CN1365681A - Nano medicine 'Awei Huapi' and its preparing process - Google Patents
Nano medicine 'Awei Huapi' and its preparing process Download PDFInfo
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- CN1365681A CN1365681A CN 01100300 CN01100300A CN1365681A CN 1365681 A CN1365681 A CN 1365681A CN 01100300 CN01100300 CN 01100300 CN 01100300 A CN01100300 A CN 01100300A CN 1365681 A CN1365681 A CN 1365681A
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- 239000003814 drug Substances 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title claims description 12
- 239000000463 material Substances 0.000 claims abstract description 20
- 241000234653 Cyperus Species 0.000 claims abstract description 9
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 17
- 210000000582 semen Anatomy 0.000 claims description 16
- 241001116389 Aloe Species 0.000 claims description 8
- 241000125175 Angelica Species 0.000 claims description 8
- 241000213006 Angelica dahurica Species 0.000 claims description 8
- 241000717739 Boswellia sacra Species 0.000 claims description 8
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 8
- 241000283956 Manis Species 0.000 claims description 8
- 241001057584 Myrrha Species 0.000 claims description 8
- 244000044425 Quisqualis indica Species 0.000 claims description 8
- 241000219061 Rheum Species 0.000 claims description 8
- 235000009411 Rheum rhabarbarum Nutrition 0.000 claims description 8
- 235000011399 aloe vera Nutrition 0.000 claims description 8
- 239000009286 sanguis draxonis Substances 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 4
- 241000510609 Ferula Species 0.000 claims description 4
- 239000004863 Frankincense Substances 0.000 claims description 4
- 235000009815 Momordica Nutrition 0.000 claims description 4
- 241000218984 Momordica Species 0.000 claims description 4
- 239000010238 camphora Substances 0.000 claims description 4
- 229940025250 camphora Drugs 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 229910052957 realgar Inorganic materials 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 239000011858 nanopowder Substances 0.000 abstract description 3
- 235000003405 Curcuma zedoaria Nutrition 0.000 abstract 1
- 240000009138 Curcuma zedoaria Species 0.000 abstract 1
- 241001673966 Magnolia officinalis Species 0.000 abstract 1
- 241000233932 Sparganium Species 0.000 abstract 1
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 abstract 1
- 235000019509 white turmeric Nutrition 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 8
- 210000001015 abdomen Anatomy 0.000 description 4
- 239000011505 plaster Substances 0.000 description 4
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000003187 abdominal effect Effects 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000035931 haemagglutination Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
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- 239000002086 nanomaterial Substances 0.000 description 2
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- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 201000000660 Pyloric Stenosis Diseases 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 206010019847 hepatosplenomegaly Diseases 0.000 description 1
- 208000003243 intestinal obstruction Diseases 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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Abstract
A nano medicine "Aweihuapi" is prepared from the nano powders of 24 Chinese-medicinal materials including cyperus tuber, magnolia bark, burreed tuber, zedoary, etc. through proportioning, microwave extracting, pressure reduction concentrating, and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages include high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of eliminating mass and relieving fullness removing food stagnancy, cure mainly the nano medicine ' Awei Huapi ' of qi stagnation hemagglutination, abdomen mass in the abdomen, epigastric pain etc., the invention still further relates to the method for this medication preparation.
Awei huapi plaster, awei huapi gao is a kind of classical Chinese patent medicine, mainly contains effects such as antitumor, analgesia, is used for qi stagnation hemagglutination, abdomen mass in the abdomen, epigastric pain.But traditional awei huapi plaster, awei huapi gao absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Awei Huapi ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Awei Huapi '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano cyperus tuber 10-30 part nanometer Cortex Magnoliae Officinalis 10-30 part nanometer rhizoma sparganic 10-30 part
Nanometer Rhizoma Curcumae 10-30 part nano Chinese angelica 10-30 part nanometer Radix Aconiti Kusnezoffii 10-30 part
Nanometer Radix Aconiti 10-30 part nanometer Bulbus Allii 10-30 part nanometer Fructus Quisqualis 10-30 part
Nano angelica root 10-30 part nanometer Squama Manis 10-30 part nanometer Semen Momordicae 10-30 part
Nanometer Catharsii molossi 10-30 part nanometer Rhizoma Picrorhizae 10-30 part nano rhubarb 10-30 part
Nanometer Semen Ricini 10-30 part nanometer Olibanum 1-8 part nanometer Myrrha 1-8 part
Nano aloe 1-8 part nanometer Sanguis Draxonis 1-8 part nanometer-size realgar 10-25 part
Nanometer Cortex Cinnamomi 10-25 part nanometer Camphora 10-25 part nanometer Resina Ferulae 12-30 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano cyperus tuber 15-25 part nanometer Cortex Magnoliae Officinalis 15-25 part nanometer rhizoma sparganic 15-25 part
Nanometer Rhizoma Curcumae 15-25 part nano Chinese angelica 15-25 part nanometer Radix Aconiti Kusnezoffii 15-25 part
Nanometer Radix Aconiti 15-25 part nanometer Bulbus Allii 15-25 part nanometer Fructus Quisqualis 15-25 part
Nano angelica root 15-25 part nanometer Squama Manis 15-25 part nanometer Semen Momordicae 15-25 part
Nanometer Catharsii molossi 15-25 part nanometer Rhizoma Picrorhizae 15-25 part nano rhubarb 15-25 part
Nanometer Semen Ricini 15-25 part nanometer Olibanum 1-5 part nanometer Myrrha 1-5 part
Nano aloe 1-5 part nanometer Sanguis Draxonis 1-5 part nanometer-size realgar 12-18 part
Nanometer Cortex Cinnamomi 12-18 part nanometer Camphora 12-18 part nanometer Resina Ferulae 15-25 part
The optimum weight proportioning of medicine of the present invention is:
20 parts of 20 parts of nanometer rhizoma sparganic of 20 parts of nanometer Cortex Magnoliae Officinalis of nano cyperus tuber
20 parts of 20 parts of nanometer Radix Aconiti Kusnezoffii of 20 parts of nano Chinese angelicas of nanometer Rhizoma Curcumae
20 parts of 20 parts of nanometer Fructus Quisqualis of 20 parts of nanometer Bulbus Alliis of nanometer Radix Aconiti
20 parts of 20 parts of nanometer Semen Momordicaes of 20 parts of nanometer Squama Maniss of nano angelica root
20 parts of 20 parts of nano rhubarbs of 20 parts of nanometer Rhizoma Picrorhizae of nanometer Catharsii molossi
3 parts of 3 parts of nanometer Myrrhas of 20 parts of nanometer Olibanums of nanometer Semen Ricini
15 parts of 3 parts of nanometer-size realgars of 3 parts of nanometer Sanguis Draxonis of nano aloe
20 parts of 15 parts of nanometer Resina Ferulaes of 15 parts of nanometer Camphoras of nanometer Cortex Cinnamomi
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has traditional material physical and chemical performance when not possessing.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Awei Huapi ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Awei Huapi ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common awei huapi plaster, awei huapi gao preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano medicine ' Awei Huapi ' etc. had no precedent in the past.
It is that abdominal part has piece by it that pharmaceutical preparation of the present invention can be used for intestinal obstruction, pyloric obstruction, hepatosplenomegaly clinical manifestation, expand or pain, poor appetite, become thin, weak etc. belong to healthy energy lose tie in empty, the blood stasis due to treatment of conditions such as disease, clinical efficacy significantly is better than traditional awei huapi plaster, awei huapi gao.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
20 parts of 20 parts of nanometer rhizoma sparganic of 20 parts of nanometer Cortex Magnoliae Officinalis of nano cyperus tuber
20 parts of 20 parts of nanometer Radix Aconiti Kusnezoffii of 20 parts of nano Chinese angelicas of nanometer Rhizoma Curcumae
20 parts of 20 parts of nanometer Fructus Quisqualis of 20 parts of nanometer Bulbus Alliis of nanometer Radix Aconiti
20 parts of 20 parts of nanometer Semen Momordicaes of 20 parts of nanometer Squama Maniss of nano angelica root
20 parts of 20 parts of nano rhubarbs of 20 parts of nanometer Rhizoma Picrorhizae of nanometer Catharsii molossi
3 parts of 3 parts of nanometer Myrrhas of 20 parts of nanometer Olibanums of nanometer Semen Ricini
15 parts of 3 parts of nanometer-size realgars of 3 parts of nanometer Sanguis Draxonis of nano aloe
20 parts of 15 parts of nanometer Resina Ferulaes of 15 parts of nanometer Camphoras of nanometer Cortex Cinnamomi
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to a preparation capsule of Chinese Pharmacopoeia version in 2000 standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
20 parts of 20 parts of nanometer rhizoma sparganic of 20 parts of nanometer Cortex Magnoliae Officinalis of nano cyperus tuber
20 parts of 20 parts of nanometer Radix Aconiti Kusnezoffii of 20 parts of nano Chinese angelicas of nanometer Rhizoma Curcumae
20 parts of 20 parts of nanometer Fructus Quisqualis of 20 parts of nanometer Bulbus Alliis of nanometer Radix Aconiti
20 parts of 20 parts of nanometer Semen Momordicaes of 20 parts of nanometer Squama Maniss of nano angelica root
20 parts of 20 parts of nano rhubarbs of 20 parts of nanometer Rhizoma Picrorhizae of nanometer Catharsii molossi
3 parts of 3 parts of nanometer Myrrhas of 20 parts of nanometer Olibanums of nanometer Semen Ricini
15 parts of 3 parts of nanometer-size realgars of 3 parts of nanometer Sanguis Draxonis of nano aloe
20 parts of 15 parts of nanometer Resina Ferulaes of 15 parts of nanometer Camphoras of nanometer Cortex Cinnamomi
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer Resina Ferulae eliminating mass and relieving fullness membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine ' Awei Huapi ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano cyperus tuber 10-30 part nanometer Cortex Magnoliae Officinalis 10-30 part nanometer rhizoma sparganic 10-30 part
Nanometer Rhizoma Curcumae 10-30 part nano Chinese angelica 10-30 part nanometer Radix Aconiti Kusnezoffii 10-30 part
Nanometer Radix Aconiti 10-30 part nanometer Bulbus Allii 10-30 part nanometer Fructus Quisqualis 10-30 part
Nano angelica root 10-30 part nanometer Squama Manis 10-30 part nanometer Semen Momordicae 10-30 part
Nanometer Catharsii molossi 10-30 part nanometer Rhizoma Picrorhizae 10-30 part nano rhubarb 10-30 part
Nanometer Semen Ricini 10-30 part nanometer Olibanum 1-8 part nanometer Myrrha 1-8 part
Nano aloe 1-8 part nanometer Sanguis Draxonis 1-8 part nanometer-size realgar 10-25 part
Nanometer Cortex Cinnamomi 10-25 part nanometer Camphora 10-25 part nanometer Resina Ferulae 12-30 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Awei Huapi ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nano cyperus tuber 15-25 part nanometer Cortex Magnoliae Officinalis 15-25 part nanometer rhizoma sparganic 15-25 part
Nanometer Rhizoma Curcumae 15-25 part nano Chinese angelica 15-25 part nanometer Radix Aconiti Kusnezoffii 15-25 part
Nanometer Radix Aconiti 15-25 part nanometer Bulbus Allii 15-25 part nanometer Fructus Quisqualis 15-25 part
Nano angelica root 15-25 part nanometer Squama Manis 15-25 part nanometer Semen Momordicae 15-25 part
Nanometer Catharsii molossi 15-25 part nanometer Rhizoma Picrorhizae 15-25 part nano rhubarb 15-25 part
Nanometer Semen Ricini 15-25 part nanometer Olibanum 1-5 part nanometer Myrrha 1-5 part
Nano aloe 1-5 part nanometer Sanguis Draxonis 1-5 part nanometer-size realgar 12-18 part
Nanometer Cortex Cinnamomi 12-18 part nanometer Camphora 12-18 part nanometer Resina Ferulae 15-25 part
3, nano medicine ' Awei Huapi ' according to claim 1, wherein the weight proportion of each nano raw material is:
20 parts of 20 parts of nanometer rhizoma sparganic of 20 parts of nanometer Cortex Magnoliae Officinalis of nano cyperus tuber
20 parts of 20 parts of nanometer Radix Aconiti Kusnezoffii of 20 parts of nano Chinese angelicas of nanometer Rhizoma Curcumae
20 parts of 20 parts of nanometer Fructus Quisqualis of 20 parts of nanometer Bulbus Alliis of nanometer Radix Aconiti
20 parts of 20 parts of nanometer Semen Momordicaes of 20 parts of nanometer Squama Maniss of nano angelica root
20 parts of 20 parts of nano rhubarbs of 20 parts of nanometer Rhizoma Picrorhizae of nanometer Catharsii molossi
3 parts of 3 parts of nanometer Myrrhas of 20 parts of nanometer Olibanums of nanometer Semen Ricini
15 parts of 3 parts of nanometer-size realgars of 3 parts of nanometer Sanguis Draxonis of nano aloe
20 parts of 15 parts of nanometer Resina Ferulaes of 15 parts of nanometer Camphoras of nanometer Cortex Cinnamomi
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Awei Huapi 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Awei Huapi 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100300 CN1365681A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Awei Huapi' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100300 CN1365681A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Awei Huapi' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
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| CN1365681A true CN1365681A (en) | 2002-08-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01100300 Pending CN1365681A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Awei Huapi' and its preparing process |
Country Status (1)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055272A (en) * | 2013-01-29 | 2013-04-24 | 上海浦东高星生物技术研究所 | Aweisanpi plaster |
-
2001
- 2001-01-18 CN CN 01100300 patent/CN1365681A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055272A (en) * | 2013-01-29 | 2013-04-24 | 上海浦东高星生物技术研究所 | Aweisanpi plaster |
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