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AR037069A2 - Un nuevo derivado de la quinolin-4-carboxamida, la n-(alfa-etilbencil)-3-hidroxi-2-fenilquinolin-4-carboxamida, una composicion farmaceutica que lo contiene y su uso para la fabricacion de medicamentos - Google Patents

Un nuevo derivado de la quinolin-4-carboxamida, la n-(alfa-etilbencil)-3-hidroxi-2-fenilquinolin-4-carboxamida, una composicion farmaceutica que lo contiene y su uso para la fabricacion de medicamentos

Info

Publication number
AR037069A2
AR037069A2 ARP000103117A ARP000103117A AR037069A2 AR 037069 A2 AR037069 A2 AR 037069A2 AR P000103117 A ARP000103117 A AR P000103117A AR P000103117 A ARP000103117 A AR P000103117A AR 037069 A2 AR037069 A2 AR 037069A2
Authority
AR
Argentina
Prior art keywords
carboxamide
disorders
phenylquinolin
manufacture
compound
Prior art date
Application number
ARP000103117A
Other languages
English (en)
Original Assignee
Smithkline Beecham Farma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT94MI001099A external-priority patent/ITMI941099A1/it
Priority claimed from IT95MI000494 external-priority patent/IT1293558B1/it
Application filed by Smithkline Beecham Farma filed Critical Smithkline Beecham Farma
Publication of AR037069A2 publication Critical patent/AR037069A2/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632—Organic additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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Abstract

El compuesto N-(alfa-etilbencil)-3-hidroxi-2-fenilquinolin-4-carboxamida, caracterizado por la fórmula (1) en donde: Ar es fenilo; R es etilo; R1, R2 y R3 son hidrógeno; R4 es hidroxi; R5 es fenilo; y X es O, ó una sal ó un solvato del mismo. La forma estereoquímica (S) de este compuesto es especialmente potente como sustancia activa para el tratamiento y/o la profilaxis de trastornos pulmonares, trastornos y picazón de la piel, inflamación neurogénica y trastornos del SNC, trastornos convulsivos, epilepsia, trastornos renales, incontinencia urinaria, inflamación ocular, dolor inflamatorio, trastornos alimenticios, rinitis alérgicas, trastornos neurodegenerativos, soriasis, enfermedad de Huntington, ó depresión. La presente también se refiere a composiciones farmacéuticas que contienen dicho compuesto y al uso del mismo para la fabricación de un medicamento.
ARP000103117A 1994-05-27 2000-06-22 Un nuevo derivado de la quinolin-4-carboxamida, la n-(alfa-etilbencil)-3-hidroxi-2-fenilquinolin-4-carboxamida, una composicion farmaceutica que lo contiene y su uso para la fabricacion de medicamentos AR037069A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT94MI001099A ITMI941099A1 (it) 1994-05-27 1994-05-27 Derivati chinolinici
IT95MI000494 IT1293558B1 (it) 1995-03-14 1995-03-14 Derivati chinolinici

Publications (1)

Publication Number Publication Date
AR037069A2 true AR037069A2 (es) 2004-10-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000103117A AR037069A2 (es) 1994-05-27 2000-06-22 Un nuevo derivado de la quinolin-4-carboxamida, la n-(alfa-etilbencil)-3-hidroxi-2-fenilquinolin-4-carboxamida, una composicion farmaceutica que lo contiene y su uso para la fabricacion de medicamentos

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US (5) US6608083B1 (es)
EP (2) EP0804419B1 (es)
JP (5) JP3664492B2 (es)
KR (1) KR100316571B1 (es)
CN (3) CN1092642C (es)
AP (1) AP578A (es)
AR (1) AR037069A2 (es)
AT (2) ATE246677T1 (es)
AU (1) AU699319B2 (es)
BG (2) BG64004B1 (es)
BR (1) BR9507788A (es)
CA (1) CA2191352C (es)
CZ (1) CZ291476B6 (es)
DE (2) DE69531458T2 (es)
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IL (1) IL113844A (es)
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MY (1) MY129596A (es)
NO (2) NO307783B1 (es)
NZ (1) NZ287442A (es)
OA (1) OA10592A (es)
PL (2) PL186665B1 (es)
PT (2) PT804419E (es)
RO (1) RO114445B1 (es)
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SK (2) SK282721B6 (es)
TW (2) TW427977B (es)
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Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69531458T2 (de) * 1994-05-27 2004-08-05 Glaxosmithkline S.P.A. Chinolinderivate als tachykinin nk3 rezeptor antagonisten
GB9524104D0 (en) * 1995-11-24 1996-01-24 Smithkline Beecham Spa Novel compounds
AR004735A1 (es) * 1995-11-24 1999-03-10 Smithkline Beecham Spa Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento.
GB9524137D0 (en) 1995-11-24 1996-01-24 Smithkline Beecham Spa Novel compounds
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