AR017858A1 - Derivados de acido fenilaminoalquilcarboxilico utiles como estimulantes de los beta3-adrenoceptores, composicion farmaceutica, estimulante de losbeta3-adrenoceptores, usos en la fabricacion de medicamentos y procedimiento de fabricacion - Google Patents
Derivados de acido fenilaminoalquilcarboxilico utiles como estimulantes de los beta3-adrenoceptores, composicion farmaceutica, estimulante de losbeta3-adrenoceptores, usos en la fabricacion de medicamentos y procedimiento de fabricacionInfo
- Publication number
- AR017858A1 AR017858A1 ARP980106341A ARP980106341A AR017858A1 AR 017858 A1 AR017858 A1 AR 017858A1 AR P980106341 A ARP980106341 A AR P980106341A AR P980106341 A ARP980106341 A AR P980106341A AR 017858 A1 AR017858 A1 AR 017858A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- adrenoceptors
- atom
- derivatives
- manufacture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/18—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Derivados de ácido fenilaminoalquilcarboxílico representado por la formula general (I), (donde R1 representa un grupo hidroxi, un grupo alcoxi inferior, ungrupo aralcoxi, un grupo amino, un grupo amino alicíclico o un grupo mono- o di- (alquil inferior)amino, que puede tener un grupo hidroxi o un grupo alcoxiinferior como substituyente; R2 representa un grupo hidroxi o un grupo alquilo inferior; R3 representa un átomo de hidrogeno o un átomo de halogeno; R4 y R5son iguales o diferentes y cada uno representa átomo de hidrogeno, un átomo de halogeno o un grupo alquilo inferior; A representa un grupo alquileno inferior;el átomo de C marcado con (R) representa un átomo de C en configuracion (R), y el átomo de C marcado con (S) representa un átomo de C en configuracion (S)) ouna sal farmacéuticamente aceptable del mismo, que tiene un excelente efecto estimulante de los beta3-adrenoceptores y es util como agente para la prevencion otratamiento de la obesidad, la hiperglicemia, las enfermedades causadas por hipermotilidad intestinal, la polaquiuria, la incontinencia urinaria, la depresiono las enfermedades causadas por cálculos biliares o hipermotilidad del tracto biliar. Composicion farmacéutica y estimulante que incluye dichos derivados. Unagente para tratamiento de enfermedades. Usos de dichos derivados en la fabricacion de medicamentos. Procedimiento para la fabricacion de una composicionfarmacéutica que comprende la utilizacion como constituyente esencial de dicha composicion farmacéutica de dicho derivado o una sal farmacéuticamente aceptabledel mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP37008797 | 1997-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR017858A1 true AR017858A1 (es) | 2001-10-24 |
Family
ID=18496040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980106341A AR017858A1 (es) | 1997-12-18 | 1998-12-15 | Derivados de acido fenilaminoalquilcarboxilico utiles como estimulantes de los beta3-adrenoceptores, composicion farmaceutica, estimulante de losbeta3-adrenoceptores, usos en la fabricacion de medicamentos y procedimiento de fabricacion |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6353025B1 (es) |
| EP (1) | EP1043308B1 (es) |
| JP (1) | JP4156799B2 (es) |
| KR (1) | KR100545474B1 (es) |
| AR (1) | AR017858A1 (es) |
| AT (1) | ATE250570T1 (es) |
| AU (1) | AU754317B2 (es) |
| CA (1) | CA2315235C (es) |
| CO (1) | CO5070654A1 (es) |
| CZ (1) | CZ296433B6 (es) |
| DE (1) | DE69818516T2 (es) |
| ES (1) | ES2209226T3 (es) |
| HU (1) | HUP0100102A3 (es) |
| IL (1) | IL136612A (es) |
| MY (1) | MY120466A (es) |
| NO (1) | NO20003105L (es) |
| NZ (1) | NZ505103A (es) |
| PE (1) | PE20000131A1 (es) |
| PL (1) | PL341221A1 (es) |
| SA (1) | SA99191012B1 (es) |
| TW (1) | TW503229B (es) |
| WO (1) | WO1999031045A1 (es) |
| ZA (1) | ZA9811655B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL138994A (en) * | 1998-04-14 | 2004-02-19 | Kissei Pharmaceutical | 2-methylpropionic acid derivatives and medicinal compositions containing the same |
| AU2710301A (en) * | 2000-01-28 | 2001-08-07 | Asahi Kasei Kabushiki Kaisha | Novel remedies with the use of beta3 agonist |
| TWI249515B (en) | 2001-11-13 | 2006-02-21 | Theravance Inc | Aryl aniline beta2 adrenergic receptor agonists |
| WO2003042160A1 (en) | 2001-11-13 | 2003-05-22 | Theravance, Inc. | Aryl aniline beta-2 adrenergic receptor agonists |
| BR0316080A (pt) * | 2002-11-07 | 2005-09-27 | Astellas Pharma Inc | Remédio para bexiga superativa compreendendo derivado de ácido acético anildo como o ingrediente ativo |
| EP1424079A1 (en) * | 2002-11-27 | 2004-06-02 | Boehringer Ingelheim International GmbH | Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine |
| WO2004106283A1 (ja) * | 2003-05-28 | 2004-12-09 | Kissei Pharmaceutical Co., Ltd. | アミノアルコール誘導体、それを含有する医薬組成物およびそれらの用途 |
| EP1765812B1 (en) | 2004-07-02 | 2009-04-29 | Bracco Imaging S.p.A | Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (mri) which contain a chelating moiety with polyhydroxylated substituents |
| US8109981B2 (en) | 2005-01-25 | 2012-02-07 | Valam Corporation | Optical therapies and devices |
| TWI478712B (zh) | 2008-09-30 | 2015-04-01 | Astellas Pharma Inc | 釋控性醫藥組成物 |
| CA2737349A1 (en) | 2008-10-09 | 2010-04-09 | Asahi Kasei Pharma Corporation | Indazole derivatives |
| WO2010041569A1 (ja) | 2008-10-09 | 2010-04-15 | 旭化成ファーマ株式会社 | インダゾール化合物 |
| US20100222404A1 (en) * | 2008-11-04 | 2010-09-02 | Asahi Kasei Pharma Corporation | Indazole derivative dihydrochloride |
| WO2011122524A1 (ja) | 2010-03-29 | 2011-10-06 | アステラス製薬株式会社 | 放出制御医薬組成物 |
| US12097189B1 (en) | 2024-02-09 | 2024-09-24 | Astellas Pharma Inc. | Pharmaceutical composition for modified release |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4146638A (en) * | 1976-02-17 | 1979-03-27 | Boehringer Ingelheim Gmbh | N-(3-phenoxy-2-hydroxy-propyl)-n-(2-phenyl-2-hydroxy-ethyl)-amines |
| EP0068669A1 (en) | 1981-06-20 | 1983-01-05 | Beecham Group Plc | Secondary phenylethanol amines, processes for their preparation and their pharmaceutical application |
| DE3368258D1 (en) | 1982-07-16 | 1987-01-22 | Beecham Group Plc | 2-aminoethyl ether derivatives, processes for their preparation and pharmaceutical compositions containing them |
| ZA835126B (en) * | 1982-07-16 | 1984-06-27 | Beecham Group Plc | Secondary amines |
| GB8528633D0 (en) | 1985-11-21 | 1985-12-24 | Beecham Group Plc | Compounds |
-
1998
- 1998-12-11 PL PL98341221A patent/PL341221A1/xx unknown
- 1998-12-11 ES ES98959168T patent/ES2209226T3/es not_active Expired - Lifetime
- 1998-12-11 AT AT98959168T patent/ATE250570T1/de not_active IP Right Cessation
- 1998-12-11 KR KR1020007006652A patent/KR100545474B1/ko not_active Expired - Fee Related
- 1998-12-11 AU AU15061/99A patent/AU754317B2/en not_active Ceased
- 1998-12-11 NZ NZ505103A patent/NZ505103A/xx unknown
- 1998-12-11 EP EP98959168A patent/EP1043308B1/en not_active Expired - Lifetime
- 1998-12-11 JP JP2000538976A patent/JP4156799B2/ja not_active Expired - Fee Related
- 1998-12-11 DE DE69818516T patent/DE69818516T2/de not_active Expired - Lifetime
- 1998-12-11 IL IL13661298A patent/IL136612A/xx not_active IP Right Cessation
- 1998-12-11 WO PCT/JP1998/005605 patent/WO1999031045A1/ja not_active Ceased
- 1998-12-11 CZ CZ20002244A patent/CZ296433B6/cs not_active IP Right Cessation
- 1998-12-11 HU HU0100102A patent/HUP0100102A3/hu unknown
- 1998-12-11 US US09/581,851 patent/US6353025B1/en not_active Expired - Fee Related
- 1998-12-11 CA CA002315235A patent/CA2315235C/en not_active Expired - Fee Related
- 1998-12-15 AR ARP980106341A patent/AR017858A1/es unknown
- 1998-12-15 MY MYPI98005656A patent/MY120466A/en unknown
- 1998-12-16 CO CO98074901A patent/CO5070654A1/es unknown
- 1998-12-17 PE PE1998001241A patent/PE20000131A1/es not_active Application Discontinuation
- 1998-12-17 TW TW087121030A patent/TW503229B/zh not_active IP Right Cessation
- 1998-12-18 ZA ZA9811655A patent/ZA9811655B/xx unknown
-
1999
- 1999-01-27 SA SA99191012A patent/SA99191012B1/ar unknown
-
2000
- 2000-06-16 NO NO20003105A patent/NO20003105L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU1506199A (en) | 1999-07-05 |
| HUP0100102A2 (hu) | 2001-05-28 |
| DE69818516T2 (de) | 2004-07-08 |
| US6353025B1 (en) | 2002-03-05 |
| EP1043308B1 (en) | 2003-09-24 |
| ES2209226T3 (es) | 2004-06-16 |
| NZ505103A (en) | 2003-03-28 |
| PE20000131A1 (es) | 2000-03-15 |
| KR20010024747A (ko) | 2001-03-26 |
| CA2315235A1 (en) | 1999-06-24 |
| CZ296433B6 (cs) | 2006-03-15 |
| IL136612A (en) | 2003-11-23 |
| ZA9811655B (en) | 1999-06-23 |
| TW503229B (en) | 2002-09-21 |
| CO5070654A1 (es) | 2001-08-28 |
| ATE250570T1 (de) | 2003-10-15 |
| HUP0100102A3 (en) | 2002-11-28 |
| AU754317B2 (en) | 2002-11-14 |
| EP1043308A1 (en) | 2000-10-11 |
| SA99191012B1 (ar) | 2006-07-03 |
| KR100545474B1 (ko) | 2006-01-24 |
| DE69818516D1 (de) | 2003-10-30 |
| CZ20002244A3 (cs) | 2000-11-15 |
| IL136612A0 (en) | 2001-06-14 |
| NO20003105D0 (no) | 2000-06-16 |
| EP1043308A4 (en) | 2001-11-14 |
| PL341221A1 (en) | 2001-03-26 |
| WO1999031045A1 (en) | 1999-06-24 |
| JP4156799B2 (ja) | 2008-09-24 |
| CA2315235C (en) | 2009-07-28 |
| NO20003105L (no) | 2000-08-17 |
| MY120466A (en) | 2005-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |