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EE04682B1 - Oktahdro-6,10-diokso-6H-pridasino[1,2-a][1,2]diasepiin-1-karbokslhappe derivaadid, nende ratseemiline segu, valmistamismeetod ja kasutamine - Google Patents

Oktahdro-6,10-diokso-6H-pridasino[1,2-a][1,2]diasepiin-1-karbokslhappe derivaadid, nende ratseemiline segu, valmistamismeetod ja kasutamine

Info

Publication number
EE04682B1
EE04682B1 EEP200000619A EEP200000619A EE04682B1 EE 04682 B1 EE04682 B1 EE 04682B1 EE P200000619 A EEP200000619 A EE P200000619A EE P200000619 A EEP200000619 A EE P200000619A EE 04682 B1 EE04682 B1 EE 04682B1
Authority
EE
Estonia
Prior art keywords
pyridazino
diazepine
dioxo
preparation
carboxylic acid
Prior art date
Application number
EEP200000619A
Other languages
English (en)
Estonian (et)
Inventor
Colladant Colette
Crocq V�ronique
Patrick Larkin John
Roussel Patrick
Original Assignee
Hoechst Marion Roussel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel filed Critical Hoechst Marion Roussel
Publication of EE200000619A publication Critical patent/EE200000619A/xx
Publication of EE04682B1 publication Critical patent/EE04682B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
EEP200000619A 1998-04-27 1999-04-26 Oktahdro-6,10-diokso-6H-pridasino[1,2-a][1,2]diasepiin-1-karbokslhappe derivaadid, nende ratseemiline segu, valmistamismeetod ja kasutamine EE04682B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9805243A FR2777889B1 (fr) 1998-04-27 1998-04-27 Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs
PCT/FR1999/000981 WO1999055724A1 (fr) 1998-04-27 1999-04-26 NOUVEAUX DERIVES DE L'ACIDE OCTAHYDRO-6,10-DIOXO-6H-PYRIDAZINO[1,2-a] [1,2] DIAZEPINE-1-CARBOXYLIQUE, LEUR PROCEDE DE PREPARATION ET LEUR APPLICATION A LA PREPARATION DE COMPOSES THERAPEUTIQUEMENT ACTIFS

Publications (2)

Publication Number Publication Date
EE200000619A EE200000619A (et) 2002-06-17
EE04682B1 true EE04682B1 (et) 2006-08-15

Family

ID=9525705

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000619A EE04682B1 (et) 1998-04-27 1999-04-26 Oktahdro-6,10-diokso-6H-pridasino[1,2-a][1,2]diasepiin-1-karbokslhappe derivaadid, nende ratseemiline segu, valmistamismeetod ja kasutamine

Country Status (37)

Country Link
US (3) US6548664B1 (xx)
EP (1) EP1073673B1 (xx)
JP (2) JP4332298B2 (xx)
KR (1) KR100561582B1 (xx)
CN (1) CN1167711C (xx)
AP (1) AP1518A (xx)
AR (1) AR016466A1 (xx)
AU (1) AU755286B2 (xx)
BG (1) BG65282B1 (xx)
BR (1) BR9910020A (xx)
CA (1) CA2330492C (xx)
CU (1) CU23155A3 (xx)
CY (1) CY1107599T1 (xx)
DE (1) DE69934790T2 (xx)
DK (1) DK1073673T3 (xx)
EA (1) EA003280B1 (xx)
EE (1) EE04682B1 (xx)
ES (1) ES2279617T3 (xx)
FR (1) FR2777889B1 (xx)
GE (1) GEP20033119B (xx)
HR (1) HRP20000733B1 (xx)
HU (1) HU230060B1 (xx)
ID (1) ID26292A (xx)
IL (3) IL139102A0 (xx)
ME (2) MEP40808A (xx)
NO (1) NO328864B1 (xx)
NZ (1) NZ507618A (xx)
PL (1) PL203762B1 (xx)
PT (1) PT1073673E (xx)
RS (1) RS50423B (xx)
SI (1) SI1073673T1 (xx)
SK (1) SK288050B6 (xx)
TR (1) TR200003142T2 (xx)
TW (1) TWI249537B (xx)
UA (1) UA71913C2 (xx)
WO (1) WO1999055724A1 (xx)
ZA (1) ZA200006081B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6201118B1 (en) 1998-08-19 2001-03-13 Vertex Pharmaceuticals Inc. Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor
US6177565B1 (en) 1998-08-19 2001-01-23 Vertex Pharmaceuticals Inc. Process for synthesizing piperazic acid
FR2853901B1 (fr) * 2003-04-16 2005-06-17 Isochem Sa Procede de preparation de derives de l'acide hexahydropyridazine-3-carboxylique
WO2005028449A1 (en) * 2003-06-26 2005-03-31 Honeywell Specialty Chemicals Seelze Gmbh Improved process for the manufacture of 1,2-disubstituted hexahydropyridazine-3-carboxylic acids and esters thereof
CN100404516C (zh) * 2004-02-13 2008-07-23 大连绿源药业有限责任公司 六氢哒嗪三羧酸酯的制备方法
WO2005122682A2 (en) 2004-06-18 2005-12-29 Ranbaxy Laboratories Limited Process for the preparation of esters of piperazic acid
WO2012049646A1 (en) 2010-10-12 2012-04-19 Ranbaxy Laboratories Limited Process for the preparation of an intermediate of cilazapril

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
HU223663B1 (hu) * 1992-05-15 2004-11-29 Merrel Dow Pharmaceuticals Inc. Enkefalináz és ACE gátló hatású 9-[(2-acetil-tio-3-fenil)-propanoil-amino]-piridazo[1,2-a][1,2]diazepin-származékok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
US5552400A (en) * 1994-06-08 1996-09-03 Sterling Winthrop Inc. Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors
US5756466A (en) * 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US6201118B1 (en) * 1998-08-19 2001-03-13 Vertex Pharmaceuticals Inc. Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor
US6177565B1 (en) * 1998-08-19 2001-01-23 Vertex Pharmaceuticals Inc. Process for synthesizing piperazic acid

Also Published As

Publication number Publication date
RS50423B (sr) 2009-12-31
WO1999055724A1 (fr) 1999-11-04
HUP0102447A2 (hu) 2001-11-28
EE200000619A (et) 2002-06-17
CA2330492A1 (fr) 1999-11-04
JP2002513030A (ja) 2002-05-08
NO328864B1 (no) 2010-05-31
HUP0102447A3 (en) 2003-05-28
HRP20000733A2 (en) 2001-02-28
IL190120A (en) 2011-10-31
SI1073673T1 (sl) 2007-04-30
IL190120A0 (en) 2008-08-07
AU3427499A (en) 1999-11-16
SK288050B6 (sk) 2013-03-01
PL203762B1 (pl) 2009-11-30
CN1167711C (zh) 2004-09-22
HK1039131A1 (en) 2002-04-12
CA2330492C (fr) 2012-03-13
NO20005391L (no) 2000-12-19
EA200001107A1 (ru) 2001-04-23
DK1073673T3 (da) 2007-05-07
NZ507618A (en) 2003-07-25
AP1518A (en) 2005-12-12
AU755286B2 (en) 2002-12-05
ZA200006081B (en) 2001-10-29
US6570012B2 (en) 2003-05-27
US20020128473A1 (en) 2002-09-12
DE69934790D1 (de) 2007-02-22
CN1306539A (zh) 2001-08-01
ID26292A (id) 2000-12-14
ES2279617T3 (es) 2007-08-16
EP1073673B1 (fr) 2007-01-10
KR100561582B1 (ko) 2006-03-20
CU23155A3 (es) 2006-07-18
CY1107599T1 (el) 2013-03-13
GEP20033119B (en) 2003-11-25
AP2000001973A0 (en) 2000-12-31
HRP20000733B1 (hr) 2009-06-30
SK16002000A3 (sk) 2001-09-11
BG65282B1 (bg) 2007-11-30
US20030130269A1 (en) 2003-07-10
JP4332298B2 (ja) 2009-09-16
NO20005391D0 (no) 2000-10-26
ME00300B (me) 2011-05-10
JP2009155343A (ja) 2009-07-16
IL139102A0 (en) 2001-11-25
BG104891A (en) 2001-10-31
IL139102A (en) 2008-06-05
EA003280B1 (ru) 2003-04-24
EP1073673A1 (fr) 2001-02-07
AR016466A1 (es) 2001-07-04
FR2777889A1 (fr) 1999-10-29
HU230060B1 (hu) 2015-06-29
US6548664B1 (en) 2003-04-15
PT1073673E (pt) 2007-03-30
DE69934790T2 (de) 2007-10-31
YU65800A (sh) 2003-01-31
UA71913C2 (uk) 2005-01-17
TR200003142T2 (tr) 2001-03-21
PL343720A1 (en) 2001-09-10
BR9910020A (pt) 2001-01-09
MEP40808A (en) 2011-02-10
FR2777889B1 (fr) 2004-07-09
TWI249537B (en) 2006-02-21
JP5101558B2 (ja) 2012-12-19
KR20010043033A (ko) 2001-05-25

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Legal Events

Date Code Title Description
GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231