AR040408A1 - Derivados de benzotiadiazepina, procesos para su preparacion y composiciones farmaceuticas que los contienen - Google Patents
Derivados de benzotiadiazepina, procesos para su preparacion y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR040408A1 AR040408A1 AR20030101448A ARP030101448A AR040408A1 AR 040408 A1 AR040408 A1 AR 040408A1 AR 20030101448 A AR20030101448 A AR 20030101448A AR P030101448 A ARP030101448 A AR P030101448A AR 040408 A1 AR040408 A1 AR 040408A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- carbamoyl
- heterocyclyl
- hydrogen
- sulfamoyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 38
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 33
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 28
- -1 hydroxy, amino, mercapto Chemical group 0.000 abstract 27
- 229910052739 hydrogen Inorganic materials 0.000 abstract 15
- 239000001257 hydrogen Substances 0.000 abstract 15
- 125000000623 heterocyclic group Chemical group 0.000 abstract 13
- 125000002947 alkylene group Chemical group 0.000 abstract 11
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 11
- 125000001589 carboacyl group Chemical group 0.000 abstract 11
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 229910052799 carbon Inorganic materials 0.000 abstract 9
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 8
- 125000001475 halogen functional group Chemical group 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 7
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 7
- 150000002431 hydrogen Chemical group 0.000 abstract 6
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 abstract 5
- 125000004452 carbocyclyl group Chemical group 0.000 abstract 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 5
- 125000001424 substituent group Chemical group 0.000 abstract 5
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 239000012453 solvate Substances 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 3
- 125000005884 carbocyclylalkyl group Chemical group 0.000 abstract 3
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 abstract 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 239000003613 bile acid Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
- MRJJQAVHEGLQJJ-UHFFFAOYSA-N n-formylacetamide Chemical compound CC(=O)NC=O MRJJQAVHEGLQJJ-UHFFFAOYSA-N 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/36—Seven-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Surgery (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Compuestos de fórmula (1) y sus sales aceptables para uso farmacéutico, solvatos, solvatos de dichas sales y prodrogas del mismo, así como su uso como inhibidores del transporte ileal de ácidos biliares (IBAT) para el tratamiento de la hiperlipidemia. Procesos para su fabricación y composiciones farmacéuticas que los contienen. Reivindicación 1: Un compuesto caracterizado porque responde a la fórmula (1) donde: Rv se selecciona entre hidrógeno o alquilo C1-6; uno de R1 y R2 se selecciona entre hidrógeno o alquilo C1-6 y el otro se selecciona entre alquilo C1-6; Rx y Ry se seleccionan en forma independiente entre hidrógeno, hidroxi, amino, mercapto, alquilo C1-6, C1-6alcoxi, N- (alquil C1-6)amino, NN-(alquil C1-6)2amino, alquilo C1-6S(O)a donde a es entre 0 y 2; RZ se selecciona entre halo, nitro, ciano, hidroxi, amino, carboxi, carbamoilo, mercapto, sulfamoilo, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, alcoxi C1-6, alcanoilo C1-6, alcanoiloxi C1-6, N(alquil C1-6)amino, N,N-(alquil C1-6)2amino, alcanoil C1-6amino, N-(alquil C1-6)carbamoilo, N,N-(alquil C1-6)2carbamoilo, alquilo C1-6S(O)a donde a es entre 0 y 2, alcoxi C1-6carbonilo, N(alquil C1-6)sulfamoilo y N,N-(alquil C1-6)2sulfamoilo; v es 0-5; uno de R4 y R5 es un grupo de fórmula (2); R3 y R6 y el otro de R4 y R5 se seleccionan en forma independiente entre hidrógeno, halo, nitro, ciano, hidroxi, amino, carboxi, carbamoilo, mercapto, sulfamoilo, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, alcoxi C1-6, alcanoilo C1-6, alcanoiloxi C1-6, N-(alquil C1-6)amino, N,N-(alquil C1-6)2amino, alcanoil C1-6amino, N-(alquil C1-6)carbamoilo, N,N-(alquil C1-6)2carbamoilo, alquilo C1-6S(O)a donde a es entre 0 y 2, alcoxi C1-6carbonilo, N (alquil C1-6)sulfamoilo y N,N-(alquil C1-6)2sulfamoilo; donde R3 y R6 y el otro de R4 y R5 pueden ser substituidos opcionalmente sobre carbono por uno o más R17; X es -O-, -N(Ra)-, -S(O)b- o -CH(Ra)-; donde Ra es hidrógeno o alquilo C1-6 y b es 0-2; el anillo A es arilo o heteroarilo; donde el anillo A es opcionalmente substituido sobre carbono por uno o más substituyentes seleccionados entre R18; R7 es hidrógeno, alquilo C1-6, carbociclilo o heterociclilo; donde R7 es opcionalmente substituido sobre carbono por uno o más substituyentes seleccionados entre R19; y donde si dicho heterociclilo contiene un grupo -NH-, dicho nitrógeno puede ser opcionalmente substituido por un grupo seleccionado entre R20; R8 es hidrógeno o alquilo C1-6; R9 es hidrógeno o alquilo C1-6; R10 es hidrógeno, halo, nitro, ciano, hidroxi, amino, carbamoilo, mercapto, sulfamoilo, hidroxiaminocarbonilo, alquilo C1-10, alquenilo C2-10, alquinilo C2-10, alcoxi C1-10, alcanoilo C1-10, alcanoiloxi C1-10, N-(alquil C1-10)amino, N,N-(alquil C1-10)2amino, N,N,N(alquil C1-10)3amonio, alcanoil C1-10amino, N-(alquil C1-10)carbamoilo, N,N(alquil C1-10)2carbamoilo, alquilo C1-10S(O)a donde a es entre 0 y 2, N-(alquil C1-10)sulfamoilo, N,N-(alquil C1-10)2sulfamoilo, N-(alquil C1-10)sulfamoiloamino, N,N(alquil C1-10)2sulfamoiloamino, alcoxi C1-10carbonilamino, carbociclilo, carbociclilalquilo C1-10, heterociclilo, heterociclilalquilo C1-10, carbociclil-(alquilen C1-10)p-R21-(alquileno C1-10)q- o heterociclil-(alquilen C1-10)r-R22-(alquileno C1-10)s-; donde R10 es opcionalmente substituido sobre carbono por uno o más substituyentes seleccionados entre R23; y donde si dicho heterociclilo contiene un grupo -N-, dicho nitrógeno puede ser opcionalmente substituido por un grupo seleccionado entre R24; o R10 es un grupo de fórmula (3), donde R11 es hidrógeno o alquilo C1-6; R12 y R13 se seleccionan en forma independiente entre hidrógeno, halo, carbamoilo, sulfamoilo, alquilo C1-10, alquenilo C2-10, alquinilo C2-10, alcanoilo C1-10, N-(alquil C1-10)carbamoilo, N,N-(alquil C1-10)2carbamoilo, alquilo C1-10S(O)a donde a es entre 0 y 2, N-(alquil C1-10)sulfamoilo, N,N-(alquil C1-10)2sulfamoilo, N-(alquil C1-10)sulfamoilamino, N,N-(alquil C1-10)2sulfamoilamino, carbociclilo o heterociclilo; donde R12 y R13 pueden ser opcionalmente substituidos en forma independiente sobre carbono por uno o más substituyentes seleccionados entre R25; y donde si dicho heterociclilo contiene un grupo -N-, dicho nitrógeno puede ser opcionalmente substituido por un grupo seleccionado entre R26; R14 se selecciona entre hidrógeno, halo, carbamoilo, sulfamoilo, hidroxiaminocarbonilo, alquilo C1-10, alquenilo C2-10, alquinilo C2-10, alcanoilo C1-10, N (alquil C1-10)carbamoilo, N,N-(alquil C1-10)2carbamoilo, alquilo C1-10S(O)a donde a es entre 0 y 2, N-(alquil C1-10)sulfamoilo, N,N-(alquil C1-10)2sulfamoilo, N-(alquil C1-10) sulfamoilamino, N,N(alquil C1-10)2sulfamoilamino, carbociclilo, carbociclilalquilo C1-10, heterociclilo, heterociclilalquilo C1-10, carbociclil-(alquilen C1-10)p-R27-(alquileno C1-10)q- o heterociclilalquilen C1-10)r-R28-(alquileno C1-10)s-; donde R14 puede ser opcionalmente substituido sobre carbono por uno o más substituyentes seleccionados entre R29; y donde si dicho heterociclilo contiene un grupo -N-, dicho nitrógeno puede ser opcionalmente substituido por un grupo seleccionado entre R30; o R14 es un grupo de fórmula (4), donde R15 es hidrógeno o alquilo C1-6; y R16 es hidrógeno o alquilo C1-6; donde R16 puede ser opcionalmente substituido sobre carbono por uno o más grupos seleccionados entre R31; o R15 y R16 juntos con el nitrógeno al cual están unidos forman un heterociclilo; donde dicho heterociclilo puede ser opcionalmente substituido sobre carbono por uno o más R37; y donde si dicho heterociclilo contiene un grupo -N-, dicho nitrógeno puede ser opcionalmente substituido por un grupo seleccionado entre R38; n es 1-3; donde los valores de R7 pueden ser iguales o diferentes; R17, R18, R19, R23, R25, R29, R31 y R37 se seleccionan en forma independiente entre halo, nitro, ciano, hidroxi, amino, carbamoilo, mercapto, sulfamoilo, hidroxiaminocarbonilo, alquilo C1-10, alquenilo C2-10, alquinilo C2-10, alcoxi C1-10, alcanoilo C1-10, alcanoiloxi C1-10, N(alquil C1-10)amino, N,N-(alquil C1-10)2amino, N,N,N-(alquil C1-10)3amonio, alcanoil C1-10amino, N-(alquil C1-10)carbamoilo, N,N-(alquil C1-10)2carbamoilo, alquilo C1-10S(O)a donde a es entre 0 y 2, N-(alquil C1-10)sulfamoilo, N,N-(alquil C1-10)2sulfamoilo, N-(alquil C1-10)sulfamoilamino, N,N-(alquil C1-10)2sulfamoilamino, alcoxi C1-10carbonilamino, carbociclilo, carbociclilalquilo C1-10, heterociclilo, heterociclilalquilo C1-10, carbociclilo-(alquilen C1-10)p-R32-(alquileno C1-10)q- o heterociclilo-(alquilen C1-10)r-R33-(alquileno C1-10)s-; donde R17, R18, R19, R23, R25, R29, R31 y R37 pueden ser opcionalmente substituidos en forma independiente sobre carbono por uno o más R34; y donde si dicho heterociclilo contiene un grupo -N-, dicho nitrógeno puede ser opcionalmente substituido por un grupo seleccionado entre R35; R21, R22, R27, R28, R32 o R33 se seleccionan en forma independiente entre -O-, -NR36-, -S(O)x-, -NR36C(O)NR36-, -NR36C(S)RN36-, -OC(O)N=C-, -NR36C(O)- o -C(O)NR36-; donde R36 se selecciona entre hidrógeno o alquilo C1-6, y x es 0-2; p, q, r y s se seleccionan en forma independiente entre 0-2; R34 se selecciona entre halo, hidroxi, ciano, carbamoilo, ureido, amino, nitro, mercapto, sulfamoilo, trifluorometilo, trifluorometoxi, metilo, etilo, metoxi, etoxi, vinilo, alilo, etinilo, formilo, acetilo formamido, acetilamino, acetoxi, metilamino, dimetilamino, N-metilcarbamoilo, N,N-dimetilcarbamoilo, metiltio, metilsulfinilo, mesilo, N-metilsulfamoilo, N,N-dimetilsulfamoilo, N-metilsulfamoilamino y N,N-dimetilsulfamoilamino; R20, R24, R26, R30, R35 y R36 se seleccionan en forma independiente entre alquilo C1-6, alcanoilo C1-6, alquil C1-6sulfonilo, alcoxi C1-6carbonilo, carbamoilo, N-(alquil C1-6)carbamoilo, N,N-(dialquil C1-6)carbamoilo, bencilo, benciloxicarbonilo, benzoilo y fenilsulfonilo; o una sal aceptable para uso farmacéutico, solvato, solvato de dicha sal o una prodroga del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0209467.0A GB0209467D0 (en) | 2002-04-25 | 2002-04-25 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR040408A1 true AR040408A1 (es) | 2005-04-06 |
Family
ID=9935492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR20030101448A AR040408A1 (es) | 2002-04-25 | 2003-04-25 | Derivados de benzotiadiazepina, procesos para su preparacion y composiciones farmaceuticas que los contienen |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7238684B2 (es) |
| EP (1) | EP1501813B1 (es) |
| JP (1) | JP4475960B2 (es) |
| KR (1) | KR20050007329A (es) |
| CN (1) | CN100408567C (es) |
| AR (1) | AR040408A1 (es) |
| AU (1) | AU2003226565A1 (es) |
| BR (1) | BR0309493A (es) |
| CA (1) | CA2483155A1 (es) |
| ES (1) | ES2434098T3 (es) |
| GB (1) | GB0209467D0 (es) |
| IL (1) | IL164798A0 (es) |
| IS (1) | IS7543A (es) |
| MX (1) | MXPA04010597A (es) |
| NO (1) | NO20044597L (es) |
| NZ (1) | NZ536105A (es) |
| PL (1) | PL372998A1 (es) |
| RU (1) | RU2333205C2 (es) |
| TW (1) | TW200306844A (es) |
| UA (1) | UA77797C2 (es) |
| UY (1) | UY27779A1 (es) |
| WO (1) | WO2003091232A2 (es) |
| ZA (1) | ZA200408548B (es) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
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| IL164798A0 (en) | 2005-12-18 |
| US7238684B2 (en) | 2007-07-03 |
| JP4475960B2 (ja) | 2010-06-09 |
| PL372998A1 (en) | 2005-08-08 |
| CA2483155A1 (en) | 2003-11-06 |
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