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RU2010108448A - Способы индукции конечной дифференцировки - Google Patents

Способы индукции конечной дифференцировки Download PDF

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RU2010108448A
RU2010108448A RU2010108448/15A RU2010108448A RU2010108448A RU 2010108448 A RU2010108448 A RU 2010108448A RU 2010108448/15 A RU2010108448/15 A RU 2010108448/15A RU 2010108448 A RU2010108448 A RU 2010108448A RU 2010108448 A RU2010108448 A RU 2010108448A
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pharmaceutical composition
composition according
treatment
pharmaceutically acceptable
sagc
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RU2530648C2 (ru
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Виктория М. РИЧОН (US)
Виктория М. Ричон
Х. Джуди ЧАО (US)
Х. Джуди ЧАО
Томас А. МИЛЛЕР (US)
Томас А. Миллер
В. Кевин КЕЛЛИ (US)
В. Кевин КЕЛЛИ
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МЕРК ЭйчДиЭйСи Рисерч, ЛЛС (US)
МЕРК ЭйчДиЭйСи Рисерч, ЛЛС
Слоан-Кеттеринг Инститьют Фор Кэнсер Рисерч (Us)
Слоан-Кеттеринг Инститьют Фор Кэнсер Рисерч
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Abstract

1. Фармацевтическая композиция перорального введения для лечения злокачественных опухолей у пациента, исключая не-ходжкинскую лимфому, миелодиспластический синдром, лейкоз и злокачественные опухоли с инфильтрацией лейкоцитов, содержащая примерно вплоть до 400 мг твердой лекарственной формы субероиланилида гидроксамовой кислоты (САГК), представленного следующей структурой: ! ! или его фармацевтически приемлемой соли или гидрата; и фармацевтически приемлемый носитель. ! 2. Фармацевтическая композиция по п.1, содержащая примерно 400 мг твердой лекарственной формы САГК или его фармацевтически приемлемой соли или гидрата. ! 3. Фармацевтическая композиция по п.1, содержащая примерно 200 мг твердой лекарственной формы САГК или его фармацевтически приемлемой соли или гидрата. ! 4. Фармацевтическая композиция по п.1, содержащая примерно 100 или примерно 50 мг твердой лекарственной формы САГК или его фармацевтически приемлемой соли или гидрата. ! 5. Фармацевтическая композиция по п.1, содержащая примерно 50-200 мг твердой лекарственной формы САГК или его фармацевтически приемлемой соли или гидрата. ! 6. Фармацевтическая композиция по любому из пп.1-5 для лечения злокачественной опухоли легкого. ! 7. Фармацевтическая композиция по любому из пп.1-5 для лечения миеломы. ! 8. Фармацевтическая композиция по любому из пп.1-5 для лечения злокачественной опухоли молочной железы. ! 9. Фармацевтическая композиция по любому из пп.1-5 для лечения злокачественной опухоли яичников. ! 10. Фармацевтическая композиция по любому из пп.1-5 для лечения колоректальной злокачественной опухоли. ! 11. Фармацевтическая композиция по любому из пп.1-5 для лечения

Claims (14)

1. Фармацевтическая композиция перорального введения для лечения злокачественных опухолей у пациента, исключая не-ходжкинскую лимфому, миелодиспластический синдром, лейкоз и злокачественные опухоли с инфильтрацией лейкоцитов, содержащая примерно вплоть до 400 мг твердой лекарственной формы субероиланилида гидроксамовой кислоты (САГК), представленного следующей структурой:
Figure 00000001
или его фармацевтически приемлемой соли или гидрата; и фармацевтически приемлемый носитель.
2. Фармацевтическая композиция по п.1, содержащая примерно 400 мг твердой лекарственной формы САГК или его фармацевтически приемлемой соли или гидрата.
3. Фармацевтическая композиция по п.1, содержащая примерно 200 мг твердой лекарственной формы САГК или его фармацевтически приемлемой соли или гидрата.
4. Фармацевтическая композиция по п.1, содержащая примерно 100 или примерно 50 мг твердой лекарственной формы САГК или его фармацевтически приемлемой соли или гидрата.
5. Фармацевтическая композиция по п.1, содержащая примерно 50-200 мг твердой лекарственной формы САГК или его фармацевтически приемлемой соли или гидрата.
6. Фармацевтическая композиция по любому из пп.1-5 для лечения злокачественной опухоли легкого.
7. Фармацевтическая композиция по любому из пп.1-5 для лечения миеломы.
8. Фармацевтическая композиция по любому из пп.1-5 для лечения злокачественной опухоли молочной железы.
9. Фармацевтическая композиция по любому из пп.1-5 для лечения злокачественной опухоли яичников.
10. Фармацевтическая композиция по любому из пп.1-5 для лечения колоректальной злокачественной опухоли.
11. Фармацевтическая композиция по любому из пп.1-5 для лечения лимфомы Ходжкина.
12. Фармацевтическая композиция по любому из пп.1-5 для лечения меланомы мочевого пузыря.
13. Фармацевтическая композиция по любому из пп.1-5 для лечения злокачественной опухоли почки.
14. Фармацевтическая композиция по любому из пп.1-5 для лечения злокачественной опухоли предстательной железы.
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