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PE20110383A1 - Pirazolopirimidinonas como inhibidores de la fosfodiesterasa 9a (pde9a) - Google Patents

Pirazolopirimidinonas como inhibidores de la fosfodiesterasa 9a (pde9a)

Info

Publication number
PE20110383A1
PE20110383A1 PE2011000598A PE2011000598A PE20110383A1 PE 20110383 A1 PE20110383 A1 PE 20110383A1 PE 2011000598 A PE2011000598 A PE 2011000598A PE 2011000598 A PE2011000598 A PE 2011000598A PE 20110383 A1 PE20110383 A1 PE 20110383A1
Authority
PE
Peru
Prior art keywords
pyrazolopyrimidinones
pde9a
phosphodiesterase
inhibitors
alkyl
Prior art date
Application number
PE2011000598A
Other languages
English (en)
Inventor
Klaus Fuchs
Cornelia Dorner-Ciossek
Christian Eickmeier
Dennis Fiegen
Thomas Fox
Riccardo Giovannini
Niklas Heine
Martin Hendrix
Holger Rosenbrock
Gerhard Schaenzle
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41651170&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110383(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20110383A1 publication Critical patent/PE20110383A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Urology & Nephrology (AREA)
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE PIRAZOLOPIRIMIDINONAS DE FORMULA (I) DONDE A ES CICLOALQUILO(C3-C8) O CICLOALQUENILO(C4-C8); R1 ES ALQUIL(C1-C8), ALQUENIL(C2-C8), CICLOALQUIL(C3-C7), ENTRE OTROS; R2 ES F, CN, CF3, ALQUINIL(C2-C6), ENTRE OTROS; R3 ES CN, CHF2, CF3-CH2-, ALQUIL(C1-C6), ENTRE OTROS; R4 Y R5 SON CADA UNO H, F, CH2F, ALQUIL(C1-C3), ENTRE OTROS; x ES DE 0 A 4. SON COMPUESTOS PREFERIDOS LOS DE FORMULA (a), (b), ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA FOSFODIESTERASA 9A (PDE9A) SIENDO UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, DEMENCIA CON CUERPOS DE LEWY, ENFERMEDAD DE PARKINSON, ESCLEROSIS MULTIPLE
PE2011000598A 2008-09-08 2009-09-04 Pirazolopirimidinonas como inhibidores de la fosfodiesterasa 9a (pde9a) PE20110383A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08163879 2008-09-08
EP09167675 2009-08-12

Publications (1)

Publication Number Publication Date
PE20110383A1 true PE20110383A1 (es) 2011-07-15

Family

ID=41651170

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011000598A PE20110383A1 (es) 2008-09-08 2009-09-04 Pirazolopirimidinonas como inhibidores de la fosfodiesterasa 9a (pde9a)

Country Status (23)

Country Link
US (1) US9079905B2 (es)
EP (1) EP2334684B1 (es)
JP (1) JP5453431B2 (es)
KR (1) KR20110063447A (es)
CN (1) CN102143965A (es)
AP (1) AP2011005672A0 (es)
AR (1) AR073500A1 (es)
AU (1) AU2009289240A1 (es)
BR (1) BRPI0918527A2 (es)
CA (1) CA2736304A1 (es)
CL (1) CL2011000488A1 (es)
CO (1) CO6351731A2 (es)
EA (1) EA201100446A1 (es)
EC (1) ECSP11010866A (es)
IL (1) IL210854A0 (es)
MA (1) MA32620B1 (es)
MX (1) MX2011002340A (es)
NZ (1) NZ590788A (es)
PE (1) PE20110383A1 (es)
TW (1) TW201014859A (es)
UY (1) UY32092A (es)
WO (1) WO2010026214A1 (es)
ZA (1) ZA201100482B (es)

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MA46621A (fr) 2016-10-28 2021-06-02 H Lundbeck As Traitements combinés comprenant l'administration d'imidazopyrazinones
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KR20200010220A (ko) 2017-06-01 2020-01-30 에자이 알앤드디 매니지먼트 가부시키가이샤 피라졸로퀴놀린 유도체를 함유하는 루이소체 질병 치료제
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