[go: up one dir, main page]

PE20141404A1 - Derivados de tieno[3,2-d]pirimidina que tienen actividad inhibidora por las quinasas de las proteinas - Google Patents

Derivados de tieno[3,2-d]pirimidina que tienen actividad inhibidora por las quinasas de las proteinas

Info

Publication number
PE20141404A1
PE20141404A1 PE2014001048A PE2014001048A PE20141404A1 PE 20141404 A1 PE20141404 A1 PE 20141404A1 PE 2014001048 A PE2014001048 A PE 2014001048A PE 2014001048 A PE2014001048 A PE 2014001048A PE 20141404 A1 PE20141404 A1 PE 20141404A1
Authority
PE
Peru
Prior art keywords
amino
alkyl
kinases
pyrimidine
proteins
Prior art date
Application number
PE2014001048A
Other languages
English (en)
Inventor
In Hwan Bae
Jung Beom Son
Sang Mi Han
Eun Joo Kwak
Ho Seok Kim
Ji Young Song
Eun Young Byun
Seung Ah Jun
Young Gil Ahn
Kwee Hyun Suh
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48697978&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20141404(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of PE20141404A1 publication Critical patent/PE20141404A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE TIENO[3,2-d]PIRIMIDINA DE FORMULA (I) DONDE A ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C6), ENTRE OTROS; W ES O, S, S(O), ENTRE OTROS; X E Y SON CADA UNO CH O N; Z ES H, ALQUILO(C1-C3) O NR3R4, DONDE R3 Y R4 SON CADA UNO H, ALQUILO(C1-C6), ENTRE OTROS; R1 ES H, HALOGENO, ALQUILO(C1-C3) O ALCOXI(C1-C3); R2 ES H, HALOGENO, -CF3, -NO2, ENTRE OTROS; m ES DE 0 A 5; n ES DE 0 A 2. SON COMPUESTOS PREFERIDOS: 4-AMINO-N-(1-((4-CLOROFENIL)AMINO)-6-METILISOQUINOLIN-5-IL)TIENO[3,2-d]PIRIMIDIN-7-CARBOXAMIDA; 4-AMINO-N-(6-METIL-1-((3-(TRIFLUOROMETIL)FENIL)AMINO)ISOQUINOLIN-5-IL)TIENO[3,2-d]PIRIMIDIN-7-CARBOXAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE QUINASAS DE LAS PROTEINAS SIENDO UTILES EN EL TRATAMIENTO DEL CANCER GASTRICO, MELANOMA, PSORIASIS
PE2014001048A 2011-12-30 2012-12-27 Derivados de tieno[3,2-d]pirimidina que tienen actividad inhibidora por las quinasas de las proteinas PE20141404A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20110146818 2011-12-30

Publications (1)

Publication Number Publication Date
PE20141404A1 true PE20141404A1 (es) 2014-10-28

Family

ID=48697978

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014001048A PE20141404A1 (es) 2011-12-30 2012-12-27 Derivados de tieno[3,2-d]pirimidina que tienen actividad inhibidora por las quinasas de las proteinas

Country Status (32)

Country Link
US (2) USRE47451E1 (es)
EP (2) EP2797927B1 (es)
JP (1) JP5797345B2 (es)
KR (1) KR101490761B1 (es)
CN (1) CN104039798B (es)
AR (1) AR089489A1 (es)
AU (1) AU2012363558C1 (es)
BR (2) BR122019019582B1 (es)
CA (1) CA2859668C (es)
CL (1) CL2014001729A1 (es)
CO (1) CO7010840A2 (es)
DK (1) DK2797927T3 (es)
ES (2) ES3013322T3 (es)
HR (1) HRP20191840T8 (es)
HU (1) HUE045957T2 (es)
IL (2) IL233441B (es)
IN (1) IN2014DN06101A (es)
LT (1) LT2797927T (es)
MX (2) MX363659B (es)
MY (1) MY170988A (es)
PE (1) PE20141404A1 (es)
PH (1) PH12014501504B1 (es)
PL (1) PL2797927T3 (es)
PT (1) PT2797927T (es)
RS (1) RS59420B1 (es)
RU (2) RU2625799C2 (es)
SG (2) SG11201402765TA (es)
SI (1) SI2797927T1 (es)
TW (1) TWI462927B (es)
UA (1) UA109614C2 (es)
WO (1) WO2013100632A1 (es)
ZA (1) ZA201405583B (es)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2628418T3 (es) 2010-05-20 2017-08-02 Array Biopharma, Inc. Compuestos macrocíclicos como inhibidores de la TRK cinasa
TWI713455B (zh) 2014-06-25 2020-12-21 美商伊凡克特治療公司 ＭｎＫ抑制劑及其相關方法
US10040745B2 (en) 2014-10-14 2018-08-07 Syngenta Participations Ag Process for the preparation of 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethanone and derivatives thereof
WO2017011776A1 (en) 2015-07-16 2017-01-19 Array Biopharma, Inc. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
AU2016343687A1 (en) 2015-10-29 2018-06-07 Effector Therapeutics, Inc. Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2
AU2016343980A1 (en) 2015-10-29 2018-06-07 Effector Therapeutics, Inc. Pyrrolo-, pyrazolo-, imidazo-pyrimidine and pyridine compounds that inhibit Mnk1 and Mnk2
WO2017087808A1 (en) 2015-11-20 2017-05-26 Effector Therapeutics, Inc. Heterocyclic compounds that inhibit the kinase activity of mnk useful for treating various cancers
CN106928252B (zh) * 2015-12-31 2019-09-27 成都先导药物开发股份有限公司 一种抑制rock的化合物及其制备方法与应用
WO2017137334A1 (en) * 2016-02-08 2017-08-17 F. Hoffmann-La Roche Ag Spiroindolinones as ddr1 inhibitors
KR20180134347A (ko) 2016-04-15 2018-12-18 제넨테크, 인크. 암의 진단 및 치료 방법
CN106153920B (zh) * 2016-07-25 2018-04-27 四川大学华西医院 一种肺癌筛查试剂盒
TWI704148B (zh) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
JOP20190077A1 (ar) 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
US11440898B2 (en) * 2016-12-28 2022-09-13 Minoryx Therapeutics S.L. Isoquinoline compounds, methods for their preparation, and therapeutic uses thereof in conditions associated with the alteration of the activity of beta galactosidase
WO2018136663A1 (en) 2017-01-18 2018-07-26 Array Biopharma, Inc. Ret inhibitors
EP3571203B1 (en) 2017-01-18 2023-06-07 Array BioPharma Inc. Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors
ES2969988T3 (es) 2017-02-14 2024-05-23 Effector Therapeutics Inc Inhibidores de Mnk sustituidos con piperidina y métodos relacionados con los mismos
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
SI3658552T1 (sl) 2017-07-28 2023-11-30 Yuhan Corporation Postopek za pripravo N-(5-((4-(4-((dimetilamino)metil)-3-fenil-1H-pirazol-1-il)pirimidin-2-il )amino)-4-metoksi-2-morfolinofenil)akrilamida z reagiranjem ustreznega amina s 3-halo-propionil kloridom
JP7530829B2 (ja) 2017-09-08 2024-08-08 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト がんの診断及び治療方法
TWI791053B (zh) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
TWI876442B (zh) 2017-10-10 2025-03-11 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
MX2020005564A (es) * 2017-11-30 2020-11-06 Hanmi Pharm Ind Co Ltd Sales de 4-amino-n-(1-((3-cloro-2-fluorofnil)amino)-6-metilisoquin olin-5-il)tieno[3,2-d]pirimidino-7-carboxamida, y formas cristalinas de las mismas.
KR20200084899A (ko) * 2017-11-30 2020-07-13 한미약품 주식회사 단백질 키나제에 대한 억제 활성을 갖는 티에노[3,2-d]피리미딘 화합물
WO2019143977A1 (en) 2018-01-18 2019-07-25 Array Biopharma Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
EP3740490A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors
WO2019143994A1 (en) 2018-01-18 2019-07-25 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
US20210008047A1 (en) 2018-02-13 2021-01-14 Vib Vzw Targeting minimal residual disease in cancer with rxr antagonists
WO2019170543A1 (en) 2018-03-07 2019-09-12 Bayer Aktiengesellschaft Identification and use of erk5 inhibitors
EP3849986B1 (en) 2018-09-10 2022-06-08 Array Biopharma, Inc. Fused heterocyclic compounds as ret kinase inhibitors
JP2022505846A (ja) 2018-10-24 2022-01-14 イーフェクター セラピューティクス， インコーポレイテッド Ｍｎｋ阻害剤の結晶形態
MA55147A (fr) 2018-11-21 2021-09-29 Univ Texas Compositions et procédés de modulation de l'activité de la déshydrogénase à chaîne courte
EP3903828A4 (en) 2018-12-21 2022-10-05 Daiichi Sankyo Company, Limited ANTIBODY-DRUG CONJUGATE AND KINAS INHIBITOR COMBINATION
CN110183464B (zh) * 2019-05-31 2021-08-31 淮阴工学院 一种抗癌化合物艾斯替尼及其合成方法和应用
CA3178927A1 (en) * 2020-05-26 2021-12-02 Hanmi Pharm. Co., Ltd. Belvarafenib for use in cancer treatment
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds
EP4238967A1 (en) * 2020-10-27 2023-09-06 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Arylamide compound, pharmaceutical composition comprising same, and preparation method therefor and use thereof
CN116472041B (zh) * 2020-11-24 2024-12-06 正大天晴药业集团股份有限公司 氘修饰的噻吩并吡啶酮化合物
JP2024509269A (ja) 2021-03-09 2024-02-29 ジェネンテック， インコーポレイテッド 脳がんの治療における使用のためのベルバラフェニブ
US20240366609A1 (en) 2021-04-06 2024-11-07 Genentech, Inc. Combination therapy with belvarafenib and cobimetinib or with belvarafenib, cobimetinib, and atezolizumab
CN117202897A (zh) 2021-04-09 2023-12-08 基因泰克公司 使用raf抑制剂和pd-1轴抑制剂的组合疗法
JP2024525477A (ja) 2021-06-30 2024-07-12 ジェネンテック， インコーポレイテッド ４－アミノ－ｎ－（１－（（３－クロロ－２－フルオロフェニル）アミノ）－６－メチルイソキノリン－５－イル）チエノ［３，２－ｄ］ピリミジン－７－カルボキサミドのビス－メシレート塩及びその中間体の合成
CN114213430B (zh) * 2021-12-28 2022-12-02 深圳湾实验室 4-氨基噻吩[3,2-d]嘧啶-7-羧酸的制备方法、蛋白激酶抑制剂中间体
CN114524826A (zh) * 2022-02-18 2022-05-24 郑州猫眼农业科技有限公司 7-溴-4-氯噻吩并[3,2-d]嘧啶的制备工艺
TW202342766A (zh) 2022-03-02 2023-11-01 瑞士商諾華公司 用於癌症治療之精準療法
WO2024033381A1 (en) 2022-08-10 2024-02-15 Vib Vzw Inhibition of tcf4/itf2 in the treatment of cancer

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402518D0 (en) * 2004-02-05 2004-03-10 Astrazeneca Ab Therapeutic agents
RU2525115C2 (ru) 2004-06-24 2014-08-10 Вертекс Фармасьютикалз Инкорпорейтед Способ модуляции транспортеров атф-связывающей кассеты
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
MY146795A (en) 2005-06-09 2012-09-28 Novartis Ag Process for the synthesis of organic compounds
US7989461B2 (en) 2005-12-23 2011-08-02 Amgen Inc. Substituted quinazolinamine compounds for the treatment of cancer
JP2009530288A (ja) * 2006-03-16 2009-08-27 ノバルティス アクチエンゲゼルシャフト 特に黒色腫の処置のためのヘテロ環式有機化合物
EA200802118A1 (ru) * 2006-04-07 2009-04-28 Девелоджен Ациенгезельшафт Обладающие ингибирующей активностью в отношении mnk1/mnk2 тиенопиримидины, предназначенные для применения в фармацевтических композициях
WO2008044688A1 (en) * 2006-10-11 2008-04-17 Daiichi Sankyo Company, Limited Urea derivative
ES2554513T3 (es) 2008-05-23 2015-12-21 Novartis Ag Derivados de quinolinas y quinoxalinas como inhibidores de la proteína tirosina quinasa
MX2011005788A (es) * 2008-12-05 2011-06-21 Arqule Inc Inhibidores raf y sus usos.
US8691828B2 (en) 2009-03-05 2014-04-08 Takeda Pharmaceutical Company Limited Thienopyrimidine as CDC7 kinase inhibitors
DE102009035754A1 (de) 2009-07-24 2011-01-27 Hartmetall-Werkzeugfabrik Paul Horn Gmbh Schneideinsatz für ein Schneidwerkzeug zur spanenden Bearbeitung, insbesondere zum Hochvorschubfräsen
JP2013503188A (ja) * 2009-08-28 2013-01-31 アレイ バイオファーマ、インコーポレイテッド Ｒａｆ阻害化合物およびその使用方法
KR101147550B1 (ko) 2009-10-22 2012-05-17 한국과학기술연구원 단백질 키나아제 저해활성을 가지는 2,7-치환된 티에노［3,2-ｄ］피리미딘 화합물
KR101094446B1 (ko) 2009-11-19 2011-12-15 한국과학기술연구원 단백질 키나아제 저해활성을 가지는 2,4,7-치환된 티에노［3,2-ｄ］피리미딘 화합물
KR101483215B1 (ko) 2010-01-29 2015-01-16 한미약품 주식회사 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체
EP2528925B1 (en) * 2010-01-29 2017-07-05 Hanmi Science Co., Ltd. THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES
CN102985426B (zh) * 2010-07-13 2015-10-07 弗·哈夫曼-拉罗切有限公司 作为irak4调节剂的吡唑并[1,5a]嘧啶和噻吩并[3,2b]嘧啶衍生物

Also Published As

Publication number Publication date
UA109614C2 (uk) 2015-09-10
EP2797927A4 (en) 2015-07-08
JP5797345B2 (ja) 2015-10-21
MX2019003468A (es) 2019-06-06
IL266285B (en) 2021-12-01
AU2012363558C1 (en) 2019-08-29
PT2797927T (pt) 2019-10-30
CO7010840A2 (es) 2014-07-31
JP2015503553A (ja) 2015-02-02
SI2797927T1 (sl) 2019-12-31
CA2859668A1 (en) 2013-07-04
CL2014001729A1 (es) 2014-09-26
SG10201701999QA (en) 2017-04-27
HRP20191840T1 (hr) 2019-12-27
MX363659B (es) 2019-03-28
USRE47451E1 (en) 2019-06-25
BR122019019582B1 (pt) 2021-07-13
ES2751608T3 (es) 2020-04-01
IL233441B (en) 2019-05-30
TWI462927B (zh) 2014-12-01
TW201331209A (zh) 2013-08-01
BR112014015720A8 (pt) 2017-07-04
CN104039798A (zh) 2014-09-10
US20140371219A1 (en) 2014-12-18
MX2014007230A (es) 2015-05-15
PH12014501504A1 (en) 2014-10-08
DK2797927T3 (da) 2019-10-28
PL2797927T3 (pl) 2019-12-31
PH12014501504B1 (en) 2014-10-08
EP3617213A1 (en) 2020-03-04
MY170988A (en) 2019-09-23
US9156852B2 (en) 2015-10-13
RU2014131390A (ru) 2016-02-20
HK1200833A1 (en) 2015-08-14
NZ628013A (en) 2016-07-29
IL233441A0 (en) 2014-08-31
WO2013100632A1 (en) 2013-07-04
RU2705577C2 (ru) 2019-11-08
BR112014015720A2 (pt) 2017-06-13
AU2012363558A1 (en) 2014-08-21
AU2012363558B2 (en) 2015-11-19
KR101490761B1 (ko) 2015-02-09
RU2017124993A3 (es) 2019-01-30
BR112014015720B1 (pt) 2020-03-17
RU2017124993A (ru) 2019-01-30
SG11201402765TA (en) 2014-06-27
IN2014DN06101A (es) 2015-08-14
EP3617213B1 (en) 2025-02-19
ZA201405583B (en) 2015-10-28
RU2625799C2 (ru) 2017-07-19
RS59420B1 (sr) 2019-11-29
MX378640B (es) 2025-03-10
IL266285A (en) 2019-06-30
ES3013322T3 (en) 2025-04-11
KR20130079256A (ko) 2013-07-10
EP2797927B1 (en) 2019-09-25
CN104039798B (zh) 2016-08-24
HUE045957T2 (hu) 2020-01-28
EP3617213C0 (en) 2025-02-19
CA2859668C (en) 2019-01-15
LT2797927T (lt) 2019-10-25
EP2797927A1 (en) 2014-11-05
AR089489A1 (es) 2014-08-27
HRP20191840T8 (hr) 2020-02-07

Similar Documents

Publication Publication Date Title
PE20141404A1 (es) Derivados de tieno[3,2-d]pirimidina que tienen actividad inhibidora por las quinasas de las proteinas
PE20090773A1 (es) Derivados de morfolina pirimidina
PE20142340A1 (es) Inhibidores de bromodominios
PE20141974A1 (es) Compuestos de heterociclilo
PE20100138A1 (es) Derivados de morfolino pirimidina usados en enfermedades relacionadas en mtor quinasa y/o pi3k
JO3025B1 (ar) الأندازولات المستبدلة بالأوكسازول كمثبطات كيناز pi3
PE20161443A1 (es) Compuestos
AR083578A1 (es) INHIBIDORES DE N/N-LACTAMA ACETIL-CoA CARBOXILASA
PE20141120A1 (es) Compuestos heterociclicos
PE20110196A1 (es) 5-alquinil-pirimidinas
AR087913A1 (es) Inhibidores sustituidos de n-[1-ciano-2-(fenil)etil]-2-azabiciclo[2,2,1]heptan-3-carboxamida de catepsina c
PE20140192A1 (es) Derivados de bencimidazol como inhibidores de cinasa pi3
AR078278A1 (es) Antagonistas de la tiazol y oxazol hepcidina, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de anemias y enfermedades asociadas a deficiencias de hierro.
PE20160540A1 (es) Inhibidores de bromodominios
PE20170268A1 (es) Compuestos de heteroarilo para la inhibicion de cinasa
PE20141371A1 (es) Compuestos heterociclicos y usos de los mismos
PE20161066A1 (es) Derivados de piperidinil-indol como inhibidores del factor de complemento b y usos de los mismos
CY1117122T1 (el) Παραγωγα πυραζολοσπειροκετονης για χρηση ως αναστολεις ακετyλ-coa καρβοξυλασης
CO6361936A2 (es) Imidazopiridazinacarbonitrilos utiles como inhibidores de quinasa
NZ708864A (en) Substituted pyrimidine aminoalkyl-quinazolones as phosphatidylinositol 3-kinase inhibitors
PE20110545A1 (es) Compuestos de triazolopiridina como inhibidores de jak
PE20130306A1 (es) Morfolinopirimidinas y su uso en terapia
PE20151981A1 (es) Pontenciador de inhibidores del homologo de zeste
PE20151601A1 (es) Compuestos novedosos de pirimidina y piridina y su uso
PE20151764A1 (es) Derivados de pirrolo[2,3-d]pirimidina

Legal Events

Date Code Title Description
FG Grant, registration