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MX2019000097A - Metodo para la produccion de una inmunoglobulina glicosilada. - Google Patents

Metodo para la produccion de una inmunoglobulina glicosilada.

Info

Publication number
MX2019000097A
MX2019000097A MX2019000097A MX2019000097A MX2019000097A MX 2019000097 A MX2019000097 A MX 2019000097A MX 2019000097 A MX2019000097 A MX 2019000097A MX 2019000097 A MX2019000097 A MX 2019000097A MX 2019000097 A MX2019000097 A MX 2019000097A
Authority
MX
Mexico
Prior art keywords
immunoglobulin
production
cultivation medium
amount
time unit
Prior art date
Application number
MX2019000097A
Other languages
English (en)
Inventor
Chikashi Hirashima
Thomas Link
Yoshinori Takagi
Shinya Takuma
Yuriko Tsuda
Reinhard Franze
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42060615&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2019000097(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2019000097A publication Critical patent/MX2019000097A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

En la presente se reporta un método para la producción de una inmunoglobulina que comprende los siguientes pasos: a) proveer una célula eucariótica que comprende un ácido nucleico que codifica la inmunoglobulina, b) cultivar la célula eucariótica en un medio de cultivo en donde la cantidad de glucosa disponible en el medio de cultivo por unidad de tiempo se mantiene constante y limitada a menos de 80% de la cantidad que podría ser utilizada al máximo por las células en el medio de cultivo por unidad de tiempo, y c) recuperar la inmunoglobulina del cultivo.
MX2019000097A 2009-10-26 2012-04-20 Metodo para la produccion de una inmunoglobulina glicosilada. MX2019000097A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09013455 2009-10-26

Publications (1)

Publication Number Publication Date
MX2019000097A true MX2019000097A (es) 2023-01-05

Family

ID=42060615

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2012004682A MX2012004682A (es) 2009-10-26 2010-10-25 Metodo para la produccion de una inmunoglobulina glicosilada.
MX2019000097A MX2019000097A (es) 2009-10-26 2012-04-20 Metodo para la produccion de una inmunoglobulina glicosilada.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2012004682A MX2012004682A (es) 2009-10-26 2010-10-25 Metodo para la produccion de una inmunoglobulina glicosilada.

Country Status (19)

Country Link
US (8) US20110117087A1 (es)
EP (3) EP4406615A3 (es)
JP (7) JP5711751B2 (es)
KR (8) KR101860175B1 (es)
CN (2) CN102596995B (es)
AU (1) AU2010311567B2 (es)
BR (2) BR112012009828B8 (es)
CA (1) CA2773522C (es)
DK (1) DK2493922T3 (es)
ES (2) ES2622366T3 (es)
HR (1) HRP20240920T1 (es)
HU (2) HUE033758T2 (es)
IL (2) IL218997A0 (es)
MX (2) MX2012004682A (es)
PL (2) PL3202785T3 (es)
SG (2) SG10201913329XA (es)
SI (2) SI3202785T1 (es)
TW (8) TWI670375B (es)
WO (1) WO2011051231A1 (es)

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