CN1362155A - Nano antirheumatic medicine and its preparation - Google Patents
Nano antirheumatic medicine and its preparation Download PDFInfo
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- CN1362155A CN1362155A CN 01100310 CN01100310A CN1362155A CN 1362155 A CN1362155 A CN 1362155A CN 01100310 CN01100310 CN 01100310 CN 01100310 A CN01100310 A CN 01100310A CN 1362155 A CN1362155 A CN 1362155A
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Abstract
The present invention discloses a nano anti-rheumatism preparation medicine. It is made up by using 13 Chinese medicinal materials of nano specious millettia, nano shiny bramble, nano taiwan schefflera, nano pterospermum, nano scarlet kadsura root and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to that a kind of wind dispelling dries, promoting blood circulation to remove obstruction in the collateral, the strong knee joint nano antirheumatic preparation medicine of strong waist, the invention still further relates to the method for this medication preparation.
Rheumatism liquid is a kind of classical Chinese patent medicine, mainly contains that wind dispelling dries, effects such as promoting blood circulation to remove obstruction in the collateral, the strong knee joint of strong waist, is used for chronic rheumatic arthritis, rheumatoid arthritis, waist and takes off diseases such as pain, medicine for treating sciatic nerve diseases, the sour numbness of extremity and lumbar muscle strain.But traditional rheumatism liquid absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano antirheumatic preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano antirheumatic preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Millettia Speciosa 20-40 part nanometer Radix Zanthoxyli 5-25 part nanometer Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 5-25 part
Nanometer Pterospermi Heterophylli 15-45 part nanometer kadsura root 10-35 part nanometer Corii Cuon alpini Camphor tree 10-35 part
Nanometer Fructus Liquidambaris 5-20 nanometer Radix seu Caulis Verntilaginis Leiocarpae 10-35 part nanometer Cortex Periplocae 10-35 part
Nanometer Rhizoma Polygoni Cuspidati 10-35 part nanometer Radix Flemingiae Philippinensis 15-45 part nanometer Radix Ilicis Pubescentis 5-35 part
Nanometer Caulis Spatholobi 10-35 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Millettia Speciosa 25-35 part nanometer Radix Zanthoxyli 10-15 part nanometer Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10-15 part
Nanometer Pterospermi Heterophylli 25-35 part nanometer kadsura root 15-25 part nanometer Corii Cuon alpini Camphor tree 15-25 part
Nanometer Fructus Liquidambaris 10-15 part nanometer Radix seu Caulis Verntilaginis Leiocarpae 15-25 part nanometer Cortex Periplocae 15-25 part
Nanometer Rhizoma Polygoni Cuspidati 15-25 part nanometer Radix Flemingiae Philippinensis 25-35 part nanometer Radix Ilicis Pubescentis 15-25 part
Nanometer Caulis Spatholobi 15-25 part
The optimum weight proportioning of medicine of the present invention is:
12 parts of 12 parts of nanometer Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s of 30 parts of nanometer Radix Zanthoxylis of nanometer Millettia Speciosa
20 parts of 20 parts of nanometer Corii Cuon alpini of 20 parts of nanometer kadsura roots of nanometer Pterospermi Heterophylli Camphor trees
20 parts of 20 parts of nanometer Cortex Periplocaes of 12 parts of nanometer Radix seu Caulis Verntilaginis Leiocarpae of nanometer Fructus Liquidambaris
20 parts of 30 parts of nanometer Radix Ilicis Pubescentiss of 18 parts of nanometer Radix Flemingiae Philippinensiss of nanometer Rhizoma Polygoni Cuspidati
18 parts of nanometer Caulis Spatholobis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05Mpa pressure,, get the antirheumatic agent nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano antirheumatic preparation medicine is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common rheumatism liquid formulation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano antirheumatic preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as wind dispelling dries, promoting blood circulation to remove obstruction in the collateral, the strong knee joint of strong waist, and clinical efficacy is remarkable.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
12 parts of 12 parts of nanometer Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s of 30 parts of nanometer Radix Zanthoxylis of nanometer Millettia Speciosa
20 parts of 20 parts of nanometer Corii Cuon alpini of 20 parts of nanometer kadsura roots of nanometer Pterospermi Heterophylli Camphor trees
20 parts of 20 parts of nanometer Cortex Periplocaes of 12 parts of nanometer Radix seu Caulis Verntilaginis Leiocarpae of nanometer Fructus Liquidambaris
20 parts of 30 parts of nanometer Radix Ilicis Pubescentiss of 18 parts of nanometer Radix Flemingiae Philippinensiss of nanometer Rhizoma Polygoni Cuspidati
18 parts of nanometer Caulis Spatholobis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly, make capsule with the fully-automatic capsule racking machine, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time at every turn.
Embodiment 2:
Prepare nano raw material by preceding method:
12 parts of 12 parts of nanometer Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s of 30 parts of nanometer Radix Zanthoxylis of nanometer Millettia Speciosa
20 parts of 20 parts of nanometer Corii Cuon alpini of 20 parts of nanometer kadsura roots of nanometer Pterospermi Heterophylli Camphor trees
20 parts of 20 parts of nanometer Cortex Periplocaes of 12 parts of nanometer Radix seu Caulis Verntilaginis Leiocarpae of nanometer Fructus Liquidambaris
20 parts of 30 parts of nanometer Radix Ilicis Pubescentiss of 18 parts of nanometer Radix Flemingiae Philippinensiss of nanometer Rhizoma Polygoni Cuspidati
18 parts of nanometer Caulis Spatholobis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make the nano Fengshi powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
12 parts of 12 parts of nanometer Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s of 30 parts of nanometer Radix Zanthoxylis of nanometer Millettia Speciosa
20 parts of 20 parts of nanometer Corii Cuon alpini of 20 parts of nanometer kadsura roots of nanometer Pterospermi Heterophylli Camphor trees
20 parts of 20 parts of nanometer Cortex Periplocaes of 12 parts of nanometer Radix seu Caulis Verntilaginis Leiocarpae of nanometer Fructus Liquidambaris
20 parts of 30 parts of nanometer Radix Ilicis Pubescentiss of 18 parts of nanometer Radix Flemingiae Philippinensiss of nanometer Rhizoma Polygoni Cuspidati
18 parts of nanometer Caulis Spatholobis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make the nano Fengshi membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: the affected part.
Claims (6)
1, a kind of nano antirheumatic preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Millettia Speciosa 20-40 part nanometer Radix Zanthoxyli 5-25 part nanometer Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 5-25 part
Nanometer Pterospermi Heterophylli 15-45 part nanometer kadsura root 10-35 part nanometer Corii Cuon alpini Camphor tree 10-35 part
Nanometer Fructus Liquidambaris 5-20 nanometer Radix seu Caulis Verntilaginis Leiocarpae 10-35 part nanometer Cortex Periplocae 10-35 part
Nanometer Rhizoma Polygoni Cuspidati 10-35 part nanometer Radix Flemingiae Philippinensis 15-45 part nanometer Radix Ilicis Pubescentis 5-35 part
Nanometer Caulis Spatholobi 10-35 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano antirheumatic preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Millettia Speciosa 25-35 part nanometer Radix Zanthoxyli 10-15 part nanometer Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10-15 part
Nanometer Pterospermi Heterophylli 25-35 part nanometer kadsura root 15-25 part nanometer Corii Cuon alpini Camphor tree 15-25 part
Nanometer Fructus Liquidambaris 10-15 part nanometer Radix seu Caulis Verntilaginis Leiocarpae 15-25 part nanometer Cortex Periplocae 15-25 part
Nanometer Rhizoma Polygoni Cuspidati 15-25 part nanometer Radix Flemingiae Philippinensis 25-35 part nanometer Radix Ilicis Pubescentis 15-25 part
Nanometer Caulis Spatholobi 15-25 part
3, nano antirheumatic preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
12 parts of 12 parts of nanometer Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s of 30 parts of nanometer Radix Zanthoxylis of nanometer Millettia Speciosa
20 parts of 20 parts of nanometer Corii Cuon alpini of 20 parts of nanometer kadsura roots of nanometer Pterospermi Heterophylli Camphor trees
20 parts of 20 parts of nanometer Cortex Periplocaes of 12 parts of nanometer Radix seu Caulis Verntilaginis Leiocarpae of nanometer Fructus Liquidambaris
20 parts of 30 parts of nanometer Radix Ilicis Pubescentiss of 18 parts of nanometer Radix Flemingiae Philippinensiss of nanometer Rhizoma Polygoni Cuspidati
18 parts of nanometer Caulis Spatholobis
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano antirheumatic preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano antirheumatic preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100310 CN1362155A (en) | 2001-01-02 | 2001-01-02 | Nano antirheumatic medicine and its preparation |
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| CN 01100310 CN1362155A (en) | 2001-01-02 | 2001-01-02 | Nano antirheumatic medicine and its preparation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872301A (en) * | 2012-08-15 | 2013-01-16 | 邓水苟 | Anti-rheumatism medicinal liquor and using method thereof |
| CN105288544A (en) * | 2015-11-04 | 2016-02-03 | 广西纯良生物科技有限公司 | Traditional Chinese medicine preparation for treating rheumatism and rheumatoid and preparation method thereof |
| CN107648304A (en) * | 2017-11-23 | 2018-02-02 | 鹿寨县众生园中药材种植专业合作社 | Beautiful millettia root medicine materical crude slice and preparation method thereof |
-
2001
- 2001-01-02 CN CN 01100310 patent/CN1362155A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872301A (en) * | 2012-08-15 | 2013-01-16 | 邓水苟 | Anti-rheumatism medicinal liquor and using method thereof |
| CN102872301B (en) * | 2012-08-15 | 2014-07-23 | 邓水苟 | Anti-rheumatism medicinal liquor and using method thereof |
| CN105288544A (en) * | 2015-11-04 | 2016-02-03 | 广西纯良生物科技有限公司 | Traditional Chinese medicine preparation for treating rheumatism and rheumatoid and preparation method thereof |
| CN107648304A (en) * | 2017-11-23 | 2018-02-02 | 鹿寨县众生园中药材种植专业合作社 | Beautiful millettia root medicine materical crude slice and preparation method thereof |
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