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AR016466A1 - Nuevos derivados del acido octahidro-6,10-dioxo-6h-piridazino[1,2-a][1,2]-diazepin-1-carboxilico, su procedimiento de preparacion y su aplicacion a lapreparacion de compuestos terapeuticamente activos - Google Patents

Nuevos derivados del acido octahidro-6,10-dioxo-6h-piridazino[1,2-a][1,2]-diazepin-1-carboxilico, su procedimiento de preparacion y su aplicacion a lapreparacion de compuestos terapeuticamente activos

Info

Publication number
AR016466A1
AR016466A1 ARP990101859A ARP990101859A AR016466A1 AR 016466 A1 AR016466 A1 AR 016466A1 AR P990101859 A ARP990101859 A AR P990101859A AR P990101859 A ARP990101859 A AR P990101859A AR 016466 A1 AR016466 A1 AR 016466A1
Authority
AR
Argentina
Prior art keywords
preparation
piridazino
octahidro
diazepin
dioxo
Prior art date
Application number
ARP990101859A
Other languages
English (en)
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of AR016466A1 publication Critical patent/AR016466A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La invencion tiene por objeto los compuestos de formula (I), de configuracion SR o en forma de mezcla SR + SS, en la que R representa un átomo dehidrogeno, un radical alquilo o aralquilo C1-18, pudiendo estar la funcion amina libre o protegida. Losc ompuestos de formula (I) pueden ser utilizados parapreparar principios activos de medicamentos.
ARP990101859A 1998-04-27 1999-04-22 Nuevos derivados del acido octahidro-6,10-dioxo-6h-piridazino[1,2-a][1,2]-diazepin-1-carboxilico, su procedimiento de preparacion y su aplicacion a lapreparacion de compuestos terapeuticamente activos AR016466A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9805243A FR2777889B1 (fr) 1998-04-27 1998-04-27 Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs

Publications (1)

Publication Number Publication Date
AR016466A1 true AR016466A1 (es) 2001-07-04

Family

ID=9525705

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990101859A AR016466A1 (es) 1998-04-27 1999-04-22 Nuevos derivados del acido octahidro-6,10-dioxo-6h-piridazino[1,2-a][1,2]-diazepin-1-carboxilico, su procedimiento de preparacion y su aplicacion a lapreparacion de compuestos terapeuticamente activos

Country Status (37)

Country Link
US (3) US6548664B1 (es)
EP (1) EP1073673B1 (es)
JP (2) JP4332298B2 (es)
KR (1) KR100561582B1 (es)
CN (1) CN1167711C (es)
AP (1) AP1518A (es)
AR (1) AR016466A1 (es)
AU (1) AU755286B2 (es)
BG (1) BG65282B1 (es)
BR (1) BR9910020A (es)
CA (1) CA2330492C (es)
CU (1) CU23155A3 (es)
CY (1) CY1107599T1 (es)
DE (1) DE69934790T2 (es)
DK (1) DK1073673T3 (es)
EA (1) EA003280B1 (es)
EE (1) EE04682B1 (es)
ES (1) ES2279617T3 (es)
FR (1) FR2777889B1 (es)
GE (1) GEP20033119B (es)
HR (1) HRP20000733B1 (es)
HU (1) HU230060B1 (es)
ID (1) ID26292A (es)
IL (3) IL139102A0 (es)
ME (2) MEP40808A (es)
NO (1) NO328864B1 (es)
NZ (1) NZ507618A (es)
PL (1) PL203762B1 (es)
PT (1) PT1073673E (es)
RS (1) RS50423B (es)
SI (1) SI1073673T1 (es)
SK (1) SK288050B6 (es)
TR (1) TR200003142T2 (es)
TW (1) TWI249537B (es)
UA (1) UA71913C2 (es)
WO (1) WO1999055724A1 (es)
ZA (1) ZA200006081B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6201118B1 (en) 1998-08-19 2001-03-13 Vertex Pharmaceuticals Inc. Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor
US6177565B1 (en) 1998-08-19 2001-01-23 Vertex Pharmaceuticals Inc. Process for synthesizing piperazic acid
FR2853901B1 (fr) * 2003-04-16 2005-06-17 Isochem Sa Procede de preparation de derives de l'acide hexahydropyridazine-3-carboxylique
WO2005028449A1 (en) * 2003-06-26 2005-03-31 Honeywell Specialty Chemicals Seelze Gmbh Improved process for the manufacture of 1,2-disubstituted hexahydropyridazine-3-carboxylic acids and esters thereof
CN100404516C (zh) * 2004-02-13 2008-07-23 大连绿源药业有限责任公司 六氢哒嗪三羧酸酯的制备方法
WO2005122682A2 (en) 2004-06-18 2005-12-29 Ranbaxy Laboratories Limited Process for the preparation of esters of piperazic acid
WO2012049646A1 (en) 2010-10-12 2012-04-19 Ranbaxy Laboratories Limited Process for the preparation of an intermediate of cilazapril

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
HU223663B1 (hu) * 1992-05-15 2004-11-29 Merrel Dow Pharmaceuticals Inc. Enkefalináz és ACE gátló hatású 9-[(2-acetil-tio-3-fenil)-propanoil-amino]-piridazo[1,2-a][1,2]diazepin-származékok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
US5552400A (en) * 1994-06-08 1996-09-03 Sterling Winthrop Inc. Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors
US5756466A (en) * 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US6201118B1 (en) * 1998-08-19 2001-03-13 Vertex Pharmaceuticals Inc. Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor
US6177565B1 (en) * 1998-08-19 2001-01-23 Vertex Pharmaceuticals Inc. Process for synthesizing piperazic acid

Also Published As

Publication number Publication date
RS50423B (sr) 2009-12-31
WO1999055724A1 (fr) 1999-11-04
HUP0102447A2 (hu) 2001-11-28
EE200000619A (et) 2002-06-17
EE04682B1 (et) 2006-08-15
CA2330492A1 (fr) 1999-11-04
JP2002513030A (ja) 2002-05-08
NO328864B1 (no) 2010-05-31
HUP0102447A3 (en) 2003-05-28
HRP20000733A2 (en) 2001-02-28
IL190120A (en) 2011-10-31
SI1073673T1 (sl) 2007-04-30
IL190120A0 (en) 2008-08-07
AU3427499A (en) 1999-11-16
SK288050B6 (sk) 2013-03-01
PL203762B1 (pl) 2009-11-30
CN1167711C (zh) 2004-09-22
HK1039131A1 (en) 2002-04-12
CA2330492C (fr) 2012-03-13
NO20005391L (no) 2000-12-19
EA200001107A1 (ru) 2001-04-23
DK1073673T3 (da) 2007-05-07
NZ507618A (en) 2003-07-25
AP1518A (en) 2005-12-12
AU755286B2 (en) 2002-12-05
ZA200006081B (en) 2001-10-29
US6570012B2 (en) 2003-05-27
US20020128473A1 (en) 2002-09-12
DE69934790D1 (de) 2007-02-22
CN1306539A (zh) 2001-08-01
ID26292A (id) 2000-12-14
ES2279617T3 (es) 2007-08-16
EP1073673B1 (fr) 2007-01-10
KR100561582B1 (ko) 2006-03-20
CU23155A3 (es) 2006-07-18
CY1107599T1 (el) 2013-03-13
GEP20033119B (en) 2003-11-25
AP2000001973A0 (en) 2000-12-31
HRP20000733B1 (hr) 2009-06-30
SK16002000A3 (sk) 2001-09-11
BG65282B1 (bg) 2007-11-30
US20030130269A1 (en) 2003-07-10
JP4332298B2 (ja) 2009-09-16
NO20005391D0 (no) 2000-10-26
ME00300B (me) 2011-05-10
JP2009155343A (ja) 2009-07-16
IL139102A0 (en) 2001-11-25
BG104891A (en) 2001-10-31
IL139102A (en) 2008-06-05
EA003280B1 (ru) 2003-04-24
EP1073673A1 (fr) 2001-02-07
FR2777889A1 (fr) 1999-10-29
HU230060B1 (hu) 2015-06-29
US6548664B1 (en) 2003-04-15
PT1073673E (pt) 2007-03-30
DE69934790T2 (de) 2007-10-31
YU65800A (sh) 2003-01-31
UA71913C2 (uk) 2005-01-17
TR200003142T2 (tr) 2001-03-21
PL343720A1 (en) 2001-09-10
BR9910020A (pt) 2001-01-09
MEP40808A (en) 2011-02-10
FR2777889B1 (fr) 2004-07-09
TWI249537B (en) 2006-02-21
JP5101558B2 (ja) 2012-12-19
KR20010043033A (ko) 2001-05-25

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