahydropyridazine-3-carboxylic acids and esters thereof
CN100404516C (zh) *	2004-02-13	2008-07-23	大连绿源药业有限责任公司	六氢哒嗪三羧酸酯的制备方法
WO2005122682A2 (en)	2004-06-18	2005-12-29	Ranbaxy Laboratories Limited	Process for the preparation of esters of piperazic acid
WO2012049646A1 (en)	2010-10-12	2012-04-19	Ranbaxy Laboratories Limited	Process for the preparation of an intermediate of cilazapril

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6204261B1 (en) *	1995-12-20	2001-03-20	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β Converting enzyme inhibitors
GB2128984B (en) *	1982-05-12	1985-05-22	Hoffmann La Roche	Diaza-bicyclic compounds
US5552397A (en) *	1992-05-18	1996-09-03	E. R. Squibb & Sons, Inc.	Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
HU223663B1 (hu) *	1992-05-15	2004-11-29	Merrel Dow Pharmaceuticals Inc.	Enkefalináz és ACE gátló hatású 9-[(2-acetil-tio-3-fenil)-propanoil-amino]-piridazo[1,2-a][1,2]diazepin-származékok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
US5552400A (en) *	1994-06-08	1996-09-03	Sterling Winthrop Inc.	Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors
US5756466A (en) *	1994-06-17	1998-05-26	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US6177565B1 (en) *	1998-08-19	2001-01-23	Vertex Pharmaceuticals Inc.	Process for synthesizing piperazic acid
US6201118B1 (en) *	1998-08-19	2001-03-13	Vertex Pharmaceuticals Inc.	Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor

1998
- 1998-04-27 FR FR9805243A patent/FR2777889B1/fr not_active Expired - Lifetime
1999
- 1999-04-07 TW TW088105540A patent/TWI249537B/zh not_active IP Right Cessation
- 1999-04-22 AR ARP990101859A patent/AR016466A1/es not_active Application Discontinuation
- 1999-04-26 ME MEP-2008-408A patent/ME00300B/me unknown
- 1999-04-26 JP JP2000545882A patent/JP4332298B2/ja not_active Expired - Fee Related
- 1999-04-26 EP EP99915834A patent/EP1073673B1/fr not_active Expired - Lifetime
- 1999-04-26 PL PL343720A patent/PL203762B1/pl unknown
- 1999-04-26 HU HU0102447A patent/HU230060B1/hu not_active IP Right Cessation
- 1999-04-26 SK SK1600-2000A patent/SK288050B6/sk not_active IP Right Cessation
- 1999-04-26 EE EEP200000619A patent/EE04682B1/xx unknown
- 1999-04-26 PT PT99915834T patent/PT1073673E/pt unknown
- 1999-04-26 DE DE69934790T patent/DE69934790T2/de not_active Expired - Lifetime
- 1999-04-26 DK DK99915834T patent/DK1073673T3/da active
- 1999-04-26 ES ES99915834T patent/ES2279617T3/es not_active Expired - Lifetime
- 1999-04-26 RS YUP-658/00A patent/RS50423B/sr unknown
- 1999-04-26 US US09/674,327 patent/US6548664B1/en not_active Expired - Lifetime
- 1999-04-26 HR HR20000733A patent/HRP20000733B1/xx not_active IP Right Cessation
- 1999-04-26 WO PCT/FR1999/000981 patent/WO1999055724A1/fr not_active Ceased
- 1999-04-26 CA CA2330492A patent/CA2330492C/fr not_active Expired - Fee Related
- 1999-04-26 AP APAP/P/2000/001973A patent/AP1518A/en active
- 1999-04-26 ME MEP-408/08A patent/MEP40808A/xx unknown
- 1999-04-26 BR BR9910020-7A patent/BR9910020A/pt not_active IP Right Cessation
- 1999-04-26 EA EA200001107A patent/EA003280B1/ru not_active IP Right Cessation
- 1999-04-26 IL IL13910299A patent/IL139102A0/xx active IP Right Grant
- 1999-04-26 UA UA2000116680A patent/UA71913C2/uk unknown
- 1999-04-26 SI SI9930952T patent/SI1073673T1/sl unknown
- 1999-04-26 TR TR2000/03142T patent/TR200003142T2/xx unknown
- 1999-04-26 AU AU34274/99A patent/AU755286B2/en not_active Ceased
- 1999-04-26 NZ NZ507618A patent/NZ507618A/en not_active IP Right Cessation
- 1999-04-26 ID IDW20002188A patent/ID26292A/id unknown
- 1999-04-26 KR KR1020007011895A patent/KR100561582B1/ko not_active Expired - Fee Related
- 1999-04-26 CN CNB998076139A patent/CN1167711C/zh not_active Expired - Fee Related
- 1999-04-26 GE GEAP19995634A patent/GEP20033119B/en unknown
2000
- 2000-10-18 IL IL139102A patent/IL139102A/en not_active IP Right Cessation
- 2000-10-25 CU CU229A patent/CU23155A3/es unknown
- 2000-10-26 BG BG104891A patent/BG65282B1/bg unknown
- 2000-10-26 NO NO20005391A patent/NO328864B1/no not_active IP Right Cessation
- 2000-10-27 ZA ZA200006081A patent/ZA200006081B/xx unknown
2002
- 2002-03-20 US US10/102,591 patent/US6570012B2/en not_active Expired - Lifetime
- 2002-12-06 US US10/313,422 patent/US20030130269A1/en not_active Abandoned
2007
- 2007-03-22 CY CY20071100404T patent/CY1107599T1/el unknown
2008
- 2008-03-12 IL IL190120A patent/IL190120A/en not_active IP Right Cessation
2009
- 2009-04-10 JP JP2009096241A patent/JP5101558B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1073673B1 (fr)	2007-01-10
US20030130269A1 (en)	2003-07-10
BR9910020A (pt)	2001-01-09
RS50423B (sr)	2009-12-31
BG104891A (en)	2001-10-31
HRP20000733A2 (en)	2001-02-28
ZA200006081B (en)	2001-10-29
IL139102A (en)	2008-06-05
PL203762B1 (pl)	2009-11-30
IL190120A0 (en)	2008-08-07
WO1999055724A1 (fr)	1999-11-04
EA200001107A1 (ru)	2001-04-23
CA2330492A1 (fr)	1999-11-04
IL190120A (en)	2011-10-31
KR20010043033A (ko)	2001-05-25
HUP0102447A2 (hu)	2001-11-28
TR200003142T2 (tr)	2001-03-21
EA003280B1 (ru)	2003-04-24
CU23155A3 (es)	2006-07-18
SI1073673T1 (sl)	2007-04-30
DE69934790T2 (de)	2007-10-31
CN1167711C (zh)	2004-09-22
DK1073673T3 (da)	2007-05-07
MEP40808A (en)	2011-02-10
NO20005391D0 (no)	2000-10-26
JP5101558B2 (ja)	2012-12-19
CY1107599T1 (el)	2013-03-13
KR100561582B1 (ko)	2006-03-20
CN1306539A (zh)	2001-08-01
US20020128473A1 (en)	2002-09-12
SK16002000A3 (sk)	2001-09-11
TWI249537B (en)	2006-02-21
FR2777889A1 (fr)	1999-10-29
UA71913C2 (uk)	2005-01-17
JP4332298B2 (ja)	2009-09-16
PT1073673E (pt)	2007-03-30
HRP20000733B1 (hr)	2009-06-30
BG65282B1 (bg)	2007-11-30
ES2279617T3 (es)	2007-08-16
HUP0102447A3 (en)	2003-05-28
NO328864B1 (no)	2010-05-31
NO20005391L (no)	2000-12-19
ME00300B (me)	2011-05-10
AP1518A (en)	2005-12-12
AU3427499A (en)	1999-11-16
IL139102A0 (en)	2001-11-25
YU65800A (sh)	2003-01-31
FR2777889B1 (fr)	2004-07-09
HK1039131A1 (en)	2002-04-12
CA2330492C (fr)	2012-03-13
DE69934790D1 (de)	2007-02-22
PL343720A1 (en)	2001-09-10
AU755286B2 (en)	2002-12-05
EE04682B1 (et)	2006-08-15
HU230060B1 (hu)	2015-06-29
JP2009155343A (ja)	2009-07-16
EP1073673A1 (fr)	2001-02-07
ID26292A (id)	2000-12-14
JP2002513030A (ja)	2002-05-08
AP2000001973A0 (en)	2000-12-31
NZ507618A (en)	2003-07-25
EE200000619A (et)	2002-06-17
GEP20033119B (en)	2003-11-25
US6570012B2 (en)	2003-05-27
AR016466A1 (es)	2001-07-04
US6548664B1 (en)	2003-04-15

Publication	Publication Date	Title
JP5101558B2 (ja)	2012-12-19	オクタヒドロ−６，１０−ジオキソ−６Ｈ−ピリダジノ［１，２−ａ］［１，２］ジアゼピン−１−カルボン酸の新規な誘導体
AU2003200034B2 (en)	2006-07-20	New derivatives of octahydro-6, 10-dioxo-6H-pyridazino [1,2-A][1,2]diazepine-1-carboxylic acid, their preparation process and their use in the preparation of therapeutically active compounds
FR2878524A1 (fr)	2006-06-02	Nouveaux derives d'arylpiperazine
CA2166470C (en)	2001-12-18	Pharmacologically active enantiomers
CZ20003956A3 (cs)	2001-05-16	Nové deriváty oktahydro-6,10-dioxo-6Hpyridazino[ 1,2-a][1,2]diazepin-l-karboxylové kyseliny, způsob jejich přípravy a jejich použití při přípravě terapeuticky aktivních sloučenin.
EP1280780A2 (en)	2003-02-05	Asymmetric synthesis of piperazic acid and derivatives thereof
CA1265806A (en)	1990-02-13	1-cyclohexyl-3,4-dihydroisoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them
JP4601826B2 (ja)	2010-12-22	二環式化合物の製造方法及びこの方法のｉｃｅ阻害剤化合物の製造への使用
MXPA00010457A (es)	2001-09-07	Novedosos derivados del acido octahidro-6, 10-dioxo-6h-piridazino [1,2-a][1,2]diazepin-1-carboxilico, su procedimiento de preparacion y su aplicacion para la preparacion de compuestos terapeuticamente activos
HK1039131B (en)	2005-05-13	Derivatives of octahydro-6,10-dioxo-6h-pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid, the preparation process and the use thereof

Legal Events

Date	Code	Title	Description
2019-01-08	MM4A	Patent lapsed due to non-payment of maintenance fees	Effective date: 20180426