RU2015143910A - Ингибиторы амид-гидролазы жирных кислот - Google Patents
Ингибиторы амид-гидролазы жирных кислот Download PDFInfo
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- RU2015143910A RU2015143910A RU2015143910A RU2015143910A RU2015143910A RU 2015143910 A RU2015143910 A RU 2015143910A RU 2015143910 A RU2015143910 A RU 2015143910A RU 2015143910 A RU2015143910 A RU 2015143910A RU 2015143910 A RU2015143910 A RU 2015143910A
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- Prior art keywords
- faah
- colitis
- mediated condition
- eosinophilic
- disease
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- 235000014113 dietary fatty acids Nutrition 0.000 title claims 2
- 229930195729 fatty acid Natural products 0.000 title claims 2
- 239000000194 fatty acid Substances 0.000 title claims 2
- 150000004665 fatty acids Chemical class 0.000 title claims 2
- 239000004093 hydrolase inhibitor Substances 0.000 title 1
- 102100027297 Fatty acid 2-hydroxylase Human genes 0.000 claims 9
- 101000937693 Homo sapiens Fatty acid 2-hydroxylase Proteins 0.000 claims 9
- 101000918494 Homo sapiens Fatty-acid amide hydrolase 1 Proteins 0.000 claims 9
- 230000001404 mediated effect Effects 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 208000011231 Crohn disease Diseases 0.000 claims 4
- 206010009887 colitis Diseases 0.000 claims 4
- 206010009900 Colitis ulcerative Diseases 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 3
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 208000003243 intestinal obstruction Diseases 0.000 claims 3
- 210000000936 intestine Anatomy 0.000 claims 3
- 208000027496 Behcet disease Diseases 0.000 claims 2
- 206010009895 Colitis ischaemic Diseases 0.000 claims 2
- 206010056979 Colitis microscopic Diseases 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 230000002327 eosinophilic effect Effects 0.000 claims 2
- 201000008222 ischemic colitis Diseases 0.000 claims 2
- 208000004341 lymphocytic colitis Diseases 0.000 claims 2
- 206010051153 Diabetic gastroparesis Diseases 0.000 claims 1
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 claims 1
- 102000004157 Hydrolases Human genes 0.000 claims 1
- 108090000604 Hydrolases Proteins 0.000 claims 1
- 206010021518 Impaired gastric emptying Diseases 0.000 claims 1
- 206010062501 Non-cardiac chest pain Diseases 0.000 claims 1
- 208000008469 Peptic Ulcer Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 206010000059 abdominal discomfort Diseases 0.000 claims 1
- 208000007784 diverticulitis Diseases 0.000 claims 1
- 201000006549 dyspepsia Diseases 0.000 claims 1
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 1
- 201000001561 eosinophilic gastritis Diseases 0.000 claims 1
- 201000001564 eosinophilic gastroenteritis Diseases 0.000 claims 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 1
- 208000030304 gastrointestinal bleeding Diseases 0.000 claims 1
- 208000001288 gastroparesis Diseases 0.000 claims 1
- 208000011906 peptic ulcer disease Diseases 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
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- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
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- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Addiction (AREA)
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Claims (11)
1. Способ лечения состояния, опосредованного гидролазой амида жирной кислоты (FAAH), включающий введение субъекту, нуждающемуся в этом, терапевтически эффективного количества твердой формы кристаллического соединения формулы 1:
или его фармацевтически приемлемой соли, гидрата или сольвата, где кристаллическое соединение формулы 1 представляет собой кристаллическую форму А формулы 1, имеющая рентгеновскую порошковую дифрактограмму, содержащую пики, в приблизительных положениях пиков: 17,26±0,10, 21,60±0,10 и 27,73±0,10 градусов 2θ и по меньшей мере в приблизительных положениях пиков: 9,68±0,10, 24,68±0,10, 25,48±0,10 и 29,08±0,10 градусов 2θ, где FAAH-опосредованное состояние включает желудочнокишечное нарушение.
2. Способ по п. 1, где FAAH-опосредованное состояние представляет собой пептические язвы, региональный энтерит, дивертикулит, желудочно-кишечное кровотечение, эозинофильное желудочно-кишечное расстройство, эозинофильный эзофагит, эозинофильный гастрит, эозинофильный гастроэнтерит, эозинофильный колит, гастрит, диарею, гастроэзофагеальный рефлюкс, воспалительное заболевание кишечника, болезнь Крона, язвенный колит, коллагеновый колит, лимфоцитарный колит,
ишемический колит, воспаление в отключенной кишке, Синдром Бехета, недифференцированный колит или синдром воспаленного кишечника.
3. Способ по п. 1, где FAAH-опосредованное состояние представляет собой кишечную непроходимость, послеоперационную кишечную непроходимость, кишечную непроходимость при сепсисе, гастропарез, диабетический гастропарез, не-язвенную диспепсию или не-сердечную боль в области грудной клетки.
4. Способ по п. 1, где FAAH-опосредованное состояние представляет собой воспалительное заболевание кишечника.
5. Способ по п. 1, где FAAH-опосредованное состояние представляет собой болезнь Крона, язвенный колит, коллагеновый колит, лимфоцитарный колит, ишемический колит, воспаление в отключенной кишке, Синдром Бехета, недифференцированный колит.
6. Способ по п. 1, где FAAH-опосредованное состояние представляет собой болезнь Крона.
7. Способ по п. 1, где FAAH-опосредованное состояние представляет собой язвенный колит.
8. Способ по п. 1, где FAAH-опосредованное состояние представляет собой синдром воспаленного кишечника.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30118110P | 2010-02-03 | 2010-02-03 | |
| US61/301,181 | 2010-02-03 | ||
| US41273410P | 2010-11-11 | 2010-11-11 | |
| US61/412,734 | 2010-11-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012137246/04A Division RU2569061C2 (ru) | 2010-02-03 | 2011-02-01 | Ингибиторы амид-гидролазы жирных кислот |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015143910A true RU2015143910A (ru) | 2018-12-28 |
| RU2015143910A3 RU2015143910A3 (ru) | 2019-03-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012137246/04A RU2569061C2 (ru) | 2010-02-03 | 2011-02-01 | Ингибиторы амид-гидролазы жирных кислот |
| RU2015143910A RU2015143910A (ru) | 2010-02-03 | 2011-02-01 | Ингибиторы амид-гидролазы жирных кислот |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2012137246/04A RU2569061C2 (ru) | 2010-02-03 | 2011-02-01 | Ингибиторы амид-гидролазы жирных кислот |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9034849B2 (ru) |
| EP (1) | EP2531511A1 (ru) |
| JP (2) | JP2013518886A (ru) |
| KR (1) | KR101888026B1 (ru) |
| CN (1) | CN102834401B (ru) |
| AR (1) | AR080127A1 (ru) |
| AU (1) | AU2011213072C1 (ru) |
| BR (1) | BR112012019120A2 (ru) |
| CA (1) | CA2788587C (ru) |
| IL (1) | IL221281A (ru) |
| MX (3) | MX361692B (ru) |
| RU (2) | RU2569061C2 (ru) |
| WO (1) | WO2011097233A1 (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3598B1 (ar) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
| WO2011097233A1 (en) | 2010-02-03 | 2011-08-11 | Infinity Pharmaceuticals, Inc. | Fatty acid amide hydrolase inhibitors |
| KR101271991B1 (ko) * | 2011-07-06 | 2013-06-05 | 삼성에스디아이 주식회사 | 이차 전지 |
| US9159934B2 (en) * | 2012-06-01 | 2015-10-13 | Semiconductor Energy Laboratory Co., Ltd. | Organic material, light-emitting element, light-emitting device, electronic appliance, and lighting device |
| US20150105562A1 (en) * | 2012-08-20 | 2015-04-16 | Manac Inc. | Method for preparing borinic acid derivatives and novel borinic acid derivatives |
| AU2020313976B2 (en) * | 2019-07-17 | 2023-06-15 | Percipiad, Inc. | Boron-containing rho kinase inhibitors |
| JP2021147381A (ja) * | 2020-03-13 | 2021-09-27 | 東ソー株式会社 | ハロゲン化合物の製造方法 |
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-
2011
- 2011-02-01 WO PCT/US2011/023352 patent/WO2011097233A1/en not_active Ceased
- 2011-02-01 BR BR112012019120A patent/BR112012019120A2/pt not_active Application Discontinuation
- 2011-02-01 MX MX2016001116A patent/MX361692B/es unknown
- 2011-02-01 JP JP2012552035A patent/JP2013518886A/ja active Pending
- 2011-02-01 CN CN201180017689.3A patent/CN102834401B/zh not_active Expired - Fee Related
- 2011-02-01 US US13/019,262 patent/US9034849B2/en not_active Expired - Fee Related
- 2011-02-01 RU RU2012137246/04A patent/RU2569061C2/ru not_active IP Right Cessation
- 2011-02-01 CA CA2788587A patent/CA2788587C/en not_active Expired - Fee Related
- 2011-02-01 AU AU2011213072A patent/AU2011213072C1/en not_active Ceased
- 2011-02-01 KR KR1020127022842A patent/KR101888026B1/ko not_active Expired - Fee Related
- 2011-02-01 RU RU2015143910A patent/RU2015143910A/ru unknown
- 2011-02-01 MX MX2015011157A patent/MX361011B/es unknown
- 2011-02-01 EP EP11702906A patent/EP2531511A1/en not_active Withdrawn
- 2011-02-01 MX MX2012008904A patent/MX336742B/es unknown
- 2011-02-03 AR ARP110100368A patent/AR080127A1/es unknown
-
2012
- 2012-08-02 IL IL221281A patent/IL221281A/en not_active IP Right Cessation
-
2015
- 2015-02-25 US US14/631,712 patent/US9951089B2/en not_active Expired - Fee Related
-
2016
- 2016-01-27 JP JP2016012894A patent/JP2016128472A/ja active Pending
-
2018
- 2018-04-23 US US15/959,663 patent/US20180244700A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AR080127A1 (es) | 2012-03-14 |
| MX2012008904A (es) | 2012-11-12 |
| RU2569061C2 (ru) | 2015-11-20 |
| KR101888026B1 (ko) | 2018-08-13 |
| CA2788587C (en) | 2020-03-10 |
| WO2011097233A1 (en) | 2011-08-11 |
| MX336742B (es) | 2016-01-29 |
| US9951089B2 (en) | 2018-04-24 |
| CN102834401A (zh) | 2012-12-19 |
| CN102834401B (zh) | 2016-08-24 |
| IL221281A (en) | 2017-04-30 |
| RU2012137246A (ru) | 2014-03-10 |
| BR112012019120A2 (pt) | 2016-06-28 |
| MX361011B (es) | 2018-11-26 |
| KR20130019375A (ko) | 2013-02-26 |
| MX361692B (es) | 2018-12-13 |
| JP2016128472A (ja) | 2016-07-14 |
| AU2011213072B2 (en) | 2016-09-22 |
| US9034849B2 (en) | 2015-05-19 |
| US20110201574A1 (en) | 2011-08-18 |
| AU2011213072A1 (en) | 2012-08-16 |
| AU2011213072C1 (en) | 2016-12-15 |
| IL221281A0 (en) | 2012-10-31 |
| US20180244700A1 (en) | 2018-08-30 |
| US20150239912A1 (en) | 2015-08-27 |
| EP2531511A1 (en) | 2012-12-12 |
| RU2015143910A3 (ru) | 2019-03-12 |
| JP2013518886A (ja) | 2013-05-23 |
| CA2788587A1 (en) | 2011-08-11 |
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