TW427977B - Quinoline derivatives - Google Patents

Quinoline derivatives

Info

Publication number: TW427977B
Authority: TW; Taiwan
Prior art keywords: quinoline derivatives; disorders; useful; formula; inter alia
Prior art date: 1994-05-27

Application number

TW084105319A

Other languages

English (en)

Inventor

Carlo Farina

Giuseppe Arnaldo Mari Giardina

Mario Grugni

Luca Francesco Raveglia

Original Assignee

Smithkline Beecham Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-27

Filing date

1995-05-26

Publication date

2001-04-01

1994-05-27 Priority claimed from IT94MI001099A external-priority patent/ITMI941099A1/it

1995-03-14 Priority claimed from ITMI950494 external-priority patent/IT1293558B1/it

1995-05-26 Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa

2001-04-01 Application granted granted Critical

2001-04-01 Publication of TW427977B publication Critical patent/TW427977B/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pulmonology (AREA)
Manufacturing & Machinery (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Ceramic Engineering (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Inorganic Chemistry (AREA)
Psychology (AREA)
Materials Engineering (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Structural Engineering (AREA)
Hospice & Palliative Care (AREA)
Nutrition Science (AREA)
Gastroenterology & Hepatology (AREA)
Otolaryngology (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)

TW084105319A 1994-05-27 1995-05-26 Quinoline derivatives TW427977B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT94MI001099A ITMI941099A1 (it)	1994-05-27	1994-05-27	Derivati chinolinici
ITMI950494 IT1293558B1 (it)	1995-03-14	1995-03-14	Derivati chinolinici

Publications (1)

Publication Number	Publication Date
TW427977B true TW427977B (en)	2001-04-01

Family

ID=26331143

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
TW084105319A TW427977B (en)	1994-05-27	1995-05-26	Quinoline derivatives
TW088121625A TW533199B (en)	1994-05-27	1995-05-26	Quinoline derivatives

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
TW088121625A TW533199B (en)	1994-05-27	1995-05-26	Quinoline derivatives

Country Status (34)

Country	Link
US (5)	US5811553A (zh)
EP (2)	EP0940391B1 (zh)
JP (5)	JP3664492B2 (zh)
KR (1)	KR100316571B1 (zh)
CN (3)	CN1092642C (zh)
AP (1)	AP578A (zh)
AR (1)	AR037069A2 (zh)
AT (2)	ATE273959T1 (zh)
AU (1)	AU699319B2 (zh)
BG (2)	BG64004B1 (zh)
BR (1)	BR9507788A (zh)
CA (1)	CA2191352C (zh)
CZ (1)	CZ291476B6 (zh)
DE (2)	DE69533408T2 (zh)
DK (1)	DK0804419T3 (zh)
DZ (1)	DZ1889A1 (zh)
ES (2)	ES2227769T3 (zh)
FI (2)	FI115052B (zh)
HU (1)	HU226535B1 (zh)
IL (1)	IL113844A (zh)
MA (1)	MA23560A1 (zh)
MX (1)	MX9605903A (zh)
MY (1)	MY129596A (zh)
NO (2)	NO307783B1 (zh)
NZ (1)	NZ287442A (zh)
OA (1)	OA10592A (zh)
PL (2)	PL186665B1 (zh)
PT (2)	PT940391E (zh)
RO (1)	RO114445B1 (zh)
SA (1)	SA95160290B1 (zh)
SK (2)	SK282721B6 (zh)
TW (2)	TW427977B (zh)
UA (1)	UA51623C2 (zh)
WO (1)	WO1995032948A1 (zh)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2227769T3 (es) *	1994-05-27	2005-04-01	Glaxosmithkline S.P.A.	Derivados de quinolina como antagonistas del receptor nk3 de taquiquinina.
GB9524104D0 (en)	1995-11-24	1996-01-24	Smithkline Beecham Spa	Novel compounds
AR004735A1 (es) *	1995-11-24	1999-03-10	Smithkline Beecham Spa	Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento.
SK66798A3 (en) *	1995-11-24	1999-01-11	Smithkline Beecham Spa	Quinoline derivative, preparation method thereof, pharmaceutical composition containing the same and its use
GB9524137D0 (en) *	1995-11-24	1996-01-24	Smithkline Beecham Spa	Novel compounds
AU757836B2 (en) *	1995-11-24	2003-03-06	Smithkline Beecham Spa	Quinoline derivatives
DE69824582T2 (de) *	1997-03-14	2005-07-07	Smithkline Beecham Corp.	Neuartige Chinolin- und Naphthalincarboxamide, pharmazeutische Zusammensetzungen und Verfahren zum Inhibieren von Calpain
US6077850A (en) *	1997-04-21	2000-06-20	G.D. Searle & Co.	Substituted benzopyran analogs for the treatment of inflammation
US20010012846A1 (en) *	1997-05-23	2001-08-09	Glardina Giuseppe Arnaldo Maria	Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists
CN1264378A (zh) *	1997-05-23	2000-08-23	史密丝克莱恩比彻姆股份公司	作为nk－2和nk－3受体拮抗剂的喹啉－4－甲酰胺衍生物
EP1652840A3 (en) *	1997-09-17	2006-05-17	Smithkline Beecham Corporation	(-)-(S)-N-(.alpha.-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide
AP1201A (en) *	1997-09-17	2003-09-01	Smithkline Beecham Corp	Method for the synthesis of quinoline derivatives.
US6083944A (en) *	1997-10-07	2000-07-04	Cephalon, Inc.	Quinoline-containing α-ketoamide cysteine and serine protease inhibitors
US6780875B2 (en) *	1998-11-20	2004-08-24	Smithkline Beecham S.P.A.	Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists
GB9825554D0 (en) *	1998-11-20	1999-01-13	Smithkline Beecham Spa	Novel Compounds
EP1131295A1 (en) *	1998-11-20	2001-09-12	Smithkline Beecham S.p.A.	Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
JP2002535274A (ja) *	1999-01-25	2002-10-22	スミスクライン・ビーチャム・コーポレイション	抗アンドロゲン剤および疾病の治療方法
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1995
- 1995-05-23 ES ES98204483T patent/ES2227769T3/es not_active Expired - Lifetime
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2000
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2001
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2002
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Publication number	Publication date
PL186075B1 (pl)	2003-10-31
PT940391E (pt)	2004-12-31
SK4799A3 (en)	1999-06-11
DZ1889A1 (fr)	2002-02-17
CZ291476B6 (cs)	2003-03-12
CN1092642C (zh)	2002-10-16
US20050096316A1 (en)	2005-05-05
DK0804419T3 (da)	2003-11-24
JP2002179594A (ja)	2002-06-26
WO1995032948A1 (en)	1995-12-07
OA10592A (en)	2002-08-27
PL186665B1 (pl)	2004-02-27
SK151496A3 (en)	1997-07-09
CN1428145A (zh)	2003-07-09
CZ347096A3 (en)	1997-10-15
EP0940391B1 (en)	2004-08-18
US20030236281A1 (en)	2003-12-25
PL317381A1 (en)	1997-04-01
NO307783B1 (no)	2000-05-29
SK282721B6 (sk)	2002-11-06
FI990268L (fi)	1999-02-10
US20060160846A1 (en)	2006-07-20
DE69531458D1 (de)	2003-09-11
DE69531458T2 (de)	2004-08-05
AU2616495A (en)	1995-12-21
ATE273959T1 (de)	2004-09-15
AU699319B2 (en)	1998-12-03
BG64004B1 (bg)	2003-09-30
NZ287442A (en)	1998-05-27
US6608083B1 (en)	2003-08-19
FI964712L (fi)	1997-01-23
EP0940391A2 (en)	1999-09-08
ATE246677T1 (de)	2003-08-15
HU226535B1 (en)	2009-03-30
US5811553A (en)	1998-09-22
EP0940391A3 (en)	1999-11-10
HU9603262D0 (en)	1997-01-28
MA23560A1 (fr)	1995-12-31
FI964712A0 (fi)	1996-11-26
BG103181A (bg)	1999-09-30
JP2005068155A (ja)	2005-03-17
TW533199B (en)	2003-05-21
FI115052B (fi)	2005-02-28
MY129596A (en)	2007-04-30
CN1156451A (zh)	1997-08-06
DE69533408T2 (de)	2005-09-08
JP2007126475A (ja)	2007-05-24
NO965036D0 (no)	1996-11-26
SA95160290B1 (ar)	2006-06-21
HK1024469A1 (zh)	2000-10-13
FI119721B (fi)	2009-02-27
JPH10500697A (ja)	1998-01-20
NO991813L (no)	1997-01-24
BG101008A (en)	1997-08-29
HUT76286A (en)	1997-07-28
AP578A (en)	1997-03-26
KR100316571B1 (ko)	2002-05-30
NO326714B1 (no)	2009-02-02
NO991813D0 (no)	1999-04-16
DE69533408D1 (de)	2004-09-23
HK1003884A1 (zh)	1998-11-13
JP3664492B2 (ja)	2005-06-29
PT804419E (pt)	2003-12-31
SA95160290A (ar)	2005-12-03
EP0804419A1 (en)	1997-11-05
SK282722B6 (sk)	2002-11-06
JP2000026314A (ja)	2000-01-25
MX9605903A (es)	1998-08-30
CN1276211A (zh)	2000-12-13
UA51623C2 (uk)	2002-12-16
CA2191352A1 (en)	1995-12-07
IL113844A0 (en)	1995-08-31
NO965036L (no)	1997-01-24
AP9500745A0 (en)	1995-07-31
RO114445B1 (ro)	1999-04-30
BR9507788A (pt)	1997-09-23
IL113844A (en)	2005-05-17
ES2227769T3 (es)	2005-04-01
US7482458B2 (en)	2009-01-27
AR037069A2 (es)	2004-10-20
ES2204952T3 (es)	2004-05-01
CA2191352C (en)	2001-01-30
EP0804419B1 (en)	2003-08-06
FI990268A0 (fi)	1999-02-10

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