CN1365673A - Nano medicine 'Fengliaoxing' for treating rheumatism, bone fracture and injury and its preparing process - Google Patents
Nano medicine 'Fengliaoxing' for treating rheumatism, bone fracture and injury and its preparing process Download PDFInfo
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- CN1365673A CN1365673A CN 01100292 CN01100292A CN1365673A CN 1365673 A CN1365673 A CN 1365673A CN 01100292 CN01100292 CN 01100292 CN 01100292 A CN01100292 A CN 01100292A CN 1365673 A CN1365673 A CN 1365673A
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- 239000003814 drug Substances 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title claims description 12
- 208000010392 Bone Fractures Diseases 0.000 title 1
- 206010061363 Skeletal injury Diseases 0.000 title 1
- 230000006378 damage Effects 0.000 title 1
- 239000000463 material Substances 0.000 claims abstract description 20
- 241000213006 Angelica dahurica Species 0.000 claims abstract description 9
- 239000000843 powder Substances 0.000 claims abstract description 8
- 241000218671 Ephedra Species 0.000 claims abstract description 5
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 238000002360 preparation method Methods 0.000 claims description 19
- 229940079593 drug Drugs 0.000 claims description 17
- 210000000582 semen Anatomy 0.000 claims description 16
- 208000025747 Rheumatic disease Diseases 0.000 claims description 14
- 230000000552 rheumatic effect Effects 0.000 claims description 14
- 241000125175 Angelica Species 0.000 claims description 8
- 241000255789 Bombyx mori Species 0.000 claims description 8
- 241000717739 Boswellia sacra Species 0.000 claims description 8
- 241000234653 Cyperus Species 0.000 claims description 8
- 241001501111 Erycibe Species 0.000 claims description 8
- 239000004863 Frankincense Substances 0.000 claims description 8
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 8
- 241001057584 Myrrha Species 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 235000005903 Dioscorea Nutrition 0.000 claims description 4
- 235000000504 Dioscorea villosa Nutrition 0.000 claims description 4
- 241001446509 Psoralea Species 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 235000004879 dioscorea Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 244000281702 Dioscorea villosa Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 239000003795 chemical substances by application Substances 0.000 description 4
- 241000234273 Dioscorea Species 0.000 description 3
- 210000003414 extremity Anatomy 0.000 description 3
- 208000006820 Arthralgia Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
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- 210000003127 knee Anatomy 0.000 description 2
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- 210000003205 muscle Anatomy 0.000 description 2
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- 239000007962 solid dispersion Substances 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000008035 Back Pain Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
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- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
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- 230000008961 swelling Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
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Abstract
A nanometre medicine "Fengliaoxing Fengshidieda" is prepared from the nanometre powders of 27 Chinese-medicinal materials including cinammon twigs, ephedra, notopterygium root, Chinese angelica root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages include high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of dispelling wind and removing obstruction in the collateral, dispersing cold for relieving pain, cure mainly anemofrigid-damp arthralgia, numb limbs and tense tendons, muscles and bones is ached, weakness of the waist and knees, old nanometer Feng who hinders recurrence property rheumatic bone-setting preparation medicine, the invention still further relates to the method for this medication preparation.
FENGLIAOXING FENGSHI DIEDA YAOJIU is a kind of classical Chinese patent medicine, mainly contains analgesia, antiinflammatory, and calmness, lax skeletal muscle improves effects such as blood circulation, is used for anemofrigid-damp arthralgia, numb limbs and tense tendons, muscles and bones is ached, weakness of the waist and knees, the old wound recurred.But traditional FENGLIAOXING FENGSHI DIEDA YAOJIU absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorb fully, nanometer Feng of increase evident in efficacy property rheumatic bone-setting preparation medicine.
The preparation method of property rheumatic bone-setting preparation medicine that another object of the present invention provides this nanometer Feng.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Caulis Erycibes 1500-4000 part nanometer Ramulus Cinnamomi 50-95 part nanometer Herba Ephedrae 70-150 part
Nanometer Rhizoma Et Radix Notopterygii 4-9 part nano Chinese angelica 3-9 part nanometer Rhizoma Chuanxiong 3-9 part
Nano angelica root 3-9 nanometer Fructus Psoraleae 3-9 part nanometer Olibanum 3-12 part
Nanometer Fructus Gleditsiae Abnormalis 3-9 part nanometer Pericarpium Citri Reticulatae 20-55 part nanometer Rhizoma Atractylodis 3-9 part
Nanometer Cortex Magnoliae Officinalis 3-12 part nano cyperus tuber 2-9 part nanometer Radix Aucklandiae 3-9 part
Nanometer Fructus Aurantii 30-80 part nanometer Rhizoma Atractylodis Macrocephalae 3-9 part nanometer Rhizoma Dioscoreae 3-12 part
Nanometer Rhizoma Polygonati 10-35 part nanometer Semen Cuscutae 3-9 part nanometer Fructus Foeniculi 5-10 part
Nanometer Semen Armeniacae Amarum 3-9 part nanometer Rhizoma Alismatis 3-9 part nanometer Oletum Trogopterori 5-12 part
Nanometer silkworm excrement 10-25 part nanometer Cortex Moutan 3-9 part nanometer Myrrha 5-10 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Caulis Erycibes 2000-3000 part nanometer Ramulus Cinnamomi 60-80 part nanometer Herba Ephedrae 80-120 part
Nanometer Rhizoma Et Radix Notopterygii 5-9 part nano Chinese angelica 5-9 part nanometer Rhizoma Chuanxiong 5-9 part
Nano angelica root 5-9 nanometer Fructus Psoraleae 5-9 part nanometer Olibanum 5-9 part
Nanometer Fructus Gleditsiae Abnormalis 5-9 part nanometer Pericarpium Citri Reticulatae 25-40 part nanometer Rhizoma Atractylodis 5-9 part
Nanometer Cortex Magnoliae Officinalis 5-9 part nano cyperus tuber 5-9 part nanometer Radix Aucklandiae 5-9 part
Nanometer Fructus Aurantii 40-60 part nanometer Rhizoma Atractylodis Macrocephalae 5-9 part nanometer Rhizoma Dioscoreae 5-9 part
Nanometer Rhizoma Polygonati 15-25 part nanometer Semen Cuscutae 5-9 part nanometer Fructus Foeniculi 5-9 part
Nanometer Semen Armeniacae Amarum 5-9 part nanometer Rhizoma Alismatis 5-9 part nanometer Oletum Trogopterori 5-9 part
Nanometer silkworm excrement 12-20 part nanometer Cortex Moutan 5-9 part nanometer Myrrha 5-9 part
The optimum weight proportioning of medicine of the present invention is:
7.5 parts of 93.8 parts of nanometer Rhizoma Et Radix Notopterygiis of 75 parts of nanometer Herba Ephedraes of 2500 parts of nanometer Ramulus Cinnamomi of nanometer Caulis Erycibes
7.5 parts of 7.5 parts of nanometer Fructus Psoraleaes of 7.5 parts of nano angelica roots of 7.5 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
7.5 parts of 33.1 parts of nanometer Rhizoma Atractylodis of 7.5 parts of nanometer Pericarpium Citri Reticulataes of 7.5 parts of nanometer Fructus Gleditsiae Abnormalis of nanometer Olibanum
50 parts of 7.5 parts of nanometer Fructus Aurantiis of 7.5 parts of nanometer Radix Aucklandiae of 7.5 parts of nano cyperus tubers of nanometer Cortex Magnoliae Officinalis
7.5 parts of 20 parts of nanometer Semen Cuscutae of 7.5 parts of nanometer Rhizoma Polygonatis of 7.5 parts of nanometer Rhizoma Dioscoreaes of the nanometer Rhizoma Atractylodis Macrocephalae
7.5 parts of 7.5 parts of nanometer Oletum Trogopteroris of 7.5 parts of nanometer Rhizoma Alismatis of 7.5 portions of nanometer Semen Armeniacae Amarums of nanometer Fructus Foeniculi
7.5 parts of 7.5 parts of nanometer Myrrhas of 16.2 parts of nanometer Cortex Moutans of nanometer silkworm excrement
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour:
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with the instantaneous drying of hypersonic velocity jet, Feng property rheumatic bone-setting preparation nano powder;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
Above-mentioned two kinds of methods make nanometer Feng the pharmacological effect of property rheumatic bone-setting preparation medicine identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common FENGLIAOXING FENGSHI DIEDA YAOJIU preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also the created nanometer Feng new drug formulations had no precedent in the past such as the pill of property rheumatic bone-setting preparation medicine, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, syrup, oral solution.
Pharmaceutical preparation of the present invention can be used for rheumatic ostalgia, numb hand and foot, and extremity are aching and limp, and lumbago and skelalgia, traumatic injury are wounded and are amassed treatment of conditions such as swelling due to stasis, and clinical efficacy significantly is better than traditional FENGLIAOXING FENGSHI DIEDA YAOJIU.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
7.5 parts of 93.8 parts of nanometer Rhizoma Et Radix Notopterygiis of 75 parts of nanometer Herba Ephedraes of 2500 parts of nanometer Ramulus Cinnamomi of nanometer Caulis Erycibes
7.5 parts of 7.5 parts of nanometer Fructus Psoraleaes of 7.5 parts of nano angelica roots of 7.5 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
7.5 parts of 33.1 parts of nanometer Rhizoma Atractylodis of 7.5 parts of nanometer Pericarpium Citri Reticulataes of 7.5 parts of nanometer Fructus Gleditsiae Abnormalis of nanometer Olibanum
50 parts of 7.5 parts of nanometer Fructus Aurantiis of 7.5 parts of nanometer Radix Aucklandiae of 7.5 parts of nano cyperus tubers of nanometer Cortex Magnoliae Officinalis
7.5 parts of 20 parts of nanometer Semen Cuscutae of 7.5 parts of nanometer Rhizoma Polygonatis of 7.5 parts of nanometer Rhizoma Dioscoreaes of the nanometer Rhizoma Atractylodis Macrocephalae
7.5 parts of 7.5 parts of nanometer Oletum Trogopteroris of 7.5 parts of nanometer Rhizoma Alismatis of 7.5 portions of nanometer Semen Armeniacae Amarums of nanometer Fructus Foeniculi
7.5 parts of 7.5 parts of nanometer Myrrhas of 16.2 parts of nanometer Cortex Moutans of nanometer silkworm excrement
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
7.5 parts of 93.8 parts of nanometer Rhizoma Et Radix Notopterygiis of 75 parts of nanometer Herba Ephedraes of 2500 parts of nanometer Ramulus Cinnamomi of nanometer Caulis Erycibes
7.5 parts of 7.5 parts of nanometer Fructus Psoraleaes of 7.5 parts of nano angelica roots of 7.5 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
7.5 parts of 33.1 parts of nanometer Rhizoma Atractylodis of 7.5 parts of nanometer Pericarpium Citri Reticulataes of 7.5 parts of nanometer Fructus Gleditsiae Abnormalis of nanometer Olibanum
50 parts of 7.5 parts of nanometer Fructus Aurantiis of 7.5 parts of nanometer Radix Aucklandiae of 7.5 parts of nano cyperus tubers of nanometer Cortex Magnoliae Officinalis
7.5 parts of 20 parts of nanometer Semen Cuscutae of 7.5 parts of nanometer Rhizoma Polygonatis of 7.5 parts of nanometer Rhizoma Dioscoreaes of the nanometer Rhizoma Atractylodis Macrocephalae
7.5 parts of 7.5 parts of nanometer Oletum Trogopteroris of 7.5 parts of nanometer Rhizoma Alismatis of 7.5 portions of nanometer Semen Armeniacae Amarums of nanometer Fructus Foeniculi
7.5 parts of 7.5 parts of nanometer Myrrhas of 16.2 parts of nanometer Cortex Moutans of nanometer silkworm excrement
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, the property rheumatic bone-setting membrane of having made nanometer Feng, every membrane area size is the 2-100 square centimeter, content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, waist or affected part.
Claims (6)
1, a kind of nanometer Feng property rheumatic bone-setting preparation medicine, it is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Caulis Erycibes 1500-4000 part nanometer Ramulus Cinnamomi 50-95 part nanometer Herba Ephedrae 70-150 part
Nanometer Rhizoma Et Radix Notopterygii 4-9 part nano Chinese angelica 3-9 part nanometer Rhizoma Chuanxiong 3-9 part
Nano angelica root 3-9 nanometer Fructus Psoraleae 3-9 part nanometer Olibanum 3-12 part
Nanometer Fructus Gleditsiae Abnormalis 3-9 part nanometer Pericarpium Citri Reticulatae 20-55 part nanometer Rhizoma Atractylodis 3-9 part
Nanometer Cortex Magnoliae Officinalis 3-12 part nano cyperus tuber 2-9 part nanometer Radix Aucklandiae 3-9 part
Nanometer Fructus Aurantii 30-80 part nanometer Rhizoma Atractylodis Macrocephalae 3-9 part nanometer Rhizoma Dioscoreae 3-12 part
Nanometer Rhizoma Polygonati 10-35 part nanometer Semen Cuscutae 3-9 part nanometer Fructus Foeniculi 5-10 part
Nanometer Semen Armeniacae Amarum 3-9 part nanometer Rhizoma Alismatis 3-9 part nanometer Oletum Trogopterori 5-12 part
Nanometer silkworm excrement 10-25 part nanometer Cortex Moutan 3-9 part nanometer Myrrha 5-10 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer Feng according to claim 1 property rheumatic bone-setting preparation medicine, wherein the weight proportion of each nano raw material is:
Nanometer Caulis Erycibes 2000-3000 part nanometer Ramulus Cinnamomi 60-80 part nanometer Herba Ephedrae 80-120 part
Nanometer Rhizoma Et Radix Notopterygii 5-9 part nano Chinese angelica 5-9 part nanometer Rhizoma Chuanxiong 5-9 part
Nano angelica root 5-9 nanometer Fructus Psoraleae 5-9 part nanometer Olibanum 5-9 part
Nanometer Fructus Gleditsiae Abnormalis 5-9 part nanometer Pericarpium Citri Reticulatae 25-40 part nanometer Rhizoma Atractylodis 5-9 part
Nanometer Cortex Magnoliae Officinalis 5-9 part nano cyperus tuber 5-9 part nanometer Radix Aucklandiae 5-9 part
Nanometer Fructus Aurantii 40-60 part nanometer Rhizoma Atractylodis Macrocephalae 5-9 part nanometer Rhizoma Dioscoreae 5-9 part
Nanometer Rhizoma Polygonati 15-25 part nanometer Semen Cuscutae 5-9 part nanometer Fructus Foeniculi 5-9 part
Nanometer Semen Armeniacae Amarum 5-9 part nanometer Rhizoma Alismatis 5-9 part nanometer Oletum Trogopterori 5-9 part
Nanometer silkworm excrement 12-20 part nanometer Cortex Moutan 5-9 part nanometer Myrrha 5-9 part
3, nanometer Feng according to claim 1 property rheumatic bone-setting preparation medicine, wherein the weight proportion of each nano raw material is:
7.5 parts of 93.8 parts of nanometer Rhizoma Et Radix Notopterygiis of 75 parts of nanometer Herba Ephedraes of 2500 parts of nanometer Ramulus Cinnamomi of nanometer Caulis Erycibes
7.5 parts of 7.5 parts of nanometer Fructus Psoraleaes of 7.5 parts of nano angelica roots of 7.5 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
7.5 parts of 33.1 parts of nanometer Rhizoma Atractylodis of 7.5 parts of nanometer Pericarpium Citri Reticulataes of 7.5 parts of nanometer Fructus Gleditsiae Abnormalis of nanometer Olibanum
50 parts of 7.5 parts of nanometer Fructus Aurantiis of 7.5 parts of nanometer Radix Aucklandiae of 7.5 parts of nano cyperus tubers of nanometer Cortex Magnoliae Officinalis
7.5 parts of 20 parts of nanometer Semen Cuscutae of 7.5 parts of nanometer Rhizoma Polygonatis of 7.5 parts of nanometer Rhizoma Dioscoreaes of the nanometer Rhizoma Atractylodis Macrocephalae
7.5 parts of 7.5 parts of nanometer Oletum Trogopteroris of 7.5 parts of nanometer Rhizoma Alismatis of 7.5 portions of nanometer Semen Armeniacae Amarums of nanometer Fructus Foeniculi
7.5 parts of 7.5 parts of nanometer Myrrhas of 16.2 parts of nanometer Cortex Moutans of nanometer silkworm excrement
4, according to claim 1 or 2 or 3 described nanometer Feng property rheumatic bone-setting preparation medicine, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5, according to claim 1 or 2 or 3 described nanometer Feng the pharmaceutical methods of property rheumatic bone-setting preparation medicine, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100292 CN1365673A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Fengliaoxing' for treating rheumatism, bone fracture and injury and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100292 CN1365673A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Fengliaoxing' for treating rheumatism, bone fracture and injury and its preparing process |
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| CN1365673A true CN1365673A (en) | 2002-08-28 |
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| CN 01100292 Pending CN1365673A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Fengliaoxing' for treating rheumatism, bone fracture and injury and its preparing process |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104971219A (en) * | 2015-06-30 | 2015-10-14 | 张锐 | Traditional Chinese medicine prescription for treating rheumatic bone pain and preparation method of traditional Chinese medicine prescription |
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2001
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104971219A (en) * | 2015-06-30 | 2015-10-14 | 张锐 | Traditional Chinese medicine prescription for treating rheumatic bone pain and preparation method of traditional Chinese medicine prescription |
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