PE20091833A1 - Derivados heterociclicos espiro biciclicos o heterociclicos biciclicos, puenteados, de pirazolo [1,5-a]pirimidinas como inhibidores de quinasas raf y metodos para su preparacion - Google Patents
Derivados heterociclicos espiro biciclicos o heterociclicos biciclicos, puenteados, de pirazolo [1,5-a]pirimidinas como inhibidores de quinasas raf y metodos para su preparacionInfo
- Publication number
- PE20091833A1 PE20091833A1 PE2009000313A PE2009000313A PE20091833A1 PE 20091833 A1 PE20091833 A1 PE 20091833A1 PE 2009000313 A PE2009000313 A PE 2009000313A PE 2009000313 A PE2009000313 A PE 2009000313A PE 20091833 A1 PE20091833 A1 PE 20091833A1
- Authority
- PE
- Peru
- Prior art keywords
- bicycle
- bridged
- pyridin
- members
- pirazolo
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 102000009929 raf Kinases Human genes 0.000 title abstract 2
- 108010077182 raf Kinases Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- -1 PYRAZOLO [1,5-a] PYRIMIDINE DERIVATIVE HETEROCYCLIC COMPOUND Chemical class 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
REFERIDA A UN COMPUESTO HETEROCICLICO DERIVADO DE PIRAZOLO[1,5-a]PIRIMIDINA DE FORMULA (A), DONDE R1 ES UN ANILLO HETEROCICLICO DE 5 A 7 MIEMBROS OPCIONALMENTE SUSTITUIDO CON NO, CHO, CN, N3, ENTRE OTROS; R2 ES UN ANILLO BICICLICO DE 9 A 14 MIEMBROS, UN ANILLO HETEROARILO DE 5 A 7 MIEMBROS, UN ANILLO HETEROARILO BICICLICO DE 9 A 14 MIEMBROS, ENTRE OTROS; R3, R4 Y R5 SON CN, ALQUILO C1-C6, C(O)OR7, ENTRE OTROS; R7 ES H, ALQUILO C1-C6, ANILLO HETEROARILO DE 5 A 10 MIEMBROS, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-(7-{6-[(1-AZABICICLO[2.2.2]OCT-4-ILMETIL)AMINO]PIRIDIN-3-IL}-2-PIRIDIN-4-ILPIRAZOLO[1,5-a]PIRIMIDIN-3-IL)FENOL, 3-(7-{6-[(3S)-1-AZABICICLO[2.2.2]OCT-3-ILAMINO]PIRIDIN-3-IL}-2-PIRIDIN-4-ILPIRAZOLO[1,5-a]PIRIMIDIN-3-IL)FENOL, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS INHIBEN LAS TIROSINA QUINASAS, K-Raf Y QUINASAS Raf Y SON UTILES EN EL TRATAMIENTO DE CELULAS CANCERIGENAS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6784308P | 2008-02-29 | 2008-02-29 | |
| US11680908P | 2008-11-21 | 2008-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091833A1 true PE20091833A1 (es) | 2009-11-22 |
Family
ID=40548843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2009000313A PE20091833A1 (es) | 2008-02-29 | 2009-02-27 | Derivados heterociclicos espiro biciclicos o heterociclicos biciclicos, puenteados, de pirazolo [1,5-a]pirimidinas como inhibidores de quinasas raf y metodos para su preparacion |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20100029657A1 (es) |
| EP (1) | EP2271649A1 (es) |
| JP (1) | JP2011513334A (es) |
| KR (1) | KR20100123725A (es) |
| CN (1) | CN102083835A (es) |
| AP (1) | AP2010005363A0 (es) |
| AR (1) | AR070728A1 (es) |
| AU (1) | AU2009219175A1 (es) |
| BR (1) | BRPI0908403A2 (es) |
| CA (1) | CA2716499A1 (es) |
| CO (1) | CO6321261A2 (es) |
| CR (1) | CR11650A (es) |
| DO (1) | DOP2010000261A (es) |
| EA (1) | EA201001188A1 (es) |
| EC (1) | ECSP10010429A (es) |
| IL (1) | IL207576A0 (es) |
| MA (1) | MA32110B1 (es) |
| MX (1) | MX2010009458A (es) |
| NI (1) | NI201000143A (es) |
| PE (1) | PE20091833A1 (es) |
| SV (1) | SV2010003654A (es) |
| TW (1) | TW200951134A (es) |
| WO (1) | WO2009108838A1 (es) |
| ZA (1) | ZA201005603B (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007089031A (ja) | 2005-09-26 | 2007-04-05 | Fuji Xerox Co Ltd | 出力装置 |
| PT1976828T (pt) | 2005-12-29 | 2017-03-10 | Celtaxsys Inc | Derivados de diamina como inibidores de leucotrieno a4 hidrolase |
| CA2781390A1 (en) * | 2009-12-14 | 2011-06-23 | Inspire Pharmaceuticals, Inc. | Bridged bicyclic rho kinase inhibitor compounds, composition and use |
| RU2570426C2 (ru) | 2009-12-18 | 2015-12-10 | Мицубиси Танабе Фарма Корпорейшн | Новое антитромботическое средство |
| EP2402343A1 (en) * | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazole-fused bicyclic compounds |
| US8969363B2 (en) | 2011-07-19 | 2015-03-03 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US9957271B2 (en) | 2011-10-20 | 2018-05-01 | Glaxosmithkline Llc | Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators |
| CN103998451A (zh) * | 2011-10-20 | 2014-08-20 | 葛兰素史密斯克莱有限责任公司 | 用作沉默调节蛋白调节剂的取代的双环氮杂杂环化合物和类似物 |
| US9408885B2 (en) | 2011-12-01 | 2016-08-09 | Vib Vzw | Combinations of therapeutic agents for treating melanoma |
| EP2920181B1 (en) | 2012-11-16 | 2019-01-09 | University Health Network | Pyrazolopyrimidine compounds |
| ES2864862T3 (es) | 2013-03-12 | 2021-10-14 | Celltaxis Llc | Métodos de inhibición de la leucotrieno A4 hidrolasa |
| MX2015011677A (es) | 2013-03-14 | 2016-07-08 | Celtaxsys Inc | Inhibidores de leucotrieno a4 hidrolasa. |
| WO2014152518A2 (en) | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
| CA2906086A1 (en) | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
| EP3129376B1 (en) | 2014-03-27 | 2018-12-26 | Janssen Pharmaceutica NV | Substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine derivatives and 5,6,7,8-tetrahydro-4h-pyrazolo[1,5-a][1,4]diazepine derivatives as ros1 inhibitors |
| US10342795B2 (en) * | 2014-03-27 | 2019-07-09 | Janssen Pharmaceutica Nv | Substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine derivatives and 2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives as ROS1 inhibitors |
| AR100448A1 (es) | 2014-05-21 | 2016-10-05 | Bayer Cropscience Ag | 5-(hetero)aril-piridazinonas y su uso como herbicida |
| WO2017011776A1 (en) * | 2015-07-16 | 2017-01-19 | Array Biopharma, Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors |
| IL265115B (en) | 2016-08-31 | 2022-07-01 | Agios Pharmaceuticals Inc | Inhibitors of metabolic processes in the cell |
| EP3579872A1 (en) | 2017-02-10 | 2019-12-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway |
| EP3728228A1 (en) | 2017-12-22 | 2020-10-28 | Ravenna Pharmaceuticals, Inc. | Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| WO2019133810A1 (en) | 2017-12-28 | 2019-07-04 | Tract Pharmaceuticals, Inc. | Stem cell culture systems for columnar epithelial stem cells, and uses related thereto |
| AU2019278935B2 (en) | 2018-05-31 | 2025-02-13 | Celltaxis, Llc | Method of reducing pulmonary exacerbations in respiratory disease patients |
| EP3852737A4 (en) * | 2018-09-18 | 2022-05-11 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
| IL295956A (en) * | 2020-02-28 | 2022-10-01 | Remix Therapeutics Inc | Heterocyclic amides and their use for modulating splicing |
| WO2021188695A1 (en) | 2020-03-18 | 2021-09-23 | Metacrine, Inc. | Formulations of a farnesoid x receptor agonist |
| IL297963A (en) * | 2020-05-07 | 2023-01-01 | Adorx Therapeutics Ltd | Antagonists of the adenosine a2a receptor |
| US20250145628A1 (en) * | 2022-02-15 | 2025-05-08 | Novo Nordisk A/S | Pyrazolopyrimidines, compositions comprising them and uses thereof |
| TW202525819A (zh) * | 2023-09-08 | 2025-07-01 | 加拿大商薩泰洛斯生物科學公司 | Ａｐ２相關激酶１抑制劑及其用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4178449A (en) * | 1978-04-17 | 1979-12-11 | American Cyanamid Company | Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines |
| US4236005A (en) * | 1979-07-02 | 1980-11-25 | American Cyanamid Company | Imidazo[1,5-a]pyrimidines |
| US4281000A (en) * | 1979-07-09 | 1981-07-28 | American Cyanamid Company | Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents |
| US4900836A (en) * | 1983-06-23 | 1990-02-13 | American Cyanamid Company | (3-amino-1H-pyrazol-4-yl) (aryl)methanones |
| US4626538A (en) * | 1983-06-23 | 1986-12-02 | American Cyanamid Company | [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines |
| US4654347A (en) * | 1983-06-23 | 1987-03-31 | American Cyanamid Company | Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones |
| US4521422A (en) * | 1983-06-23 | 1985-06-04 | American Cyanamid Company | Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones |
| AU2003299651A1 (en) * | 2002-12-11 | 2004-06-30 | Merck And Co., Inc. | Tyrosine kinase inhibitors |
| US7176210B2 (en) * | 2003-02-10 | 2007-02-13 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| CA2560269A1 (en) * | 2004-03-19 | 2005-09-29 | The Penn State Research Foundation | Combinatorial methods and compositions for treatment of melanoma |
| BRPI0708813A2 (pt) * | 2006-03-17 | 2011-05-24 | Wyeth Corp | composto; composição; método de tratamento, inibição do crescimento ou erradicaçõ de neoplasias em um mamìfero necessitado; método de tratamento dse cáncer em um mamìfero necessitado; e mistura |
-
2009
- 2009-02-26 US US12/393,565 patent/US20100029657A1/en not_active Abandoned
- 2009-02-27 MX MX2010009458A patent/MX2010009458A/es not_active Application Discontinuation
- 2009-02-27 JP JP2010548895A patent/JP2011513334A/ja not_active Withdrawn
- 2009-02-27 PE PE2009000313A patent/PE20091833A1/es not_active Application Discontinuation
- 2009-02-27 EP EP09713876A patent/EP2271649A1/en not_active Withdrawn
- 2009-02-27 EA EA201001188A patent/EA201001188A1/ru unknown
- 2009-02-27 WO PCT/US2009/035422 patent/WO2009108838A1/en not_active Ceased
- 2009-02-27 KR KR1020107020750A patent/KR20100123725A/ko not_active Ceased
- 2009-02-27 CA CA2716499A patent/CA2716499A1/en not_active Abandoned
- 2009-02-27 TW TW098106566A patent/TW200951134A/zh unknown
- 2009-02-27 BR BRPI0908403-7A patent/BRPI0908403A2/pt not_active IP Right Cessation
- 2009-02-27 AR ARP090100723A patent/AR070728A1/es not_active Application Discontinuation
- 2009-02-27 AP AP2010005363A patent/AP2010005363A0/en unknown
- 2009-02-27 CN CN2009801153285A patent/CN102083835A/zh active Pending
- 2009-02-27 AU AU2009219175A patent/AU2009219175A1/en not_active Abandoned
-
2010
- 2010-08-05 ZA ZA2010/05603A patent/ZA201005603B/en unknown
- 2010-08-12 IL IL207576A patent/IL207576A0/en unknown
- 2010-08-24 CO CO10104173A patent/CO6321261A2/es not_active Application Discontinuation
- 2010-08-25 CR CR11650A patent/CR11650A/es not_active Application Discontinuation
- 2010-08-26 MA MA33124A patent/MA32110B1/fr unknown
- 2010-08-27 EC EC2010010429A patent/ECSP10010429A/es unknown
- 2010-08-27 NI NI201000143A patent/NI201000143A/es unknown
- 2010-08-27 DO DO2010000261A patent/DOP2010000261A/es unknown
- 2010-08-27 SV SV2010003654A patent/SV2010003654A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011513334A (ja) | 2011-04-28 |
| CO6321261A2 (es) | 2011-09-20 |
| WO2009108838A8 (en) | 2009-11-12 |
| WO2009108838A1 (en) | 2009-09-03 |
| TW200951134A (en) | 2009-12-16 |
| EA201001188A1 (ru) | 2011-04-29 |
| NI201000143A (es) | 2011-03-09 |
| DOP2010000261A (es) | 2010-09-15 |
| CN102083835A (zh) | 2011-06-01 |
| MX2010009458A (es) | 2010-09-24 |
| SV2010003654A (es) | 2011-03-23 |
| AR070728A1 (es) | 2010-04-28 |
| AU2009219175A1 (en) | 2009-09-03 |
| KR20100123725A (ko) | 2010-11-24 |
| EP2271649A1 (en) | 2011-01-12 |
| US20100029657A1 (en) | 2010-02-04 |
| CR11650A (es) | 2010-09-14 |
| ECSP10010429A (es) | 2010-09-30 |
| ZA201005603B (en) | 2011-05-25 |
| BRPI0908403A2 (pt) | 2015-08-11 |
| IL207576A0 (en) | 2010-12-30 |
| AP2010005363A0 (en) | 2010-08-31 |
| MA32110B1 (fr) | 2011-02-01 |
| CA2716499A1 (en) | 2009-09-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20091833A1 (es) | Derivados heterociclicos espiro biciclicos o heterociclicos biciclicos, puenteados, de pirazolo [1,5-a]pirimidinas como inhibidores de quinasas raf y metodos para su preparacion | |
| PE20110545A1 (es) | Compuestos de triazolopiridina como inhibidores de jak | |
| PE20090944A1 (es) | PIRIMIDINAS BICICLICAS FUSIONADAS COMO INHIBIDORES DE LA VIA Pi3K/AKT | |
| PE20091211A1 (es) | Derivados de pirazolopirimidina como moduladores de pde9a | |
| PE20120534A1 (es) | PIRIMIDINAS FUSIONADAS COMO INHIBIDORES DE Akt | |
| PE20080266A1 (es) | 4-amino-pirido[3,2-e]pirazinas, su uso como inhibidores de fosfodiesterasa 10 y procesos para su preparacion | |
| PE20120172A1 (es) | Compuestos heterociclicos fusionados que contiene nitrogeno como inhibidores de la produccion de beta-amiloide | |
| EA201170771A1 (ru) | Органические соединения | |
| PE20110387A1 (es) | Aminotriazolo-piridinas como inhibidores de cinasa | |
| PE20080315A1 (es) | DERIVADOS DE PIRAZOLO-[3,4-d]-PIRIMIDINAS COMO INHIBIDORES DE CINASA PI-3 | |
| PE20120493A1 (es) | Pirimidinonas como inhibidores de pi3k | |
| PE20151249A1 (es) | Derivados de pirazolopirimidina como inhibidores de jak quinasas | |
| PE20090511A1 (es) | Imidazopiridinonas | |
| AR080785A1 (es) | Derivados de imidazo[1,2-a]pirimidina ,proceso para prepararlos e intermediarios de dicha sintesis, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de patologias del sistema nervioso central,tales como esquizofrenia y parkinson, entre otros. | |
| PE20090596A1 (es) | Imidazoles biciclicos fusionados | |
| PE20140927A1 (es) | Compuestos heterociclicos como inhibidores de cinasas | |
| PE20081806A1 (es) | Imidazo- y triazolopirimidinas sustituidas | |
| PE20130012A1 (es) | Derivados de pirazol como inhibidores de jak | |
| PE20121506A1 (es) | Compuestos triazolopiridinas como inhibidores de c-met | |
| PE20110411A1 (es) | Imidazopiridazinacarbonitrilos como inhibidores de quinasa | |
| PE20081612A1 (es) | Analogos de las pterinas | |
| EA201170769A1 (ru) | Органические соединения | |
| PE20061198A1 (es) | Derivados de pirazol como inhibidores de cdk y gsk | |
| PE20120506A1 (es) | Derivados de pirazolopiridina como inhibidores de quinasas | |
| PE20070002A1 (es) | Compuestos derivados de heteroaril como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa tipo i |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |