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NO20064895L - 6,6-Bisykliske ring-substituerte heterobisykliske protein-kinase inhibitorer - Google Patents

6,6-Bisykliske ring-substituerte heterobisykliske protein-kinase inhibitorer

Info

Publication number
NO20064895L
NO20064895L NO20064895A NO20064895A NO20064895L NO 20064895 L NO20064895 L NO 20064895L NO 20064895 A NO20064895 A NO 20064895A NO 20064895 A NO20064895 A NO 20064895A NO 20064895 L NO20064895 L NO 20064895L
Authority
NO
Norway
Prior art keywords
bisyclic
ring
protein kinase
kinase inhibitors
substituted heterobicyclic
Prior art date
Application number
NO20064895A
Other languages
English (en)
Inventor
Andrew Philip Crew
Radoslaw Laufer
An-Hu Li
Han-Qing Dong
Ayako Honda
Anthony Innocenzo Nigro
Mark Joseph Mulvihill
Kenneth Foreman
Arno G Steinig
Qinghua Weng
Douglas Werner
Lee D Arnold
Cara Cesario
Heather Coate
Kristen Michelle Mulvihill
Bijoy Panicker
Yingchuan Sun
Michael J Wyle
Tao Zhang
Original Assignee
Osi Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc
Publication of NO20064895L publication Critical patent/NO20064895L/no

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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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Abstract

Det beskrives forbindelser med formel og farmasøytisk akseptable salter derav, hvor X1, X2, X3, X4, X5, X6, X7, R1 og Q1 er som definert i beskrivelsen, som hemmer IGF-1R-enzymet og er anvendelige til behandling og/eller forebyggelse av hyperproliferative sykdommer, så som kreft, inflammasjon, psoriasis, allergi/astma, sykdommer og tilstander i immunsystemet, sykdommer og tilstander i sentralnervesystemet.
NO20064895A 2004-04-02 2006-10-26 6,6-Bisykliske ring-substituerte heterobisykliske protein-kinase inhibitorer NO20064895L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55925004P 2004-04-02 2004-04-02
PCT/US2005/010606 WO2005097800A1 (en) 2004-04-02 2005-03-31 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors

Publications (1)

Publication Number Publication Date
NO20064895L true NO20064895L (no) 2006-12-19

Family

ID=34967819

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20064895A NO20064895L (no) 2004-04-02 2006-10-26 6,6-Bisykliske ring-substituerte heterobisykliske protein-kinase inhibitorer

Country Status (29)

Country Link
US (6) US7534797B2 (no)
EP (4) EP2305682A1 (no)
JP (2) JP4832426B2 (no)
KR (1) KR101079272B1 (no)
CN (2) CN1960993A (no)
AP (1) AP2139A (no)
AR (1) AR048518A1 (no)
AT (1) ATE433979T1 (no)
AU (1) AU2005230818B2 (no)
BR (1) BRPI0509576A (no)
CA (1) CA2561950C (no)
CY (1) CY1109372T1 (no)
DE (1) DE602005014964D1 (no)
DK (1) DK1740591T3 (no)
EA (1) EA012873B1 (no)
ES (2) ES2328833T3 (no)
HR (1) HRP20090495T1 (no)
IL (1) IL178419A0 (no)
MX (1) MXPA06011423A (no)
MY (1) MY143225A (no)
NO (1) NO20064895L (no)
PL (2) PL2168968T3 (no)
PT (2) PT2168968T (no)
RU (1) RU2379308C2 (no)
SG (1) SG163576A1 (no)
SI (1) SI1740591T1 (no)
TW (2) TWI378934B (no)
UA (1) UA89493C2 (no)
WO (1) WO2005097800A1 (no)

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AR053090A1 (es) 2004-07-20 2007-04-25 Osi Pharm Inc Imidazotriazinas como inhibidores de proteina quinasas y su uso para la preparacion de medicamentos
EP1831225A2 (en) 2004-11-19 2007-09-12 The Regents of the University of California Anti-inflammatory pyrazolopyrimidines
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JP2010500365A (ja) 2006-08-07 2010-01-07 インサイト・コーポレイション キナーゼ阻害剤としてのトリアゾロトリアジン
DE102006043443A1 (de) * 2006-09-15 2008-03-27 Bayer Healthcare Ag Neue aza-bicyclische Verbindungen und ihre Verwendung
JP5572388B2 (ja) 2006-11-22 2014-08-13 インサイト・コーポレイション キナーゼ阻害剤としてのイミダゾトリアジンおよびイミダゾピリミジン
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CN101730700A (zh) * 2007-05-09 2010-06-09 雅培制药有限公司 用作蛋白激酶抑制剂的稠合杂环化合物
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JP2010532756A (ja) * 2007-07-06 2010-10-14 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド ｍＴＯＲＣ１及びｍＴＯＲＣ２の両方の阻害剤を含む組み合わせ抗癌療法
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