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MX2017001459A - Sintesis de fosforamidatos. - Google Patents

Sintesis de fosforamidatos.

Info

Publication number
MX2017001459A
MX2017001459A MX2017001459A MX2017001459A MX2017001459A MX 2017001459 A MX2017001459 A MX 2017001459A MX 2017001459 A MX2017001459 A MX 2017001459A MX 2017001459 A MX2017001459 A MX 2017001459A MX 2017001459 A MX2017001459 A MX 2017001459A
Authority
MX
Mexico
Prior art keywords
compound
formula
mixture
phosphoramidates
synthesis
Prior art date
Application number
MX2017001459A
Other languages
English (en)
Inventor
Wilhelm Thorsten
Peter Spitzenstätter Hans-
SCHÖNE Olga
Richter Frank
Schreiner Erwin
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of MX2017001459A publication Critical patent/MX2017001459A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6521—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C07F9/65324—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describe un procedimiento para la preparación de un compuesto de la fórmula (I) incluyendo todos los isómeros, estereoisómeros, enantiómeros y diastereómeros del mismo, y sales del mismo; el procedimiento comprende proveer una mezcla que comprende un compuesto de la fórmula (II) y un compuesto de la fórmula (III), someter la mezcla provista en a) a condiciones de reacción en presencia de uno o más ácidos de Lewis a la mezcla provista en a), obteniendo una mezcla que comprende el compuesto de la fórmula (I).
MX2017001459A 2014-07-31 2015-07-31 Sintesis de fosforamidatos. MX2017001459A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14179385 2014-07-31
PCT/EP2015/067720 WO2016016447A1 (en) 2014-07-31 2015-07-31 Synthesis of phosphoramidates

Publications (1)

Publication Number Publication Date
MX2017001459A true MX2017001459A (es) 2017-05-23

Family

ID=51257395

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017001459A MX2017001459A (es) 2014-07-31 2015-07-31 Sintesis de fosforamidatos.

Country Status (9)

Country Link
US (1) US20170218006A1 (es)
EP (1) EP3174892A1 (es)
JP (1) JP2017522343A (es)
CN (1) CN106661074A (es)
AU (1) AU2015295274A1 (es)
BR (1) BR112017001847A2 (es)
CA (1) CA2954940A1 (es)
MX (1) MX2017001459A (es)
WO (1) WO2016016447A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ307789B6 (cs) * 2014-04-15 2019-05-09 Zentiva, K.S. Způsob výroby biologicky účinných fosforamidátových léčiv
SI3524234T1 (sl) 2014-06-13 2021-05-31 Ratiopharm Gmbh Trdne oblike sofosbuvira
CN105461774B (zh) * 2014-09-30 2020-11-24 江苏豪森药业集团有限公司 索非布韦的制备方法
WO2016064797A1 (en) * 2014-10-20 2016-04-28 Merck Sharp & Dohme Corp. Process for making nucleoside phosphoramidate compounds
WO2016160646A1 (en) * 2015-04-02 2016-10-06 Merck Sharp & Dohme Corp. Process for making phosphoramidate protected nucleoside compounds
US10676498B2 (en) 2015-06-03 2020-06-09 Teva Pharmaceuticals International Gmbh Processes for the preparation of sofosbuvir and intermediates thereof
JP7337797B2 (ja) * 2017-11-16 2023-09-04 シンジェンタ パーティシペーションズ アーゲー 鏡像異性的に及びジアステレオマー的に富化したシクロブタンアミン及びアミドの調製方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2794671C (en) * 2010-03-31 2018-05-01 Gilead Pharmasset Llc Stereoselective synthesis of phosphorus containing actives
SI2609923T1 (sl) * 2010-03-31 2017-10-30 Gilead Pharmasset Llc Postopek za kristalizacijo (s)-izopropil 2-(((s)-(perfluorofenoksi) (fenoksi)fosforil)amino)propanoata
RS56038B1 (sr) * 2012-11-16 2017-09-29 Univ College Cardiff Consultants Ltd Smeša rp/sp gemcitabin-[fenil-(benziloksi-l-alaninil)]-fosfata
GB201221064D0 (en) * 2012-11-23 2013-01-09 Secr Defence A deformable element
WO2014134146A1 (en) * 2013-02-26 2014-09-04 Jacobs Vehicle Systems, Inc. Intra-cylinder auxiliary actuation of engine valves through selective discontinuation of main valve events
WO2014164533A1 (en) * 2013-03-11 2014-10-09 Vertex Pharmaceuticals Incorporated Methods of stereoselective synthesis of substituted nucleoside analogs
AU2014250764A1 (en) * 2013-04-12 2015-10-29 Achillion Pharmaceuticals, Inc. Deuterated nucleoside prodrugs useful for treating HCV
CA2986812A1 (en) * 2015-05-26 2016-12-01 Sandoz Ag Selective process for synthesis of nucleoside phosphoramidates

Also Published As

Publication number Publication date
CN106661074A (zh) 2017-05-10
US20170218006A1 (en) 2017-08-03
WO2016016447A1 (en) 2016-02-04
BR112017001847A2 (pt) 2018-02-27
EP3174892A1 (en) 2017-06-07
CA2954940A1 (en) 2016-02-04
AU2015295274A1 (en) 2017-01-12
JP2017522343A (ja) 2017-08-10

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