MX2013002144A - Alimentacion alcalina. - Google Patents
Alimentacion alcalina.Info
- Publication number
- MX2013002144A MX2013002144A MX2013002144A MX2013002144A MX2013002144A MX 2013002144 A MX2013002144 A MX 2013002144A MX 2013002144 A MX2013002144 A MX 2013002144A MX 2013002144 A MX2013002144 A MX 2013002144A MX 2013002144 A MX2013002144 A MX 2013002144A
- Authority
- MX
- Mexico
- Prior art keywords
- polypeptide
- cultivating
- cell
- producing
- amino acid
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 239000012670 alkaline solution Substances 0.000 abstract 1
- 239000003637 basic solution Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 230000029219 regulation of pH Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
En la presente se reporta un método para cultivar una célula bacteriana que comprende la adición de un aminoácido en solución alcalina utilizado para regulación de pH. También un aspecto es un método para producir un polipéptido que comprende las etapas de: a) proporcionar una célula bacteriana que comprende un ácido nucleico que codifica para el polipéptido, b) cultivar la célula proporcionada, c) ajustar el valor de pH durante el cultivo con una solución básica que comprende un aminoácido, d) recuperar el polipéptido de la célula para el medio de cultivo y de esta manera producir el polipéptido.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10008997 | 2010-08-30 | ||
| PCT/EP2011/064598 WO2012028522A1 (en) | 2010-08-30 | 2011-08-25 | Alkaline feed |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013002144A true MX2013002144A (es) | 2013-04-03 |
| MX339227B MX339227B (es) | 2016-05-17 |
Family
ID=43088050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013002144A MX339227B (es) | 2010-08-30 | 2011-08-25 | Alimentacion alcalina. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8951756B2 (es) |
| EP (1) | EP2611900B1 (es) |
| JP (2) | JP5798193B2 (es) |
| KR (1) | KR101584414B1 (es) |
| CN (1) | CN103068967B (es) |
| BR (1) | BR112013004396A2 (es) |
| CA (1) | CA2807428A1 (es) |
| ES (1) | ES2558751T3 (es) |
| MX (1) | MX339227B (es) |
| RU (1) | RU2631001C2 (es) |
| WO (1) | WO2012028522A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2611900B1 (en) * | 2010-08-30 | 2015-11-25 | F.Hoffmann-La Roche Ag | Alkaline feed |
| EP2748191A1 (en) | 2011-08-25 | 2014-07-02 | F.Hoffmann-La Roche Ag | Shortened tetranectin-apolipoprotein a-i fusion protein, a lipid particle containing it, and uses thereof |
| US20130053551A1 (en) | 2011-08-25 | 2013-02-28 | Hoffman-La Roche. Inc. | Cation and anion exchange chromatography method |
| AU2012366182B2 (en) * | 2012-01-19 | 2017-08-17 | University Of Cincinnati | Method of treating diabetes using non-glycosylated apolipoprotein A-IV |
| SG11201505916XA (en) | 2013-02-22 | 2015-09-29 | Hoffmann La Roche | Use of an amino acid auxotrophy cured prokaryotic strain for the recombinant production of a polypeptide |
| EP3184547A1 (en) | 2015-10-29 | 2017-06-28 | F. Hoffmann-La Roche AG | Anti-tpbg antibodies and methods of use |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60118196A (ja) * | 1983-11-30 | 1985-06-25 | Takeda Chem Ind Ltd | インタ−フェロンの製造法 |
| DD295867A5 (de) | 1988-07-28 | 1991-11-14 | Zi F. Mikrobiologie U. Exper. Therapie, | Verfahren zur steuerung des wachstums von aerob-submersen mikroorganismen-kulturen |
| DE4001518A1 (de) | 1990-01-19 | 1991-07-25 | Biotechnolog Forschung Gmbh | Verfahren zur hochzelldichte-fermentation von escherichia coli in einem ruehrkesselfermentor |
| SE9203753D0 (sv) * | 1992-12-11 | 1992-12-11 | Kabi Pharmacia Ab | Expression system for producing apolipoprotein ai-m |
| AR005035A1 (es) * | 1995-12-11 | 1999-04-07 | Merck Patent Ges Mit Beschränkter Haftung | Procedimiento para preparar proteinas recombinantes en e. coli, mediante fermentacion con gran concentracion de celulas. |
| GB9602825D0 (en) | 1996-02-12 | 1996-04-10 | Therexsys Ltd | Method of plasmid dna production and purification |
| US6291245B1 (en) * | 1998-07-15 | 2001-09-18 | Roche Diagnostics Gmbh | Host-vector system |
| EP2343317A1 (en) | 2000-11-10 | 2011-07-13 | F. Hoffmann-La Roche Ltd. | Apolipoprotein analogues |
| WO2003048374A1 (en) | 2001-12-05 | 2003-06-12 | Dsm Ip Assets B.V. | Process for the production of an aromatic amino acid metabolite or derivative thereof |
| CA2443365C (en) | 2002-11-19 | 2010-01-12 | F. Hoffmann-La Roche Ag | Methods for the recombinant production of antifusogenic peptides |
| EP2611900B1 (en) * | 2010-08-30 | 2015-11-25 | F.Hoffmann-La Roche Ag | Alkaline feed |
-
2011
- 2011-08-25 EP EP11748406.3A patent/EP2611900B1/en not_active Not-in-force
- 2011-08-25 RU RU2013112563A patent/RU2631001C2/ru not_active IP Right Cessation
- 2011-08-25 MX MX2013002144A patent/MX339227B/es active IP Right Grant
- 2011-08-25 JP JP2013526412A patent/JP5798193B2/ja not_active Expired - Fee Related
- 2011-08-25 WO PCT/EP2011/064598 patent/WO2012028522A1/en not_active Ceased
- 2011-08-25 BR BR112013004396A patent/BR112013004396A2/pt not_active IP Right Cessation
- 2011-08-25 KR KR1020137007871A patent/KR101584414B1/ko not_active Expired - Fee Related
- 2011-08-25 ES ES11748406.3T patent/ES2558751T3/es active Active
- 2011-08-25 CA CA2807428A patent/CA2807428A1/en not_active Abandoned
- 2011-08-25 CN CN201180041407.3A patent/CN103068967B/zh not_active Expired - Fee Related
- 2011-08-25 US US13/217,540 patent/US8951756B2/en not_active Expired - Fee Related
-
2015
- 2015-01-28 US US14/607,932 patent/US9845347B2/en not_active Expired - Fee Related
- 2015-07-10 JP JP2015139021A patent/JP2016005461A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP5798193B2 (ja) | 2015-10-21 |
| US8951756B2 (en) | 2015-02-10 |
| US20130323783A1 (en) | 2013-12-05 |
| RU2013112563A (ru) | 2014-10-10 |
| EP2611900B1 (en) | 2015-11-25 |
| JP2016005461A (ja) | 2016-01-14 |
| HK1181811A1 (zh) | 2013-11-15 |
| WO2012028522A1 (en) | 2012-03-08 |
| EP2611900A1 (en) | 2013-07-10 |
| MX339227B (es) | 2016-05-17 |
| US20150132802A1 (en) | 2015-05-14 |
| CN103068967B (zh) | 2016-05-04 |
| CA2807428A1 (en) | 2012-03-08 |
| JP2013537432A (ja) | 2013-10-03 |
| KR101584414B1 (ko) | 2016-01-13 |
| RU2631001C2 (ru) | 2017-09-15 |
| CN103068967A (zh) | 2013-04-24 |
| BR112013004396A2 (pt) | 2016-05-17 |
| KR20130100301A (ko) | 2013-09-10 |
| US9845347B2 (en) | 2017-12-19 |
| ES2558751T3 (es) | 2016-02-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |