CN1366937A - Nano quiet heart and supplement kidney preparation medicine and preparation method - Google Patents
Nano quiet heart and supplement kidney preparation medicine and preparation method Download PDFInfo
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- CN1366937A CN1366937A CN 01102079 CN01102079A CN1366937A CN 1366937 A CN1366937 A CN 1366937A CN 01102079 CN01102079 CN 01102079 CN 01102079 A CN01102079 A CN 01102079A CN 1366937 A CN1366937 A CN 1366937A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 210000003734 kidney Anatomy 0.000 title claims description 23
- 239000013589 supplement Substances 0.000 title claims description 21
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 13
- 241000756943 Codonopsis Species 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 235000006487 Euryale ferox Nutrition 0.000 claims abstract description 5
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 210000000582 semen Anatomy 0.000 claims description 63
- 229940079593 drug Drugs 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 11
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 9
- 210000003899 penis Anatomy 0.000 claims description 9
- 210000001550 testis Anatomy 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 235000005903 Dioscorea Nutrition 0.000 claims description 5
- 241000234273 Dioscorea Species 0.000 claims description 5
- 235000000504 Dioscorea villosa Nutrition 0.000 claims description 5
- 235000004879 dioscorea Nutrition 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 241000600871 Euryale <brittle star> Species 0.000 claims description 4
- 230000008859 change Effects 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000008569 process Effects 0.000 abstract description 2
- 241001061264 Astragalus Species 0.000 abstract 1
- 241000123589 Dipsacus Species 0.000 abstract 1
- 244000268590 Euryale ferox Species 0.000 abstract 1
- 241001278833 Rosa laevigata Species 0.000 abstract 1
- 235000000661 Rosa laevigata Nutrition 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 210000004233 talus Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 208000010228 Erectile Dysfunction Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010021118 Hypotonia Diseases 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- 208000009205 Tinnitus Diseases 0.000 description 2
- 206010047513 Vision blurred Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 208000017561 flaccidity Diseases 0.000 description 2
- 201000001881 impotence Diseases 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 206010029410 night sweats Diseases 0.000 description 2
- 230000036565 night sweats Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 231100000886 tinnitus Toxicity 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a nano Ningxin Bushen preparation medicine. It is made up by using 20 Chinese medicinal materials of nano codonopsis, nano dipsacus, nano complanate astragalus seed, nano cherokee rose fruit, nano euryale and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm.
Description
The present invention relates to a kind of quiet heart and supplement kidney, the smart nano quiet heart and supplement kidney preparation medicine that ends flaccidity of benefit, the invention still further relates to the method for this medication preparation.
The quiet heart and supplement kidney ball is a kind of classical Chinese patent medicine, mainly contains that quiet heart and supplement kidney, benefit are smart to end effect such as flaccidity, is used for that tinnitus due to deficiency of the kidney, dizziness and blurred vision, palpitation with fear are peaceful, the night sweat body is tired, seminal emission, sterile, the soreness of the waist and knees of sexual impotence.But traditional quiet heart and supplement kidney ball disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano quiet heart and supplement kidney preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano quiet heart and supplement kidney preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Codonopsis 1000-2500 part nanometer Radix Dipsaci 150-400 part nanometer Semen Astragali Complanati 200-400 part
Nanometer Fructus Rosae Laevigatae 150-400 part nanometer Semen Euryales 180-400 part nm acid Semen Ziziphi Spinosae 150-400 part
Nanometer Stamen Nelumbinis 220-400 part nanometer Os Draconis 150-400 part nanometer Radix Polygoni Multiflori 220-400 part
Nanometer Semen Juglandis 150-400 part nanometer Fructus Lycii 250-450 part nano Poria 100-250 part
Nanometer Fructus Psoraleae 300-650 part nanometer Fructus Rubi 100-250 part nanometer Rhizoma Dioscoreae 150-400 part
Nanometer Semen Allii Tuberosi 100-250 part nanometer Semen Cuscutae 150-400 part nanometer Testis Et penis Bovis seu Bubali 60-150 part
Nanometer Semen Nelumbinis 150-400 part nanometer Fructus Amomi 30-65 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Codonopsis 1200-2000 part nanometer Radix Dipsaci 200-300 part nanometer Semen Astragali Complanati 250-350 part
Nanometer Fructus Rosae Laevigatae 200-300 part nanometer Semen Euryales 250-350 part nm acid Semen Ziziphi Spinosae 200-300 part
Nanometer Stamen Nelumbinis 250-350 part nanometer Os Draconis 200-300 part nanometer Radix Polygoni Multiflori 270-350 part
Nanometer Semen Juglandis 200-300 part nanometer Fructus Lycii 270-350 part nano Poria 120-200 part
Nanometer Fructus Psoraleae 350-550 part nanometer Fructus Rubi 120-200 part nanometer Rhizoma Dioscoreae 200-300 part
Nanometer Semen Allii Tuberosi 120-200 part nanometer Semen Cuscutae 200-300 part nanometer Testis Et penis Bovis seu Bubali 80-120 part
Nanometer Semen Nelumbinis 200-300 part nanometer Fructus Amomi 35-55 part
The optimum weight proportioning of medicine of the present invention is:
320 parts of 241 parts of nanometer Semen Astragali Complanatis of 1600 parts of nanometer Radix Dipsacis of nanometer Radix Codonopsis
241 parts of 320 parts of nm acid Semen Ziziphi Spinosaes of 241 portions of nanometer Semen Euryaless of nanometer Fructus Rosae Laevigatae
320 parts of 241 parts of nanometer Radix Polygoni Multiflori of 320 parts of nanometer Os Draconis of nanometer Stamen Nelumbinis
160 parts of 320 parts of nano Porias of 241 parts of nanometer Fructus Lycii of nanometer Semen Juglandis
241 parts of 160 parts of nanometer Rhizoma Dioscoreaes of 400 parts of nanometer Fructus Rubies of nanometer Fructus Psoraleae
100 parts of 241 portions of nanometer Testis Et penis Bovis seu Bubali of 160 parts of nanometer Semen Cuscutae of nanometer Semen Allii Tuberosi
47.5 parts of 241 parts of nanometer Fructus Amomis of nanometer Semen Nelumbinis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the quiet heart and supplement kidney preparation nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano quiet heart and supplement kidney preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common quiet heart and supplement kidney pill material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano quiet heart and supplement kidney preparation medicine etc. is had no precedent in the past.
Treatment of conditions such as pharmaceutical preparation of the present invention can be used for that tinnitus due to deficiency of the kidney, dizziness and blurred vision, palpitation with fear are peaceful, the night sweat body is tired, seminal emission, sexual impotence are sterile, soreness of the waist and knees, clinical efficacy significantly is better than traditional quiet heart and supplement kidney ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
320 parts of 241 parts of nanometer Semen Astragali Complanatis of 1600 parts of nanometer Radix Dipsacis of nanometer Radix Codonopsis
241 parts of 320 parts of nm acid Semen Ziziphi Spinosaes of 241 portions of nanometer Semen Euryaless of nanometer Fructus Rosae Laevigatae
320 parts of 241 parts of nanometer Radix Polygoni Multiflori of 320 parts of nanometer Os Draconis of nanometer Stamen Nelumbinis
160 parts of 320 parts of nano Porias of 241 parts of nanometer Fructus Lycii of nanometer Semen Juglandis
241 parts of 160 parts of nanometer Rhizoma Dioscoreaes of 400 parts of nanometer Fructus Rubies of nanometer Fructus Psoraleae
100 parts of 241 portions of nanometer Testis Et penis Bovis seu Bubali of 160 parts of nanometer Semen Cuscutae of nanometer Semen Allii Tuberosi
47.5 parts of 241 parts of nanometer Fructus Amomis of nanometer Semen Nelumbinis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
320 parts of 241 parts of nanometer Semen Astragali Complanatis of 1600 parts of nanometer Radix Dipsacis of nanometer Radix Codonopsis
241 parts of 320 parts of nm acid Semen Ziziphi Spinosaes of 241 portions of nanometer Semen Euryaless of nanometer Fructus Rosae Laevigatae
320 parts of 241 parts of nanometer Radix Polygoni Multiflori of 320 parts of nanometer Os Draconis of nanometer Stamen Nelumbinis
160 parts of 320 parts of nano Porias of 241 parts of nanometer Fructus Lycii of nanometer Semen Juglandis
241 parts of 160 parts of nanometer Rhizoma Dioscoreaes of 400 parts of nanometer Fructus Rubies of nanometer Fructus Psoraleae
100 parts of 241 portions of nanometer Testis Et penis Bovis seu Bubali of 160 parts of nanometer Semen Cuscutae of nanometer Semen Allii Tuberosi
47.5 parts of 241 parts of nanometer Fructus Amomis of nanometer Semen Nelumbinis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano quiet heart and supplement kidney powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
320 parts of 241 parts of nanometer Semen Astragali Complanatis of 1600 parts of nanometer Radix Dipsacis of nanometer Radix Codonopsis
241 parts of 320 parts of nm acid Semen Ziziphi Spinosaes of 241 portions of nanometer Semen Euryaless of nanometer Fructus Rosae Laevigatae
320 parts of 241 parts of nanometer Radix Polygoni Multiflori of 320 parts of nanometer Os Draconis of nanometer Stamen Nelumbinis
160 parts of 320 parts of nano Porias of 241 parts of nanometer Fructus Lycii of nanometer Semen Juglandis
241 parts of 160 parts of nanometer Rhizoma Dioscoreaes of 400 parts of nanometer Fructus Rubies of nanometer Fructus Psoraleae
100 parts of 241 portions of nanometer Testis Et penis Bovis seu Bubali of 160 parts of nanometer Semen Cuscutae of nanometer Semen Allii Tuberosi
47.5 parts of 241 parts of nanometer Fructus Amomis of nanometer Semen Nelumbinis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano quiet heart and supplement kidney membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano quiet heart and supplement kidney preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Codonopsis 1000-2500 part nanometer Radix Dipsaci 150-400 part nanometer Semen Astragali Complanati 200-400 part
Nanometer Fructus Rosae Laevigatae 150-400 part nanometer Semen Euryales 180-400 part nm acid Semen Ziziphi Spinosae 150-400 part
Nanometer Stamen Nelumbinis 220-400 part nanometer Os Draconis 150-400 part nanometer Radix Polygoni Multiflori 220-400 part
Nanometer Semen Juglandis 150-400 part nanometer Fructus Lycii 250-450 powder nano Poria 100-250 part
Nanometer Fructus Psoraleae 300-650 part nanometer Fructus Rubi 100-250 part nanometer Rhizoma Dioscoreae 150-400 part
Nanometer Semen Allii Tuberosi 100-250 part nanometer Semen Cuscutae 150-400 part nanometer Testis Et penis Bovis seu Bubali 60-150 part
Nanometer Semen Nelumbinis 150-400 part nanometer Fructus Amomi 30-65 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano quiet heart and supplement kidney preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Codonopsis 1200-2000 part nanometer Radix Dipsaci 200-300 part nanometer Semen Astragali Complanati 250-350 part
Nanometer Fructus Rosae Laevigatae 200-300 part nanometer Semen Euryales 250-350 part nm acid Semen Ziziphi Spinosae 200-300 part
Nanometer Stamen Nelumbinis 250-350 part nanometer Os Draconis 200-300 part nanometer Radix Polygoni Multiflori 270-350 part
Nanometer Semen Juglandis 200-300 part nanometer Fructus Lycii 270-350 part nano Poria 120-200 part
Nanometer Fructus Psoraleae 350-550 part nanometer Fructus Rubi 120-200 part nanometer Rhizoma Dioscoreae 200-300 part
Nanometer Semen Allii Tuberosi 120-200 part nanometer Semen Cuscutae 200-300 part nanometer Testis Et penis Bovis seu Bubali 80-120 part
Nanometer Semen Nelumbinis 200-300 part nanometer Fructus Amomi 35-55 part
3, nano quiet heart and supplement kidney preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
320 parts of 241 parts of nanometer Semen Astragali Complanatis of 1600 parts of nanometer Radix Dipsacis of nanometer Radix Codonopsis
241 parts of 320 parts of nm acid Semen Ziziphi Spinosaes of 241 portions of nanometer Semen Euryaless of nanometer Fructus Rosae Laevigatae
320 parts of 241 parts of nanometer Radix Polygoni Multiflori of 320 parts of nanometer Os Draconis of nanometer Stamen Nelumbinis
160 parts of 320 parts of nano Porias of 241 parts of nanometer Fructus Lycii of nanometer Semen Juglandis
241 parts of 160 parts of nanometer Rhizoma Dioscoreaes of 400 parts of nanometer Fructus Rubies of nanometer Fructus Psoraleae
100 parts of 241 portions of nanometer Testis Et penis Bovis seu Bubali of 160 parts of nanometer Semen Cuscutae of nanometer Semen Allii Tuberosi
47.5 parts of 241 parts of nanometer Fructus Amomis of nanometer Semen Nelumbinis
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano quiet heart and supplement kidney preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano quiet heart and supplement kidney preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102079 CN1366937A (en) | 2001-01-22 | 2001-01-22 | Nano quiet heart and supplement kidney preparation medicine and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102079 CN1366937A (en) | 2001-01-22 | 2001-01-22 | Nano quiet heart and supplement kidney preparation medicine and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1366937A true CN1366937A (en) | 2002-09-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01102079 Pending CN1366937A (en) | 2001-01-22 | 2001-01-22 | Nano quiet heart and supplement kidney preparation medicine and preparation method |
Country Status (1)
| Country | Link |
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| CN (1) | CN1366937A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104116887A (en) * | 2014-08-15 | 2014-10-29 | 徐美春 | Pharmaceutical composition for treating arrhythmia and preparation method of pharmaceutical composition |
| CN104839551A (en) * | 2015-05-22 | 2015-08-19 | 遵义市杨老大米粉厂 | Nutritious rice flour and preparation method thereof |
-
2001
- 2001-01-22 CN CN 01102079 patent/CN1366937A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104116887A (en) * | 2014-08-15 | 2014-10-29 | 徐美春 | Pharmaceutical composition for treating arrhythmia and preparation method of pharmaceutical composition |
| CN104839551A (en) * | 2015-05-22 | 2015-08-19 | 遵义市杨老大米粉厂 | Nutritious rice flour and preparation method thereof |
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