RU2015110632A - Молекулы, связывающиеся с 4-1вв - Google Patents
Молекулы, связывающиеся с 4-1вв Download PDFInfo
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- RU2015110632A RU2015110632A RU2015110632/10A RU2015110632A RU2015110632A RU 2015110632 A RU2015110632 A RU 2015110632A RU 2015110632/10 A RU2015110632/10 A RU 2015110632/10A RU 2015110632 A RU2015110632 A RU 2015110632A RU 2015110632 A RU2015110632 A RU 2015110632A
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- antibody
- binding fragment
- antigen binding
- mammal
- cancer
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- 239000000427 antigen Substances 0.000 claims abstract 22
- 102000036639 antigens Human genes 0.000 claims abstract 22
- 108091007433 antigens Proteins 0.000 claims abstract 22
- 239000012634 fragment Substances 0.000 claims abstract 22
- 238000000034 method Methods 0.000 claims abstract 14
- 241000124008 Mammalia Species 0.000 claims abstract 11
- 206010028980 Neoplasm Diseases 0.000 claims abstract 9
- 201000011510 cancer Diseases 0.000 claims abstract 9
- 239000003937 drug carrier Substances 0.000 claims abstract 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 4
- 206010009944 Colon cancer Diseases 0.000 claims abstract 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims abstract 3
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims abstract 3
- 206010060862 Prostate cancer Diseases 0.000 claims abstract 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims abstract 3
- 201000001441 melanoma Diseases 0.000 claims abstract 3
- 230000004614 tumor growth Effects 0.000 claims abstract 3
- 125000000539 amino acid group Chemical group 0.000 claims abstract 2
- 238000004458 analytical method Methods 0.000 claims abstract 2
- 238000010494 dissociation reaction Methods 0.000 claims abstract 2
- 230000005593 dissociations Effects 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims abstract 2
- 239000002955 immunomodulating agent Substances 0.000 claims 4
- 229960004641 rituximab Drugs 0.000 claims 2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
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- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1. Выделенное антитело или его антигенсвязывающий фрагмент, где указанное антитело или его антигенсвязывающий фрагмент связываются с внеклеточным доменом человеческого 4-1ВВ в эпитопе, локализованном в пределах аминокислотных остатков 115-156 в SEQ ID NO: 68.2. Антитело или его антигенсвязывающий фрагмент по п. 1, где указанное антитело или его антигенсвязывающий фрагмент связываются с человеческим 4-1ВВ с константной диссоциации (K) 10 нМ или менее для внеклеточного домена человеческого 4-1ВВ, как измерено с использованием анализа посредством поверхностного плазмонного резонанса.3. Антитело или антигенсвязывающий фрагмент по п. 2, где указанное антитело или его антигенсвязывающий фрагмент содержат Vи Vобласть, где аминокислотная последовательность Vобласти изложена в SEQ ID NO: 43, и аминокислотная последовательность Vобласти изложена в SEQ ID NO: 45.4. Фармацевтическая композиция, содержащая антитело или его антигенсвязывающий фрагмент по п. 1 и фармацевтически приемлемый носитель.5. Способ снижения опухолевого роста у нуждающегося в этом субъекта, включающий введение указанному субъекту эффективного количества антитела или его антигенсвязывающего фрагмента по п. 1 и фармацевтически приемлемого носителя.6. Способ лечения рака у млекопитающего, включающий введение млекопитающему, нуждающемуся в лечении, терапевтически эффективного количества антитела или его антигенсвязывающего фрагмента по п. 1 и фармацевтически приемлемого носителя.7. Способ по п. 6, где указанный рак выбран из группы, состоящей из колоректального рака, неходжкинской лимфомы, рака предстательной железы или меланомы.8. Способ лечения рака у млекопитающего, вкл
Claims (14)
1. Выделенное антитело или его антигенсвязывающий фрагмент, где указанное антитело или его антигенсвязывающий фрагмент связываются с внеклеточным доменом человеческого 4-1ВВ в эпитопе, локализованном в пределах аминокислотных остатков 115-156 в SEQ ID NO: 68.
2. Антитело или его антигенсвязывающий фрагмент по п. 1, где указанное антитело или его антигенсвязывающий фрагмент связываются с человеческим 4-1ВВ с константной диссоциации (KD) 10 нМ или менее для внеклеточного домена человеческого 4-1ВВ, как измерено с использованием анализа посредством поверхностного плазмонного резонанса.
3. Антитело или антигенсвязывающий фрагмент по п. 2, где указанное антитело или его антигенсвязывающий фрагмент содержат VH и VL область, где аминокислотная последовательность VH области изложена в SEQ ID NO: 43, и аминокислотная последовательность VL области изложена в SEQ ID NO: 45.
4. Фармацевтическая композиция, содержащая антитело или его антигенсвязывающий фрагмент по п. 1 и фармацевтически приемлемый носитель.
5. Способ снижения опухолевого роста у нуждающегося в этом субъекта, включающий введение указанному субъекту эффективного количества антитела или его антигенсвязывающего фрагмента по п. 1 и фармацевтически приемлемого носителя.
6. Способ лечения рака у млекопитающего, включающий введение млекопитающему, нуждающемуся в лечении, терапевтически эффективного количества антитела или его антигенсвязывающего фрагмента по п. 1 и фармацевтически приемлемого носителя.
7. Способ по п. 6, где указанный рак выбран из группы, состоящей из колоректального рака, неходжкинской лимфомы, рака предстательной железы или меланомы.
8. Способ лечения рака у млекопитающего, включающий введение млекопитающему терапевтически эффективного количества антитела или его антигенсвязывающего фрагмента по п. 3 в комбинации с иммунотерапевтическим агентом.
9. Способ по п. 8, где указанный иммунотерапевтический агент представляет собой ритуксимаб.
10. Способ снижения опухолевого роста у нуждающегося в этом субъекта, включающий введение указанному субъекту эффективного количества антитела или его антигенсвязывающего фрагмента по п. 3 и фармацевтически приемлемого носителя.
11. Способ лечения рака у млекопитающего, включающий введение млекопитающему, нуждающемуся в лечении, терапевтически эффективного количества антитела или его антигенсвязывающего фрагмента по п. 3 и фармацевтически приемлемого носителя.
12. Способ по п. 11, где указанный рак выбран из группы, состоящей из колоректального рака, неходжкинской лимфомы, рака предстательной железы или меланомы.
13. Способ лечения рака у млекопитающего, включающий введение млекопитающему терапевтически эффективного количества антитела или его антигенсвязывающего фрагмента по п. 1 в комбинации с иммунотерапевтическим агентом.
14. Способ по п. 13, где указанный иммунотерапевтический агент представляет собой ритуксимаб.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38121010P | 2010-09-09 | 2010-09-09 | |
| US61/381,210 | 2010-09-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013110576/10A Division RU2551963C2 (ru) | 2010-09-09 | 2011-08-26 | Молекулы, связывающиеся с 4-1вв |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2015110632A true RU2015110632A (ru) | 2015-08-10 |
| RU2015110632A3 RU2015110632A3 (ru) | 2018-11-30 |
| RU2710717C2 RU2710717C2 (ru) | 2020-01-10 |
Family
ID=44759732
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015110632A RU2710717C2 (ru) | 2010-09-09 | 2011-08-26 | Молекулы, связывающиеся с 4-1ВВ |
| RU2013110576/10A RU2551963C2 (ru) | 2010-09-09 | 2011-08-26 | Молекулы, связывающиеся с 4-1вв |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013110576/10A RU2551963C2 (ru) | 2010-09-09 | 2011-08-26 | Молекулы, связывающиеся с 4-1вв |
Country Status (27)
| Country | Link |
|---|---|
| US (5) | US8337850B2 (ru) |
| EP (2) | EP3441404A1 (ru) |
| JP (4) | JP6105470B2 (ru) |
| KR (2) | KR101527297B1 (ru) |
| CN (2) | CN103221428B (ru) |
| AR (2) | AR082916A1 (ru) |
| AU (3) | AU2011300445B2 (ru) |
| BR (1) | BR112013005699B1 (ru) |
| CA (1) | CA2810359C (ru) |
| CO (1) | CO6690759A2 (ru) |
| DK (1) | DK2614082T3 (ru) |
| ES (1) | ES2699648T3 (ru) |
| HU (1) | HUE041958T2 (ru) |
| IL (3) | IL225001A (ru) |
| MX (2) | MX337040B (ru) |
| MY (2) | MY162737A (ru) |
| NZ (4) | NZ607710A (ru) |
| PE (1) | PE20131465A1 (ru) |
| PH (2) | PH12013500395B1 (ru) |
| PL (1) | PL2614082T3 (ru) |
| PT (1) | PT2614082T (ru) |
| RU (2) | RU2710717C2 (ru) |
| SG (3) | SG188313A1 (ru) |
| SI (1) | SI2614082T1 (ru) |
| TW (4) | TWI641621B (ru) |
| WO (1) | WO2012032433A1 (ru) |
| ZA (1) | ZA201502914B (ru) |
Families Citing this family (414)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2614082T1 (sl) * | 2010-09-09 | 2018-12-31 | Pfizer Inc. | Molekule, ki vežejo 4-1BB |
| WO2012088446A1 (en) | 2010-12-22 | 2012-06-28 | Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
| CA3019531A1 (en) * | 2011-04-19 | 2012-10-26 | Pfizer Inc. | Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer |
| CA2874721A1 (en) | 2012-05-30 | 2013-12-05 | Tomoyuki Igawa | Target tissue-specific antigen-binding molecule |
| EP2951199A4 (en) * | 2013-01-31 | 2016-07-20 | Univ Jefferson | Fusion proteins for the modulation of regulatory and effector T cells |
| EP2970909A4 (en) | 2013-03-15 | 2017-02-15 | The University of Chicago | Methods and compositions related to t-cell activity |
| JP6598680B2 (ja) | 2013-04-02 | 2019-10-30 | 中外製薬株式会社 | Ｆｃ領域改変体 |
| CN105722860A (zh) | 2013-09-24 | 2016-06-29 | 梅迪塞纳医疗股份有限公司 | 白介素-2融合蛋白及其应用 |
| EP3066127A1 (en) * | 2013-11-06 | 2016-09-14 | Bristol-Myers Squibb Company | Immunotherapeutic dosing regimens and combinations thereof |
| BR112016012094A2 (pt) | 2013-12-04 | 2017-09-26 | Chugai Pharmaceutical Co Ltd | moléculas de ligação a antígeno, cuja atividade de ligação a antígeno varia de acordo com a concentração de compostos e bibliotecas das ditas moléculas |
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