AR056354A1 - DERIVADOS DE PIRAZOL, UN MÉTODO DE PREPARACIoN DEL COMPUESTO, COMPOSICIoN FARMACÉUTICA Y PREPARACIoN DE UN MEDICAMENTO - Google Patents
DERIVADOS DE PIRAZOL, UN MÉTODO DE PREPARACIoN DEL COMPUESTO, COMPOSICIoN FARMACÉUTICA Y PREPARACIoN DE UN MEDICAMENTOInfo
- Publication number
- AR056354A1 AR056354A1 ARP060101974A ARP060101974A AR056354A1 AR 056354 A1 AR056354 A1 AR 056354A1 AR P060101974 A ARP060101974 A AR P060101974A AR P060101974 A ARP060101974 A AR P060101974A AR 056354 A1 AR056354 A1 AR 056354A1
- Authority
- AR
- Argentina
- Prior art keywords
- 6alkyl
- carbamoyl
- amino
- optionally substituted
- sulfamoyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 41
- -1 hydroxy, amino, mercapto Chemical group 0.000 abstract 30
- 229910052757 nitrogen Inorganic materials 0.000 abstract 22
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 11
- 125000000623 heterocyclic group Chemical group 0.000 abstract 11
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 7
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 6
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 6
- 229910052799 carbon Inorganic materials 0.000 abstract 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 6
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 abstract 5
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 5
- 125000004452 carbocyclyl group Chemical group 0.000 abstract 5
- 125000001475 halogen functional group Chemical group 0.000 abstract 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 4
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 2
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- AHADSRNLHOHMQK-UHFFFAOYSA-N methylidenecopper Chemical class [Cu].[C] AHADSRNLHOHMQK-UHFFFAOYSA-N 0.000 abstract 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003217 pyrazoles Chemical class 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos de pirazol, sus composiciones farmacéuticas y métodos de preparacion de los compuestos. Estos compuestos proveen un tratamiento para el cáncer. REIVINDICACION 1.- Un compuesto caracterizado porque responde a la Formula (I): donde: R1 se selecciona entre hidrogeno, hidroxi, amino, mercapto, C1-6alquilo, C2-6alquenilo, C2-6alquinilo, C1-6alcoxi, C1-6alcanoiloxi, N-(C1-6alquil)amino, N,N-(C1-6alquil)2amino, C1-6alcanoilamino, C1-6alquilsulfonilamino, carbociclilo de entre 3 y 5 miembros o heterociclilo de entre 3 y 5 miembros; donde R1 puede estar opcionalmente sustituido cobre carbono con uno o más R6; y donde si dicho heterociclilo contiene una porcion -NH- ese nitrogeno puede estar opcionalmente sustituido con un grupo seleccionado entre R7; R2 y R3 se seleccionan en forma independiente entre hidrogeno, halo, nitro, ciano, hidroxi, amino, carboxi, carbamoilo, mercapto, sulfamoilo, C1-6alquilo, C2-6alquenilo, C2-6alquinilo, C1-6alcoxi, C1-6alcanoilo, C1- 6alcanoiloxi, N-(C1-6alquil)amino; N,N-(C1-6alquil)amino, C1-6alcanoilamino, N-(C1-6alquil)carbamoilo, N,N-(C1-6alquil)2carbamoilo, C1-6alquilS(O)a donde a es entre 0 y 2, C1-6alcoxicarbonilo, N-(C1-6alquil)sulfamoilo, N,N-(C1-6alquil)2sulfamoilo, C1-6alquilsulfonilamino, carbociclil-R19- o heterociclil- R21-; donde R2 y R3 en forma independiente enter sí pueden estar opcionalmente sustituidos sobre carbono con uno o más R8; y donde si dicho heterociclilo contiene una porcion -NH- ese nitrogeno puede estar opcionalmente sustituido con un grupo seleccionado entre R9; R4 se selecciona entre ciano, carboxi, carbamoilo, C1-6alquilo, C2-6alquenilo, C2-6alquinilo, C1-6alcanoilo, N-(C1-6alquil)carbamoilo, N,N-(C1-6alquil)2carbamoilo, C1- 6alcoxicarbonilo, carbociclilo o heterociclilo; donde R4 puede estar opcionalmente sustituido sobre carbono con uno o más R10; y donde si dicho heterociclilo contiene una porcion -NH- ese nitrogeno puede estar opcionalmente sustituido con un grupo seleccionado entre R11; R5 se selecciona entre halo, nitro, ciano, hidroxi, amino, carboxi, carbamoilo, mercapto, sulfamoilo, C1-6alquilo, C2-6alquenilo, C2-6alquinilo, C1-6alcoxi, C1-6alcanoilo, C1-6alcanoiloxi, n-(C1-6alquil)amino, N,N-(C1- 6alquil)2amino, C1-6alcanoilamino, N-(C1-6alquil)carbamoilo, N,N-(C1-6alquil)2carbamoilo, C1-6alquilS(O)a donde a es entre 0 y 2, C1-6alcoxicarbonilo, N-(C1-6alquil)sulfamoilo, N,N-(C1-6alquil)2sulfamoilo, C1-6alquilsulfonilamino, carbociclilo o hterociclilo; donde R5 puede estar opcionalmente sustituido sobre carbono con uno o más R12; y donde si dicho heterociclico contiene una porcion -NH- ese nitrogeno puede estar opcionalmente sustituido con un grupo seleccionado entre R13; n = 1, 2 o 3; donde los valores de R5 pueden ser iguales o direfentes; R6, R8, R10 y R12 se seleccionan en forma independiente entre halo, nitro, ciano, hidroxi, amino, carboxi, carbamoilo, crecapto, sulfamoilo, C1-6anquilo, C2-6alquenilo, C2-6alquinilo, C- 16alcoxi, C1-6alcanoilo, C1-6alcanoiloxi, N-(C21-6alquill)amino, N,N-V1-6alquil)2amino; C1-6 alcanoilamino, N-(C1-6alquil)carbamoilo, N,N-(C1-6alquil)2carbamoilo, C1-6alquilS(O)a donde a es entre 0 y 2, C1-6alcoxicarbonilo, N-(C1-6alquil)sulfamoilo, N,N-(C1-6alquil)2sulfamoilo, C1-6alquilsulfonilamino, carbociclilo o heterociclilo; donde R6, R8, R10 y R12 en forma independiente entre sí pueden estar opcionalmente sustituidos sobre carbono con uno o más R14; y donde si dicho heterociclilo contiene una porcion -NH- ese nitrogeno puede estar opcionalmente sustituido con un grupo seleccionado entre R15; R7, R9, R11 y R15 se seleccionan en forma independiente entre C1-6alquilo, C1-6alcanoilo, C1-6alquilsulfonilo, C1-6alcoxicarbonilo, carbamoilo, N-(C1-6alquil)carbamoilo, N,N-(C1-6alquil)carbamoilo, bencilo, benciloxicarbonilo, benzoilo y fenilsulfonilo; donde R7, R9, R11, R13 y R15 en forma independiente entre sí pueden estar opcionalmente sustituidos sobre carbono con uno o más R16; R14 y R16 se seleccionan en forma independiente entre halo, nitro, ciano, hidroxi, amino, carboxi, carbamoilo, mercapto, sulfamoilo, C1-6alquilo, C2-6alquenilo, C2-6alquinilo, C1-6alcoxi, C1-6alcanoilo, C1-6alcanoiloxi, N-(C1-6alquil)amino, N,N-(C1-6)alquil)2amino, C1-6alcanoilamino, N-(C1-6alquil)carbamoilo, N,N-(C1-6alquil)2carbamoilo, C1-6alquilS(O)a donde a es entre 0 y 2, C1-6alcoxicarbonilo, N-(C1-6alquil)sulfamoilo, N,N-(C1-6alquil)2sulfamoilo, C1-6alquilsulfonilamino, carbociclilo o heterociclilo; donde R14 y R16 es forma independientemente entre sí pueden estar opcionalmente sustituidos sobre carbono con uno o más R17; y donde si dicho heterociclilo contiene una porcion -NH- ese nitrogeno puede estar opcionalmente sustituido con un grupo seleccionado entre R18; R17 se selecciona entre halo, nitro, ciano, hidroxi, trifluorometoxi, trifluorometilo, amino, carboxi, carbamoilo, mercapto, sulfamoilo, metilo, etilo, metoxi, etoxi, acetilo, acetoxi, metilamino, etilamino, dimetilamino, dietilamino, N-metil-N-etilamino, acetilamino, N-metilcarbamoilo, N-etilcarbamoilo, N,N-dimetilcarbamoilo, N,N-dietilcarbamoilo, N-metil-N-etilcarbamoilo, metiltio, etiltio, metilsulfinilo, etilsulfinilo, mesilo, etilsulfonilo, metoxicarbonilo, etoxicarbonilo, N-metilsulfamoilo, N-etilsulfamoilo, N,N-dimetilsulfamoilo, N,N-dietilsulfamoilo o N-metil-N-etilsulfamoilo; y R19 y R21 se seleccionanm en forma independiente entre un enlace directo, -O-, N(R22)- , - C(O)-, -N(R23)C(O)-, -C(O)N(R24)-, -S(O)s-, SO2N(R25)- o -N(R26)SO2-; donde R22, R23, R24, R25 y R26 se seleccionan en forma independiente entre hidrogeno o C1-6alquilo y s es 0-2; R18 se seleciona entre C1-6alquilo, C1-6alcanoilo, C1- 6alquinsulfonilo, C1-6 alcoxicarbonilo, carbamoilo, N-(C1-6alquil)carbamoilo, N,N-(C1-6alquil) carbamoilo, bencilo, benciloxicarbonilo, benzoilo y fenilsulfonilo; o una sl aceptable para uso farmacéutico del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68151505P | 2005-05-16 | 2005-05-16 | |
| US72228205P | 2005-09-30 | 2005-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR056354A1 true AR056354A1 (es) | 2007-10-03 |
Family
ID=37087720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060101974A AR056354A1 (es) | 2005-05-16 | 2006-05-16 | DERIVADOS DE PIRAZOL, UN MÉTODO DE PREPARACIoN DEL COMPUESTO, COMPOSICIoN FARMACÉUTICA Y PREPARACIoN DE UN MEDICAMENTO |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20080287437A1 (es) |
| EP (1) | EP1899323A2 (es) |
| JP (1) | JP2008540622A (es) |
| KR (1) | KR20080015409A (es) |
| AR (1) | AR056354A1 (es) |
| AU (1) | AU2006248780B2 (es) |
| BR (1) | BRPI0610184A2 (es) |
| CA (1) | CA2608009A1 (es) |
| IL (1) | IL186845A0 (es) |
| MX (1) | MX2007014328A (es) |
| NO (1) | NO20075647L (es) |
| NZ (1) | NZ564317A (es) |
| TW (1) | TW200716606A (es) |
| UY (1) | UY29530A1 (es) |
| WO (1) | WO2006123113A2 (es) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03005001A (es) * | 2000-12-05 | 2003-09-05 | Vertex Pharma | Inhibidores de n- terminal c-jun cinasas (jnk) y otras proteinas cinasas. |
| SI1846394T1 (sl) | 2005-02-04 | 2012-06-29 | Astrazeneca Ab | Pirazolilaminopiridinski derivati uporabni kot kinazni inhibitorji |
| BRPI0607455A2 (pt) | 2005-02-16 | 2009-09-01 | Astrazeneca Ab | composto, processo para a preparação do mesmo, uso de um composto, e composição farmacêutica |
| JP2008540622A (ja) * | 2005-05-16 | 2008-11-20 | アストラゼネカ アクチボラグ | 化合物 |
| EP1945631B8 (en) * | 2005-10-28 | 2013-01-02 | AstraZeneca AB | 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer |
| TW200823196A (en) * | 2006-11-01 | 2008-06-01 | Astrazeneca Ab | New use |
| WO2008117050A1 (en) * | 2007-03-27 | 2008-10-02 | Astrazeneca Ab | Pyrazolyl-amino-substituted pyrazines and their use for the treatment of cancer |
| WO2008129255A1 (en) * | 2007-04-18 | 2008-10-30 | Astrazeneca Ab | 5-aminopyrazol-3-yl-3h-imidazo [4,5-b] pyridine derivatives and their use for the treatment of cancer |
| WO2008132502A1 (en) * | 2007-04-25 | 2008-11-06 | Astrazeneca Ab | Pyrazolyl-amino-substituted pyrimidines and their use for the treatment of cancer |
| UA99459C2 (en) * | 2007-05-04 | 2012-08-27 | Астразенека Аб | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer |
| CN101687863B (zh) * | 2007-05-04 | 2012-09-12 | 阿斯利康(瑞典)有限公司 | 氨基-噻唑基-嘧啶衍生物及其治疗癌症的用途 |
| WO2009007753A2 (en) * | 2007-07-11 | 2009-01-15 | Astrazeneca Ab | 4- (3-aminopyrazole) -pyrimidine derivativee and their use as tyrosine kinase inhibitors for the treatment of cancer |
| WO2009013545A2 (en) * | 2007-07-26 | 2009-01-29 | Astrazeneca Ab | Chemical compounds |
| TW200906818A (en) * | 2007-07-31 | 2009-02-16 | Astrazeneca Ab | Chemical compounds |
| WO2009027736A2 (en) * | 2007-08-27 | 2009-03-05 | Astrazeneca Ab | 2,4 diaminopyrimid'lnes for the treatment of myeloproliferative disorders and cancer |
| WO2009056886A1 (en) * | 2007-11-01 | 2009-05-07 | Astrazeneca Ab | Pyrimidine derivatives and their use as modulators of fgfr activity |
| WO2009095712A2 (en) * | 2008-01-29 | 2009-08-06 | Astrazeneca Ab | Chemical compounds |
| TW201006830A (en) * | 2008-06-11 | 2010-02-16 | Astrazeneca Ab | Chemical compounds |
| US8450322B2 (en) | 2008-09-22 | 2013-05-28 | Array Biopharma Inc. | Substituted imidazo[1,2b]pyridazine compounds as Trk kinase inhibitors |
| MX2011003447A (es) * | 2008-09-30 | 2011-07-29 | Astrazeneca Ab | Inhibidores heterociclicos de jak quinasa. |
| KR102037619B1 (ko) | 2008-10-22 | 2019-10-28 | 어레이 바이오파마 인크. | ＴＲＫ 키나아제 억제제로서 치환된 피라졸로［１,５ａ］ 피리미딘 화합물 |
| EP2181980A1 (en) * | 2008-10-28 | 2010-05-05 | Chemo Ibérica, S.A. | A process for the preparation of (R)-1-aminoindanes |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| ES2628418T3 (es) | 2010-05-20 | 2017-08-02 | Array Biopharma, Inc. | Compuestos macrocíclicos como inhibidores de la TRK cinasa |
| WO2012050141A1 (ja) * | 2010-10-14 | 2012-04-19 | 住友化学株式会社 | ヘテロ芳香環化合物およびその有害生物防除用途 |
| US9102673B2 (en) | 2011-07-12 | 2015-08-11 | Merck Sharp & Dohme Corp. | Substituted pyrrolo[3,2-c]pyridines as TrkA kinase inhibitors |
| EP2554544A1 (en) | 2011-08-01 | 2013-02-06 | Almirall, S.A. | Pyridin-2(1h)-one derivatives as jak inhibitors |
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| KR20140103972A (ko) * | 2011-12-22 | 2014-08-27 | 에프. 호프만-라 로슈 아게 | 세린/트레오닌 키나아제 억제제로서의 2,4-다이아민-피리미딘 유도체 |
| EP2858501A4 (en) | 2012-05-22 | 2015-12-09 | Merck Sharp & Dohme | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHOD THEREFOR |
| WO2015017533A1 (en) | 2013-07-30 | 2015-02-05 | Blueprint Medicines Corporation | Ntrk2 fusions |
| WO2015039334A1 (en) | 2013-09-22 | 2015-03-26 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
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| BR112017025773A2 (en) | 2015-06-01 | 2018-08-14 | Loxo Oncology, Inc. | cancer diagnosis and treatment methods |
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- 2006-05-12 MX MX2007014328A patent/MX2007014328A/es unknown
- 2006-05-12 KR KR1020077026987A patent/KR20080015409A/ko not_active Ceased
- 2006-05-12 BR BRPI0610184-4A patent/BRPI0610184A2/pt not_active IP Right Cessation
- 2006-05-12 NZ NZ564317A patent/NZ564317A/en not_active IP Right Cessation
- 2006-05-12 EP EP06727105A patent/EP1899323A2/en not_active Withdrawn
- 2006-05-12 US US11/914,492 patent/US20080287437A1/en not_active Abandoned
- 2006-05-12 AU AU2006248780A patent/AU2006248780B2/en not_active Ceased
- 2006-05-12 WO PCT/GB2006/001760 patent/WO2006123113A2/en not_active Ceased
- 2006-05-15 UY UY29530A patent/UY29530A1/es unknown
- 2006-05-16 AR ARP060101974A patent/AR056354A1/es not_active Application Discontinuation
- 2006-05-16 TW TW095117309A patent/TW200716606A/zh unknown
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| US20100210648A1 (en) | 2010-08-19 |
| CA2608009A1 (en) | 2006-11-23 |
| UY29530A1 (es) | 2006-12-29 |
| MX2007014328A (es) | 2008-02-12 |
| KR20080015409A (ko) | 2008-02-19 |
| IL186845A0 (en) | 2008-02-09 |
| US8114989B2 (en) | 2012-02-14 |
| JP2008540622A (ja) | 2008-11-20 |
| NZ564317A (en) | 2011-01-28 |
| US20080287437A1 (en) | 2008-11-20 |
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| AU2006248780B2 (en) | 2010-06-03 |
| AU2006248780A1 (en) | 2006-11-23 |
| BRPI0610184A2 (pt) | 2012-09-25 |
| WO2006123113A3 (en) | 2007-01-04 |
| WO2006123113A2 (en) | 2006-11-23 |
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