BG102041A - Oxidized heterocycles containing sulphonamide aspartylprotease inhibitors - Google Patents

Oxidized heterocycles containing sulphonamide aspartylprotease inhibitors

Info

Publication number: BG102041A
Authority: BG; Bulgaria
Prior art keywords: aspartylprotease; inhibitors; oxidized; hiv; heterocycles containing
Prior art date: 1995-04-19

Application number

BG102041A

Other languages

Bulgarian (bg)

English (en)

Inventor

Roger Tung

Govinda BHISETTI

Original Assignee

Vertex Pharmaceuticals Incorporated

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-19

Filing date

1997-11-13

Publication date

1998-09-30

1997-11-13 Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated

1998-09-30 Publication of BG102041A publication Critical patent/BG102041A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C07D317/36—Alkylene carbonates; Substituted alkylene carbonates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Furan Compounds (AREA)
Pyrane Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Peptides Or Proteins (AREA)
Enzymes And Modification Thereof (AREA)

BG102041A 1995-04-19 1997-11-13 Oxidized heterocycles containing sulphonamide aspartylprotease inhibitors BG102041A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/424,810 US5691372A (en)	1995-04-19	1995-04-19	Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
PCT/US1996/005473 WO1996033187A1 (en)	1995-04-19	1996-04-18	Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease

Publications (1)

Publication Number	Publication Date
BG102041A true BG102041A (en)	1998-09-30

Family

ID=23683966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG102041A BG102041A (en)	1995-04-19	1997-11-13	Oxidized heterocycles containing sulphonamide aspartylprotease inhibitors

Country Status (34)

Country	Link
US (2)	US5691372A (is)
EP (3)	EP1136479B1 (is)
JP (1)	JP4240532B2 (is)
KR (1)	KR100485237B1 (is)
CN (1)	CN1110491C (is)
AP (2)	AP9600827A0 (is)
AR (1)	AR004663A1 (is)
AT (3)	ATE212344T1 (is)
AU (1)	AU712913B2 (is)
BG (1)	BG102041A (is)
BR (1)	BR9608033A (is)
CA (1)	CA2217745C (is)
CO (1)	CO4700433A1 (is)
CZ (1)	CZ329497A3 (is)
DE (3)	DE69618779T2 (is)
DK (1)	DK0833826T3 (is)
EA (1)	EA000906B1 (is)
EE (1)	EE9700254A (is)
ES (3)	ES2171670T3 (is)
GE (1)	GEP20001915B (is)
HU (1)	HUP9801948A3 (is)
IL (1)	IL117962A0 (is)
IS (1)	IS4575A (is)
MY (1)	MY115797A (is)
NO (1)	NO974744D0 (is)
NZ (1)	NZ307342A (is)
PE (1)	PE43697A1 (is)
PL (1)	PL322904A1 (is)
PT (1)	PT833826E (is)
SK (1)	SK143097A3 (is)
TR (1)	TR199701194T1 (is)
TW (1)	TW404945B (is)
WO (1)	WO1996033187A1 (is)
ZA (1)	ZA962891B (is)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040122000A1 (en)	1981-01-07	2004-06-24	Vertex Pharmaceuticals Incorporated.	Inhibitors of aspartyl protease
KR100296463B1 (ko)	1992-08-25	2001-10-24	죤 에이치. 뷰센	레트로바이러스프로테아제저해제로서유용한히드록시에틸아미노술폰아미드
US7141609B2 (en)	1992-08-25	2006-11-28	G.D. Searle & Co.	α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US5942253A (en)	1995-10-12	1999-08-24	Immunex Corporation	Prolonged release of GM-CSF
US5874449A (en) *	1996-12-31	1999-02-23	Gpi Nil Holdings, Inc.	N-linked sulfonamides of heterocyclic thioesters
NZ335480A (en)	1996-12-31	2001-04-27	Guilford Pharm Inc	Neurotrophic low molecular weight N-linked sulfonamides of heterocyclic thioesters and their use as inhibitors of immunophilin proteins
BR9809124A (pt) *	1997-05-17	2000-08-01	Glaxo Group Ltd	Combinação, formulação, farmacêutica, processo para o tratamento de uma infecção por hiv em um animal, infectado, uso de (-)-(1s, 4r)-4-[2-amino-6-(ciclopropilamino)-9h-purin-9-il)-2-cicl openteno-1-metanol, e, pacote de paciente
US20010049381A1 (en)	1997-06-04	2001-12-06	Gpl Nil Holdings, Inc.,	Pyrrolidine derivative hair growth compositions and uses
US5945441A (en)	1997-06-04	1999-08-31	Gpi Nil Holdings, Inc.	Pyrrolidine carboxylate hair revitalizing agents
US6576231B2 (en) *	1997-09-12	2003-06-10	Schering Ag	Methods for treating HIV-Infected Patients by the Administration of GM-CSF and a protease inhibitor
US6436989B1 (en)	1997-12-24	2002-08-20	Vertex Pharmaceuticals, Incorporated	Prodrugs of aspartyl protease inhibitors
HUP0101598A3 (en) *	1997-12-24	2002-08-28	Vertex Pharmaceuticals Inc Cam	Prodrugs of aspartyl protease inhibitors and medicaments containing them
NZ508855A (en) *	1998-06-19	2003-10-31	Vertex Pharma	Sulfonamide inhibitors of HIV aspartyl protease
US7470506B1 (en)	1998-06-23	2008-12-30	The United States Of America As Represented By The Department Of Health And Human Services	Fitness assay and associated methods
US6337340B1 (en)	1998-08-14	2002-01-08	Gpi Nil Holdings, Inc.	Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6395758B1 (en)	1998-08-14	2002-05-28	Gpi Nil Holdings, Inc.	Small molecule carbamates or ureas for vision and memory disorders
US6399648B1 (en)	1998-08-14	2002-06-04	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US7338976B1 (en)	1998-08-14	2008-03-04	Gpi Nil Holdings, Inc.	Heterocyclic esters or amides for vision and memory disorders
US6218423B1 (en)	1998-08-14	2001-04-17	Gpi Nil Holdings, Inc.	Pyrrolidine derivatives for vision and memory disorders
US6339101B1 (en)	1998-08-14	2002-01-15	Gpi Nil Holdings, Inc.	N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6376517B1 (en)	1998-08-14	2002-04-23	Gpi Nil Holdings, Inc.	Pipecolic acid derivatives for vision and memory disorders
US6462072B1 (en)	1998-09-21	2002-10-08	Gpi Nil Holdings, Inc.	Cyclic ester or amide derivatives
DK1159278T3 (da) *	1999-02-12	2006-04-10	Vertex Pharma	Inhibitorer af aspartylprotease
TNSN00027A1 (fr)	1999-02-12	2005-11-10	Vertex Pharma	Inhibiteurs de l'aspartyle protease
AR031520A1 (es) *	1999-06-11	2003-09-24	Vertex Pharma	Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
ES2307533T3 (es) *	1999-10-06	2008-12-01	Tibotec Pharmaceuticals Ltd.	Hexahidrofuro(2,3)furan-3-il-n-(3-((1,3-benzodioxol-5-ilsulfonil)(is obuti)amino)-1-bencil-2-hidroxipropil carbamato como inhibidor de la proteasa retroviral.
MXPA02009534A (es)	2000-03-30	2003-05-14	Squibb Bristol Myers Co	Granulos de liberacion sostenida que contienen estavudina.
IL158092A0 (en) *	2001-04-09	2004-03-28	Tibotec Pharm Ltd	Broadspectrum 2- (substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors
WO2003064406A1 (en) *	2002-01-07	2003-08-07	Sequoia Pharmaceuticals	Resistance-repellent retroviral protease inhibitors
US7157489B2 (en) *	2002-03-12	2007-01-02	The Board Of Trustees Of The University Of Illinois	HIV protease inhibitors
WO2004033152A1 (en) *	2002-10-11	2004-04-22	Semplastics, L.L.C.	Retaining ring for use on a carrier of a polishing apparatus
WO2004050609A1 (en) *	2002-11-27	2004-06-17	Elan Pharmaceutical, Inc.	Substituted ureas and carbamates
US20050131042A1 (en) *	2003-12-11	2005-06-16	Flentge Charles A.	HIV protease inhibiting compounds
US7763609B2 (en) *	2003-12-15	2010-07-27	Schering Corporation	Heterocyclic aspartyl protease inhibitors
JP2008533017A (ja) *	2005-03-11	2008-08-21	スミスクラインビーチャムコーポレーション	Ｈｉｖプロテアーゼ阻害薬
JP2007202679A (ja) *	2006-01-31	2007-08-16	Juki Corp	ミシンの糸調子装置
JP2007202833A (ja) *	2006-02-02	2007-08-16	Juki Corp	ミシンの糸調子装置
WO2008133734A2 (en) *	2006-11-21	2008-11-06	Purdue Research Foundation	Method and compositions for treating hiv infections
US20110046199A1 (en)	2008-01-17	2011-02-24	Purdue Research Foundation	Small molecule inhibitors of hiv proteases
US8791135B2 (en)	2008-07-01	2014-07-29	Purdue Research Foundation	Nonpeptide HIV-1 protease inhibitors
WO2010006050A1 (en)	2008-07-09	2010-01-14	Purdue Research Foundation	Hiv protease inhibitors and methods for using
CN105272991B (zh) *	2014-06-26	2017-11-07	成都中医药大学	一种化合物晶型
US11090030B2 (en)	2016-11-10	2021-08-17	Leltek Inc.	Ultrasound apparatus and ultrasound emission method

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3743722A (en) *	1971-07-14	1973-07-03	Abbott Lab	Anti-coagulant isolation
FR2459235A1 (fr) *	1979-06-14	1981-01-09	Sanofi Sa	Nouveaux derives de sulfonyl-aniline, leur procede de preparation et leur application therapeutique
JPS5946252A (ja) *	1982-09-09	1984-03-15	Dainippon Ink & Chem Inc	含フツ素アミノカルボキシレ−トおよびその製法
JPS5948449A (ja) *	1982-09-13	1984-03-19	Dainippon Ink & Chem Inc	直鎖状含フツ素アニオン化合物およびその製造方法
JPS6171830A (ja) *	1984-09-17	1986-04-12	Dainippon Ink & Chem Inc	界面活性剤組成物
US4616088A (en) *	1984-10-29	1986-10-07	E. R. Squibb & Sons, Inc.	Amino acid ester and amide renin inhibitor
US4629724A (en) *	1984-12-03	1986-12-16	E. R. Squibb & Sons, Inc.	Amino acid ester and amide renin inhibitors
DE3635907A1 (de) *	1986-10-22	1988-04-28	Merck Patent Gmbh	Hydroxy-aminosaeurederivate
NL8800100A (nl) *	1987-01-21	1988-08-16	Sandoz Ag	Nieuwe peptidederivaten en werkwijzen voor het bereiden en toepassen van deze derivaten.
CA1340588C (en) *	1988-06-13	1999-06-08	Balraj Krishan Handa	Amino acid derivatives
IL91780A (en) *	1988-10-04	1995-08-31	Abbott Lab	History of the amine of the xenon-preventing xanine acid, the process for their preparation and the pharmaceutical preparations containing them
WO1990007330A1 (en) *	1989-01-06	1990-07-12	The Regents Of The University Of California	Selection method for specific useful pharmaceutical compounds
US5151438A (en) *	1989-05-23	1992-09-29	Abbott Laboratories	Retroviral protease inhibiting compounds
US5354866A (en) *	1989-05-23	1994-10-11	Abbott Laboratories	Retroviral protease inhibiting compounds
IE902295A1 (en) *	1989-07-07	1991-01-16	Abbott Lab	Amino acid analog cck antagonists
GB8927913D0 (en) *	1989-12-11	1990-02-14	Hoffmann La Roche	Amino acid derivatives
HUT64738A (en) *	1990-06-01	1994-02-28	Du Pont Merck Pharma	Process for preparing 1,4-diamino-2,3-dihydroxi-butane compounds and pharmaceutical compositions contianing them
TW225540B (is) *	1990-06-28	1994-06-21	Shionogi & Co
DK0815856T3 (da) *	1990-11-19	2005-10-03	Monsanto Co	Retrovirale proteaseinhibitorer
DE69118907T2 (de) *	1990-11-19	1996-11-14	Monsanto Co	Retrovirale proteaseinhibitoren
ATE155779T1 (de) *	1990-11-19	1997-08-15	Monsanto Co	Retrovirale protease-inhibitoren
WO1993023388A1 (en) *	1992-05-20	1993-11-25	G.D. Searle & Co.	Method for making intermediates useful in synthesis of retroviral protease inhibitors
ATE147378T1 (de) *	1990-11-19	1997-01-15	Monsanto Co	Retrovirale protease inhibitoren
IE913840A1 (en) *	1990-11-20	1992-05-20	Abbott Lab	Retroviral protease inhibiting compounds
EP0541168B1 (en) *	1991-11-08	1998-03-11	Merck & Co. Inc.	HIV protease inhibitors useful for the treatment of aids
CA2136312A1 (en) *	1992-05-21	1993-11-25	Michael Clare	Retroviral protease inhibitors
KR100296463B1 (ko) *	1992-08-25	2001-10-24	죤 에이치. 뷰센	레트로바이러스프로테아제저해제로서유용한히드록시에틸아미노술폰아미드
CA2140928C (en) *	1992-08-25	2008-01-29	Michael L. Vazquez	Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US5463104A (en) *	1992-08-25	1995-10-31	G. D. Searle & Co.	Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US5723490A (en) *	1992-09-08	1998-03-03	Vertex Pharmaceuticals Incorporated	THF-containing sulfonamide inhibitors of aspartyl protease
IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5583132A (en) *	1992-10-30	1996-12-10	Vazquez; Michael L.	Sulfonylalkanoylamino hydroxyethylamino sulfamic acids useful as retroviral protease inhibitors
ATE167669T1 (de) *	1992-10-30	1998-07-15	Searle & Co	Hydroxyethylaminosulfamidsäure-derivate verwendbar als inhibitoren retroviraler proteasen
WO1994018192A1 (en) *	1993-02-12	1994-08-18	Merck & Co., Inc.	Piperazine derivatives as hiv protease inhibitors
MY128102A (en) *	1993-02-17	2007-01-31	Chugai Pharmaceutical Co Ltd	Indolin-2-one-derivatives
DE69415326T2 (de) *	1993-08-24	1999-06-02	G.D. Searle & Co., Chicago, Ill.	Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
UA49803C2 (uk) *	1994-06-03	2002-10-15	Дж.Д. Сьорль Енд Ко	Спосіб лікування ретровірусних інфекцій

1995
- 1995-04-19 US US08/424,810 patent/US5691372A/en not_active Expired - Lifetime
1996
- 1996-04-11 ZA ZA962891A patent/ZA962891B/xx unknown
- 1996-04-11 TW TW085104278A patent/TW404945B/zh not_active IP Right Cessation
- 1996-04-17 AP APAP/P/1996/000827A patent/AP9600827A0/en unknown
- 1996-04-17 AR ARP960102210A patent/AR004663A1/es unknown
- 1996-04-18 AU AU56655/96A patent/AU712913B2/en not_active Expired
- 1996-04-18 IL IL11796296A patent/IL117962A0/xx unknown
- 1996-04-18 ES ES96913811T patent/ES2171670T3/es not_active Expired - Lifetime
- 1996-04-18 EP EP01113575A patent/EP1136479B1/en not_active Expired - Lifetime
- 1996-04-18 SK SK1430-97A patent/SK143097A3/sk unknown
- 1996-04-18 PL PL96322904A patent/PL322904A1/xx unknown
- 1996-04-18 AT AT96913811T patent/ATE212344T1/de active
- 1996-04-18 DE DE69618779T patent/DE69618779T2/de not_active Expired - Lifetime
- 1996-04-18 EP EP05028389A patent/EP1637528B1/en not_active Expired - Lifetime
- 1996-04-18 CA CA2217745A patent/CA2217745C/en not_active Expired - Lifetime
- 1996-04-18 ES ES01113575T patent/ES2256117T3/es not_active Expired - Lifetime
- 1996-04-18 EA EA199700330A patent/EA000906B1/ru not_active IP Right Cessation
- 1996-04-18 JP JP53195396A patent/JP4240532B2/ja not_active Expired - Lifetime
- 1996-04-18 MY MYPI96001465A patent/MY115797A/en unknown
- 1996-04-18 EE EE9700254A patent/EE9700254A/xx unknown
- 1996-04-18 CN CN96193903A patent/CN1110491C/zh not_active Expired - Fee Related
- 1996-04-18 HU HU9801948A patent/HUP9801948A3/hu unknown
- 1996-04-18 ES ES05028389T patent/ES2351970T3/es not_active Expired - Lifetime
- 1996-04-18 GE GEAP19963972A patent/GEP20001915B/en unknown
- 1996-04-18 KR KR1019970707346A patent/KR100485237B1/ko not_active Expired - Lifetime
- 1996-04-18 DK DK96913811T patent/DK0833826T3/da active
- 1996-04-18 AT AT05028389T patent/ATE479674T1/de not_active IP Right Cessation
- 1996-04-18 DE DE69635679T patent/DE69635679T2/de not_active Expired - Lifetime
- 1996-04-18 EP EP96913811A patent/EP0833826B1/en not_active Expired - Lifetime
- 1996-04-18 AP APAP/P/1997/001104A patent/AP862A/en active
- 1996-04-18 PT PT96913811T patent/PT833826E/pt unknown
- 1996-04-18 TR TR97/01194T patent/TR199701194T1/xx unknown
- 1996-04-18 WO PCT/US1996/005473 patent/WO1996033187A1/en not_active Ceased
- 1996-04-18 BR BR9608033A patent/BR9608033A/pt not_active Application Discontinuation
- 1996-04-18 PE PE1996000266A patent/PE43697A1/es not_active Application Discontinuation
- 1996-04-18 AT AT01113575T patent/ATE314360T1/de active
- 1996-04-18 CZ CZ973294A patent/CZ329497A3/cs unknown
- 1996-04-18 DE DE69638252T patent/DE69638252D1/de not_active Expired - Lifetime
- 1996-04-19 CO CO96019067A patent/CO4700433A1/es unknown
1997
- 1997-10-02 IS IS4575A patent/IS4575A/is unknown
- 1997-10-08 NZ NZ307342A patent/NZ307342A/en unknown
- 1997-10-14 NO NO974744A patent/NO974744D0/no not_active Application Discontinuation
- 1997-11-13 BG BG102041A patent/BG102041A/xx unknown
- 1997-11-24 US US08/977,365 patent/US5990155A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH11504628A (ja)	1999-04-27
NO974744L (no)	1997-10-14
CN1184474A (zh)	1998-06-10
KR19990007823A (ko)	1999-01-25
CN1110491C (zh)	2003-06-04
EE9700254A (et)	1998-04-15
ES2351970T3 (es)	2011-02-14
DK0833826T3 (da)	2002-05-06
AU712913B2 (en)	1999-11-18
ATE212344T1 (de)	2002-02-15
DE69635679T2 (de)	2006-08-31
ES2256117T3 (es)	2006-07-16
CA2217745C (en)	2011-07-05
DE69618779T2 (de)	2002-08-29
ZA962891B (en)	1996-10-15
EA000906B1 (ru)	2000-06-26
PL322904A1 (en)	1998-03-02
EP1637528B1 (en)	2010-09-01
EP1637528A1 (en)	2006-03-22
PT833826E (pt)	2002-06-28
AP862A (en)	2000-08-04
MY115797A (en)	2003-09-30
WO1996033187A1 (en)	1996-10-24
EP0833826A1 (en)	1998-04-08
ES2171670T3 (es)	2002-09-16
NZ307342A (en)	1999-04-29
NO974744D0 (no)	1997-10-14
DE69618779D1 (de)	2002-03-14
AP9600827A0 (en)	1997-10-17
GEP20001915B (en)	2000-01-05
AU5665596A (en)	1996-11-07
EP1136479B1 (en)	2005-12-28
TW404945B (en)	2000-09-11
SK143097A3 (en)	1998-03-04
DE69635679D1 (de)	2006-02-02
CA2217745A1 (en)	1996-10-24
HUP9801948A3 (en)	2002-04-29
US5691372A (en)	1997-11-25
IL117962A0 (en)	1996-08-04
JP4240532B2 (ja)	2009-03-18
KR100485237B1 (ko)	2005-09-30
HUP9801948A2 (hu)	1999-09-28
CO4700433A1 (es)	1998-12-29
AR004663A1 (es)	1999-03-10
HK1009811A1 (en)	1999-06-11
DE69638252D1 (de)	2010-10-14
CZ329497A3 (cs)	1998-03-18
AP9701104A0 (en)	1997-10-31
BR9608033A (pt)	1999-01-12
HK1092791A1 (en)	2007-02-16
EA199700330A1 (ru)	1998-04-30
TR199701194T1 (xx)	1998-03-21
IS4575A (is)	1997-10-02
EP1136479A1 (en)	2001-09-26
PE43697A1 (es)	1997-10-11
US5990155A (en)	1999-11-23
ATE314360T1 (de)	2006-01-15
ATE479674T1 (de)	2010-09-15
EP0833826B1 (en)	2002-01-23

Publication	Publication Date	Title
BG102041A (en)	1998-09-30	Oxidized heterocycles containing sulphonamide aspartylprotease inhibitors
BG102048A (en)	1998-08-31	Tetrahydrofuran-containing sulphonamides as aspartylprotease inhibitors
MX9603909A (es)	1997-03-29	Derivados de sulfonamida como inhibidores de proteasa aspartilo.
CA2143208A1 (en)	1994-03-17	Sulfonamide inhibitors of hiv-aspartyl protease
GR3024181T3 (en)	1997-10-31	N-(alkanoylamino-2-hydroxypropyl)-sulfonamides useful as retroviral protease inhibitors.
CA2210889A1 (en)	1996-07-25	Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
ES2127938T3 (es)	1999-05-01	Hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas.
KR950702960A (ko)	1995-08-23	레트로바이러스 프로테아제 저해제로서 유용한 히드록시에틸아미노 술폰아미드(hydroxyethylamino sulfonamides useful as retroviral protease inhibitors)
CA2140928A1 (en)	1994-02-26	Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
FI891716A0 (fi)	1989-04-11	Hiv-proteasinhibitorer, som aer anvaendbara vid behandling av aids.
AU9125191A (en)	1992-06-11	Retroviral protease inhibitors
FI935778A7 (fi)	1994-06-23	HIV-proteaasin inhibiittoreita, jotka ovat hyödyllisiä AIDSin hoitoa varten
AU5736494A (en)	1994-07-19	Cyclic sulfone containing retroviral protease inhibitors
CA2096409A1 (en)	1992-05-20	Retroviral protease inhibitors
MY119031A (en)	2005-03-31	Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hiv and other retroviruses
NZ303861A (en)	1999-02-25	Amino acid hydroxyethylamine sulphonamide derivatives as protease inhibitors
CA2215066A1 (en)	1996-09-19	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
HU9301446D0 (en)	1993-11-29	Inhibitors or fetrovirus protease
EP1637518A3 (en)	2013-04-10	Inhibitors of aspartyl protease
FI935779L (fi)	1994-06-23	HIV-proteaasin inhibiittoreita, jotka ovat hyödyllisiä AIDSin hoitoa varten
GR3023044T3 (en)	1997-07-30	Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors.
MX9708055A (es)	1998-01-31	Inhibidores de aspartil proteasa consistentes en sulfonamida que contiene heterociclo oxigenado.
MX9708057A (es)	1998-01-31	Sulfonamidas que contienen thf inhibidoras de la aspartilproteasa.
ES8609253A1 (es)	1986-09-01	Un procedimiento para la preparacion de derivados de dihi- dropiridina
CA2155129A1 (en)	1994-09-01	Combinations of Retroviral Inhibitors