NO964008L - Substituerte azetidinonforbindelser som er anvendbare som hypokolesterolemiske midler - Google Patents
Substituerte azetidinonforbindelser som er anvendbare som hypokolesterolemiske midlerInfo
- Publication number
- NO964008L NO964008L NO964008A NO964008A NO964008L NO 964008 L NO964008 L NO 964008L NO 964008 A NO964008 A NO 964008A NO 964008 A NO964008 A NO 964008A NO 964008 L NO964008 L NO 964008L
- Authority
- NO
- Norway
- Prior art keywords
- aryl
- lower alkyl
- substituted
- halogen
- hydrogen
- Prior art date
Links
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003529 anticholesteremic agent Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000003118 aryl group Chemical group 0.000 abstract 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 239000000543 intermediate Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Substituerte azetidinonhypo- kolesterolemiske midler av formel (D R1 Ar1-A-Yq-C- Ar3 (i) O eller et farmasøytisk akseptabelt salt derav, hvori: Ar er R - 2 4 substituert aryl; Ar er R -substi- 3 c tuert aryl; Ar er R -substituert aryl; Y og Z er uavhengig -CH2~, -CH(lavere alkyl)- eller -c(di- lavere alkyl)-; A er -O-, -S-, .-S(O)- eller -S(O),-; R1 er -OR6, -O(CO)R6, -O(CO)OR eller -0(CO)NR6R7; R er hydrogen, lavere alkyl eller aryl; eller R og R er sammen =0; q er l, 2 eller 3; p er O, l, 2, 3 eller 4; R er 1- 3 substituenter uavhengig valgt fra -OR6, -O(CO)R6, -O(CO)OR9, -0(CH2),5OR9, -0(CO)NR6R7, -NR6R7, -NR6(CO)R , -NR6(CO)OR9, -NR6(CO)NR7R8, -NR6SO_-lavere alkyl, -NR6SO?-aryl, -CONR6R ¿ ~COR / -S02NR5R?, S(O)0_2-alkyl, S (O)Q_2~ alkyl; og R er lavere alkyl, aryl i eller aryl-substituert lavere alkyl; er beskrevet, så vel som en metode : for nedsettelse av serumkolesterol - med administrering av angitte for- bindelser, farmasøytiske preparater i inneholdende disse, kombinasjonen av ! et substituert azetidinon og en . kolesterolbiosynteseinhibitor for behandling og forhindring av ! arteriosklerose, nye mellomprodukter i og metoder for fremstilling av ' angitte mellomprodukter, j aryl, -O(CH2)1_lp-COOR6, , -0(CH2)0_10-CONR^R7, o-halogen, m- I halogen, o-lavere alkyl, m-lavere alkyl, -(lavere alkylen)-COOR6 og -CH=CH-COOR ; R3 og R4 er 1-3 sub- stituenter uavhengig valgt fra R , hydrogen, p-lavere alkyl, aryl, -N02, CF3 og p-halogen; R , R7 og R er hydrogen, lavere alkyl, .aryl eller aryl-substituert lavere
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21849894A | 1994-03-25 | 1994-03-25 | |
| PCT/US1995/003196 WO1995026334A1 (en) | 1994-03-25 | 1995-03-22 | Substituted azetidinone compounds useful as hypocholesterolemic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO964008D0 NO964008D0 (no) | 1996-09-24 |
| NO964008L true NO964008L (no) | 1996-11-22 |
Family
ID=22815366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO964008A NO964008L (no) | 1994-03-25 | 1996-09-24 | Substituerte azetidinonforbindelser som er anvendbare som hypokolesterolemiske midler |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US5627176A (no) |
| EP (1) | EP0751934B1 (no) |
| JP (1) | JP3524927B2 (no) |
| KR (1) | KR100338171B1 (no) |
| CN (1) | CN1144522A (no) |
| AT (1) | ATE183738T1 (no) |
| AU (1) | AU686361B2 (no) |
| CA (1) | CA2186364C (no) |
| CZ (1) | CZ281596A3 (no) |
| DE (1) | DE69511687T2 (no) |
| DK (1) | DK0751934T3 (no) |
| ES (1) | ES2135050T3 (no) |
| FI (1) | FI963817A7 (no) |
| GR (1) | GR3031105T3 (no) |
| HU (1) | HU221309B1 (no) |
| NO (1) | NO964008L (no) |
| NZ (1) | NZ283528A (no) |
| PL (1) | PL316431A1 (no) |
| SK (1) | SK119796A3 (no) |
| WO (1) | WO1995026334A1 (no) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5633246A (en) * | 1994-11-18 | 1997-05-27 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5624920A (en) * | 1994-11-18 | 1997-04-29 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
| KR100311554B1 (ko) | 1995-10-31 | 2002-06-20 | 둘락 노먼 씨. | 콜레스테롤저하제로유용한슈가-치환된2-아제티디논 |
| AU7472896A (en) * | 1995-11-02 | 1997-05-22 | Schering Corporation | Process for preparing 1-(4-fluorophenyl)-3(r)-(3(s)-hydroxy-3-({phenyl or 4-fluorophenyl})-propyl)-4(s)-(4-hydroxyphenyl)-2-azetidinon |
| US5756470A (en) * | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
| WO2000063703A1 (en) | 1999-04-16 | 2000-10-26 | Schering Corporation | Use of azetidinone compounds |
| US6584357B1 (en) * | 2000-10-17 | 2003-06-24 | Sony Corporation | Method and system for forming an acoustic signal from neural timing difference data |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| PE20020718A1 (es) * | 2000-12-20 | 2002-08-09 | Schering Corp | 2-azetidinonas sustituidas con azucares utiles como agentes hipocolesterolemicos |
| EP1911462A3 (en) | 2001-01-26 | 2011-11-30 | Schering Corporation | Compositions comprising a sterol absorption inhibitor |
| AU2005246926B2 (en) * | 2001-01-26 | 2008-02-28 | Merck Sharp & Dohme Corp. | The use of substituted azetidinone compounds for the treatment of sitosterolemia |
| ATE331512T1 (de) * | 2001-01-26 | 2006-07-15 | Schering Corp | Verwendung azetidinone-substituierter verbindungen zur behandlung der sitosterolhämie |
| US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| MEP27808A (en) * | 2001-01-26 | 2010-10-10 | Schering Corp | Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
| JP2004517920A (ja) * | 2001-01-26 | 2004-06-17 | シェーリング コーポレイション | 血管状態を治療するためのステロール吸収阻害剤と血液調整剤との組合せ |
| CN1275949C (zh) | 2001-03-28 | 2006-09-20 | 先灵公司 | 2－吖丁啶酮中间体化合物的对映体选择性合成 |
| SI1429756T1 (sl) * | 2001-09-21 | 2007-02-28 | Schering Corp | Zdravljenje ksantomov z azetidinonskimi derivati kot inhibitorji absorpcije sterola |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| JP2005504091A (ja) | 2001-09-21 | 2005-02-10 | シェーリング コーポレイション | ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置 |
| US20030204096A1 (en) * | 2002-03-25 | 2003-10-30 | Schering Corporation | Enantioselective synthesis of azetidinone intermediate compounds |
| GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
| US7135556B2 (en) * | 2002-07-19 | 2006-11-14 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
| US20040132058A1 (en) | 2002-07-19 | 2004-07-08 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
| AR040588A1 (es) | 2002-07-26 | 2005-04-13 | Schering Corp | Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa |
| WO2004043457A1 (en) | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorptions inhibitors for the treatment of autoimmune disorders |
| EP1606287B1 (en) | 2003-03-07 | 2013-10-02 | Merck Sharp & Dohme Corp. | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
| CA2517571C (en) * | 2003-03-07 | 2011-07-05 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| MXPA05009501A (es) * | 2003-03-07 | 2005-10-18 | Schering Corp | Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
| JP2005015434A (ja) | 2003-06-27 | 2005-01-20 | Kotobuki Seiyaku Kk | 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤 |
| WO2005046797A2 (en) * | 2003-11-05 | 2005-05-26 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
| EP1918000A2 (en) | 2003-11-05 | 2008-05-07 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
| CN100471835C (zh) * | 2003-12-23 | 2009-03-25 | 默克公司 | 抗高胆固醇血症化合物 |
| US7871998B2 (en) | 2003-12-23 | 2011-01-18 | Astrazeneca Ab | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitory activity |
| MXPA06008124A (es) * | 2004-01-16 | 2007-01-26 | Merck & Co Inc | Npc1l1 (npc3) y metodos para identificar ligandos del mismo. |
| CA2581596A1 (en) * | 2004-09-29 | 2006-04-13 | Schering Corporation | Combinations of substituted azetidonones and cb1 antagonists |
| US7700597B2 (en) | 2004-12-03 | 2010-04-20 | Schering Corporation | Substituted piperazines as CB1 antagonists |
| ATE450526T1 (de) * | 2005-06-20 | 2009-12-15 | Schering Corp | Als antagonisten von histamin h3 geeignete piperidinderivate |
| SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
| BRPI0706623A2 (pt) | 2006-01-18 | 2011-04-12 | Schering Corp | moduladores de receptor canabinóide |
| WO2007100807A2 (en) | 2006-02-24 | 2007-09-07 | Schering Corporation | Npc1l1 orthologues |
| BRPI0708556A2 (pt) * | 2006-03-06 | 2011-05-31 | Teva Pharma | composição de ezetimiba |
| AR060623A1 (es) | 2006-04-27 | 2008-07-02 | Astrazeneca Ab | Compuestos derivados de 2-azetidinona y un metodo de preparacion |
| AU2008221833A1 (en) | 2007-03-06 | 2008-09-12 | Teijin Pharma Limited | 1-biarylazetidinone derivatives |
| WO2008130616A2 (en) * | 2007-04-19 | 2008-10-30 | Schering Corporation | Diaryl morpholines as cb1 modulators |
| US20090047716A1 (en) * | 2007-06-07 | 2009-02-19 | Nurit Perlman | Reduction processes for the preparation of ezetimibe |
| KR20100051625A (ko) * | 2007-06-28 | 2010-05-17 | 인터벳 인터내셔널 비.브이. | Ｃｂ1 길항제로서의 치환된 피페라진 |
| JP2010531874A (ja) * | 2007-06-28 | 2010-09-30 | インターベット インターナショナル ベー． フェー． | Ｃｂ１アンタゴニストとしての置換ピペラジン |
| WO2009032264A1 (en) * | 2007-08-30 | 2009-03-12 | Teva Pharmaceutical Industries Ltd. | Processes for preparing intermediates of ezetimibe by microbial reduction |
| CN101200443B (zh) * | 2007-10-17 | 2011-06-29 | 中国药科大学 | 氮杂环丁酮衍生物、其制备方法及含有它们的药物组合 |
| WO2010100255A1 (en) | 2009-03-06 | 2010-09-10 | Lipideon Biotechnology Ag | Pharmaceutical hypocholesterolemic compositions |
| CN101993403B (zh) | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | 氮杂环丁酮类化合物及医药应用 |
| PT2844233T (pt) | 2012-05-01 | 2020-06-25 | Althera Life Sciences Llc | Formulação de comprimido oral que consiste numa combinação fixa de rosuvastatina e ezetimiba para o tratamento de hiperlipidemia e doenças cardiovasculares |
| JP5969958B2 (ja) * | 2013-06-27 | 2016-08-17 | 国立大学法人お茶の水女子大学 | 光学活性含フッ素アミノ酸類の製造方法 |
| CN105294426B (zh) | 2014-06-09 | 2019-05-14 | 浙江海正药业股份有限公司 | 氮杂环丁酮化合物制备方法及其中间体 |
| CN104860980B (zh) * | 2015-04-23 | 2018-06-19 | 上海弈柯莱生物医药科技有限公司 | 一种用于合成依折麦布的中间体及其制备方法和应用 |
| EP3572075A2 (en) | 2017-01-23 | 2019-11-27 | Dong Wha Pharm. Co., Ltd. | Complex formulation comprising hmg-coa reductase inhibitor and clopidogrel |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4680391A (en) * | 1983-12-01 | 1987-07-14 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| US4803266A (en) * | 1986-10-17 | 1989-02-07 | Taisho Pharmaceutical Co., Ltd. | 3-Oxoalkylidene-2-azetidinone derivatives |
| IL89835A0 (en) * | 1988-04-11 | 1989-12-15 | Merck & Co Inc | Substituted azetidinones,their preparation and pharmaceutical compositions containing them |
| JPH02268144A (ja) * | 1989-04-11 | 1990-11-01 | Ube Ind Ltd | β―アミノエステルの製造法 |
| US4983597A (en) * | 1989-08-31 | 1991-01-08 | Merck & Co., Inc. | Beta-lactams as anticholesterolemic agents |
| US5120729A (en) * | 1990-06-20 | 1992-06-09 | Merck & Co., Inc. | Beta-lactams as antihypercholesterolemics |
| IL102582A0 (en) * | 1991-07-23 | 1993-01-14 | Schering Corp | Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof |
-
1995
- 1995-03-13 US US08/403,081 patent/US5627176A/en not_active Expired - Lifetime
- 1995-03-22 WO PCT/US1995/003196 patent/WO1995026334A1/en not_active Ceased
- 1995-03-22 HU HU9602616A patent/HU221309B1/hu not_active IP Right Cessation
- 1995-03-22 NZ NZ283528A patent/NZ283528A/en not_active IP Right Cessation
- 1995-03-22 DK DK95914719T patent/DK0751934T3/da active
- 1995-03-22 AU AU21596/95A patent/AU686361B2/en not_active Ceased
- 1995-03-22 CA CA002186364A patent/CA2186364C/en not_active Expired - Fee Related
- 1995-03-22 PL PL95316431A patent/PL316431A1/xx unknown
- 1995-03-22 AT AT95914719T patent/ATE183738T1/de not_active IP Right Cessation
- 1995-03-22 CZ CZ962815A patent/CZ281596A3/cs unknown
- 1995-03-22 ES ES95914719T patent/ES2135050T3/es not_active Expired - Lifetime
- 1995-03-22 CN CN95192277A patent/CN1144522A/zh active Pending
- 1995-03-22 EP EP95914719A patent/EP0751934B1/en not_active Expired - Lifetime
- 1995-03-22 JP JP52518495A patent/JP3524927B2/ja not_active Expired - Fee Related
- 1995-03-22 KR KR1019960705349A patent/KR100338171B1/ko not_active Expired - Fee Related
- 1995-03-22 SK SK1197-96A patent/SK119796A3/sk unknown
- 1995-03-22 DE DE69511687T patent/DE69511687T2/de not_active Expired - Lifetime
- 1995-05-18 US US08/444,167 patent/US5688990A/en not_active Expired - Lifetime
-
1996
- 1996-09-24 NO NO964008A patent/NO964008L/no unknown
- 1996-09-25 FI FI963817A patent/FI963817A7/fi unknown
-
1999
- 1999-08-27 GR GR990402188T patent/GR3031105T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR100338171B1 (ko) | 2002-11-23 |
| WO1995026334A1 (en) | 1995-10-05 |
| HU221309B1 (en) | 2002-09-28 |
| AU686361B2 (en) | 1998-02-05 |
| FI963817A0 (fi) | 1996-09-25 |
| CA2186364A1 (en) | 1995-10-05 |
| US5688990A (en) | 1997-11-18 |
| ATE183738T1 (de) | 1999-09-15 |
| EP0751934A1 (en) | 1997-01-08 |
| KR970702246A (ko) | 1997-05-13 |
| CN1144522A (zh) | 1997-03-05 |
| US5627176A (en) | 1997-05-06 |
| PL316431A1 (en) | 1997-01-06 |
| NO964008D0 (no) | 1996-09-24 |
| AU2159695A (en) | 1995-10-17 |
| CZ281596A3 (en) | 1997-05-14 |
| MX9604030A (es) | 1997-09-30 |
| JPH09510970A (ja) | 1997-11-04 |
| HUT74887A (en) | 1997-02-28 |
| CA2186364C (en) | 2008-12-30 |
| NZ283528A (en) | 1997-12-19 |
| HU9602616D0 (en) | 1996-11-28 |
| DE69511687T2 (de) | 2000-03-16 |
| ES2135050T3 (es) | 1999-10-16 |
| JP3524927B2 (ja) | 2004-05-10 |
| GR3031105T3 (en) | 1999-12-31 |
| EP0751934B1 (en) | 1999-08-25 |
| DK0751934T3 (da) | 1999-12-13 |
| SK119796A3 (en) | 1997-05-07 |
| DE69511687D1 (de) | 1999-09-30 |
| FI963817A7 (fi) | 1996-09-25 |
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