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NO20070514L - Pyrrolotriazin kinase inhibitorer - Google Patents

Pyrrolotriazin kinase inhibitorer

Info

Publication number
NO20070514L
NO20070514L NO20070514A NO20070514A NO20070514L NO 20070514 L NO20070514 L NO 20070514L NO 20070514 A NO20070514 A NO 20070514A NO 20070514 A NO20070514 A NO 20070514A NO 20070514 L NO20070514 L NO 20070514L
Authority
NO
Norway
Prior art keywords
kinase inhibitors
pyrrolotriazine kinase
useful
protein kinase
pyrrolotriazine
Prior art date
Application number
NO20070514A
Other languages
English (en)
Inventor
John T Hunt
Michael A Poss
Robert M Borzilleri
Kyoung S Kim
Tram Huynh
Gretchen M Schroeder
Zhong Chen
Xiao Tao Chen
Wayne Vaccaro
Tai W Wong
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20070514L publication Critical patent/NO20070514L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)

Abstract

Generelt omfatter foreliggende oppfinnelse forbindelser med formlene I og II omfattende farmasøytisk akseptable salter derav. Forbindelsene ifølge oppfinnelsen er anvendelige som proteinkinase inhibitorer og er derfor anvendelige for behandling av kreft og andre proteinkinase medierte sykdommer.
NO20070514A 2004-06-28 2007-01-26 Pyrrolotriazin kinase inhibitorer NO20070514L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58345904P 2004-06-28 2004-06-28
US61256304P 2004-09-23 2004-09-23
PCT/US2005/023099 WO2006004833A2 (en) 2004-06-28 2005-06-28 Pyrrolotriazine kinase inhibitors

Publications (1)

Publication Number Publication Date
NO20070514L true NO20070514L (no) 2007-03-12

Family

ID=35457856

Family Applications (3)

Application Number Title Priority Date Filing Date
NO20070453A NO20070453L (no) 2004-06-28 2007-01-24 Kondenserte heterocykliske kinase inhibitorer
NO20070506A NO20070506L (no) 2004-06-28 2007-01-26 Fremgangsmater og mellomprodukter nyttige for fremstilling av kondenserte heterocykliske kinase inhibitorer.
NO20070514A NO20070514L (no) 2004-06-28 2007-01-26 Pyrrolotriazin kinase inhibitorer

Family Applications Before (2)

Application Number Title Priority Date Filing Date
NO20070453A NO20070453L (no) 2004-06-28 2007-01-24 Kondenserte heterocykliske kinase inhibitorer
NO20070506A NO20070506L (no) 2004-06-28 2007-01-26 Fremgangsmater og mellomprodukter nyttige for fremstilling av kondenserte heterocykliske kinase inhibitorer.

Country Status (14)

Country Link
US (2) US20050288290A1 (no)
EP (3) EP1771177A4 (no)
JP (3) JP4860609B2 (no)
KR (3) KR20070037448A (no)
AR (2) AR049536A1 (no)
AU (2) AU2005260056B2 (no)
BR (1) BRPI0512722A (no)
CA (1) CA2571680A1 (no)
IL (1) IL180325A0 (no)
MX (2) MXPA06015192A (no)
NO (3) NO20070453L (no)
PE (2) PE20060374A1 (no)
TW (2) TW200604184A (no)
WO (3) WO2006004636A2 (no)

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US7173031B2 (en) 2007-02-06
WO2006004833A3 (en) 2006-07-13
AU2005260056B2 (en) 2009-08-27
KR20070037448A (ko) 2007-04-04
IL180325A0 (en) 2007-07-04
CA2571680A1 (en) 2006-01-12
WO2006004884A3 (en) 2006-03-23
BRPI0512722A (pt) 2008-04-01
EP1761268A2 (en) 2007-03-14
WO2006004636A2 (en) 2006-01-12
MXPA06015032A (es) 2007-02-08
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JP4782117B2 (ja) 2011-09-28
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