CN1214011C - 作为整联蛋白拮抗剂的间－氮杂环氨基苯甲酸化合物及其衍生物 - Google Patents

作为整联蛋白拮抗剂的间－氮杂环氨基苯甲酸化合物及其衍生物 Download PDF

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Publication number: CN1214011C
Authority: CN; China
Prior art keywords: compound; solution; add; preparation; product
Prior art date: 1998-03-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CNB998035815A

Other languages

English (en)

Chinese (zh)

Other versions

CN1291978A (zh

Inventor

T·E·罗格斯

P·G·鲁敏斯基

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

GD Searle LLC

Original Assignee

GD Searle LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-04

Filing date

1999-02-22

Publication date

2005-08-10

1999-02-22 Application filed by GD Searle LLC filed Critical GD Searle LLC

2001-04-18 Publication of CN1291978A publication Critical patent/CN1291978A/zh

2005-08-10 Application granted granted Critical

2005-08-10 Publication of CN1214011C publication Critical patent/CN1214011C/zh

2019-02-22 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Oncology (AREA)
Endocrinology (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

CNB998035815A 1998-03-04 1999-02-22 作为整联蛋白拮抗剂的间－氮杂环氨基苯甲酸化合物及其衍生物 Expired - Fee Related CN1214011C (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3427098A	1998-03-04	1998-03-04
US09/034,270		1998-03-04

Publications (2)

Publication Number	Publication Date
CN1291978A CN1291978A (zh)	2001-04-18
CN1214011C true CN1214011C (zh)	2005-08-10

Family

ID=21875345

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CNB998035815A Expired - Fee Related CN1214011C (zh)	1998-03-04	1999-02-22	作为整联蛋白拮抗剂的间－氮杂环氨基苯甲酸化合物及其衍生物

Country Status (29)

Country	Link
EP (1)	EP1060164A1 (xx)
JP (1)	JP2002505323A (xx)
KR (1)	KR20010041584A (xx)
CN (1)	CN1214011C (xx)
AP (1)	AP1244A (xx)
AR (1)	AR018139A1 (xx)
AU (1)	AU753230B2 (xx)
BG (1)	BG104740A (xx)
BR (1)	BR9908470A (xx)
CA (1)	CA2322207A1 (xx)
EA (1)	EA200000804A1 (xx)
EE (1)	EE200000506A (xx)
GE (1)	GEP20033118B (xx)
HR (1)	HRP20000574A2 (xx)
HU (1)	HUP0100865A3 (xx)
ID (1)	ID25591A (xx)
IL (1)	IL137653A0 (xx)
IS (1)	IS5582A (xx)
MY (1)	MY123908A (xx)
NO (1)	NO315703B1 (xx)
NZ (1)	NZ506598A (xx)
OA (1)	OA11530A (xx)
PL (1)	PL342726A1 (xx)
SK (1)	SK13002000A3 (xx)
TR (1)	TR200002542T2 (xx)
UA (1)	UA71906C2 (xx)
WO (1)	WO1999044994A1 (xx)
YU (1)	YU52000A (xx)
ZA (1)	ZA994406B (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9805655D0 (en)	1998-03-16	1998-05-13	Celltech Therapeutics Ltd	Chemical compounds
GB9814414D0 (en)	1998-07-03	1998-09-02	Celltech Therapeutics Ltd	Chemical compounds
GB9821061D0 (en)	1998-09-28	1998-11-18	Celltech Therapeutics Ltd	Chemical compounds
GB9826174D0 (en)	1998-11-30	1999-01-20	Celltech Therapeutics Ltd	Chemical compounds
US6518283B1 (en)	1999-05-28	2003-02-11	Celltech R&D Limited	Squaric acid derivatives
US6455539B2 (en)	1999-12-23	2002-09-24	Celltech R&D Limited	Squaric acid derivates
ES2295150T3 (es)	2000-04-17	2008-04-16	Ucb Pharma, S.A.	Derivados de enamina como moleculas de adhesion celular.
US6545013B2 (en)	2000-05-30	2003-04-08	Celltech R&D Limited	2,7-naphthyridine derivatives
US6403608B1 (en)	2000-05-30	2002-06-11	Celltech R&D, Ltd.	3-Substituted isoquinolin-1-yl derivatives
US6921767B2 (en) *	2000-06-15	2005-07-26	Pharmacia Corporation	Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
AU2001275724A1 (en)	2000-08-02	2002-02-13	Celltech R&D Limited	3-substituted isoquinolin-1-yl derivatives
BR0317487A (pt) *	2002-12-20	2005-11-29	Pharmacia Corp	O r-isÈmero de compostos de aminoácido beta como derivados de antagonistas de receptores de integrina
UA87854C2 (xx)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-бензил)-2-фенілбутанаміди як модулятори рецептора андрогену$n-(2-бензил)-2-фенилбутанамиды как модуляторы рецептора андрогена
BRPI0611814A2 (pt) *	2005-06-10	2008-12-09	Bipar Sciences Inc	moduladores parp e tratamento de cÂnceres
JP2010520238A (ja)	2007-03-01	2010-06-10	マリンクロットインコーポレイテッド	統合された光活性低分子および統合された光活性低分子使用
JP4792124B1 (ja) *	2010-11-15	2011-10-12	エフイートレード株式会社	車両用保護フィルムの型取り方法、及び、車両用保護フィルムの製造方法
IN2015DN00099A (xx)	2012-07-18	2015-05-29	Univ Saint Louis
US8716226B2 (en)	2012-07-18	2014-05-06	Saint Louis University	3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
MX2016015467A (es)	2014-05-30	2017-03-23	Pfizer	Derivados de carbonitrilo como moduladores selectivos del receptor de androgenos.
CN106659162B (zh) *	2014-06-04	2020-10-27	孟山都技术公司	3,6-二氯水杨酸化合物以及相关合成方法
CN108779077A (zh)	2015-12-30	2018-11-09	圣路易斯大学	作为pan整合素拮抗剂的间位氮杂环氨基苯甲酸衍生物
JP7661969B2 (ja)	2020-05-14	2025-04-15	Ｕｂｅ株式会社	１，４，５，６－テトラヒドロピリミジン－２－アミン誘導体
WO2023275715A1 (en)	2021-06-30	2023-01-05	Pfizer Inc.	Metabolites of selective androgen receptor modulators
EP4431098A4 (en)	2021-11-12	2025-10-08	Ube Corp	PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OR PREVENTION OF ALPORT SYNDROME

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH11510814A (ja) *	1995-08-30	1999-09-21	ジー．ディー．サールアンドカンパニー	インテグリンアンタゴニストとしてのメタ−グアニジン、尿素、チオ尿素またはアザ環状アミノ安息香酸誘導体

1999
- 1999-02-11 ZA ZA9904406A patent/ZA994406B/xx unknown
- 1999-02-22 OA OA1200000238A patent/OA11530A/en unknown
- 1999-02-22 EP EP99937927A patent/EP1060164A1/en active Pending
- 1999-02-22 ID IDW20001695A patent/ID25591A/id unknown
- 1999-02-22 WO PCT/US1999/003281 patent/WO1999044994A1/en not_active Ceased
- 1999-02-22 JP JP2000534538A patent/JP2002505323A/ja active Pending
- 1999-02-22 HU HU0100865A patent/HUP0100865A3/hu unknown
- 1999-02-22 YU YU52000A patent/YU52000A/sh unknown
- 1999-02-22 CA CA002322207A patent/CA2322207A1/en not_active Abandoned
- 1999-02-22 TR TR2000/02542T patent/TR200002542T2/xx unknown
- 1999-02-22 KR KR1020007009774A patent/KR20010041584A/ko not_active Ceased
- 1999-02-22 AU AU32947/99A patent/AU753230B2/en not_active Ceased
- 1999-02-22 HR HR20000574A patent/HRP20000574A2/hr not_active Application Discontinuation
- 1999-02-22 NZ NZ506598A patent/NZ506598A/en unknown
- 1999-02-22 GE GEAP19995537A patent/GEP20033118B/en unknown
- 1999-02-22 SK SK1300-2000A patent/SK13002000A3/sk unknown
- 1999-02-22 BR BR9908470-8A patent/BR9908470A/pt not_active Application Discontinuation
- 1999-02-22 UA UA2000095148A patent/UA71906C2/uk unknown
- 1999-02-22 IL IL13765399A patent/IL137653A0/xx unknown
- 1999-02-22 EA EA200000804A patent/EA200000804A1/ru unknown
- 1999-02-22 EE EEP200000506A patent/EE200000506A/xx unknown
- 1999-02-22 PL PL99342726A patent/PL342726A1/xx unknown
- 1999-02-22 AP APAP/P/2000/001893A patent/AP1244A/en active
- 1999-02-22 CN CNB998035815A patent/CN1214011C/zh not_active Expired - Fee Related
- 1999-03-02 AR ARP990100880A patent/AR018139A1/es unknown
- 1999-03-03 MY MYPI99000772A patent/MY123908A/en unknown
2000
- 2000-08-04 IS IS5582A patent/IS5582A/is unknown
- 2000-08-30 NO NO20004316A patent/NO315703B1/no not_active IP Right Cessation
- 2000-09-01 BG BG104740A patent/BG104740A/xx unknown

Also Published As

Publication number	Publication date
CA2322207A1 (en)	1999-09-10
AP2000001893A0 (en)	2000-09-30
NO315703B1 (no)	2003-10-13
PL342726A1 (en)	2001-07-02
HRP20000574A2 (en)	2001-08-31
TR200002542T2 (tr)	2001-05-21
SK13002000A3 (sk)	2001-07-10
AP1244A (en)	2004-02-04
ID25591A (id)	2000-10-19
YU52000A (sh)	2003-02-28
BR9908470A (pt)	2000-12-05
BG104740A (en)	2001-02-28
OA11530A (en)	2004-05-17
MY123908A (en)	2006-06-30
AU753230B2 (en)	2002-10-10
IS5582A (is)	2000-08-04
HUP0100865A2 (hu)	2001-08-28
AR018139A1 (es)	2001-10-31
ZA994406B (en)	2000-02-11
EA200000804A1 (ru)	2001-04-23
NO20004316L (no)	2000-11-06
AU3294799A (en)	1999-09-20
NO20004316D0 (no)	2000-08-30
HUP0100865A3 (en)	2001-11-28
UA71906C2 (en)	2005-01-17
CN1291978A (zh)	2001-04-18
EP1060164A1 (en)	2000-12-20
IL137653A0 (en)	2001-10-31
EE200000506A (et)	2002-04-15
KR20010041584A (ko)	2001-05-25
WO1999044994A1 (en)	1999-09-10
JP2002505323A (ja)	2002-02-19
GEP20033118B (en)	2003-11-25
NZ506598A (en)	2003-07-25

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Legal Events

Date	Code	Title
2001-04-18	C06	Publication
2001-04-18	PB01	Publication
2001-04-25	C10	Entry into substantive examination
2001-04-25	SE01	Entry into force of request for substantive examination
2005-08-10	C14	Grant of patent or utility model
2005-08-10	GR01	Patent grant
2007-04-25	C19	Lapse of patent right due to non-payment of the annual fee
2007-04-25	CF01	Termination of patent right due to non-payment of annual fee