HRP20000733B1 - NOVI DERIVATI OKTAHIDRO-6,10-DIOKSO-6H-PIRIDAZINO [1,2-a] [1,2]DIAZEPIN-1-KARBOKSILNE KISELINE, POSTUPAK NJIHOVOG DOBIVANJA I UPOTREBA U DOBIVANJU TERAPEUTSKI AKTIVNIH SPOJEVA - Google Patents

NOVI DERIVATI OKTAHIDRO-6,10-DIOKSO-6H-PIRIDAZINO [1,2-a] [1,2]DIAZEPIN-1-KARBOKSILNE KISELINE, POSTUPAK NJIHOVOG DOBIVANJA I UPOTREBA U DOBIVANJU TERAPEUTSKI AKTIVNIH SPOJEVA

Info

Publication number: HRP20000733B1
Authority: HR; Croatia
Prior art keywords: oxtahidro; piridazino; diazepine; dioxo; new
Prior art date: 1998-04-27

Application number

HR20000733A

Other languages

English (en)

Croatian (hr)

Inventor

Colladant Colette

Crocq Veronique

Patrick Larkin John

Roussel Patrick

Original Assignee

Aventis Pharma S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-27

Filing date

1999-04-26

Publication date

2009-06-30

1999-04-26 Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.

2001-02-28 Publication of HRP20000733A2 publication Critical patent/HRP20000733A2/hr

2009-06-30 Publication of HRP20000733B1 publication Critical patent/HRP20000733B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)

HR20000733A 1998-04-27 1999-04-26 NOVI DERIVATI OKTAHIDRO-6,10-DIOKSO-6H-PIRIDAZINO [1,2-a] [1,2]DIAZEPIN-1-KARBOKSILNE KISELINE, POSTUPAK NJIHOVOG DOBIVANJA I UPOTREBA U DOBIVANJU TERAPEUTSKI AKTIVNIH SPOJEVA HRP20000733B1 (hr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9805243A FR2777889B1 (fr)	1998-04-27	1998-04-27	Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs
PCT/FR1999/000981 WO1999055724A1 (fr)	1998-04-27	1999-04-26	NOUVEAUX DERIVES DE L'ACIDE OCTAHYDRO-6,10-DIOXO-6H-PYRIDAZINO[1,2-a] [1,2] DIAZEPINE-1-CARBOXYLIQUE, LEUR PROCEDE DE PREPARATION ET LEUR APPLICATION A LA PREPARATION DE COMPOSES THERAPEUTIQUEMENT ACTIFS

Publications (2)

Publication Number	Publication Date
HRP20000733A2 HRP20000733A2 (en)	2001-02-28
HRP20000733B1 true HRP20000733B1 (hr)	2009-06-30

Family

ID=9525705

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20000733A HRP20000733B1 (hr)	1998-04-27	1999-04-26	NOVI DERIVATI OKTAHIDRO-6,10-DIOKSO-6H-PIRIDAZINO [1,2-a] [1,2]DIAZEPIN-1-KARBOKSILNE KISELINE, POSTUPAK NJIHOVOG DOBIVANJA I UPOTREBA U DOBIVANJU TERAPEUTSKI AKTIVNIH SPOJEVA

Country Status (37)

Country	Link
US (3)	US6548664B1 (es)
EP (1)	EP1073673B1 (es)
JP (2)	JP4332298B2 (es)
KR (1)	KR100561582B1 (es)
CN (1)	CN1167711C (es)
AP (1)	AP1518A (es)
AR (1)	AR016466A1 (es)
AU (1)	AU755286B2 (es)
BG (1)	BG65282B1 (es)
BR (1)	BR9910020A (es)
CA (1)	CA2330492C (es)
CU (1)	CU23155A3 (es)
CY (1)	CY1107599T1 (es)
DE (1)	DE69934790T2 (es)
DK (1)	DK1073673T3 (es)
EA (1)	EA003280B1 (es)
EE (1)	EE04682B1 (es)
ES (1)	ES2279617T3 (es)
FR (1)	FR2777889B1 (es)
GE (1)	GEP20033119B (es)
HR (1)	HRP20000733B1 (es)
HU (1)	HU230060B1 (es)
ID (1)	ID26292A (es)
IL (3)	IL139102A0 (es)
ME (2)	MEP40808A (es)
NO (1)	NO328864B1 (es)
NZ (1)	NZ507618A (es)
PL (1)	PL203762B1 (es)
PT (1)	PT1073673E (es)
RS (1)	RS50423B (es)
SI (1)	SI1073673T1 (es)
SK (1)	SK288050B6 (es)
TR (1)	TR200003142T2 (es)
TW (1)	TWI249537B (es)
UA (1)	UA71913C2 (es)
WO (1)	WO1999055724A1 (es)
ZA (1)	ZA200006081B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6201118B1 (en)	1998-08-19	2001-03-13	Vertex Pharmaceuticals Inc.	Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor
US6177565B1 (en)	1998-08-19	2001-01-23	Vertex Pharmaceuticals Inc.	Process for synthesizing piperazic acid
FR2853901B1 (fr) *	2003-04-16	2005-06-17	Isochem Sa	Procede de preparation de derives de l'acide hexahydropyridazine-3-carboxylique
WO2005028449A1 (en) *	2003-06-26	2005-03-31	Honeywell Specialty Chemicals Seelze Gmbh	Improved process for the manufacture of 1,2-disubstituted hexahydropyridazine-3-carboxylic acids and esters thereof
CN100404516C (zh) *	2004-02-13	2008-07-23	大连绿源药业有限责任公司	六氢哒嗪三羧酸酯的制备方法
WO2005122682A2 (en)	2004-06-18	2005-12-29	Ranbaxy Laboratories Limited	Process for the preparation of esters of piperazic acid
WO2012049646A1 (en)	2010-10-12	2012-04-19	Ranbaxy Laboratories Limited	Process for the preparation of an intermediate of cilazapril

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4512924A (en) *	1982-05-12	1985-04-23	Hoffmann-La Roche Inc.	Pyridazo[1,2-a][1,2]diazepines
WO1993023403A1 (en) *	1992-05-15	1993-11-25	Merrell Dow Pharmaceuticals Inc.	NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE
US5723602A (en) *	1992-05-18	1998-03-03	E. R. Squibb & Sons, Inc.	Dual action inhibitors containing a pyridazinodiazepine or pyrazolodiazepine lactam ring

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6204261B1 (en) *	1995-12-20	2001-03-20	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β Converting enzyme inhibitors
US5552400A (en) *	1994-06-08	1996-09-03	Sterling Winthrop Inc.	Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors
US5756466A (en) *	1994-06-17	1998-05-26	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US6201118B1 (en) *	1998-08-19	2001-03-13	Vertex Pharmaceuticals Inc.	Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor
US6177565B1 (en) *	1998-08-19	2001-01-23	Vertex Pharmaceuticals Inc.	Process for synthesizing piperazic acid

1998
- 1998-04-27 FR FR9805243A patent/FR2777889B1/fr not_active Expired - Lifetime
1999
- 1999-04-07 TW TW088105540A patent/TWI249537B/zh not_active IP Right Cessation
- 1999-04-22 AR ARP990101859A patent/AR016466A1/es not_active Application Discontinuation
- 1999-04-26 ME MEP-408/08A patent/MEP40808A/xx unknown
- 1999-04-26 SK SK1600-2000A patent/SK288050B6/sk not_active IP Right Cessation
- 1999-04-26 TR TR2000/03142T patent/TR200003142T2/xx unknown
- 1999-04-26 EP EP99915834A patent/EP1073673B1/fr not_active Expired - Lifetime
- 1999-04-26 US US09/674,327 patent/US6548664B1/en not_active Expired - Lifetime
- 1999-04-26 ES ES99915834T patent/ES2279617T3/es not_active Expired - Lifetime
- 1999-04-26 RS YUP-658/00A patent/RS50423B/sr unknown
- 1999-04-26 ME MEP-2008-408A patent/ME00300B/me unknown
- 1999-04-26 NZ NZ507618A patent/NZ507618A/en not_active IP Right Cessation
- 1999-04-26 GE GEAP19995634A patent/GEP20033119B/en unknown
- 1999-04-26 BR BR9910020-7A patent/BR9910020A/pt not_active IP Right Cessation
- 1999-04-26 AP APAP/P/2000/001973A patent/AP1518A/en active
- 1999-04-26 EA EA200001107A patent/EA003280B1/ru not_active IP Right Cessation
- 1999-04-26 KR KR1020007011895A patent/KR100561582B1/ko not_active Expired - Fee Related
- 1999-04-26 CN CNB998076139A patent/CN1167711C/zh not_active Expired - Fee Related
- 1999-04-26 HU HU0102447A patent/HU230060B1/hu not_active IP Right Cessation
- 1999-04-26 CA CA2330492A patent/CA2330492C/fr not_active Expired - Fee Related
- 1999-04-26 JP JP2000545882A patent/JP4332298B2/ja not_active Expired - Fee Related
- 1999-04-26 UA UA2000116680A patent/UA71913C2/uk unknown
- 1999-04-26 WO PCT/FR1999/000981 patent/WO1999055724A1/fr not_active Ceased
- 1999-04-26 SI SI9930952T patent/SI1073673T1/sl unknown
- 1999-04-26 IL IL13910299A patent/IL139102A0/xx active IP Right Grant
- 1999-04-26 EE EEP200000619A patent/EE04682B1/xx unknown
- 1999-04-26 ID IDW20002188A patent/ID26292A/id unknown
- 1999-04-26 PT PT99915834T patent/PT1073673E/pt unknown
- 1999-04-26 AU AU34274/99A patent/AU755286B2/en not_active Ceased
- 1999-04-26 HR HR20000733A patent/HRP20000733B1/xx not_active IP Right Cessation
- 1999-04-26 DK DK99915834T patent/DK1073673T3/da active
- 1999-04-26 PL PL343720A patent/PL203762B1/pl unknown
- 1999-04-26 DE DE69934790T patent/DE69934790T2/de not_active Expired - Lifetime
2000
- 2000-10-18 IL IL139102A patent/IL139102A/en not_active IP Right Cessation
- 2000-10-25 CU CU229A patent/CU23155A3/es unknown
- 2000-10-26 NO NO20005391A patent/NO328864B1/no not_active IP Right Cessation
- 2000-10-26 BG BG104891A patent/BG65282B1/bg unknown
- 2000-10-27 ZA ZA200006081A patent/ZA200006081B/xx unknown
2002
- 2002-03-20 US US10/102,591 patent/US6570012B2/en not_active Expired - Lifetime
- 2002-12-06 US US10/313,422 patent/US20030130269A1/en not_active Abandoned
2007
- 2007-03-22 CY CY20071100404T patent/CY1107599T1/el unknown
2008
- 2008-03-12 IL IL190120A patent/IL190120A/en not_active IP Right Cessation
2009
- 2009-04-10 JP JP2009096241A patent/JP5101558B2/ja not_active Expired - Fee Related

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4512924A (en) *	1982-05-12	1985-04-23	Hoffmann-La Roche Inc.	Pyridazo[1,2-a][1,2]diazepines
WO1993023403A1 (en) *	1992-05-15	1993-11-25	Merrell Dow Pharmaceuticals Inc.	NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE
US5723602A (en) *	1992-05-18	1998-03-03	E. R. Squibb & Sons, Inc.	Dual action inhibitors containing a pyridazinodiazepine or pyrazolodiazepine lactam ring

Also Published As

Publication number	Publication date
SI1073673T1 (sl)	2007-04-30
MEP40808A (en)	2011-02-10
JP2009155343A (ja)	2009-07-16
HUP0102447A2 (hu)	2001-11-28
HRP20000733A2 (en)	2001-02-28
ES2279617T3 (es)	2007-08-16
TR200003142T2 (tr)	2001-03-21
EE200000619A (et)	2002-06-17
GEP20033119B (en)	2003-11-25
TWI249537B (en)	2006-02-21
JP5101558B2 (ja)	2012-12-19
AU755286B2 (en)	2002-12-05
JP4332298B2 (ja)	2009-09-16
NZ507618A (en)	2003-07-25
DK1073673T3 (da)	2007-05-07
AP2000001973A0 (en)	2000-12-31
BG104891A (en)	2001-10-31
YU65800A (sh)	2003-01-31
FR2777889A1 (fr)	1999-10-29
JP2002513030A (ja)	2002-05-08
CN1306539A (zh)	2001-08-01
HK1039131A1 (en)	2002-04-12
FR2777889B1 (fr)	2004-07-09
WO1999055724A1 (fr)	1999-11-04
AP1518A (en)	2005-12-12
BR9910020A (pt)	2001-01-09
CA2330492A1 (fr)	1999-11-04
KR20010043033A (ko)	2001-05-25
ME00300B (me)	2011-05-10
AU3427499A (en)	1999-11-16
CN1167711C (zh)	2004-09-22
ZA200006081B (en)	2001-10-29
US6570012B2 (en)	2003-05-27
EP1073673A1 (fr)	2001-02-07
DE69934790D1 (de)	2007-02-22
US6548664B1 (en)	2003-04-15
IL139102A0 (en)	2001-11-25
IL190120A0 (en)	2008-08-07
NO328864B1 (no)	2010-05-31
DE69934790T2 (de)	2007-10-31
US20020128473A1 (en)	2002-09-12
IL190120A (en)	2011-10-31
HUP0102447A3 (en)	2003-05-28
PT1073673E (pt)	2007-03-30
ID26292A (id)	2000-12-14
NO20005391L (no)	2000-12-19
IL139102A (en)	2008-06-05
US20030130269A1 (en)	2003-07-10
RS50423B (sr)	2009-12-31
EP1073673B1 (fr)	2007-01-10
PL343720A1 (en)	2001-09-10
CU23155A3 (es)	2006-07-18
AR016466A1 (es)	2001-07-04
HU230060B1 (hu)	2015-06-29
SK16002000A3 (sk)	2001-09-11
CA2330492C (fr)	2012-03-13
EA003280B1 (ru)	2003-04-24
EE04682B1 (et)	2006-08-15
BG65282B1 (bg)	2007-11-30
CY1107599T1 (el)	2013-03-13
SK288050B6 (sk)	2013-03-01
PL203762B1 (pl)	2009-11-30
EA200001107A1 (ru)	2001-04-23
NO20005391D0 (no)	2000-10-26
UA71913C2 (uk)	2005-01-17
KR100561582B1 (ko)	2006-03-20

Publication	Publication Date	Title
HUP0100394A2 (hu)	2001-09-28	2-es Helyzetben fenil-szubsztituenst hordozó imidazo-triazinon-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
CA2304713A1 (en)	1999-04-22	Biphenyl-5-alkanoic acid derivatives and use thereof
PL317580A1 (en)	1997-04-14	Novel inhibitors of farnesil transferase, method of obtaining them and pharmaceutic compositions containing such inhibitors
HUP9902256A1 (hu)	1999-10-28	Proteázgátló amidinoszármazékok, valamint e vegyületeket tartalmazó gyógyászati készítmények
ATE60763T1 (de)	1991-02-15	Pyrrolidinylamidesterderivate mit antiprolylendopeptidaseaktivitaet, ihre herstellung, ihre verwendung und sie enthaltende pharmazeutische zubereitungen.
IE872588L (en)	1988-03-27	Compounds
WO2002007677A3 (en)	2002-05-30	Use of derivatives of valproic acid and 2-valproenic acid amides for the treatment of mania in bipolar disorder
HRP20000733B1 (hr)	2009-06-30	NOVI DERIVATI OKTAHIDRO-6,10-DIOKSO-6H-PIRIDAZINO [1,2-a] [1,2]DIAZEPIN-1-KARBOKSILNE KISELINE, POSTUPAK NJIHOVOG DOBIVANJA I UPOTREBA U DOBIVANJU TERAPEUTSKI AKTIVNIH SPOJEVA
ES437541A1 (es)	1977-01-16	Procedimiento para la obtencion de composiciones formadoras de espuma.
MX9803730A (es)	1998-11-30	Nuevo proceso de preparacion de derivados de fenilimidazolidina.
IL88396A (en)	1992-12-01	Preparation of 6-methylene derivatives of androsta-1,4- diene-3,17-diones and pharmaceutical compositions containing them
ZA912618B (en)	1992-01-29	3-aminochroman derivatives,process for preparing these and pharmaceutical compositions containing them
ATE251144T1 (de)	2003-10-15	Pyrazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
ZA978170B (en)	1999-03-11	Novel amino alcohol derivatives process for their manufacture and medical preparations containing these compounds
AU4953997A (en)	1998-06-29	New histidine derivatives, preparation process, and their use as free antiradical agents
TW328083B (en)	1998-03-11	New derivatives of β-methoxy acrylic acid, their preparation process and their use as pesticides
AU539348B2 (en)	1984-09-20	5,6,8,9-tetrahydro-7h-dibenz(d,f)azonine derivatives
SE9701912D0 (sv)	1997-05-22	Pharmaceutical composition and use thereof
PT75385B (en)	1985-06-28	Process for the preparation of aminoglycosides derivatives and of compositions containing these derivatives
YU49079B (sh)	2003-08-29	Novi derivati fosfolipida i postupak za njihovu proizvodnju
AU4900499A (en)	2000-01-10	Use of amino azoic dyes as markers of oil distillation products
DK0865422T3 (da)	2001-10-22	Anvendelse af aminoalkoholderivater som lægemidler, hidtil ukendte derivater og fremgangsmåde til fremstilling deraf
DE69920748D1 (de)	2004-11-04	Pseudopeptide mit inhibierender wirkung auf protein-tyrosinkinasen und sie enthaltende pharmazeutische zusammensetzungen
AU632906B2 (en)	1993-01-14	Novel derivatives of 4H-pyrrolo(1,2-a)thieno (3,2-f))1,4)- diazepine their process of preparation and the pharmaceutical compositions containing them
MY132324A (en)	2007-10-31	New piperazine derivatives and methods for the preperation thereof and compositions containing the same

Legal Events

Date	Code	Title	Description
2001-02-28	A1OB	Publication of a patent application
2001-08-22	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2004-10-28	PPPP	Transfer of rights	Owner name: AVENTIS PHARMA S.A., FR
2009-06-30	B1PR	Patent granted
2017-03-20	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20170320 Year of fee payment: 19
2018-11-07	PBON	Lapse due to non-payment of renewal fee	Effective date: 20180426