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CL2008001457A1 - Compuestos derivados de 6-(piridin-3-il)quinolina, inhibidores de la pi3 quinasa; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento de cancer en un humano que lo necesite. - Google Patents

Compuestos derivados de 6-(piridin-3-il)quinolina, inhibidores de la pi3 quinasa; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento de cancer en un humano que lo necesite.

Info

Publication number
CL2008001457A1
CL2008001457A1 CL2008001457A CL2008001457A CL2008001457A1 CL 2008001457 A1 CL2008001457 A1 CL 2008001457A1 CL 2008001457 A CL2008001457 A CL 2008001457A CL 2008001457 A CL2008001457 A CL 2008001457A CL 2008001457 A1 CL2008001457 A1 CL 2008001457A1
Authority
CL
Chile
Prior art keywords
compounds
quinoline
pharmaceutical composition
kinase inhibitors
pyridin
Prior art date
Application number
CL2008001457A
Other languages
English (en)
Inventor
Nicholas D Adams
Joelle Lorraine Burgess
Amita M Chaudhari
Michel Gerard Darcy
Dashyant Dhanak
Ca Donatelli
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of CL2008001457A1 publication Critical patent/CL2008001457A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
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    • A61K31/47—Quinolines; Isoquinolines
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Abstract

Compuestos derivados de quinolina, inhibidores de la p13 quinasa; composición farmacéutica que comprende a dichos compuestos; y su uso para tratar enfermedades inflamatorias, cardiovasculares, neurodegenerativas, alergia, asma, fallo multiorgánico, entre otras.
CL2008001457A 2007-05-18 2008-05-16 Compuestos derivados de 6-(piridin-3-il)quinolina, inhibidores de la pi3 quinasa; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento de cancer en un humano que lo necesite. CL2008001457A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93876107P 2007-05-18 2007-05-18

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