CN1362140A - Nano stone excreting medicine and its preparation - Google Patents
Nano stone excreting medicine and its preparation Download PDFInfo
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- CN1362140A CN1362140A CN 01100193 CN01100193A CN1362140A CN 1362140 A CN1362140 A CN 1362140A CN 01100193 CN01100193 CN 01100193 CN 01100193 A CN01100193 A CN 01100193A CN 1362140 A CN1362140 A CN 1362140A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 239000004575 stone Substances 0.000 title claims description 13
- 238000002360 preparation method Methods 0.000 title abstract description 9
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000004863 Frankincense Substances 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 210000000582 semen Anatomy 0.000 claims description 18
- 239000000843 powder Substances 0.000 claims description 10
- 241000717739 Boswellia sacra Species 0.000 claims description 9
- 235000012222 talc Nutrition 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 241000722953 Akebia Species 0.000 claims description 5
- 241000726094 Aristolochia Species 0.000 claims description 5
- 241000025505 Pyrrosia Species 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000000454 talc Substances 0.000 claims description 4
- 229910052623 talc Inorganic materials 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 235000003717 Boswellia sacra Nutrition 0.000 abstract 1
- 240000007551 Boswellia serrata Species 0.000 abstract 1
- 235000012035 Boswellia serrata Nutrition 0.000 abstract 1
- 235000008499 Canella winterana Nutrition 0.000 abstract 1
- 244000080208 Canella winterana Species 0.000 abstract 1
- 241001072382 Glechoma Species 0.000 abstract 1
- 229940017545 cinnamon bark Drugs 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 229940018492 plantago seed Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
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- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 230000002485 urinary effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010061695 Biliary tract infection Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
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- 208000003167 cholangitis Diseases 0.000 description 1
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- 201000010099 disease Diseases 0.000 description 1
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- 239000002547 new drug Substances 0.000 description 1
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- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention discloses a nano Paishi preparation medicine. It is made up by using 13 Chinese medicinal material of nano frankincense, nano asistolochia droot, nano cinnamon bark, nano glechoma, nano plantago seed and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of clearing away heat-damp and promoting diuresis, calculus is treating stranguria, the nano stone excreting medicine of promoting the circulation of QI to relieve pain, the invention still further relates to the method for this medication preparation.
PAISHI KELI is a kind of classical Chinese patent medicine, mainly contains effects such as diuresis, cholagogic and lithagogue, antiinflammatory, analgesia, antibacterial, detoxifcation, is used for urinary system calculus disease because of damp-heat in lower-JIAO retardance, functional activity of QI being not smooth, costa sternales wrist abdomen dull pain or twinge person unbearably.But traditional PAISHI KELI absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano stone excreting medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano stone excreting medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Olibanum 600-1200 part nanometer Radix Aristolochiae 600-1200 part nanometer Cortex Cinnamomi 100-600 part
Nanometer Herba Glechomae 3000-9000 part nanometer Semen Plantaginis 600-1500 part nanometer Caulis Akebiae 600-1500 part
Nanometer Radix Cynanchi Paniculati 600-1500 part nanometer Folium Pyrrosiae 600-1500 part nanometer Herba Dianthi 600-1500 part
Nanometer Caulis Lonicerae 1000-1900 part nanometer Talcum 1000-1900 part nanometer Semen Abutili 600-1500 part
Nanometer Radix Glycyrrhizae 1000-2000 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Olibanum 800-1000 part nanometer Radix Aristolochiae 800-1000 part nanometer Cortex Cinnamomi 150-400 part
Nanometer Herba Glechomae 5000-7000 part nanometer Semen Plantaginis 800-1000 part nanometer Caulis Akebiae 800-1000 part
Nanometer Radix Cynanchi Paniculati 800-1000 part nanometer Folium Pyrrosiae 800-1000 part nanometer Herba Dianthi 800-1000 part
Nanometer Caulis Lonicerae 1200-1800 part nanometer Talcum 1200-1800 part nanometer Semen Abutili 800-1000 part
Nanometer Radix Glycyrrhizae 1200-1800 part
The optimum weight proportioning of medicine of the present invention is:
300 parts of 938 parts of nanometer Cortex Cinnamomis of 938 parts of nanometer Radix Aristolochiaes of nanometer Olibanum
938 parts of 938 parts of nanometer Caulis Akebiaes of 6250 parts of nanometer Semen Plantaginiss of nanometer Herba Glechomae
938 parts of 938 portions of nanometer Herba Dianthis of 938 parts of nanometer Folium Pyrrosiaes of nanometer Radix Cynanchi Paniculati
938 parts of 1563 parts of nanometer Semen Abutilis of 1563 parts of nanometer Talcums of nanometer Caulis Lonicerae
1563 parts in nanometer Radix Glycyrrhizae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the stone excreting nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano stone excreting medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common PAISHI KELI preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano stone excreting medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as urinary system calculus and biliary tract infection, and clinical efficacy significantly is better than traditional PAISHI KELI.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
300 parts of 938 parts of nanometer Cortex Cinnamomis of 938 parts of nanometer Radix Aristolochiaes of nanometer Olibanum
938 parts of 938 parts of nanometer Caulis Akebiaes of 6250 parts of nanometer Semen Plantaginiss of nanometer Herba Glechomae
938 parts of 938 portions of nanometer Herba Dianthis of 938 parts of nanometer Folium Pyrrosiaes of nanometer Radix Cynanchi Paniculati
938 parts of 1563 parts of nanometer Semen Abutilis of 1563 parts of nanometer Talcums of nanometer Caulis Lonicerae
1563 parts in nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly, make capsule with the fully-automatic capsule racking machine, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time at every turn.
Embodiment 2:
Prepare nano raw material by preceding method:
300 parts of 938 parts of nanometer Cortex Cinnamomis of 938 parts of nanometer Radix Aristolochiaes of nanometer Olibanum
938 parts of 938 parts of nanometer Caulis Akebiaes of 6250 parts of nanometer Semen Plantaginiss of nanometer Herba Glechomae
938 parts of 938 portions of nanometer Herba Dianthis of 938 parts of nanometer Folium Pyrrosiaes of nanometer Radix Cynanchi Paniculati
938 parts of 1563 parts of nanometer Semen Abutilis of 1563 parts of nanometer Talcums of nanometer Caulis Lonicerae
1563 parts in nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nanometer calculus powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
300 parts of 938 parts of nanometer Cortex Cinnamomis of 938 parts of nanometer Radix Aristolochiaes of nanometer Olibanum
938 parts of 938 parts of nanometer Caulis Akebiaes of 6250 parts of nanometer Semen Plantaginiss of nanometer Herba Glechomae
938 parts of 938 portions of nanometer Herba Dianthis of 938 parts of nanometer Folium Pyrrosiaes of nanometer Radix Cynanchi Paniculati
938 parts of 1563 parts of nanometer Semen Abutilis of 1563 parts of nanometer Talcums of nanometer Caulis Lonicerae
1563 parts in nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer calculus membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, waist.
Claims (6)
1, a kind of nano stone excreting medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Olibanum 600-1200 part nanometer Radix Aristolochiae 600-1200 part nanometer Cortex Cinnamomi 100-600 part
Nanometer Herba Glechomae 3000-9000 part nanometer Semen Plantaginis 600-1500 part nanometer Caulis Akebiae 600-1500 part
Nanometer Radix Cynanchi Paniculati 600-1500 part nanometer Folium Pyrrosiae 600-1500 part nanometer Herba Dianthi 600-1500 part
Nanometer Caulis Lonicerae 1000-1900 part nanometer Talcum 1000-1900 part nanometer Semen Abutili 600-1500 part
Nanometer Radix Glycyrrhizae 1000-2000 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano stone excreting medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Olibanum 800-1000 part nanometer Radix Aristolochiae 800-1000 part nanometer Cortex Cinnamomi 150-400 part
Nanometer Herba Glechomae 5000-7000 part nanometer Semen Plantaginis 800-1000 part nanometer Caulis Akebiae 800-1000 part
Nanometer Radix Cynanchi Paniculati 800-1000 part nanometer Folium Pyrrosiae 800-1000 part nanometer Herba Dianthi 800-1000 part
Nanometer Caulis Lonicerae 1200-1800 part nanometer Talcum 1200-1800 part nanometer Semen Abutili 800-1000 part
Nanometer Radix Glycyrrhizae 1200-1800 part
3, nano stone excreting medicine according to claim 1, wherein the weight proportion of each nano raw material is:
300 parts of 938 parts of nanometer Cortex Cinnamomis of 938 parts of nanometer Radix Aristolochiaes of nanometer Olibanum
938 parts of 938 parts of nanometer Caulis Akebiaes of 6250 parts of nanometer Semen Plantaginiss of nanometer Herba Glechomae
938 parts of 938 portions of nanometer Herba Dianthis of 938 parts of nanometer Folium Pyrrosiaes of nanometer Radix Cynanchi Paniculati
938 parts of 1563 parts of nanometer Semen Abutilis of 1563 parts of nanometer Talcums of nanometer Caulis Lonicerae
1563 parts in nanometer Radix Glycyrrhizae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano stone excreting medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano stone excreting medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100193 CN1362140A (en) | 2001-01-05 | 2001-01-05 | Nano stone excreting medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100193 CN1362140A (en) | 2001-01-05 | 2001-01-05 | Nano stone excreting medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362140A true CN1362140A (en) | 2002-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100193 Pending CN1362140A (en) | 2001-01-05 | 2001-01-05 | Nano stone excreting medicine and its preparation |
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| Country | Link |
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| CN (1) | CN1362140A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302639A (en) * | 2010-11-08 | 2012-01-04 | 石启明 | Traditional Chinese medicine composition for treating retention of urine |
| CN106692316A (en) * | 2016-12-22 | 2017-05-24 | 江西济民可信药业有限公司 | Preparation method of frankincense and elecampane urinary calculus-removing granules |
-
2001
- 2001-01-05 CN CN 01100193 patent/CN1362140A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302639A (en) * | 2010-11-08 | 2012-01-04 | 石启明 | Traditional Chinese medicine composition for treating retention of urine |
| CN102302639B (en) * | 2010-11-08 | 2013-02-20 | 石启明 | Traditional Chinese medicine composition for treating retention of urine |
| CN106692316A (en) * | 2016-12-22 | 2017-05-24 | 江西济民可信药业有限公司 | Preparation method of frankincense and elecampane urinary calculus-removing granules |
| CN106692316B (en) * | 2016-12-22 | 2018-11-20 | 江西济民可信药业有限公司 | A kind of preparation method of double fragrant PAISHI KELIs |
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