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AR004663A1 - Un compuesto inhibidor de proteasa aspartilo, una composicion farmaceutica que lo comprende y metodos para inhibir la actividad de proteasa aspartilo,para adherir reversiblemente proteasa aspartilo y para evitar o tratar infecciones vih con dicho compuesto. - Google Patents

Un compuesto inhibidor de proteasa aspartilo, una composicion farmaceutica que lo comprende y metodos para inhibir la actividad de proteasa aspartilo,para adherir reversiblemente proteasa aspartilo y para evitar o tratar infecciones vih con dicho compuesto.

Info

Publication number
AR004663A1
AR004663A1 ARP960102210A AR10221096A AR004663A1 AR 004663 A1 AR004663 A1 AR 004663A1 AR P960102210 A ARP960102210 A AR P960102210A AR 10221096 A AR10221096 A AR 10221096A AR 004663 A1 AR004663 A1 AR 004663A1
Authority
AR
Argentina
Prior art keywords
aspartile
protease
compound
methods
understands
Prior art date
Application number
ARP960102210A
Other languages
English (en)
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of AR004663A1 publication Critical patent/AR004663A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C07D317/36—Alkylene carbonates; Substituted alkylene carbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Una clase de sulfonamidas inhibidoras de proteasa aspartilo las cuales tienen la fórmula (I) donde A, R, D, D y E son tal como se definen en lamemoria descriptiva. Los compuestos y las composiciones farmacéuticas que los comprenden sonparticu larmente apropiados para inhibir la actividad de laproteasa VIH-1 y VIH-2 y por consiguiente, pueden usarse ventajosamente como agentes anti-virales contra los virus VIH-1 y VIH-2. Esta invención se refieretambién a métodos para inhibirla activid ad de proteasa aspartilo VIH usando los compuestos de esta invención.
ARP960102210A 1995-04-19 1996-04-17 Un compuesto inhibidor de proteasa aspartilo, una composicion farmaceutica que lo comprende y metodos para inhibir la actividad de proteasa aspartilo,para adherir reversiblemente proteasa aspartilo y para evitar o tratar infecciones vih con dicho compuesto. AR004663A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/424,810 US5691372A (en) 1995-04-19 1995-04-19 Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease

Publications (1)

Publication Number Publication Date
AR004663A1 true AR004663A1 (es) 1999-03-10

Family

ID=23683966

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960102210A AR004663A1 (es) 1995-04-19 1996-04-17 Un compuesto inhibidor de proteasa aspartilo, una composicion farmaceutica que lo comprende y metodos para inhibir la actividad de proteasa aspartilo,para adherir reversiblemente proteasa aspartilo y para evitar o tratar infecciones vih con dicho compuesto.

Country Status (34)

Country Link
US (2) US5691372A (es)
EP (3) EP1136479B1 (es)
JP (1) JP4240532B2 (es)
KR (1) KR100485237B1 (es)
CN (1) CN1110491C (es)
AP (2) AP9600827A0 (es)
AR (1) AR004663A1 (es)
AT (3) ATE479674T1 (es)
AU (1) AU712913B2 (es)
BG (1) BG102041A (es)
BR (1) BR9608033A (es)
CA (1) CA2217745C (es)
CO (1) CO4700433A1 (es)
CZ (1) CZ329497A3 (es)
DE (3) DE69635679T2 (es)
DK (1) DK0833826T3 (es)
EA (1) EA000906B1 (es)
EE (1) EE9700254A (es)
ES (3) ES2256117T3 (es)
GE (1) GEP20001915B (es)
HU (1) HUP9801948A3 (es)
IL (1) IL117962A0 (es)
IS (1) IS4575A (es)
MY (1) MY115797A (es)
NO (1) NO974744D0 (es)
NZ (1) NZ307342A (es)
PE (1) PE43697A1 (es)
PL (1) PL322904A1 (es)
PT (1) PT833826E (es)
SK (1) SK143097A3 (es)
TR (1) TR199701194T1 (es)
TW (1) TW404945B (es)
WO (1) WO1996033187A1 (es)
ZA (1) ZA962891B (es)

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CN1184474A (zh) 1998-06-10
TR199701194T1 (xx) 1998-03-21
KR19990007823A (ko) 1999-01-25
NZ307342A (en) 1999-04-29
HUP9801948A2 (hu) 1999-09-28
GEP20001915B (en) 2000-01-05
EP0833826B1 (en) 2002-01-23
DE69638252D1 (de) 2010-10-14
HUP9801948A3 (en) 2002-04-29
EP0833826A1 (en) 1998-04-08
EA199700330A1 (ru) 1998-04-30
PL322904A1 (en) 1998-03-02
AP9600827A0 (en) 1997-10-17
US5990155A (en) 1999-11-23
NO974744L (no) 1997-10-14
EP1637528B1 (en) 2010-09-01
BG102041A (en) 1998-09-30
JPH11504628A (ja) 1999-04-27
HK1092791A1 (en) 2007-02-16
ES2171670T3 (es) 2002-09-16
CA2217745C (en) 2011-07-05
CO4700433A1 (es) 1998-12-29
PT833826E (pt) 2002-06-28
AU5665596A (en) 1996-11-07
BR9608033A (pt) 1999-01-12
TW404945B (en) 2000-09-11
AP9701104A0 (en) 1997-10-31
ATE212344T1 (de) 2002-02-15
AP862A (en) 2000-08-04
ES2256117T3 (es) 2006-07-16
DE69635679D1 (de) 2006-02-02
CA2217745A1 (en) 1996-10-24
ES2351970T3 (es) 2011-02-14
US5691372A (en) 1997-11-25
WO1996033187A1 (en) 1996-10-24
IL117962A0 (en) 1996-08-04
JP4240532B2 (ja) 2009-03-18
EP1136479B1 (en) 2005-12-28
EE9700254A (et) 1998-04-15
ATE479674T1 (de) 2010-09-15
ZA962891B (en) 1996-10-15
DE69635679T2 (de) 2006-08-31
DE69618779D1 (de) 2002-03-14
IS4575A (is) 1997-10-02
PE43697A1 (es) 1997-10-11
SK143097A3 (en) 1998-03-04
AU712913B2 (en) 1999-11-18
KR100485237B1 (ko) 2005-09-30
CZ329497A3 (cs) 1998-03-18
MY115797A (en) 2003-09-30
EA000906B1 (ru) 2000-06-26
CN1110491C (zh) 2003-06-04
NO974744D0 (no) 1997-10-14
DK0833826T3 (da) 2002-05-06
HK1009811A1 (en) 1999-06-11
ATE314360T1 (de) 2006-01-15
EP1637528A1 (en) 2006-03-22
EP1136479A1 (en) 2001-09-26
DE69618779T2 (de) 2002-08-29

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