EA000906B1 - Сульфонамидные ингибиторы аспартил-протеазы, содержащие окисленный гетероцикл - Google Patents

Сульфонамидные ингибиторы аспартил-протеазы, содержащие окисленный гетероцикл

Info

Publication number: EA000906B1
Authority: EA; Eurasian Patent Office
Prior art keywords: group; phenyl; compound; amino; pharmaceutical composition
Prior art date: 1995-04-19

Application number

EA199700330A

Other languages

English (en)

Other versions

EA199700330A1 (ru

Inventor

Роджер Д. Тунг

Говинда Рао Бисетти

Original Assignee

Вертекс Фармасьютикалз Инкорпорейтед

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-19

Filing date

1996-04-18

Publication date

2000-06-26

1996-04-18 Application filed by Вертекс Фармасьютикалз Инкорпорейтед filed Critical Вертекс Фармасьютикалз Инкорпорейтед

1998-04-30 Publication of EA199700330A1 publication Critical patent/EA199700330A1/ru

2000-06-26 Publication of EA000906B1 publication Critical patent/EA000906B1/ru

Links

125000000623 heterocyclic group Chemical group 0.000 title abstract 9
108010017640 Aspartic Acid Proteases Proteins 0.000 title abstract 6
102000004580 Aspartic Acid Proteases Human genes 0.000 title abstract 6
239000003112 inhibitor Substances 0.000 title abstract 5
229940124530 sulfonamide Drugs 0.000 title 1
150000003456 sulfonamides Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 21
239000008194 pharmaceutical composition Substances 0.000 abstract 12
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 10
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 7
125000003118 aryl group Chemical group 0.000 abstract 6
125000005843 halogen group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
238000000034 method Methods 0.000 abstract 5
125000001424 substituent group Chemical group 0.000 abstract 5
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 4
KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 abstract 4
208000031886 HIV Infections Diseases 0.000 abstract 3
208000037357 HIV infectious disease Diseases 0.000 abstract 3
239000003443 antiviral agent Substances 0.000 abstract 3
208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
239000002777 nucleoside Substances 0.000 abstract 3
150000003833 nucleoside derivatives Chemical class 0.000 abstract 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
239000003419 rna directed dna polymerase inhibitor Substances 0.000 abstract 3
HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
-1 1,3-dioxan-5-yl Chemical group 0.000 abstract 2
XQSPYNMVSIKCOC-NTSWFWBYSA-N Emtricitabine Chemical compound C1=C(F)C(N)=NC(=O)N1[C@H]1O[C@@H](CO)SC1 XQSPYNMVSIKCOC-NTSWFWBYSA-N 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 2
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
XNKLLVCARDGLGL-JGVFFNPUSA-N Stavudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1C=C[C@@H](CO)O1 XNKLLVCARDGLGL-JGVFFNPUSA-N 0.000 abstract 2
239000003795 chemical substances by application Substances 0.000 abstract 2
229940126214 compound 3 Drugs 0.000 abstract 2
229940125898 compound 5 Drugs 0.000 abstract 2
125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 2
WHBIGIKBNXZKFE-UHFFFAOYSA-N delavirdine Chemical compound CC(C)NC1=CC=CN=C1N1CCN(C(=O)C=2NC3=CC=C(NS(C)(=O)=O)C=C3C=2)CC1 WHBIGIKBNXZKFE-UHFFFAOYSA-N 0.000 abstract 2
229940042399 direct acting antivirals protease inhibitors Drugs 0.000 abstract 2
239000004030 hiv protease inhibitor Substances 0.000 abstract 2
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 2
125000002950 monocyclic group Chemical group 0.000 abstract 2
NQDJXKOVJZTUJA-UHFFFAOYSA-N nevirapine Chemical compound C12=NC=CC=C2C(=O)NC=2C(C)=CC=NC=2N1C1CC1 NQDJXKOVJZTUJA-UHFFFAOYSA-N 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
229940042402 non-nucleoside reverse transcriptase inhibitor Drugs 0.000 abstract 2
239000002726 nonnucleoside reverse transcriptase inhibitor Substances 0.000 abstract 2
239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 abstract 2
229960002555 zidovudine Drugs 0.000 abstract 2
125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
IGERFAHWSHDDHX-UHFFFAOYSA-N 1,3-dioxanyl Chemical group [CH]1OCCCO1 IGERFAHWSHDDHX-UHFFFAOYSA-N 0.000 abstract 1
125000000586 2-(4-morpholinyl)ethoxy group Chemical group [H]C([H])(O*)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
BXZVVICBKDXVGW-NKWVEPMBSA-N Didanosine Chemical compound O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 BXZVVICBKDXVGW-NKWVEPMBSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
WREGKURFCTUGRC-POYBYMJQSA-N Zalcitabine Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)CC1 WREGKURFCTUGRC-POYBYMJQSA-N 0.000 abstract 1
MCGSCOLBFJQGHM-SCZZXKLOSA-N abacavir Chemical compound C=12N=CN([C@H]3C=C[C@@H](CO)C3)C2=NC(N)=NC=1NC1CC1 MCGSCOLBFJQGHM-SCZZXKLOSA-N 0.000 abstract 1
229960004748 abacavir Drugs 0.000 abstract 1
239000002671 adjuvant Substances 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
KXDHJXZQYSOELW-UHFFFAOYSA-N carbonic acid monoamide Natural products NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
150000003857 carboxamides Chemical class 0.000 abstract 1
229940125904 compound 1 Drugs 0.000 abstract 1
125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 abstract 1
229960005319 delavirdine Drugs 0.000 abstract 1
AQEFLFZSWDEAIP-UHFFFAOYSA-N di-tert-butyl ether Chemical compound CC(C)(C)OC(C)(C)C AQEFLFZSWDEAIP-UHFFFAOYSA-N 0.000 abstract 1
125000000532 dioxanyl group Chemical group 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000000945 filler Substances 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000011159 matrix material Substances 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Chemical group 0.000 abstract 1
AEABQBMUYZBBCW-UHFFFAOYSA-N pentanamide Chemical compound CC[CH]CC(N)=O AEABQBMUYZBBCW-UHFFFAOYSA-N 0.000 abstract 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 abstract 1
125000004193 piperazinyl group Chemical group 0.000 abstract 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 abstract 1
229960000311 ritonavir Drugs 0.000 abstract 1
239000007787 solid Substances 0.000 abstract 1
229960001203 stavudine Drugs 0.000 abstract 1
229910052717 sulfur Chemical group 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1
OQHZMGOXOOOFEE-SYQUUIDJSA-N tert-butyl n-[(2s,3r)-3-hydroxy-4-[[(2r,3s)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-[4-(2-morpholin-4-yl-2-oxoethoxy)phenyl]butyl]amino]-1-phenylbutan-2-yl]carbamate Chemical compound C([C@H](NC(=O)OC(C)(C)C)[C@H](O)CNC[C@@H](O)[C@H](CC=1C=CC(OCC(=O)N2CCOCC2)=CC=1)NC(=O)OC(C)(C)C)C1=CC=CC=C1 OQHZMGOXOOOFEE-SYQUUIDJSA-N 0.000 abstract 1
229940113082 thymine Drugs 0.000 abstract 1
KJAMZCVTJDTESW-UHFFFAOYSA-N tiracizine Chemical compound C1CC2=CC=CC=C2N(C(=O)CN(C)C)C2=CC(NC(=O)OCC)=CC=C21 KJAMZCVTJDTESW-UHFFFAOYSA-N 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C07D317/36—Alkylene carbonates; Substituted alkylene carbonates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Furan Compounds (AREA)
Pyrane Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Peptides Or Proteins (AREA)
Enzymes And Modification Thereof (AREA)

EA199700330A 1995-04-19 1996-04-18 Сульфонамидные ингибиторы аспартил-протеазы, содержащие окисленный гетероцикл EA000906B1 (ru)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/424,810 US5691372A (en)	1995-04-19	1995-04-19	Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
PCT/US1996/005473 WO1996033187A1 (en)	1995-04-19	1996-04-18	Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease

Publications (2)

Publication Number	Publication Date
EA199700330A1 EA199700330A1 (ru)	1998-04-30
EA000906B1 true EA000906B1 (ru)	2000-06-26

Family

ID=23683966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EA199700330A EA000906B1 (ru)	1995-04-19	1996-04-18	Сульфонамидные ингибиторы аспартил-протеазы, содержащие окисленный гетероцикл

Country Status (34)

Country	Link
US (2)	US5691372A (ru)
EP (3)	EP1136479B1 (ru)
JP (1)	JP4240532B2 (ru)
KR (1)	KR100485237B1 (ru)
CN (1)	CN1110491C (ru)
AP (2)	AP9600827A0 (ru)
AR (1)	AR004663A1 (ru)
AT (3)	ATE212344T1 (ru)
AU (1)	AU712913B2 (ru)
BG (1)	BG102041A (ru)
BR (1)	BR9608033A (ru)
CA (1)	CA2217745C (ru)
CO (1)	CO4700433A1 (ru)
CZ (1)	CZ329497A3 (ru)
DE (3)	DE69618779T2 (ru)
DK (1)	DK0833826T3 (ru)
EA (1)	EA000906B1 (ru)
EE (1)	EE9700254A (ru)
ES (3)	ES2171670T3 (ru)
GE (1)	GEP20001915B (ru)
HU (1)	HUP9801948A3 (ru)
IL (1)	IL117962A0 (ru)
IS (1)	IS4575A (ru)
MY (1)	MY115797A (ru)
NO (1)	NO974744D0 (ru)
NZ (1)	NZ307342A (ru)
PE (1)	PE43697A1 (ru)
PL (1)	PL322904A1 (ru)
PT (1)	PT833826E (ru)
SK (1)	SK143097A3 (ru)
TR (1)	TR199701194T1 (ru)
TW (1)	TW404945B (ru)
WO (1)	WO1996033187A1 (ru)
ZA (1)	ZA962891B (ru)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040122000A1 (en)	1981-01-07	2004-06-24	Vertex Pharmaceuticals Incorporated.	Inhibitors of aspartyl protease
KR100296463B1 (ko)	1992-08-25	2001-10-24	죤 에이치. 뷰센	레트로바이러스프로테아제저해제로서유용한히드록시에틸아미노술폰아미드
US7141609B2 (en)	1992-08-25	2006-11-28	G.D. Searle & Co.	α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US5942253A (en)	1995-10-12	1999-08-24	Immunex Corporation	Prolonged release of GM-CSF
US5874449A (en) *	1996-12-31	1999-02-23	Gpi Nil Holdings, Inc.	N-linked sulfonamides of heterocyclic thioesters
NZ335480A (en)	1996-12-31	2001-04-27	Guilford Pharm Inc	Neurotrophic low molecular weight N-linked sulfonamides of heterocyclic thioesters and their use as inhibitors of immunophilin proteins
BR9809124A (pt) *	1997-05-17	2000-08-01	Glaxo Group Ltd	Combinação, formulação, farmacêutica, processo para o tratamento de uma infecção por hiv em um animal, infectado, uso de (-)-(1s, 4r)-4-[2-amino-6-(ciclopropilamino)-9h-purin-9-il)-2-cicl openteno-1-metanol, e, pacote de paciente
US20010049381A1 (en)	1997-06-04	2001-12-06	Gpl Nil Holdings, Inc.,	Pyrrolidine derivative hair growth compositions and uses
US5945441A (en)	1997-06-04	1999-08-31	Gpi Nil Holdings, Inc.	Pyrrolidine carboxylate hair revitalizing agents
US6576231B2 (en) *	1997-09-12	2003-06-10	Schering Ag	Methods for treating HIV-Infected Patients by the Administration of GM-CSF and a protease inhibitor
US6436989B1 (en)	1997-12-24	2002-08-20	Vertex Pharmaceuticals, Incorporated	Prodrugs of aspartyl protease inhibitors
HUP0101598A3 (en) *	1997-12-24	2002-08-28	Vertex Pharmaceuticals Inc Cam	Prodrugs of aspartyl protease inhibitors and medicaments containing them
NZ508855A (en) *	1998-06-19	2003-10-31	Vertex Pharma	Sulfonamide inhibitors of HIV aspartyl protease
US7470506B1 (en)	1998-06-23	2008-12-30	The United States Of America As Represented By The Department Of Health And Human Services	Fitness assay and associated methods
US6337340B1 (en)	1998-08-14	2002-01-08	Gpi Nil Holdings, Inc.	Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6395758B1 (en)	1998-08-14	2002-05-28	Gpi Nil Holdings, Inc.	Small molecule carbamates or ureas for vision and memory disorders
US6399648B1 (en)	1998-08-14	2002-06-04	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
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Publication number	Publication date
JPH11504628A (ja)	1999-04-27
NO974744L (no)	1997-10-14
CN1184474A (zh)	1998-06-10
KR19990007823A (ko)	1999-01-25
CN1110491C (zh)	2003-06-04
EE9700254A (et)	1998-04-15
ES2351970T3 (es)	2011-02-14
DK0833826T3 (da)	2002-05-06
AU712913B2 (en)	1999-11-18
ATE212344T1 (de)	2002-02-15
DE69635679T2 (de)	2006-08-31
ES2256117T3 (es)	2006-07-16
CA2217745C (en)	2011-07-05
DE69618779T2 (de)	2002-08-29
ZA962891B (en)	1996-10-15
PL322904A1 (en)	1998-03-02
EP1637528B1 (en)	2010-09-01
EP1637528A1 (en)	2006-03-22
PT833826E (pt)	2002-06-28
AP862A (en)	2000-08-04
MY115797A (en)	2003-09-30
WO1996033187A1 (en)	1996-10-24
EP0833826A1 (en)	1998-04-08
ES2171670T3 (es)	2002-09-16
NZ307342A (en)	1999-04-29
BG102041A (en)	1998-09-30
NO974744D0 (no)	1997-10-14
DE69618779D1 (de)	2002-03-14
AP9600827A0 (en)	1997-10-17
GEP20001915B (en)	2000-01-05
AU5665596A (en)	1996-11-07
EP1136479B1 (en)	2005-12-28
TW404945B (en)	2000-09-11
SK143097A3 (en)	1998-03-04
DE69635679D1 (de)	2006-02-02
CA2217745A1 (en)	1996-10-24
HUP9801948A3 (en)	2002-04-29
US5691372A (en)	1997-11-25
IL117962A0 (en)	1996-08-04
JP4240532B2 (ja)	2009-03-18
KR100485237B1 (ko)	2005-09-30
HUP9801948A2 (hu)	1999-09-28
CO4700433A1 (es)	1998-12-29
AR004663A1 (es)	1999-03-10
HK1009811A1 (en)	1999-06-11
DE69638252D1 (de)	2010-10-14
CZ329497A3 (cs)	1998-03-18
AP9701104A0 (en)	1997-10-31
BR9608033A (pt)	1999-01-12
HK1092791A1 (en)	2007-02-16
EA199700330A1 (ru)	1998-04-30
TR199701194T1 (xx)	1998-03-21
IS4575A (is)	1997-10-02
EP1136479A1 (en)	2001-09-26
PE43697A1 (es)	1997-10-11
US5990155A (en)	1999-11-23
ATE314360T1 (de)	2006-01-15
ATE479674T1 (de)	2010-09-15
EP0833826B1 (en)	2002-01-23

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