AR126445A2 - Metodo para preparar inhibidores de btk - Google Patents
Metodo para preparar inhibidores de btkInfo
- Publication number
- AR126445A2 AR126445A2 ARP220101839A ARP220101839A AR126445A2 AR 126445 A2 AR126445 A2 AR 126445A2 AR P220101839 A ARP220101839 A AR P220101839A AR P220101839 A ARP220101839 A AR P220101839A AR 126445 A2 AR126445 A2 AR 126445A2
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- mixture
- reaction mixture
- reaction products
- reaction
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229940124291 BTK inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 17
- 239000011541 reaction mixture Substances 0.000 abstract 5
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 4
- 239000007795 chemical reaction product Substances 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 239000002904 solvent Substances 0.000 abstract 3
- 239000003054 catalyst Substances 0.000 abstract 2
- 229910052763 palladium Inorganic materials 0.000 abstract 2
- 125000003172 aldehyde group Chemical group 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
- B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
- B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
- B01J31/2414—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom comprising aliphatic or saturated rings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
- B01J2531/82—Metals of the platinum group
- B01J2531/824—Palladium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Reivindicación 1: Un método para preparar compuesto (200), sus estereoisómeros, sus isómeros geométricos, sus tautómeros y sus sales, estando el método caracterizado porque comprende: (i) (1) formar una primera mezcla de reacción que comprende compuesto (170), compuesto (181), un catalizador de paladio, un sistema disolvente que comprende agua, y una base, en donde la relación de volumen de solvente a peso de compuesto (170) en la mezcla de reacción es menos que 20:1 litros por kg, la proporción de equivalentes de compuesto (181) a compuesto (170) es más que 1:1, y la proporción de equivalentes del catalizador de paladio a compuesto (170) es de aproximadamente 0,005:1 a aproximadamente 0,05:1, (2) hacer reaccionar la primera mezcla de reacción para formar una primera mezcla de productos de reacción que comprende compuesto (190) de acuerdo con el siguiente esquema: [1], y (3) aislar compuesto (190) de la primera mezcla de productos de reacción; y (ii) (1) formar una segunda mezcla de reacción que comprende compuesto (190), un agente reductor, una base y un solvente, (2) hacer reaccionar la segunda mezcla de reacción para reducir el grupo aldehído del compuesto (190) y formar una segunda mezcla de productos de reacción que comprende compuesto (200), y (3) aislar compuesto (200) de la segunda mezcla de productos de reacción, en donde el rendimiento de compuesto (190) es por lo menos 50% en base al compuesto (170), y el rendimiento de compuesto (200) es por lo menos 50% en base al compuesto (190).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662434569P | 2016-12-15 | 2016-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR126445A2 true AR126445A2 (es) | 2023-10-11 |
Family
ID=61007648
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170103487A AR110357A1 (es) | 2016-12-15 | 2017-12-13 | Proceso para preparar inhibidores de btk |
| ARP220101839A AR126445A2 (es) | 2016-12-15 | 2022-07-13 | Metodo para preparar inhibidores de btk |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170103487A AR110357A1 (es) | 2016-12-15 | 2017-12-13 | Proceso para preparar inhibidores de btk |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US10385058B2 (es) |
| EP (3) | EP4574828A3 (es) |
| JP (2) | JP6800334B2 (es) |
| KR (2) | KR102375771B1 (es) |
| CN (2) | CN110446710B (es) |
| AR (2) | AR110357A1 (es) |
| AU (4) | AU2017376580B2 (es) |
| CA (2) | CA3039090C (es) |
| ES (1) | ES2894262T3 (es) |
| HR (1) | HRP20211553T1 (es) |
| IL (2) | IL284690B (es) |
| MX (2) | MX386843B (es) |
| PL (1) | PL3555099T3 (es) |
| SG (2) | SG10201913918UA (es) |
| SI (1) | SI3555099T1 (es) |
| TW (3) | TWI673271B (es) |
| WO (1) | WO2018109050A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX386843B (es) | 2016-12-15 | 2025-03-19 | Hoffmann La Roche | Proceso para preparar inhibidores de tirosina cinasa de bruton (btk) |
| KR102861971B1 (ko) * | 2018-02-19 | 2025-09-19 | 광조우 루펭 파마슈티칼 컴퍼니 엘티디. | Btk 및 그의 돌연변이체의 억제제 |
| US20210221792A1 (en) * | 2020-01-16 | 2021-07-22 | Hanmi Pharm Co., Ltd. | Convergent synthesis of poziotinib derivative |
| JP7763767B2 (ja) | 2020-02-20 | 2025-11-04 | ハチメド リミテッド | ヘテロアリール複素環式化合物およびその使用 |
| CN115715291B (zh) * | 2020-06-18 | 2025-04-29 | 上海华汇拓医药科技有限公司 | 布鲁顿酪氨酸激酶抑制剂及其制备方法 |
| JP2023542040A (ja) * | 2020-09-21 | 2023-10-04 | ハチソン メディファルマ リミテッド | ヘテロアリール複素環化合物及びその使用 |
| WO2022206924A1 (zh) * | 2021-04-02 | 2022-10-06 | 南京明德新药研发有限公司 | 含氮三并环双功能化合物及其制备方法和应用 |
| PL4334311T3 (pl) * | 2021-05-05 | 2025-04-07 | F. Hoffmann-La Roche Ag | Proces przygotowywania inhibitorów BTK |
| CN113603685A (zh) * | 2021-07-23 | 2021-11-05 | 都创(上海)医药开发有限公司 | Fenebrutinib化合物的晶型及其制备方法和用途 |
| WO2026017823A1 (en) | 2024-07-18 | 2026-01-22 | F. Hoffmann-La Roche Ag | Process for preparing btk inhibitor intermediates |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3431541A1 (de) * | 1984-08-28 | 1986-03-06 | Hoechst Ag, 6230 Frankfurt | Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung |
| EP1599475A2 (en) * | 2003-03-06 | 2005-11-30 | Eisai Co., Ltd. | Jnk inhibitors |
| SG160438A1 (en) * | 2005-03-25 | 2010-04-29 | Glaxo Group Ltd | Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5- d]pyrimidin-2(1h)-one derivatives |
| JP5469604B2 (ja) * | 2007-09-19 | 2014-04-16 | ４エスツェー アクチェンゲゼルシャフト | 新規テトラヒドロ融合ピリジン |
| CA2700058A1 (en) | 2007-09-19 | 2009-03-26 | 4Sc Ag | Novel tetrahydrofusedpyridines |
| CN101781312B (zh) * | 2009-12-30 | 2012-09-26 | 中国科学院广州生物医药与健康研究院 | 一种吲哚衍生物的合成方法 |
| CN110818724B (zh) * | 2010-05-07 | 2020-11-13 | 吉利德康涅狄格有限公司 | 吡啶酮和氮杂吡啶酮化合物及使用方法 |
| PH12014500966A1 (en) * | 2011-11-03 | 2014-06-09 | Hoffmann La Roche | Alkylated piperazine compounds as inhibitors of btk activity |
| UA111756C2 (uk) * | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
| BR112014010391A2 (pt) * | 2011-11-03 | 2017-04-18 | Hoffmann La Roche | composto, composição farmacêutica, processo de produção de uma composição farmacêutica, método de tratamento, kit e uso de uma composição farmacêutica |
| US9076830B2 (en) * | 2011-11-03 | 2015-07-07 | Applied Materials, Inc. | Robot systems and apparatus adapted to transport dual substrates in electronic device manufacturing with wrist drive motors mounted to upper arm |
| US8703953B2 (en) * | 2012-03-09 | 2014-04-22 | Bristol-Myers Squibb Company | Aryl ether-base kinase inhibitors |
| WO2014056083A1 (en) * | 2012-10-12 | 2014-04-17 | University Health Network | Kinase inhibitors and method of treating cancer with same |
| CN105358531B (zh) * | 2013-03-14 | 2017-11-14 | 利兰-斯坦福大学初级学院的董事会 | 线粒体醛脱氢酶‑2调节剂和其使用方法 |
| TWI513371B (zh) * | 2013-07-08 | 2015-12-11 | Lextar Electronics Corp | 整合無線暨有線的照明控制系統 |
| KR101813830B1 (ko) * | 2013-12-05 | 2017-12-29 | 에프. 호프만-라 로슈 아게 | 친전자성 작용기를 갖는 헤테로아릴 피리돈 및 아자-피리돈 화합물 |
| TWI659019B (zh) * | 2014-02-28 | 2019-05-11 | 日商帝人製藥股份有限公司 | 吡唑醯胺衍生物 |
| DE102015206627A1 (de) | 2014-07-09 | 2016-01-28 | Siemens Aktiengesellschaft | Selbstsichernder Umrichter |
| JP6507234B2 (ja) * | 2014-10-02 | 2019-04-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ブルトンチロシンキナーゼ（ｂｔｋ）によって介入される障害の処置における使用のためのピラゾールカルボキサミド化合物 |
| MA41169A (fr) * | 2014-12-17 | 2017-10-24 | Acraf | Composés antibactériens à large spectre d'activité |
| CA2970723C (en) | 2014-12-18 | 2023-09-05 | Principia Biopharma Inc. | Treatment of pemphigus |
| JP6457697B2 (ja) * | 2015-04-29 | 2019-01-23 | カントン チョンション ファーマシューティカル カンパニー，リミティド | キナーゼ阻害剤としての縮合環式または三環式アリールピリミジン化合物 |
| CN108367005B (zh) * | 2016-02-29 | 2022-01-07 | 豪夫迈·罗氏有限公司 | 包含酪氨酸蛋白激酶抑制剂的剂型组合物 |
| MX386843B (es) | 2016-12-15 | 2025-03-19 | Hoffmann La Roche | Proceso para preparar inhibidores de tirosina cinasa de bruton (btk) |
-
2017
- 2017-12-13 MX MX2020012097A patent/MX386843B/es unknown
- 2017-12-13 CN CN201780076739.2A patent/CN110446710B/zh active Active
- 2017-12-13 TW TW106143737A patent/TWI673271B/zh active
- 2017-12-13 SI SI201730936T patent/SI3555099T1/sl unknown
- 2017-12-13 EP EP25170183.5A patent/EP4574828A3/en active Pending
- 2017-12-13 JP JP2019528485A patent/JP6800334B2/ja active Active
- 2017-12-13 SG SG10201913918UA patent/SG10201913918UA/en unknown
- 2017-12-13 SG SG10202009148XA patent/SG10202009148XA/en unknown
- 2017-12-13 AR ARP170103487A patent/AR110357A1/es active IP Right Grant
- 2017-12-13 MX MX2019005527A patent/MX379000B/es unknown
- 2017-12-13 PL PL17832491T patent/PL3555099T3/pl unknown
- 2017-12-13 CA CA3039090A patent/CA3039090C/en active Active
- 2017-12-13 AU AU2017376580A patent/AU2017376580B2/en active Active
- 2017-12-13 EP EP20189072.0A patent/EP3825317A3/en active Pending
- 2017-12-13 HR HRP20211553TT patent/HRP20211553T1/hr unknown
- 2017-12-13 KR KR1020207037471A patent/KR102375771B1/ko active Active
- 2017-12-13 KR KR1020197016973A patent/KR102257159B1/ko active Active
- 2017-12-13 TW TW108126347A patent/TWI766176B/zh active
- 2017-12-13 TW TW108126350A patent/TW201940489A/zh unknown
- 2017-12-13 EP EP17832491.9A patent/EP3555099B1/en active Active
- 2017-12-13 ES ES17832491T patent/ES2894262T3/es active Active
- 2017-12-13 IL IL284690A patent/IL284690B/en unknown
- 2017-12-13 WO PCT/EP2017/082723 patent/WO2018109050A1/en not_active Ceased
- 2017-12-13 CA CA3104116A patent/CA3104116A1/en active Pending
- 2017-12-13 CN CN202010294389.0A patent/CN111333656B/zh active Active
- 2017-12-14 US US15/841,828 patent/US10385058B2/en active Active
-
2019
- 2019-02-26 IL IL265067A patent/IL265067B/en unknown
- 2019-07-02 US US16/460,889 patent/US10882864B2/en active Active
-
2020
- 2020-02-21 AU AU2020201260A patent/AU2020201260B2/en active Active
- 2020-02-21 AU AU2020201261A patent/AU2020201261B2/en active Active
- 2020-11-23 US US17/102,086 patent/US11661424B2/en active Active
- 2020-11-24 JP JP2020194373A patent/JP7153705B2/ja active Active
-
2021
- 2021-02-18 AU AU2021201052A patent/AU2021201052A1/en not_active Abandoned
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2022
- 2022-07-13 AR ARP220101839A patent/AR126445A2/es unknown
-
2023
- 2023-04-12 US US18/299,622 patent/US20230250103A1/en not_active Abandoned
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