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UA104408C2 - Похідні хіноліну як інгібітори pi3-кінази - Google Patents

Похідні хіноліну як інгібітори pi3-кінази

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Publication number
UA104408C2
UA104408C2 UAA200913251A UAA200913251A UA104408C2 UA 104408 C2 UA104408 C2 UA 104408C2 UA A200913251 A UAA200913251 A UA A200913251A UA A200913251 A UAA200913251 A UA A200913251A UA 104408 C2 UA104408 C2 UA 104408C2
Authority
UA
Ukraine
Prior art keywords
quinoline derivatives
diseases
kinase inhibitors
invented
pancreatitis
Prior art date
Application number
UAA200913251A
Other languages
English (en)
Russian (ru)
Inventor
Ніколас Д. Адамс
Жоель Лоррейн Бергесс
Майкл Джерард Дарсі
Карла А. Донателлі
Стівен Девід Найт
Кеннет Аллен Ньюлендер
Ленс Ріджерс
Марта Сарпонг
Стенлі Дж. Шмідт
Original Assignee
Смітклайн Бічам Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смітклайн Бічам Корпорейшн filed Critical Смітклайн Бічам Корпорейшн
Publication of UA104408C2 publication Critical patent/UA104408C2/uk

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
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  • Transplantation (AREA)

Abstract

Винахід стосується способу інгібування активності/функції РІ3-кіназ з використанням похідних хіноліну.Винахід також стосується способу лікування одного або більше хворобливих станів, вибраних з аутоімунних розладів, запальних захворювань, серцево-судинних захворювань, нейродегенеративних захворювань, алергії, астми, панкреатиту, недостатності багатьох органів, захворювань нирок, агрегації тромбоцитів, раку, рухливості сперми, відторгнення при трансплантації, відторгнення трансплантата й легеневих пошкоджень, шляхом введення похідних хіноліну.
UAA200913251A 2007-05-18 2008-05-16 Похідні хіноліну як інгібітори pi3-кінази UA104408C2 (uk)

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