AR066977A1 - Compuestos de piperidina y usos de los mismos - Google Patents
Compuestos de piperidina y usos de los mismosInfo
- Publication number
- AR066977A1 AR066977A1 ARP080102509A ARP080102509A AR066977A1 AR 066977 A1 AR066977 A1 AR 066977A1 AR P080102509 A ARP080102509 A AR P080102509A AR P080102509 A ARP080102509 A AR P080102509A AR 066977 A1 AR066977 A1 AR 066977A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- methyl
- cyano
- amino
- heterocyclyl
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- -1 methoxy, ethoxy, propoxy Chemical group 0.000 abstract 24
- 229910052757 nitrogen Inorganic materials 0.000 abstract 12
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 11
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000000623 heterocyclic group Chemical group 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 4
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 3
- 125000004760 (C1-C4) alkylsulfonylamino group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 2
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 2
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000005153 alkyl sulfamoyl group Chemical group 0.000 abstract 1
- 125000005336 allyloxy group Chemical group 0.000 abstract 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004452 carbocyclyl group Chemical group 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000006125 ethylsulfonyl group Chemical group 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- KDGKTJGPFXIBEB-UHFFFAOYSA-N n-hydroxyformamide Chemical compound > KDGKTJGPFXIBEB-UHFFFAOYSA-N 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Compuestos de la formula (1) y sus sales aceptables para uso farmacéutico. También se describen procesos para su preparacion, composiciones que los contienen, su uso como medicamentos y su uso en el tratamiento de infecciones bacterianas. Reivindicacion 1: Un compuesto caracterizado porque es de formula (1); R1 es cloro o ciano; R2' es hidrogeno, cloro, ciano o metilo; R3 es fluoro, metilo, metoxi, etoxi, propoxi, aliloxi y benciloxi: R4 es hidrogeno o alquilo C1-4; el anillo A es carbociclilo o heterociclilo; en donde si dicho heterociclilo contiene una porcion -NH- dicho nitrogeno puede estar opcionalmente sustituido con un grupo seleccionado entre R6; y en donde si dicho heterociclilo contiene una porcion -N= dicho nitrogeno puede formar un compuesto cuaternario con un grupo metilo; R5 es un sustituyente sobre carbono y se selecciona entre halo, nitro, ciano, hidroxi, amino, carboxi, carbamoilo, mercapto, sulfamoilo, sulfo, formilo, ureido, hidroxiiminometilo, N-hidroxiformamido, hidrazinocarbonilo, N-hidroxietanimidoilo, amino(hidroxiimino)metilo, aIquilo C1-4, alquenilo C2-4, alquinilo C2-4, aIcoxi C1-4, alcanoilo C1-4, alcanoiloxi C1-4, N-alquil C1-4amino, N,N-(alquil C1-4)2amino, alcanoilamino C1-4, N-alquil C1-4carbamoilo, N,N-(alquil C1-4)2carbamoilo, N-alcoxi C1-4carbamoilo, N'-alquil C1-4ureido, N',N'-(alquil C1-4)2ureido, N-alquil C1-4-N-alcoxi C1-4carbamoilo, aIquil C1-4S(O)a en donde a es entre 0 y 2, alcoxicarbonilo C1-4, alcoxicarbonilamino C1-4, N-alquiI C1-4sulfamoilo, N,N-(alquil C1-4)2sulfamoilo, alquilsulfonilamino C1-4, alquilsulfonilaminocarbonilo C1-4, N'-alquil C1-4hidrazinocarbonilo, N',N'-(alquil C1-4)2hidrazinocarbonilo, carbociclil-R7- o heterociclil-R8-; en donde R5 se puede sustituir opcionalmente sobre carbono con uno o más R9, y en donde si dicho heterociclilo contiene una porcion -NH- dicho nitrogeno puede estar opcionalmente sustituido con un grupo seleccionado entre R10; n es 0,1, 2, o 3; R9 se selecciona entre halo, nitro, ciano, hidroxi. amino, carboxi, carbamoilo, mercapto, sulfamoilo, aIquilo C1-4, alquenilo C2-4, alquinilo C2-4, aIcoxi C1-4, alcanoilo C1-4, alcanoiloxi C1-4, N-alquil C1-4amino, N,N-(alquil C1-4)2amino, alcanoilamino C1-4, N-alquil C1-4carbamoilo, N,N-(alquil C1-4)2carbamoilo, alquil C1-4S(O)a en donde a es entre 0 y 2, alcoxicarbonilo C1-4, N-alquiI C1-4sulfamoilo, N,N-(alquil C1-4)2sulfamoilo, alquilsulfonilamino C1-4,alcoxicarbonilamino C1-4, carbociclil-R11- o heterociclil-R12-; en donde R9 se puede sustituir opcionalmente sobre carbono con uno o más R13, y en donde si dicho heterociclilo contiene una porcion -NH- dicho nitrogeno puede estar opcionalmente sustituido con un grupo seleccionado entre R14; R6, R10 y R14 se seleccionan en forma independiente entre alquilo C1-4, alcanoilo C1-4, alquilsulfonilo C1-4, alcoxicarbonilo C1-4, carbamoilo, N-alquil C1-4carbamoilo, N,N-alquil C1-4carbamoilo, bencilo, benciloxicarbonilo. benzoilo y fenilsulfonilo; en donde R6, R10 y R14 se pueden sustituir opcionalmente en forma independiente sobre carbono con un grupo seleccionado entre R20; R7, R8, R11 y R12 se seleccionan en forma independiente entre un enlace directo, -O-, -N(R15)-, -C(O)-, -N(R16)C(O)-, -C(O)N(R17)-, -S(O)p-, -SO2N(R18)- o -N(R19)SO2-; en donde R15, R16, R17, R18 y R19 se seleccionan en forma independiente entre hidrogeno o aIquiIo C1-4 y p es 0-2; R13 y R20 se seleccionan en forma independiente entre halo, nitro, ciano, hidroxi, trifluorometoxi, trifluorometilo, amino, carboxi, carbamoilo, mercapto. sulfamoilo, metilo, etilo, etenilo, etinilo, metoxi, etoxi, 2-trimetilsililetoxi, acetilo, acetoxi, metilamino, etilamino, dimetilamino, dietilamino, N-metil-N-etilamino, acetilamino, N-metilcarbamoilo, N-etilcarbamoilo, N,N-dimetilcarbamoilo, N,N-dietilcarbamoilo, N-metil-N-etilcarbamoilo, metiltio, etiltio, metilsulfinilo, etilsulfinilo, mesilo, etilsulfonilo, metoxicarbonilo, etoxicarbonilo, N-metilsulfamoilo, N-etilsulfamoilo, N,N-dimetilsulfamoilo, N,N-dietilsulfamoilo o N-metil-N-etilsulfamoilo; o una sal aceptable para uso farmacéutico del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94344007P | 2007-06-12 | 2007-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR066977A1 true AR066977A1 (es) | 2009-09-23 |
Family
ID=39673349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080102509A AR066977A1 (es) | 2007-06-12 | 2008-06-12 | Compuestos de piperidina y usos de los mismos |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US20080312255A1 (es) |
| EP (1) | EP2158199B1 (es) |
| JP (1) | JP2010529184A (es) |
| KR (1) | KR20100038095A (es) |
| CN (1) | CN102648199A (es) |
| AR (1) | AR066977A1 (es) |
| AT (1) | ATE488514T1 (es) |
| AU (1) | AU2008263580A1 (es) |
| BR (1) | BRPI0812473A2 (es) |
| CA (1) | CA2689076A1 (es) |
| CL (1) | CL2008001740A1 (es) |
| CO (1) | CO6311102A2 (es) |
| CY (1) | CY1111442T1 (es) |
| DE (1) | DE602008003575D1 (es) |
| DK (1) | DK2158199T3 (es) |
| ES (1) | ES2354647T3 (es) |
| HR (1) | HRP20110048T1 (es) |
| IL (1) | IL202367A0 (es) |
| MX (1) | MX2009013501A (es) |
| NZ (1) | NZ582516A (es) |
| PE (1) | PE20090555A1 (es) |
| PL (1) | PL2158199T3 (es) |
| PT (1) | PT2158199E (es) |
| RU (1) | RU2010100352A (es) |
| SA (1) | SA08290357B1 (es) |
| SI (1) | SI2158199T1 (es) |
| TW (1) | TW200906412A (es) |
| UY (1) | UY31141A1 (es) |
| WO (1) | WO2008152418A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2598423C (en) | 2005-02-18 | 2014-05-27 | Astrazeneca Ab | Antibacterial piperidine derivatives |
| TW201026695A (en) * | 2008-12-12 | 2010-07-16 | Astrazeneca Ab | Piperidine compounds and uses thereof-596 |
| TW201026694A (en) * | 2008-12-12 | 2010-07-16 | Astrazeneca Ab | Compound 468 |
| WO2011024004A1 (en) | 2009-08-26 | 2011-03-03 | Astrazeneca Ab | Heterocyclic urea derivatives useful for treatment of bacterial infection |
| WO2014164195A1 (en) | 2013-03-13 | 2014-10-09 | Avon Products, Inc | Tyrosinase inhibitors |
| WO2014164200A1 (en) | 2013-03-13 | 2014-10-09 | Avon Products, Inc | Tyrosinase inhibitors |
| ES2817749T3 (es) | 2015-09-30 | 2021-04-08 | Daiichi Sankyo Co Ltd | Derivados de hidroxialquil tiadiazol |
| EP3596071A1 (en) | 2017-03-14 | 2020-01-22 | Daiichi Sankyo Company, Limited | N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives |
| WO2018174288A1 (ja) | 2017-03-24 | 2018-09-27 | 大正製薬株式会社 | ２（１ｈ）－キノリノン誘導体 |
| WO2020048949A1 (en) | 2018-09-03 | 2020-03-12 | Univerza V Ljubljani | New class of dna gyrase and/or topoisomerase iv inhibitors with activity against gram-positive and gram-negative bacteria |
| CN110172435B (zh) * | 2019-06-06 | 2020-12-29 | 江南大学 | 一种催化合成2,5-二甲基吡嗪的重组菌 |
| US20250002455A1 (en) | 2020-12-17 | 2025-01-02 | Univerza V Ljubljani | New n-phenylpyrrolamide inhibitors of dna gyrase and topoisomerase iv with antibacterial activity |
| CN115466246B (zh) * | 2021-06-11 | 2024-02-06 | 中国医学科学院药物研究所 | 吡咯酰哌啶胺类化合物及其用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4046775A (en) * | 1973-04-11 | 1977-09-06 | Sterling Drug Inc. | 4,5-Dihalopyrrole-2-carboxamides |
| US3963480A (en) * | 1973-04-11 | 1976-06-15 | Sterling Drug Inc. | Herbicidal pyrrole-2-carboxamides |
| US4791112A (en) * | 1987-02-02 | 1988-12-13 | The Boc Group, Inc. | N-heterocyclic-N-(4-piperidyl)amides and pharmaceutical compositions and methods employing such compounds |
| US4912109A (en) * | 1987-02-02 | 1990-03-27 | Boc, Inc. | N-heterocyclic-N-(4-piperidinyl) amides and pharmaceutical compositions and methods employing such compounds |
| US5739135A (en) * | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| CN1230166C (zh) * | 2000-01-18 | 2005-12-07 | 沃泰克斯药物股份有限公司 | 回旋酶抑制剂及其用途 |
| US7727992B2 (en) * | 2002-06-13 | 2010-06-01 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
| TW200526626A (en) * | 2003-09-13 | 2005-08-16 | Astrazeneca Ab | Chemical compounds |
| GB0321509D0 (en) * | 2003-09-13 | 2003-10-15 | Astrazeneca Ab | Chemical compounds |
| US20050197336A1 (en) * | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
| US7345043B2 (en) * | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
| CA2598423C (en) * | 2005-02-18 | 2014-05-27 | Astrazeneca Ab | Antibacterial piperidine derivatives |
| TW200819437A (en) * | 2006-08-17 | 2008-05-01 | Astrazeneca Ab | Chemical compounds |
-
2008
- 2008-06-10 TW TW097121574A patent/TW200906412A/zh unknown
- 2008-06-11 WO PCT/GB2008/050431 patent/WO2008152418A1/en not_active Ceased
- 2008-06-11 HR HR20110048T patent/HRP20110048T1/hr unknown
- 2008-06-11 PL PL08762541T patent/PL2158199T3/pl unknown
- 2008-06-11 DE DE602008003575T patent/DE602008003575D1/de active Active
- 2008-06-11 PT PT08762541T patent/PT2158199E/pt unknown
- 2008-06-11 CA CA002689076A patent/CA2689076A1/en not_active Abandoned
- 2008-06-11 CN CN200880102731XA patent/CN102648199A/zh active Pending
- 2008-06-11 MX MX2009013501A patent/MX2009013501A/es active IP Right Grant
- 2008-06-11 JP JP2010511728A patent/JP2010529184A/ja active Pending
- 2008-06-11 AU AU2008263580A patent/AU2008263580A1/en not_active Abandoned
- 2008-06-11 ES ES08762541T patent/ES2354647T3/es active Active
- 2008-06-11 SA SA08290357A patent/SA08290357B1/ar unknown
- 2008-06-11 NZ NZ582516A patent/NZ582516A/en not_active IP Right Cessation
- 2008-06-11 KR KR1020107000577A patent/KR20100038095A/ko not_active Withdrawn
- 2008-06-11 US US12/136,884 patent/US20080312255A1/en not_active Abandoned
- 2008-06-11 EP EP08762541A patent/EP2158199B1/en active Active
- 2008-06-11 RU RU2010100352/04A patent/RU2010100352A/ru not_active Application Discontinuation
- 2008-06-11 UY UY31141A patent/UY31141A1/es not_active Application Discontinuation
- 2008-06-11 AT AT08762541T patent/ATE488514T1/de active
- 2008-06-11 SI SI200830133T patent/SI2158199T1/sl unknown
- 2008-06-11 BR BRPI0812473-6A2A patent/BRPI0812473A2/pt not_active IP Right Cessation
- 2008-06-11 DK DK08762541.4T patent/DK2158199T3/da active
- 2008-06-12 AR ARP080102509A patent/AR066977A1/es not_active Application Discontinuation
- 2008-06-12 PE PE2008001008A patent/PE20090555A1/es not_active Application Discontinuation
- 2008-06-12 CL CL2008001740A patent/CL2008001740A1/es unknown
-
2009
- 2009-11-26 IL IL202367A patent/IL202367A0/en unknown
-
2010
- 2010-01-08 CO CO10001889A patent/CO6311102A2/es not_active Application Discontinuation
-
2011
- 2011-01-19 CY CY20111100058T patent/CY1111442T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ582516A (en) | 2012-03-30 |
| CN102648199A (zh) | 2012-08-22 |
| PT2158199E (pt) | 2011-01-19 |
| HRP20110048T1 (hr) | 2011-03-31 |
| ATE488514T1 (de) | 2010-12-15 |
| US20080312255A1 (en) | 2008-12-18 |
| MX2009013501A (es) | 2010-01-18 |
| PE20090555A1 (es) | 2009-06-04 |
| SA08290357B1 (ar) | 2011-06-22 |
| CY1111442T1 (el) | 2015-08-05 |
| SI2158199T1 (sl) | 2011-02-28 |
| EP2158199B1 (en) | 2010-11-17 |
| ES2354647T3 (es) | 2011-03-16 |
| EP2158199A1 (en) | 2010-03-03 |
| DE602008003575D1 (de) | 2010-12-30 |
| BRPI0812473A2 (pt) | 2014-12-02 |
| AU2008263580A1 (en) | 2008-12-18 |
| JP2010529184A (ja) | 2010-08-26 |
| CL2008001740A1 (es) | 2009-07-17 |
| UY31141A1 (es) | 2009-01-30 |
| IL202367A0 (en) | 2010-06-30 |
| CA2689076A1 (en) | 2008-12-18 |
| WO2008152418A1 (en) | 2008-12-18 |
| TW200906412A (en) | 2009-02-16 |
| KR20100038095A (ko) | 2010-04-12 |
| CO6311102A2 (es) | 2011-08-22 |
| DK2158199T3 (da) | 2011-02-07 |
| HK1140198A1 (en) | 2010-10-08 |
| RU2010100352A (ru) | 2011-07-20 |
| PL2158199T3 (pl) | 2011-04-29 |
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