IS4575A - Súlfonamíð tafefni aspartýl próteasa, sem innihalda misatóma hringi með súrefni - Google Patents

Súlfonamíð tafefni aspartýl próteasa, sem innihalda misatóma hringi með súrefni

Info

Publication number: IS4575A
Authority: IS; Iceland
Prior art keywords: misatomeric; sulphonamide; delayed; rings; oxygen
Prior art date: 1995-04-19

Application number

IS4575A

Other languages

English (en)

Inventor

D. Tung Roger

Rao Bhisetti Govinda

Original Assignee

Vertex Pharmaceuticals Incorporated

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-19

Filing date

1997-10-02

Publication date

1997-10-02

1997-10-02 Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated

1997-10-02 Publication of IS4575A publication Critical patent/IS4575A/is

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C07D317/36—Alkylene carbonates; Substituted alkylene carbonates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Furan Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Enzymes And Modification Thereof (AREA)

IS4575A 1995-04-19 1997-10-02 Súlfonamíð tafefni aspartýl próteasa, sem innihalda misatóma hringi með súrefni IS4575A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/424,810 US5691372A (en)	1995-04-19	1995-04-19	Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
PCT/US1996/005473 WO1996033187A1 (en)	1995-04-19	1996-04-18	Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease

Publications (1)

Publication Number	Publication Date
IS4575A true IS4575A (is)	1997-10-02

Family

ID=23683966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS4575A IS4575A (is)	1995-04-19	1997-10-02	Súlfonamíð tafefni aspartýl próteasa, sem innihalda misatóma hringi með súrefni

Country Status (34)

Country	Link
US (2)	US5691372A (is)
EP (3)	EP1637528B1 (is)
JP (1)	JP4240532B2 (is)
KR (1)	KR100485237B1 (is)
CN (1)	CN1110491C (is)
AP (2)	AP9600827A0 (is)
AR (1)	AR004663A1 (is)
AT (3)	ATE314360T1 (is)
AU (1)	AU712913B2 (is)
BG (1)	BG102041A (is)
BR (1)	BR9608033A (is)
CA (1)	CA2217745C (is)
CO (1)	CO4700433A1 (is)
CZ (1)	CZ329497A3 (is)
DE (3)	DE69635679T2 (is)
DK (1)	DK0833826T3 (is)
EA (1)	EA000906B1 (is)
EE (1)	EE9700254A (is)
ES (3)	ES2256117T3 (is)
GE (1)	GEP20001915B (is)
HU (1)	HUP9801948A3 (is)
IL (1)	IL117962A0 (is)
IS (1)	IS4575A (is)
MY (1)	MY115797A (is)
NO (1)	NO974744D0 (is)
NZ (1)	NZ307342A (is)
PE (1)	PE43697A1 (is)
PL (1)	PL322904A1 (is)
PT (1)	PT833826E (is)
SK (1)	SK143097A3 (is)
TR (1)	TR199701194T1 (is)
TW (1)	TW404945B (is)
WO (1)	WO1996033187A1 (is)
ZA (1)	ZA962891B (is)

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US20040122000A1 (en)	1981-01-07	2004-06-24	Vertex Pharmaceuticals Incorporated.	Inhibitors of aspartyl protease
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US6399648B1 (en)	1998-08-14	2002-06-04	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6337340B1 (en)	1998-08-14	2002-01-08	Gpi Nil Holdings, Inc.	Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6218423B1 (en)	1998-08-14	2001-04-17	Gpi Nil Holdings, Inc.	Pyrrolidine derivatives for vision and memory disorders
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US6319946B1 (en)	1999-02-12	2001-11-20	Vertex Pharmaceuticals Incorporated	Inhibitors of aspartyl protease
EP1159278B1 (en) *	1999-02-12	2005-11-30	Vertex Pharmaceuticals Incorporated	Inhibitors of aspartyl protease
AR031520A1 (es) *	1999-06-11	2003-09-24	Vertex Pharma	Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
ATE398623T1 (de) *	1999-10-06	2008-07-15	Tibotec Pharm Ltd	Hexahydrofuro-2,3-b furan-3-yl-n- 3-,(1,3- benzodioxol-5-ylsulfonyl)(isobutyl)amino -1- benzyl-2-hydroxypropyl carbamat als retrovirusproteasehemmer
HUP0302631A2 (hu)	2000-03-30	2003-11-28	Bristol-Myers Squibb Co.	Stavudint tartalmazó elnyújtott hatóanyag-kibocsátású szemcsék
CN100491360C (zh) *	2001-04-09	2009-05-27	泰博特克药品有限公司	广谱2-(取代的-氨基)-苯并唑磺酰胺hiv蛋白酶抑制剂
AU2003202914A1 (en) *	2002-01-07	2003-07-24	Sequoia Pharmaceuticals	Broad spectrum inhibitors
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1995
- 1995-04-19 US US08/424,810 patent/US5691372A/en not_active Expired - Lifetime
1996
- 1996-04-11 ZA ZA962891A patent/ZA962891B/xx unknown
- 1996-04-11 TW TW085104278A patent/TW404945B/zh not_active IP Right Cessation
- 1996-04-17 AR ARP960102210A patent/AR004663A1/es unknown
- 1996-04-17 AP APAP/P/1996/000827A patent/AP9600827A0/en unknown
- 1996-04-18 AU AU56655/96A patent/AU712913B2/en not_active Expired
- 1996-04-18 WO PCT/US1996/005473 patent/WO1996033187A1/en not_active Ceased
- 1996-04-18 DE DE69635679T patent/DE69635679T2/de not_active Expired - Lifetime
- 1996-04-18 EE EE9700254A patent/EE9700254A/xx unknown
- 1996-04-18 AT AT01113575T patent/ATE314360T1/de active
- 1996-04-18 SK SK1430-97A patent/SK143097A3/sk unknown
- 1996-04-18 CA CA2217745A patent/CA2217745C/en not_active Expired - Lifetime
- 1996-04-18 PT PT96913811T patent/PT833826E/pt unknown
- 1996-04-18 IL IL11796296A patent/IL117962A0/xx unknown
- 1996-04-18 ES ES01113575T patent/ES2256117T3/es not_active Expired - Lifetime
- 1996-04-18 EP EP05028389A patent/EP1637528B1/en not_active Expired - Lifetime
- 1996-04-18 KR KR1019970707346A patent/KR100485237B1/ko not_active Expired - Lifetime
- 1996-04-18 PE PE1996000266A patent/PE43697A1/es not_active Application Discontinuation
- 1996-04-18 CZ CZ973294A patent/CZ329497A3/cs unknown
- 1996-04-18 EA EA199700330A patent/EA000906B1/ru not_active IP Right Cessation
- 1996-04-18 EP EP01113575A patent/EP1136479B1/en not_active Expired - Lifetime
- 1996-04-18 AP APAP/P/1997/001104A patent/AP862A/en active
- 1996-04-18 DK DK96913811T patent/DK0833826T3/da active
- 1996-04-18 DE DE69638252T patent/DE69638252D1/de not_active Expired - Lifetime
- 1996-04-18 CN CN96193903A patent/CN1110491C/zh not_active Expired - Fee Related
- 1996-04-18 JP JP53195396A patent/JP4240532B2/ja not_active Expired - Lifetime
- 1996-04-18 TR TR97/01194T patent/TR199701194T1/xx unknown
- 1996-04-18 ES ES05028389T patent/ES2351970T3/es not_active Expired - Lifetime
- 1996-04-18 ES ES96913811T patent/ES2171670T3/es not_active Expired - Lifetime
- 1996-04-18 AT AT96913811T patent/ATE212344T1/de active
- 1996-04-18 DE DE69618779T patent/DE69618779T2/de not_active Expired - Lifetime
- 1996-04-18 EP EP96913811A patent/EP0833826B1/en not_active Expired - Lifetime
- 1996-04-18 MY MYPI96001465A patent/MY115797A/en unknown
- 1996-04-18 AT AT05028389T patent/ATE479674T1/de not_active IP Right Cessation
- 1996-04-18 HU HU9801948A patent/HUP9801948A3/hu unknown
- 1996-04-18 GE GEAP19963972A patent/GEP20001915B/en unknown
- 1996-04-18 BR BR9608033A patent/BR9608033A/pt not_active Application Discontinuation
- 1996-04-18 PL PL96322904A patent/PL322904A1/xx unknown
- 1996-04-19 CO CO96019067A patent/CO4700433A1/es unknown
1997
- 1997-10-02 IS IS4575A patent/IS4575A/is unknown
- 1997-10-08 NZ NZ307342A patent/NZ307342A/en unknown
- 1997-10-14 NO NO974744A patent/NO974744D0/no not_active Application Discontinuation
- 1997-11-13 BG BG102041A patent/BG102041A/xx unknown
- 1997-11-24 US US08/977,365 patent/US5990155A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US5990155A (en)	1999-11-23
DE69618779D1 (de)	2002-03-14
AU5665596A (en)	1996-11-07
MY115797A (en)	2003-09-30
TR199701194T1 (xx)	1998-03-21
EP0833826B1 (en)	2002-01-23
US5691372A (en)	1997-11-25
HUP9801948A3 (en)	2002-04-29
JPH11504628A (ja)	1999-04-27
DE69618779T2 (de)	2002-08-29
EP0833826A1 (en)	1998-04-08
ES2351970T3 (es)	2011-02-14
AP9600827A0 (en)	1997-10-17
EP1136479B1 (en)	2005-12-28
PT833826E (pt)	2002-06-28
DE69635679D1 (de)	2006-02-02
EE9700254A (et)	1998-04-15
ES2256117T3 (es)	2006-07-16
WO1996033187A1 (en)	1996-10-24
ATE212344T1 (de)	2002-02-15
DE69635679T2 (de)	2006-08-31
ATE479674T1 (de)	2010-09-15
PE43697A1 (es)	1997-10-11
ATE314360T1 (de)	2006-01-15
TW404945B (en)	2000-09-11
ZA962891B (en)	1996-10-15
EP1136479A1 (en)	2001-09-26
BR9608033A (pt)	1999-01-12
JP4240532B2 (ja)	2009-03-18
AU712913B2 (en)	1999-11-18
ES2171670T3 (es)	2002-09-16
HK1009811A1 (en)	1999-06-11
CO4700433A1 (es)	1998-12-29
KR100485237B1 (ko)	2005-09-30
EA199700330A1 (ru)	1998-04-30
SK143097A3 (en)	1998-03-04
DE69638252D1 (de)	2010-10-14
BG102041A (en)	1998-09-30
HUP9801948A2 (hu)	1999-09-28
HK1092791A1 (en)	2007-02-16
NZ307342A (en)	1999-04-29
IL117962A0 (en)	1996-08-04
EP1637528A1 (en)	2006-03-22
EP1637528B1 (en)	2010-09-01
CN1110491C (zh)	2003-06-04
EA000906B1 (ru)	2000-06-26
DK0833826T3 (da)	2002-05-06
CZ329497A3 (cs)	1998-03-18
AP9701104A0 (en)	1997-10-31
CA2217745C (en)	2011-07-05
PL322904A1 (en)	1998-03-02
GEP20001915B (en)	2000-01-05
CA2217745A1 (en)	1996-10-24
NO974744L (no)	1997-10-14
AP862A (en)	2000-08-04
NO974744D0 (no)	1997-10-14
AR004663A1 (es)	1999-03-10
CN1184474A (zh)	1998-06-10
KR19990007823A (ko)	1999-01-25

Publication	Publication Date	Title
IS4575A (is)	1997-10-02	Súlfonamíð tafefni aspartýl próteasa, sem innihalda misatóma hringi með súrefni
IS2155B (is)	2006-11-15	Súlfonamíð tafefni aspartýl próteasa sem innihalda THF
DZ2285A1 (fr)	2002-12-25	Inhibiteurs de protéase de la cystéine.
DE69505409D1 (de)	1998-11-19	Verbesserter, proteolytisches enzym enthaltender reiniger
DK0920431T3 (da)	2003-06-02	Thienopyrimidiner.
BR9715215B1 (pt)	2009-05-05	tampão expansìvel lateralmente.
DE59808437D1 (de)	2003-06-26	Dichtungsring
NL1000839C1 (nl)	1995-09-20	Lantaarn.
FR2701538B3 (fr)	1995-02-03	Gyrophare.
FI931040L (fi)	1993-09-11	Kompositioner av slumpartade sampolymerer av propen, vilka innehaoller en a-olefin som komonomer
FR2714272B3 (fr)	1995-12-15	Porte-monnaie annulaire.
NL1002451A1 (nl)	1996-05-30	Sluitdop.
DE59911666D1 (de)	2005-03-31	Kristallmodifikation b von 8-cyan- 1-cyclopropyl -7-(1s,6s-2, 8-diazabicyclo - 4.3.0]nonan -8-yl)-6- fluor-1, 4-dihydro- 4-oxo-3- chinolincarbonsaure
FR2701834B1 (fr)	1995-06-16	Valve phonatoire autoadhesive.
DE69400059D1 (de)	1996-02-29	Asymmetrische Benzotriazolylphenole
NL1008191A1 (nl)	1999-08-05	Afdichting.
NO975534L (no)	1998-01-30	Imidazo-£1,5\|-pyridin-avledete serinproteaseinhibitorer
DE69412166D1 (de)	1998-09-10	Ringförmige Dichtungsanordnung
FI930217A7 (fi)	1993-07-22	Hoegt tvaerbundna, smaott avdunstande organiska foereningar innehaollande ytbelaeggningskompositioner som omfattar polyuretandispersioner
AU1730797A (en)	1997-09-22	3-substituted-4-oxa-1-azabicyclo{3,2,0}heptan-7-one as cysteine protease inhibitors
FR2728596B1 (fr)	1997-01-24	Degrilleur, notamment du type courbe
DE59908620D1 (de)	2004-04-01	Dichtungsring
EP0610808A3 (de)	1994-11-02	Verbesserte hochalkalische Proteasen.
FR2705539B1 (fr)	1995-07-21	Bague réversible.
DK0714590T3 (da)	1997-08-04	Højttaler.