FI963817A0 - Substituoidut atsetidinoniyhdisteet, jotka ovat hyödyllisiä hypokolesteroleemisinä aineina - Google Patents
Substituoidut atsetidinoniyhdisteet, jotka ovat hyödyllisiä hypokolesteroleemisinä aineinaInfo
- Publication number
- FI963817A0 FI963817A0 FI963817A FI963817A FI963817A0 FI 963817 A0 FI963817 A0 FI 963817A0 FI 963817 A FI963817 A FI 963817A FI 963817 A FI963817 A FI 963817A FI 963817 A0 FI963817 A0 FI 963817A0
- Authority
- FI
- Finland
- Prior art keywords
- aryl
- lower alkyl
- substituted
- alkyl
- coor6
- Prior art date
Links
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003529 anticholesteremic agent Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000003118 aryl group Chemical group 0.000 abstract 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 239000000543 intermediate Substances 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21849894A | 1994-03-25 | 1994-03-25 | |
| PCT/US1995/003196 WO1995026334A1 (en) | 1994-03-25 | 1995-03-22 | Substituted azetidinone compounds useful as hypocholesterolemic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI963817A7 FI963817A7 (fi) | 1996-09-25 |
| FI963817A0 true FI963817A0 (fi) | 1996-09-25 |
Family
ID=22815366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI963817A FI963817A0 (fi) | 1994-03-25 | 1996-09-25 | Substituoidut atsetidinoniyhdisteet, jotka ovat hyödyllisiä hypokolesteroleemisinä aineina |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US5627176A (fi) |
| EP (1) | EP0751934B1 (fi) |
| JP (1) | JP3524927B2 (fi) |
| KR (1) | KR100338171B1 (fi) |
| CN (1) | CN1144522A (fi) |
| AT (1) | ATE183738T1 (fi) |
| AU (1) | AU686361B2 (fi) |
| CA (1) | CA2186364C (fi) |
| CZ (1) | CZ281596A3 (fi) |
| DE (1) | DE69511687T2 (fi) |
| DK (1) | DK0751934T3 (fi) |
| ES (1) | ES2135050T3 (fi) |
| FI (1) | FI963817A0 (fi) |
| GR (1) | GR3031105T3 (fi) |
| HU (1) | HU221309B1 (fi) |
| NO (1) | NO964008L (fi) |
| NZ (1) | NZ283528A (fi) |
| PL (1) | PL316431A1 (fi) |
| SK (1) | SK119796A3 (fi) |
| WO (1) | WO1995026334A1 (fi) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5633246A (en) * | 1994-11-18 | 1997-05-27 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5624920A (en) * | 1994-11-18 | 1997-04-29 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
| ATE219495T1 (de) | 1995-10-31 | 2002-07-15 | Schering Corp | Zuckersubstituierte 2-azetidinone, verwendbar als hypocholesterdenische arzneimittel |
| WO1997016424A1 (en) * | 1995-11-02 | 1997-05-09 | Schering Corporation | Process for preparing 1-(4-fluorophenyl)-3(r)-(3(s)-hydroxy-3-([phenyl or 4-fluorophenyl])-propyl)-4(s)-(4-hydroxyphenyl)-2-azetidinone |
| US5756470A (en) * | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
| WO2000063703A1 (en) | 1999-04-16 | 2000-10-26 | Schering Corporation | Use of azetidinone compounds |
| US6584357B1 (en) * | 2000-10-17 | 2003-06-24 | Sony Corporation | Method and system for forming an acoustic signal from neural timing difference data |
| SK286703B6 (sk) * | 2000-12-20 | 2009-03-05 | Schering Corporation | Cukrom-substituované 2-azetidinóny, farmaceutický prostriedok s ich obsahom a ich použitie |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| SI1355644T1 (sl) * | 2001-01-26 | 2006-10-31 | Schering Corp | Uporaba substituiranih azetidinonskih spojin za zdravljenje sitosterolemije |
| EP1911462A3 (en) | 2001-01-26 | 2011-11-30 | Schering Corporation | Compositions comprising a sterol absorption inhibitor |
| US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| KR20040025890A (ko) * | 2001-01-26 | 2004-03-26 | 쉐링 코포레이션 | 혈관성 질환을 치료하기 위한 스테롤 흡수 억제제와 혈액조절제의 조합물 |
| IL156445A0 (en) * | 2001-01-26 | 2004-01-04 | Schering Corp | Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
| AU2005246926B2 (en) * | 2001-01-26 | 2008-02-28 | Merck Sharp & Dohme Corp. | The use of substituted azetidinone compounds for the treatment of sitosterolemia |
| RS50386B (sr) | 2001-03-28 | 2009-12-31 | Schering Corporation, | Enantioselektivna sinteza intermedijarnih jedinjenja azetidinona |
| DK1429756T3 (da) | 2001-09-21 | 2007-03-19 | Schering Corp | Behandling af xanthoma med azetidinonderivater som sterolabsorptionsinhibitorer |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| SI1429756T1 (sl) * | 2001-09-21 | 2007-02-28 | Schering Corp | Zdravljenje ksantomov z azetidinonskimi derivati kot inhibitorji absorpcije sterola |
| US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| US20030204096A1 (en) * | 2002-03-25 | 2003-10-30 | Schering Corporation | Enantioselective synthesis of azetidinone intermediate compounds |
| GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
| US20040132058A1 (en) | 2002-07-19 | 2004-07-08 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
| US7135556B2 (en) * | 2002-07-19 | 2006-11-14 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
| AR040588A1 (es) | 2002-07-26 | 2005-04-13 | Schering Corp | Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa |
| US20040092499A1 (en) | 2002-11-06 | 2004-05-13 | Schering Corporation | Methods and therapeutic combinations for the treatment of autoimmune disorders |
| CN1756755A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| ATE418551T1 (de) | 2003-03-07 | 2009-01-15 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
| WO2004081002A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| JP2005015434A (ja) | 2003-06-27 | 2005-01-20 | Kotobuki Seiyaku Kk | 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤 |
| WO2005046797A2 (en) * | 2003-11-05 | 2005-05-26 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
| EP1918000A2 (en) | 2003-11-05 | 2008-05-07 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
| WO2005061452A1 (en) | 2003-12-23 | 2005-07-07 | Astrazeneca Ab | Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity |
| CN100471835C (zh) * | 2003-12-23 | 2009-03-25 | 默克公司 | 抗高胆固醇血症化合物 |
| EP1723414A4 (en) * | 2004-01-16 | 2008-03-26 | Merck & Co Inc | Npc1l1 (npc3) and methods of identifying ligands thereof |
| CA2581596A1 (en) * | 2004-09-29 | 2006-04-13 | Schering Corporation | Combinations of substituted azetidonones and cb1 antagonists |
| CA2589483C (en) | 2004-12-03 | 2013-10-29 | Schering Corporation | Substituted piperazines as cb1 antagonists |
| EP1902046B1 (en) * | 2005-06-20 | 2009-12-02 | Schering Corporation | Piperidine derivatives useful as histamine h3 antagonists |
| SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
| NZ569814A (en) | 2006-01-18 | 2011-10-28 | Schering Corp | Cannibinoid receptor modulators |
| WO2007100807A2 (en) * | 2006-02-24 | 2007-09-07 | Schering Corporation | Npc1l1 orthologues |
| CA2644905A1 (en) * | 2006-03-06 | 2007-09-13 | Teva Pharmaceutical Industries Ltd. | Ezetimibe compositions |
| AR060623A1 (es) | 2006-04-27 | 2008-07-02 | Astrazeneca Ab | Compuestos derivados de 2-azetidinona y un metodo de preparacion |
| PE20081877A1 (es) | 2007-03-06 | 2008-12-27 | Teijin Pharma Ltd | Derivado de la 1,4-diarilacetidinona |
| US20100197564A1 (en) * | 2007-04-19 | 2010-08-05 | Schering Corporation | Diaryl morpholines as cb1 modulators |
| US20090047716A1 (en) * | 2007-06-07 | 2009-02-19 | Nurit Perlman | Reduction processes for the preparation of ezetimibe |
| EP2548874A3 (en) * | 2007-06-28 | 2013-05-15 | Intervet International B.V. | Substituted piperazines as CB1 antagonists |
| CN101790521A (zh) * | 2007-06-28 | 2010-07-28 | 英特维特国际股份有限公司 | 作为cb1拮抗剂的取代哌嗪 |
| WO2009032264A1 (en) * | 2007-08-30 | 2009-03-12 | Teva Pharmaceutical Industries Ltd. | Processes for preparing intermediates of ezetimibe by microbial reduction |
| CN101200443B (zh) * | 2007-10-17 | 2011-06-29 | 中国药科大学 | 氮杂环丁酮衍生物、其制备方法及含有它们的药物组合 |
| CA2754384A1 (en) | 2009-03-06 | 2010-09-10 | Lipideon Biotechnology Ag | Pharmaceutical hypocholesterolemic compositions |
| CN101993403B (zh) | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | 氮杂环丁酮类化合物及医药应用 |
| US9763885B2 (en) | 2012-05-01 | 2017-09-19 | Althera Laboratories Ltd. | Oral tablet formulation consisting of fixed combination of rosuvastatin and ezetimibe for treatment of hyperlipidemia and cardiovascular diseases |
| JP5969958B2 (ja) * | 2013-06-27 | 2016-08-17 | 国立大学法人お茶の水女子大学 | 光学活性含フッ素アミノ酸類の製造方法 |
| CN105294426B (zh) | 2014-06-09 | 2019-05-14 | 浙江海正药业股份有限公司 | 氮杂环丁酮化合物制备方法及其中间体 |
| CN104860980B (zh) * | 2015-04-23 | 2018-06-19 | 上海弈柯莱生物医药科技有限公司 | 一种用于合成依折麦布的中间体及其制备方法和应用 |
| JP2020507621A (ja) | 2017-01-23 | 2020-03-12 | ドン ファ ファーマシューティカル カンパニー リミテッド | ＨＭＧ−ＣｏＡ還元酵素阻害剤およびクロピドグレルを含む複合製剤 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4680391A (en) * | 1983-12-01 | 1987-07-14 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| US4803266A (en) * | 1986-10-17 | 1989-02-07 | Taisho Pharmaceutical Co., Ltd. | 3-Oxoalkylidene-2-azetidinone derivatives |
| IL89835A0 (en) * | 1988-04-11 | 1989-12-15 | Merck & Co Inc | Substituted azetidinones,their preparation and pharmaceutical compositions containing them |
| JPH02268144A (ja) * | 1989-04-11 | 1990-11-01 | Ube Ind Ltd | β―アミノエステルの製造法 |
| US4983597A (en) * | 1989-08-31 | 1991-01-08 | Merck & Co., Inc. | Beta-lactams as anticholesterolemic agents |
| US5120729A (en) * | 1990-06-20 | 1992-06-09 | Merck & Co., Inc. | Beta-lactams as antihypercholesterolemics |
| DE69222532T2 (de) * | 1991-07-23 | 1998-02-26 | Schering Corp | Substituierte beta-lactam-verbindungen als hypocholesterolemische mittel und verfahren zu deren herstellung |
-
1995
- 1995-03-13 US US08/403,081 patent/US5627176A/en not_active Expired - Lifetime
- 1995-03-22 KR KR1019960705349A patent/KR100338171B1/ko not_active Expired - Fee Related
- 1995-03-22 PL PL95316431A patent/PL316431A1/xx unknown
- 1995-03-22 AU AU21596/95A patent/AU686361B2/en not_active Ceased
- 1995-03-22 DK DK95914719T patent/DK0751934T3/da active
- 1995-03-22 NZ NZ283528A patent/NZ283528A/en not_active IP Right Cessation
- 1995-03-22 WO PCT/US1995/003196 patent/WO1995026334A1/en not_active Ceased
- 1995-03-22 CA CA002186364A patent/CA2186364C/en not_active Expired - Fee Related
- 1995-03-22 JP JP52518495A patent/JP3524927B2/ja not_active Expired - Fee Related
- 1995-03-22 CZ CZ962815A patent/CZ281596A3/cs unknown
- 1995-03-22 CN CN95192277A patent/CN1144522A/zh active Pending
- 1995-03-22 HU HU9602616A patent/HU221309B1/hu not_active IP Right Cessation
- 1995-03-22 ES ES95914719T patent/ES2135050T3/es not_active Expired - Lifetime
- 1995-03-22 EP EP95914719A patent/EP0751934B1/en not_active Expired - Lifetime
- 1995-03-22 AT AT95914719T patent/ATE183738T1/de not_active IP Right Cessation
- 1995-03-22 DE DE69511687T patent/DE69511687T2/de not_active Expired - Lifetime
- 1995-03-22 SK SK1197-96A patent/SK119796A3/sk unknown
- 1995-05-18 US US08/444,167 patent/US5688990A/en not_active Expired - Lifetime
-
1996
- 1996-09-24 NO NO964008A patent/NO964008L/no unknown
- 1996-09-25 FI FI963817A patent/FI963817A0/fi unknown
-
1999
- 1999-08-27 GR GR990402188T patent/GR3031105T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1144522A (zh) | 1997-03-05 |
| KR970702246A (ko) | 1997-05-13 |
| WO1995026334A1 (en) | 1995-10-05 |
| US5688990A (en) | 1997-11-18 |
| PL316431A1 (en) | 1997-01-06 |
| CZ281596A3 (en) | 1997-05-14 |
| EP0751934B1 (en) | 1999-08-25 |
| MX9604030A (es) | 1997-09-30 |
| DE69511687D1 (de) | 1999-09-30 |
| DK0751934T3 (da) | 1999-12-13 |
| CA2186364A1 (en) | 1995-10-05 |
| AU686361B2 (en) | 1998-02-05 |
| FI963817A7 (fi) | 1996-09-25 |
| CA2186364C (en) | 2008-12-30 |
| EP0751934A1 (en) | 1997-01-08 |
| HU221309B1 (en) | 2002-09-28 |
| ES2135050T3 (es) | 1999-10-16 |
| DE69511687T2 (de) | 2000-03-16 |
| SK119796A3 (en) | 1997-05-07 |
| AU2159695A (en) | 1995-10-17 |
| ATE183738T1 (de) | 1999-09-15 |
| HUT74887A (en) | 1997-02-28 |
| JPH09510970A (ja) | 1997-11-04 |
| JP3524927B2 (ja) | 2004-05-10 |
| NO964008L (no) | 1996-11-22 |
| GR3031105T3 (en) | 1999-12-31 |
| NZ283528A (en) | 1997-12-19 |
| US5627176A (en) | 1997-05-06 |
| HU9602616D0 (en) | 1996-11-28 |
| KR100338171B1 (ko) | 2002-11-23 |
| NO964008D0 (no) | 1996-09-24 |
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