CN1368193A - Nano medicine 'Suoyanggujing' and its preparing process - Google Patents
Nano medicine 'Suoyanggujing' and its preparing process Download PDFInfo
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- CN1368193A CN1368193A CN 01102520 CN01102520A CN1368193A CN 1368193 A CN1368193 A CN 1368193A CN 01102520 CN01102520 CN 01102520 CN 01102520 A CN01102520 A CN 01102520A CN 1368193 A CN1368193 A CN 1368193A
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- 239000003814 drug Substances 0.000 title claims abstract description 50
- 238000000034 method Methods 0.000 title claims description 13
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 11
- 241000005787 Cistanche Species 0.000 claims abstract description 10
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 210000000582 semen Anatomy 0.000 claims description 36
- 229940079593 drug Drugs 0.000 claims description 22
- 235000008227 Illicium verum Nutrition 0.000 claims description 9
- 240000007232 Illicium verum Species 0.000 claims description 9
- 241000972673 Phellodendron amurense Species 0.000 claims description 9
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 9
- 239000006187 pill Substances 0.000 claims description 9
- 235000002639 sodium chloride Nutrition 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 241000605447 Anemarrhena Species 0.000 claims description 5
- 235000005903 Dioscorea Nutrition 0.000 claims description 5
- 235000000504 Dioscorea villosa Nutrition 0.000 claims description 5
- 241001523579 Ostrea Species 0.000 claims description 5
- 235000004879 dioscorea Nutrition 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 235000006487 Euryale ferox Nutrition 0.000 claims description 4
- 244000268590 Euryale ferox Species 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 239000010442 halite Substances 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 244000281702 Dioscorea villosa Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 241000804384 Cynomorium songaricum Species 0.000 abstract 1
- 240000002853 Nelumbo nucifera Species 0.000 abstract 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 abstract 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 abstract 1
- 230000002269 spontaneous effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 241000234273 Dioscorea Species 0.000 description 4
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- 208000007466 Male Infertility Diseases 0.000 description 3
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
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Abstract
A nanometre (0.1-200 nm) medicine "Suoyang Gujing" for treating spontaneous seminal emission is prepared from the nanometre powders of 24 Chinese medicinal materials including cynomorium songaricum, cistanche, lotus seed, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of the kidney warming controlling nocturnal emission with astringent drugs, cure mainly the nano medicine ' Suoyanggujing ' of deficiency of kidney-QI, the invention still further relates to the method for this medication preparation.
Suoyang gujing pills is a kind of classical Chinese patent medicine, mainly contain the adrenal cortex reinforcing function, promote the gonad function, effects such as short gonepoiesis and secretion, enhancing human body immunity function, antibiotic, antiinflammatory, be used for deficiency of kidney-QI, not solid seminal emission, premature ejaculation, sexual impotence, the male sterility in smart pass; The women's libido that also can be used for insufficiency of kidney-YANG, damage of kidney-YIN is indifferent, infertility etc.But traditional suoyang gujing pills disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Suoyanggujing ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Suoyanggujing '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Herba Cynomorii 12-30 part nanometer Herba Cistanches 15-40 part nanometer Radix Morindae Officinalis 20-45 part
Nanometer Fructus Psoraleae 15-40 part nanometer Semen Cuscutae 10-45 part nanometer Cortex Eucommiae 15-40 part
Nano star anise 15-40 part nanometer Semen Allii Tuberosi 10-35 part nanometer Semen Euryales 12-35 part
Nanometer Semen Nelumbinis 12-30 part nanometer Stamen Nelumbinis 15-40 part nanometer Concha Ostreae 12-35 part
Nanometer Os Draconis 12-30 part nano deerhorn frost 12-30 part nanometer Radix Rehmanniae Preparata 35-80 part
Nanometer Fructus Corni 10-30 part nanometer Cortex Moutan 6-15 part nanometer Rhizoma Dioscoreae 30-80 part
Nano Poria 6-18 part nanometer Rhizoma Alismatis 6-18 part nanometer Rhizoma Anemarrhenae 3-8 part
Nano phellodendron bark 3-9 part nanometer Radix Achyranthis Bidentatae 10-35 part nanometer halite 15-40 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Herba Cynomorii 15-25 part nanometer Herba Cistanches 20-30 part nanometer Radix Morindae Officinalis 25-35 part
Nanometer Fructus Psoraleae 20-30 part nanometer Semen Cuscutae 15-25 part nanometer Cortex Eucommiae 20-30 part
Nano star anise 20-30 part nanometer Semen Allii Tuberosi 15-25 part nanometer Semen Euryales 15-25 part
Nanometer Semen Nelumbinis 15-25 part nanometer Stamen Nelumbinis 20-30 part nanometer Concha Ostreae 15-25 part
Nanometer Os Draconis 15-25 part nano deerhorn frost 15-25 part nanometer Radix Rehmanniae Preparata 45-70 part
Nanometer Fructus Corni 12-25 part nanometer Cortex Moutan 8-12 part nanometer Rhizoma Dioscoreae 45-70 part
Nano Poria 8-15 part nanometer Rhizoma Alismatis 8-15 part nanometer Rhizoma Anemarrhenae 3-6 part
Nano phellodendron bark 3-6 part nanometer Radix Achyranthis Bidentatae 15-25 part nanometer halite 20-30 part
The optimum weight proportioning of medicine of the present invention is:
30 parts of 25 parts of nanometer Radix Morindae Officinaliss of 20 parts of nanometer Herba Cistanches of nanometer Herba Cynomorii
25 parts of 20 parts of nanometer Cortexs Eucommiae of 25 parts of nanometer Semen Cuscutae of nanometer Fructus Psoraleae
20 parts of 20 portions of nanometer Semen Euryaless of 25 parts of nanometer Semen Allii Tuberosi of nano star anise
20 parts of 25 parts of nanometer Concha Ostreaes of 20 parts of nanometer Stamen Nelumbiniss of nanometer Semen Nelumbinis
56 parts of 20 parts of nanometer Radix Rehmanniae Preparata of 20 parts of nano deerhorn frosts of nanometer Os Draconis
56 parts of 11 parts of nanometer Rhizoma Dioscoreaes of 17 parts of nanometer Cortex Moutans of nanometer Fructus Corni
4 parts of 11 parts of nanometer Rhizoma Anemarrhenaes of 11 parts of nanometer Rhizoma Alismatis of nano Poria
25 parts of 20 parts of nanometer halites of 4 parts of nanometer Radix Achyranthis Bidentataes of nano phellodendron bark
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Suoyanggujing ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Suoyanggujing ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Herba Cynomorii controlling nocturnal emission with astringent drugs pill material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Suoyanggujing ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as chronic prostatitis, sexual neurasthenie, male sterility, infertility, and clinical efficacy significantly is better than traditional suoyang gujing pills.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
30 parts of 25 parts of nanometer Radix Morindae Officinaliss of 20 parts of nanometer Herba Cistanches of nanometer Herba Cynomorii
25 parts of 20 parts of nanometer Cortexs Eucommiae of 25 parts of nanometer Semen Cuscutae of nanometer Fructus Psoraleae
20 parts of 20 portions of nanometer Semen Euryaless of 25 parts of nanometer Semen Allii Tuberosi of nano star anise
20 parts of 25 parts of nanometer Concha Ostreaes of 20 parts of nanometer Stamen Nelumbiniss of nanometer Semen Nelumbinis
56 parts of 20 parts of nanometer Radix Rehmanniae Preparata of 20 parts of nano deerhorn frosts of nanometer Os Draconis
56 parts of 11 parts of nanometer Rhizoma Dioscoreaes of 17 parts of nanometer Cortex Moutans of nanometer Fructus Corni
4 parts of 11 parts of nanometer Rhizoma Anemarrhenaes of 11 parts of nanometer Rhizoma Alismatis of nano Poria
25 parts of 20 parts of nanometer halites of 4 parts of nanometer Radix Achyranthis Bidentataes of nano phellodendron bark
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
30 parts of 25 parts of nanometer Radix Morindae Officinaliss of 20 parts of nanometer Herba Cistanches of nanometer Herba Cynomorii
25 parts of 20 parts of nanometer Cortexs Eucommiae of 25 parts of nanometer Semen Cuscutae of nanometer Fructus Psoraleae
20 parts of 20 portions of nanometer Semen Euryaless of 25 parts of nanometer Semen Allii Tuberosi of nano star anise
20 parts of 25 parts of nanometer Concha Ostreaes of 20 parts of nanometer Stamen Nelumbiniss of nanometer Semen Nelumbinis
56 parts of 20 parts of nanometer Radix Rehmanniae Preparata of 20 parts of nano deerhorn frosts of nanometer Os Draconis
56 parts of 11 parts of nanometer Rhizoma Dioscoreaes of 17 parts of nanometer Cortex Moutans of nanometer Fructus Corni
4 parts of 11 parts of nanometer Rhizoma Anemarrhenaes of 11 parts of nanometer Rhizoma Alismatis of nano Poria
25 parts of 20 parts of nanometer halites of 4 parts of nanometer Radix Achyranthis Bidentataes of nano phellodendron bark
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer Herba Cynomorii controlling nocturnal emission with astringent drugs powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
30 parts of 25 parts of nanometer Radix Morindae Officinaliss of 20 parts of nanometer Herba Cistanches of nanometer Herba Cynomorii
25 parts of 20 parts of nanometer Cortexs Eucommiae of 25 parts of nanometer Semen Cuscutae of nanometer Fructus Psoraleae
20 parts of 20 portions of nanometer Semen Euryaless of 25 parts of nanometer Semen Allii Tuberosi of nano star anise
20 parts of 25 parts of nanometer Concha Ostreaes of 20 parts of nanometer Stamen Nelumbiniss of nanometer Semen Nelumbinis
56 parts of 20 parts of nanometer Radix Rehmanniae Preparata of 20 parts of nano deerhorn frosts of nanometer Os Draconis
56 parts of 11 parts of nanometer Rhizoma Dioscoreaes of 17 parts of nanometer Cortex Moutans of nanometer Fructus Corni
4 parts of 11 parts of nanometer Rhizoma Anemarrhenaes of 11 parts of nanometer Rhizoma Alismatis of nano Poria
25 parts of 20 parts of nanometer halites of 4 parts of nanometer Radix Achyranthis Bidentataes of nano phellodendron bark
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer Herba Cynomorii controlling nocturnal emission with astringent drugs membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, chest.
Claims (6)
1, a kind of nano medicine ' Suoyanggujing ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Herba Cynomorii 12-30 part nanometer Herba Cistanches 15-40 part nanometer Radix Morindae Officinalis 20-45 part
Nanometer Fructus Psoraleae 15-40 part nanometer Semen Cuscutae 10-45 part nanometer Cortex Eucommiae 15-40 part
Nano star anise 15-40 part nanometer Semen Allii Tuberosi 10-35 part nanometer Semen Euryales 12-35 part
Nanometer Semen Nelumbinis 12-30 part nanometer Stamen Nelumbinis 15-40 part nanometer Concha Ostreae 12-35 part
Nanometer Os Draconis 12-30 part nano deerhorn frost 12-30 part nanometer Radix Rehmanniae Preparata 35-80 part
Nanometer Fructus Corni 10-30 part nanometer Cortex Moutan 6-15 part nanometer Rhizoma Dioscoreae 30-80 part
Nano Poria 6-18 part nanometer Rhizoma Alismatis 6-18 part nanometer Rhizoma Anemarrhenae 3-8 part
Nano phellodendron bark 3-9 part nanometer Radix Achyranthis Bidentatae 10-35 part nanometer halite 15-40 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Suoyanggujing ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Herba Cynomorii 15-25 part nanometer Herba Cistanches 20-30 part nanometer Radix Morindae Officinalis 25-35 part
Nanometer Fructus Psoraleae 20-30 part nanometer Semen Cuscutae 15-25 part nanometer Cortex Eucommiae 20-30 part
Nano star anise 20-30 part nanometer Semen Allii Tuberosi 15-25 part nanometer Semen Euryales 15-25 part
Nanometer Semen Nelumbinis 15-25 part nanometer Stamen Nelumbinis 20-30 part nanometer Concha Ostreae 15-25 part
Nanometer Os Draconis 15-25 part nano deerhorn frost 15-25 part nanometer Radix Rehmanniae Preparata 45-70 part
Nanometer Fructus Corni 12-25 part nanometer Cortex Moutan 8-12 part nanometer Rhizoma Dioscoreae 45-70 part
Nano Poria 8-15 part nanometer Rhizoma Alismatis 8-15 part nanometer Rhizoma Anemarrhenae 3-6 part
Nano phellodendron bark 3-6 part nanometer Radix Achyranthis Bidentatae 15-25 part nanometer halite 20-30 part
3, nano medicine ' Suoyanggujing ' according to claim 1, wherein the weight proportion of each nano raw material is:
30 parts of 25 parts of nanometer Radix Morindae Officinaliss of 20 parts of nanometer Herba Cistanches of nanometer Herba Cynomorii
25 parts of 20 parts of nanometer Cortexs Eucommiae of 25 parts of nanometer Semen Cuscutae of nanometer Fructus Psoraleae
20 parts of 20 portions of nanometer Semen Euryaless of 25 parts of nanometer Semen Allii Tuberosi of nano star anise
20 parts of 25 parts of nanometer Concha Ostreaes of 20 parts of nanometer Stamen Nelumbiniss of nanometer Semen Nelumbinis
56 parts of 20 parts of nanometer Radix Rehmanniae Preparata of 20 parts of nano deerhorn frosts of nanometer Os Draconis
56 parts of 11 parts of nanometer Rhizoma Dioscoreaes of 17 parts of nanometer Cortex Moutans of nanometer Fructus Corni
4 parts of 11 parts of nanometer Rhizoma Anemarrhenaes of 11 parts of nanometer Rhizoma Alismatis of nano Poria
25 parts of 20 parts of nanometer halites of 4 parts of nanometer Radix Achyranthis Bidentataes of nano phellodendron bark
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Suoyanggujing 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Suoyanggujing 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01102520 CN1368193A (en) | 2001-01-31 | 2001-01-31 | Nano medicine 'Suoyanggujing' and its preparing process |
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| CN 01102520 CN1368193A (en) | 2001-01-31 | 2001-01-31 | Nano medicine 'Suoyanggujing' and its preparing process |
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| CN1368193A true CN1368193A (en) | 2002-09-11 |
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| CN100352356C (en) * | 2006-01-25 | 2007-12-05 | 余内逊 | Method for preparing liver-benefiting, face-beautifying soybean soybean milk sheet with micron pine pollen, pearl powder for women |
| CN100352358C (en) * | 2006-01-25 | 2007-12-05 | 余内逊 | Method for preparing liver-benefiting, face-beautifying milk liquid with micron pine pollen, pearl powder for women |
| CN100360043C (en) * | 2006-01-25 | 2008-01-09 | 余内逊 | Method for preparing liver-benefiting, face-beautifying milk powder with micron pine pollen, pearl powder for women |
| CN100362931C (en) * | 2006-01-25 | 2008-01-23 | 余内逊 | Method for preparing liver-benefiting, face-beautifying soybean milk powder with micron pine pollen, pearl powder for women |
| CN107375629A (en) * | 2017-06-28 | 2017-11-24 | 禹州市合同泰药业有限公司 | The preparation technology and its instructions of taking of a kind of suoyang gujing pills |
-
2001
- 2001-01-31 CN CN 01102520 patent/CN1368193A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100352357C (en) * | 2006-01-25 | 2007-12-05 | 余内逊 | Method for preparing liver-benefiting, face-beautifying milk sheet with micron pine pollen, pearl powder for women |
| CN100352356C (en) * | 2006-01-25 | 2007-12-05 | 余内逊 | Method for preparing liver-benefiting, face-beautifying soybean soybean milk sheet with micron pine pollen, pearl powder for women |
| CN100352358C (en) * | 2006-01-25 | 2007-12-05 | 余内逊 | Method for preparing liver-benefiting, face-beautifying milk liquid with micron pine pollen, pearl powder for women |
| CN100360043C (en) * | 2006-01-25 | 2008-01-09 | 余内逊 | Method for preparing liver-benefiting, face-beautifying milk powder with micron pine pollen, pearl powder for women |
| CN100362931C (en) * | 2006-01-25 | 2008-01-23 | 余内逊 | Method for preparing liver-benefiting, face-beautifying soybean milk powder with micron pine pollen, pearl powder for women |
| CN107375629A (en) * | 2017-06-28 | 2017-11-24 | 禹州市合同泰药业有限公司 | The preparation technology and its instructions of taking of a kind of suoyang gujing pills |
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