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MX2019009967A - Moleculas de union biespecificas que son capaces de unirse a cd137 y a antigenos tumorales, y usos de las mismas. - Google Patents

Moleculas de union biespecificas que son capaces de unirse a cd137 y a antigenos tumorales, y usos de las mismas.

Info

Publication number
MX2019009967A
MX2019009967A MX2019009967A MX2019009967A MX2019009967A MX 2019009967 A MX2019009967 A MX 2019009967A MX 2019009967 A MX2019009967 A MX 2019009967A MX 2019009967 A MX2019009967 A MX 2019009967A MX 2019009967 A MX2019009967 A MX 2019009967A
Authority
MX
Mexico
Prior art keywords
binding
binding molecules
molecules
epitope
bispecific
Prior art date
Application number
MX2019009967A
Other languages
English (en)
Inventor
Ying Kao LAM Chia-
Liu Liqin
A Moore Paul
Bonvini Ezio
s johnson Leslie
Diedrich Gundo
Original Assignee
Macrogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Publication of MX2019009967A publication Critical patent/MX2019009967A/es

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    • G11C15/04—Digital stores in which information comprising one or more characteristic parts is written into the store and in which information is read-out by searching for one or more of these characteristic parts, i.e. associative or content-addressed stores using semiconductor elements
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
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  • Microbiology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se dirige a moléculas de unión que poseen uno o más sitios de unión a epítopo específicos para un epítopo de CD137 y uno o más sitios de unión a epítopo específicos para un epítopo de un antígeno tumoral (``TA´´) (por ejemplo, una ``Molécula de Unión a CD137 x TA´´). En una modalidad, tales Moléculas de Unión a CD137 x TA serán moléculas biespecíficas, especialmente diacuerpos tetravalentes biespecíficos, que se componen de dos, tres, cuatro o más de cuatro cadenas polipeptídicas y que poseen dos sitios de unión a epítopo cada uno específico de un epítopo de CD137 y dos sitios de unión a epítopo cada uno específico de un epítopo de un TA. Alternativamente, tales Moléculas de Unión a CD137 x TA serán moléculas biespecíficas, especialmente moléculas biespecíficas de unión trivalente compuestas de tres o más cadenas polipeptídicas y que poseen uno o dos sitios de unión a epítopo cada uno específico de un epítopo de CD137 y uno o dos sitios de unión a epítopo cada uno específico de un epítopo de un TA. Las Moléculas de Unión a CD137 x TA de la invención son capaces de unirse simultáneamente a CD137, y a un TA. La invención se dirige a composiciones farmacéuticas que contienen cualquier Molécula de Unión a CD137 x TA. La invención se dirige adicionalmente a métodos para el uso de tales moléculas en el tratamiento de cáncer y otras enfermedades y padecimientos. La invención también proporciona moléculas novedosas de unión a CD137, y moléculas de unión a HER2/neu, así como derivados de las mismas y usos de las mismas.
MX2019009967A 2017-02-24 2018-02-22 Moleculas de union biespecificas que son capaces de unirse a cd137 y a antigenos tumorales, y usos de las mismas. MX2019009967A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762463353P 2017-02-24 2017-02-24
US201762597594P 2017-12-12 2017-12-12
PCT/US2018/019188 WO2018156740A1 (en) 2017-02-24 2018-02-22 Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof

Publications (1)

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MX2019009967A true MX2019009967A (es) 2019-12-02

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MX2019009967A MX2019009967A (es) 2017-02-24 2018-02-22 Moleculas de union biespecificas que son capaces de unirse a cd137 y a antigenos tumorales, y usos de las mismas.

Country Status (15)

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US (3) US11459394B2 (es)
EP (2) EP3585431A4 (es)
JP (1) JP7132232B2 (es)
KR (1) KR102585848B1 (es)
CN (1) CN110325209A (es)
AU (1) AU2018224094B2 (es)
BR (1) BR112019017628A2 (es)
CA (1) CA3053803A1 (es)
IL (1) IL268836B2 (es)
MA (1) MA47612A (es)
MX (1) MX2019009967A (es)
SG (1) SG11201907753TA (es)
TW (1) TWI788327B (es)
WO (1) WO2018156740A1 (es)
ZA (1) ZA201905347B (es)

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