AR056917A1 - Procedimientos para preparar eteres aromaticos - Google Patents
Procedimientos para preparar eteres aromaticosInfo
- Publication number
- AR056917A1 AR056917A1 ARP060100070A ARP060100070A AR056917A1 AR 056917 A1 AR056917 A1 AR 056917A1 AR P060100070 A ARP060100070 A AR P060100070A AR P060100070 A ARP060100070 A AR P060100070A AR 056917 A1 AR056917 A1 AR 056917A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkoxy
- alkyl
- haloalkyl
- cycloalkyl
- alkylcarboxamide
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 hydroxy, hydroxycarbamimidoyl Chemical group 0.000 abstract 16
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 12
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 12
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 12
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 11
- 125000005431 alkyl carboxamide group Chemical group 0.000 abstract 10
- 125000004414 alkyl thio group Chemical group 0.000 abstract 10
- 229910052736 halogen Inorganic materials 0.000 abstract 10
- 150000002367 halogens Chemical class 0.000 abstract 10
- 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 abstract 9
- 125000004423 acyloxy group Chemical group 0.000 abstract 9
- 125000003282 alkyl amino group Chemical group 0.000 abstract 9
- 125000004422 alkyl sulphonamide group Chemical group 0.000 abstract 9
- 125000005392 carboxamide group Chemical class NC(=O)* 0.000 abstract 9
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 9
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 9
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 abstract 8
- 125000002252 acyl group Chemical group 0.000 abstract 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 8
- 125000005432 dialkylcarboxamide group Chemical group 0.000 abstract 8
- 125000004995 haloalkylthio group Chemical group 0.000 abstract 8
- 125000001072 heteroaryl group Chemical group 0.000 abstract 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 8
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 abstract 7
- 125000004771 (C1-C4) haloalkylsulfinyl group Chemical group 0.000 abstract 7
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 7
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 abstract 6
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000005363 dialkylsulfonamide group Chemical group 0.000 abstract 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 2
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005111 carboxyalkoxy group Chemical group 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Reivindicacion 1: Un procedimiento para preparar un compuesto de formula (1), en donde: X es N o CR7; Y es N o CR8; Z es acilo C1-5, aciloxilo C1-5, alquenilo C2-6, alcoxilo C1-4, alquilo C1-8, alquilcarboxamida C2-6, alquinilo C2-6, alquiltiocarboxamida, alquilsulfonamida C1-4, alquilsulfinilo C1-4, alquilsulfonilo C1-4, alquiltio C1-4, alquiltioureilo C1-4, alquilureilo C1-4, amino, alquilamino C1-2, dialquilamino C2-4, carbaminidoilo, carbo-alcoxiloC1-6, carboxamida, carboxilo, ciano, cicloalquilo C3-7, diacilamino C4-8, dialquilcarboxamida C2-6, dialquiltiocarboxamida C2-6, dialquilsulfonamida C2-6, dialquilsulfonilamino C2-6, formilo, haloalcoxilo C1-4, haloalquilo C1-4, haloalquilcarboxamida C1-4, haloalquilsulfinilo C1-4, haloalquilsulfonilo C1-4, haloalquiltio C1-4, halogeno, arilo, heteroarilo, heterocicloalquilo, hidroxilo, hidroxicarbamimidoilo, hidroxilamino, nitro, o tetrazolilo; en donde cada alquilo C1-8, cicloalquilo C3-7, y heterocicloalquilo está opcionalmente sustituido con 1, 2, 3 o 4 grupos seleccionados entre acilo C1-5, aciloxilo C1-5, alcoxilo C1-4, alquilo C1-7, alquilcarboxamida C1-4, alquilsulfonamida C1-4, alquilsulfinilo C1-4, alquilsulfonilo C1-4, alquiltio C1-4, alquilureilo C1-4, amino, alquilamino C1-2, dialquilamino C2-4, carbo-alcoxiloC1-6, carboxamida, carboxilo, ciano, formilo, haloalcoxilo C1-4, haloalquilsulfinilo C1-4, haloalquilsulfonilo C1-4, haloalquiltio C1-4, halogeno, hidroxilo, hidroxilamino, y nitro; R1 es H, aciloxilo C1-5, alquenilo C2-6, alcoxilo C1-4, alquilo C1-8, alquilcarboxamida C1-4, alquinilo C2-6, alquilsulfonamida C1-4, alquilsulfinilo C1-4, alquilsulfonilo C1-4, alquiltio C1-4, alquilureilo C1-4, amino, alquilamino C1-4, dialquilamino C2-8, carboxamida, ciano, cicloalquilo C3-7, dialquilcarboxamida C2-6, dialquilsulfonamida C2-6, halogeno, haloalcoxilo C1-4, haloalquilo C1-4, haloalquilsulfinilo C1-4, haloalquilsulfonilo C1-4, haloalquiltio C1-4, o hidroxilo; R2 es -R22, -CR23R24C(O)-R22, -C(O)CR23R24-R22, -C(O)-R22, -CR23R24C(O)NR25-R22, -NR25C(O)CR23R24-R22, -C(O)NR23-R22, -NR23C(O)-R22, -C(O)O-R22, -OC(O)-R22, -C(S)-R22, -C(S)NR23-R22, -NR23C(S)-R22, -C(S)O-R22, -OC(S)-R22, -CR23R24- R22, o -S(O)2-R22; R3 es alquilo C1-3, alcoxilo C1-4, carboxilo, ciano, haloalquilo C1-3, o halogeno; R4 es H, alquilo C1-8 o cicloalquilo C3-7, en donde dicho alquilo C1-8 está opcionalmente sustituido con alcoxilo C1-4, cicloalquilo C3-7, o heteroarilo; R7 y R8 son independientemente H, aciloxilo C1-5, alquenilo C2-6, alcoxilo C1-4, alquilo C1-8, alquilcarboxamida C1-4, alquinilo C2-6, alquilsulfonamida C1-4, alquilsulfinilo C1-4, alquilsulfonilo C1-4, alquiltio C1-4, alquilureilo C1- 4, amino, alquilamino C1-4, dialquilamino C2-8, carboxamida, ciano, cicloalquilo C3-7, dialquilcarboxamida C2-6, dialquilsulfonamida C2-6, halogeno, haloalcoxilo C1-4, haloalquilo C1-4, haloalquilsulfinilo C1-4, haloalquilsulfonilo C1-4, haloalquiltio C1-4, o hidroxilo; R11 es acilo C1-5, acilsulfonamida C1-6, aciloxilo C1-5, alquenilo C2-6, alcoxilo C1-4, alquilo C1-8, alquilamino C1-4, alquilcarboxamida C1-6, alquiltiocarboxamida C1-4, alquinilo C2-6, alquilsulfonamida C1-4, alquilsulfinilo C1-4, alquilsulfonilo C1-4, alquiltio C1-4, alquiltioureilo C1-4, alquilureilo C1-4, amino, arilsulfonilo, carbaminidoilo, carbo-alcoxiloC1-6, carboxamida, carboxilo, ciano, cicloalquilo C3-7, cicloalquiloxilo C3-7, dialquilamino C2- 6, dialquilcarboxamida C2-6, dialquiltiocarboxamida C2-6, guanidinilo, halogeno, haloalcoxilo C1-4, haloalquilo C1-4, haloalquilsulfinilo C1-4, haloalquilsulfonilo C1-4, haloalquiltio C1-4, heterocicloalquilo, heterocicloalquilooxilo, heterocicloalquilsulfonilo, heterocicloalquil-carbonilo, heteroarilo, heteroarilcarbonilo, hidroxilo, nitro, oxoC4-7-cicloalquilo, fenoxilo, fenilo, sulfonamida, ácido sulfonico, o tiol; y en donde cada acilo C1-5, acilsulfonamida C1-6, alcoxilo C1- 4, alquilo C1-8, alquilamino C1-4, alquilsulfonamida C1-6, alquilsulfonilo C1-4, alquiltio C1-4, arilsulfonilo, carbaminidoilo, dialquilamino C2-6, heterocicloalquilo, heterocicloalquil-carbonilo, heteroarilo, fenoxilo y fenilo está opcionalmente sustituido con 1 a 5 sustituyentes seleccionados independientemente entre acilo C1-5, aciloxilo C1-5, alquenilo C2-6, alcoxilo C1-4, alquilo C1-7, alquilamino C1-4, alquilcarboxamida C1-4, alquinilo C2-6, alquilsulfonamida C1-4, alquilsulfinilo C1- 4, alquilsulfonilo C1-4, alquiltio C1-4, alquilureilo C1-4, carbo-alcoxiloC1-6, carboxamida, carboxilo, ciano, cicloalquilo C3-7, cicloalquiloxilo C3-7, dialquilamino C2-6, dialquilcarboxamida C2-6, halogeno, haloalcoxilo C1-4, haloalquilo C1-4, haloalquilsulfinilo C1-4, haloalquilsulfonilo C1-4, haloalquiltio C1-4, heteroarilo, heterociclo, hidroxilo, nitro, fenilo, y fosfonooxilo, en donde cada alquilo C1-7 y alquilcarboxamida C1-4 está opcionalmente sustituido con 1 a 5 sustituyentes seleccionados entre alcoxilo C1-4 e hidroxilo; R12, R13, R14, y R15 son independientemente H, acilo C1-5, aciloxilo C1-5, alquenilo C2-6, alcoxilo C1-4, alquilo C1-8, alquilcarboxamida C1-4, alquinilo C2-6, alquilsulfonamida C1-4, alquilsulfinilo C1- 4, alquilsulfonilo C1-4, alquiltio C1-4, alquilureilo C1-4, carbo-alcoxiloC1-6, carboxamida, carboxilo, ciano, cicloalquilo C3-7, dialquilcarboxamida C2-6, halogeno, haloalcoxilo C1-4, haloalquilo C1-4, haloalquilsulfinilo C1-4, haloalquilsulfonilo C1-4, haloalquiltio C1-4, hidroxilo, o nitro; R22 es H, alquilo C1-8, cicloalquilo C3-7, fenilo, heteroarilo, o heterociclo cada uno opcionalmente sustituido con 1 a 5 sustituyentes seleccionados entre el grupo integrado por acilo C1-5, aciloxilo C1- 5, alquenilo C2-6, alcoxilo C1-4, alquilo C1-7, alquilamino C1-4, alquilcarboxamida C1-4, alquiltiocarboxamida C1-4, alquilsulfonamida C1-4, alquilsulfinilo C1-4, alquilsulfonilo C1-4, alquiltio C1-4, alquiltioureilo C1-4, alquilureilo C1-4, amino, carbo-alcoxiloC1-6, carboxamida, carboxilo, ciano, cicloalquilo C3-7, dialquilamino C2-8, dialquilcarboxamida C2-6, dialquiltiocarboxamida C2-6, dialquilsulfonamida C2-6, alquiltioureilo C1-4, haloalcoxilo C1-4, haloalquilo C1-4, haloalquilsulfinilo C1-4, haloalquilsulfonilo C1-4, haloalquilo C1-4, haloalquiltio C1-4, halogeno, heteroarilo, heterociclo, hidroxilo, hidroxilamino, nitro, fenilo, fenoxilo, y ácido sulfonico, en donde cada alquilo C1-7, heteroarilo, fenilo y fenoxilo está opcionalmente sustituido con 1 a 5 sustituyentes seleccionados entre el grupo integrado por acilo C1-5, aciloxilo C1-5, alcoxilo C1-4, alquilo C1-8, alquilamino C1-4, alquilcarboxamida C1-4, alquiltiocarboxamida C1-4, alquilsulfonamida C1-4, alquilsulfinilo C1-4, alquilsulfonilo C1-4, alquiltio C1-4, alquiltioureilo C1-4, alquilureilo C1-4, amino, carbo-alcoxiloC1-6, carboxamida, carboxilo, ciano, cicloalquilo C3-7, dialquilamino C2-8, dialquilcarboxamida C2-6, dialquiltiocarboxamida C2- 6, dialquilsulfonamida C2-6, alquiltioureilo C1-4, haloalcoxilo C1-4, haloalquilo C1-4, haloalquilsulfinilo C1-4, haloalquilsulfonilo C1-4, haloalquilo C1-4, haloalquiltio C1-4, halogeno, heterociclo, hidroxilo, hidroxilamino, y nitro; R23, R24 y R25 son independientemente H o alquilo C1-8; n es 0 o 1; y m es 0, 1, 2, 3, o 4; en donde dicho procedimiento comprende hacer reaccionar un compuesto de formula (2), en donde L2 es un grupo saliente, con un compuesto de formula (3), en presencia de una base y una sal, formando así el compuesto de formula (1).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64262705P | 2005-01-10 | 2005-01-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR056917A1 true AR056917A1 (es) | 2007-11-07 |
Family
ID=36297260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060100070A AR056917A1 (es) | 2005-01-10 | 2006-01-09 | Procedimientos para preparar eteres aromaticos |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7812159B2 (es) |
| EP (1) | EP1838697B1 (es) |
| JP (1) | JP2008526881A (es) |
| KR (1) | KR20070098906A (es) |
| CN (1) | CN101115739A (es) |
| AR (1) | AR056917A1 (es) |
| AT (1) | ATE462701T1 (es) |
| AU (1) | AU2006205176A1 (es) |
| BR (1) | BRPI0606676A2 (es) |
| CA (1) | CA2593344A1 (es) |
| CR (1) | CR9221A (es) |
| DE (1) | DE602006013271D1 (es) |
| DK (1) | DK1838697T3 (es) |
| DO (1) | DOP2006000010A (es) |
| EA (1) | EA014156B1 (es) |
| ES (1) | ES2341281T3 (es) |
| GE (1) | GEP20105071B (es) |
| GT (1) | GT200600007A (es) |
| HN (1) | HN2006000970A (es) |
| IL (1) | IL184366A0 (es) |
| MX (1) | MX2007008377A (es) |
| NO (1) | NO20074055L (es) |
| NZ (1) | NZ556218A (es) |
| PE (2) | PE20060836A1 (es) |
| SG (1) | SG158864A1 (es) |
| TW (1) | TW200637844A (es) |
| UA (1) | UA92733C2 (es) |
| WO (1) | WO2006076243A1 (es) |
| ZA (1) | ZA200705473B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ540612A (en) | 2003-01-14 | 2008-02-29 | Arena Pharm Inc | 1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
| AR045047A1 (es) * | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| MY148521A (en) * | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
| AU2009217359B2 (en) * | 2008-02-22 | 2011-09-01 | Irm Llc | Compounds and compositions as modulators of GPR119 activity |
| JP5856980B2 (ja) | 2010-01-27 | 2016-02-10 | アリーナ ファーマシューティカルズ， インコーポレイテッド | （Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸およびその塩の調製のためのプロセス |
| JP2013522279A (ja) | 2010-03-18 | 2013-06-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糖尿病及び関連状態の治療で用いるｇｐｒ１１９作動薬とｄｄｐ−ｉｖ阻害薬リナグリプチンの組合せ |
| WO2012025811A1 (en) | 2010-08-23 | 2012-03-01 | Lupin Limited | Indolylpyrimidines as modulators of gpr119 |
| CN103221410B (zh) | 2010-09-22 | 2017-09-15 | 艾尼纳制药公司 | Gpr119受体调节剂和对与其相关的障碍的治疗 |
| AU2011333472A1 (en) | 2010-11-26 | 2013-06-06 | Lupin Limited | Bicyclic GPR119 modulators |
| ES2602813T3 (es) | 2011-06-09 | 2017-02-22 | Rhizen Pharmaceuticals S.A. | Nuevos compuestos como moduladores de GPR-119 |
| EP4445956A3 (en) | 2015-01-06 | 2024-12-04 | Arena Pharmaceuticals, Inc. | Compound for use in treating conditions related to the s1p1 receptor |
| PL3310760T3 (pl) | 2015-06-22 | 2023-03-06 | Arena Pharmaceuticals, Inc. | Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1 |
| TW201825458A (zh) | 2016-09-20 | 2018-07-16 | 英商葛蘭素史克智慧財產（第二）有限公司 | Ｔｒｐｖ４拮抗劑 |
| EP3515889A1 (en) | 2016-09-20 | 2019-07-31 | GlaxoSmithKline Intellectual Property (No. 2) Limited | Trpv4 antagonists |
| CA3036933A1 (en) | 2016-09-20 | 2018-03-29 | Glaxosmithkline Intellectual Property (No.2) Limited | Trpv4 antagonists |
| MA47504A (fr) | 2017-02-16 | 2019-12-25 | Arena Pharm Inc | Composés et méthodes de traitement de l'angiocholite biliaire primitive |
| ES2987794T3 (es) | 2018-06-06 | 2024-11-18 | Arena Pharm Inc | Procedimientos de tratamiento de afecciones relacionadas con el receptor S1P1 |
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-
2006
- 2006-01-05 DO DO2006000010A patent/DOP2006000010A/es unknown
- 2006-01-06 PE PE2006000044A patent/PE20060836A1/es not_active Application Discontinuation
- 2006-01-06 PE PE2009000963A patent/PE20091401A1/es not_active Application Discontinuation
- 2006-01-09 GE GEAP200610222A patent/GEP20105071B/en unknown
- 2006-01-09 MX MX2007008377A patent/MX2007008377A/es active IP Right Grant
- 2006-01-09 GT GT200600007A patent/GT200600007A/es unknown
- 2006-01-09 NZ NZ556218A patent/NZ556218A/en not_active IP Right Cessation
- 2006-01-09 ES ES06717730T patent/ES2341281T3/es not_active Expired - Lifetime
- 2006-01-09 AU AU2006205176A patent/AU2006205176A1/en not_active Withdrawn
- 2006-01-09 DE DE602006013271T patent/DE602006013271D1/de not_active Expired - Lifetime
- 2006-01-09 KR KR1020077018267A patent/KR20070098906A/ko not_active Withdrawn
- 2006-01-09 AR ARP060100070A patent/AR056917A1/es not_active Application Discontinuation
- 2006-01-09 SG SG201000106-3A patent/SG158864A1/en unknown
- 2006-01-09 EA EA200701470A patent/EA014156B1/ru not_active IP Right Cessation
- 2006-01-09 JP JP2007550519A patent/JP2008526881A/ja not_active Withdrawn
- 2006-01-09 AT AT06717730T patent/ATE462701T1/de not_active IP Right Cessation
- 2006-01-09 DK DK06717730.3T patent/DK1838697T3/da active
- 2006-01-09 HN HN2006000970A patent/HN2006000970A/es unknown
- 2006-01-09 WO PCT/US2006/000565 patent/WO2006076243A1/en not_active Ceased
- 2006-01-09 US US11/327,923 patent/US7812159B2/en not_active Expired - Fee Related
- 2006-01-09 BR BRPI0606676-3A patent/BRPI0606676A2/pt not_active IP Right Cessation
- 2006-01-09 CA CA002593344A patent/CA2593344A1/en not_active Withdrawn
- 2006-01-09 CN CNA2006800018668A patent/CN101115739A/zh not_active Withdrawn
- 2006-01-09 UA UAA200709151A patent/UA92733C2/ru unknown
- 2006-01-09 TW TW095100805A patent/TW200637844A/zh unknown
- 2006-01-09 EP EP06717730A patent/EP1838697B1/en not_active Expired - Lifetime
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2007
- 2007-07-02 CR CR9221A patent/CR9221A/es not_active Application Discontinuation
- 2007-07-02 IL IL184366A patent/IL184366A0/en unknown
- 2007-07-04 ZA ZA200705473A patent/ZA200705473B/xx unknown
- 2007-08-06 NO NO20074055A patent/NO20074055L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| UA92733C2 (ru) | 2010-12-10 |
| ZA200705473B (en) | 2009-07-29 |
| JP2008526881A (ja) | 2008-07-24 |
| ATE462701T1 (de) | 2010-04-15 |
| BRPI0606676A2 (pt) | 2009-07-07 |
| US20060155129A1 (en) | 2006-07-13 |
| CN101115739A (zh) | 2008-01-30 |
| NO20074055L (no) | 2007-09-25 |
| GEP20105071B (en) | 2010-09-10 |
| TW200637844A (en) | 2006-11-01 |
| CR9221A (es) | 2007-10-23 |
| WO2006076243A1 (en) | 2006-07-20 |
| CA2593344A1 (en) | 2006-07-20 |
| DK1838697T3 (da) | 2010-06-28 |
| IL184366A0 (en) | 2007-10-31 |
| EA014156B1 (ru) | 2010-10-29 |
| NZ556218A (en) | 2010-10-29 |
| DE602006013271D1 (de) | 2010-05-12 |
| PE20060836A1 (es) | 2006-09-02 |
| DOP2006000010A (es) | 2006-07-31 |
| HK1102810A1 (en) | 2007-12-07 |
| ES2341281T3 (es) | 2010-06-17 |
| US7812159B2 (en) | 2010-10-12 |
| AU2006205176A1 (en) | 2006-07-20 |
| EA200701470A1 (ru) | 2008-02-28 |
| EP1838697B1 (en) | 2010-03-31 |
| KR20070098906A (ko) | 2007-10-05 |
| GT200600007A (es) | 2006-08-01 |
| SG158864A1 (en) | 2010-02-26 |
| PE20091401A1 (es) | 2009-09-18 |
| MX2007008377A (es) | 2007-09-07 |
| HN2006000970A (es) | 2010-04-19 |
| EP1838697A1 (en) | 2007-10-03 |
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