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MX2016010034A - Inhibidores de dihidropirrolopiridina de receptor huerfano relacionado-gamma. - Google Patents

Inhibidores de dihidropirrolopiridina de receptor huerfano relacionado-gamma.

Info

Publication number
MX2016010034A
MX2016010034A MX2016010034A MX2016010034A MX2016010034A MX 2016010034 A MX2016010034 A MX 2016010034A MX 2016010034 A MX2016010034 A MX 2016010034A MX 2016010034 A MX2016010034 A MX 2016010034A MX 2016010034 A MX2016010034 A MX 2016010034A
Authority
MX
Mexico
Prior art keywords
ror
gamma
dihydropyrrolopyridine
inhibitors
diseases
Prior art date
Application number
MX2016010034A
Other languages
English (en)
Other versions
MX371017B (es
Inventor
Jing Yuan
Wei Zhao
Suresh B Singh
Linghang Zhuang
Lanqi Jia
Yajun Zheng
Lawrence Wayne Dillard
Chengguo Dong
Yi Fan
A Claremon David
Liu Zhijie
D Lotesta Stephen
Marcus Andrew
m tice Colin
Original Assignee
Vitae Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52544571&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2016010034(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vitae Pharmaceuticals Inc filed Critical Vitae Pharmaceuticals Inc
Publication of MX2016010034A publication Critical patent/MX2016010034A/es
Publication of MX371017B publication Critical patent/MX371017B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Anesthesiology (AREA)

Abstract

La presente invención se refiere a nuevos compuestos de Fórmula (I): (ver Fórmula) sales farmacéuticamente aceptables de los mismos, y composiciones de los mismos, los cuales son útiles en el tratamiento de enfermedades y trastornos mediados por ROR?; también se proporcionan composiciones farmacéuticas que comprenden los nuevos compuestos de Fórmula (I) y métodos para su uso en el tratamiento de uno o más trastornos o enfermedades inflamatorios, metabólicos, autoinmunes y otros.
MX2016010034A 2014-02-03 2015-01-30 Inhibidores de dihidropirrolopiridina de receptor huerfano relacionado-gamma. MX371017B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461935162P 2014-02-03 2014-02-03
US201461970637P 2014-03-26 2014-03-26
PCT/US2015/013699 WO2015116904A1 (en) 2014-02-03 2015-01-30 Dihydropyrrolopyridine inhibitors of ror-gamma

Publications (2)

Publication Number Publication Date
MX2016010034A true MX2016010034A (es) 2016-11-15
MX371017B MX371017B (es) 2020-01-13

Family

ID=52544571

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016010034A MX371017B (es) 2014-02-03 2015-01-30 Inhibidores de dihidropirrolopiridina de receptor huerfano relacionado-gamma.

Country Status (26)

Country Link
US (6) US9266886B2 (es)
EP (2) EP3102576B8 (es)
JP (1) JP6466461B2 (es)
KR (1) KR102408261B1 (es)
CN (1) CN105940002B (es)
AU (1) AU2015210833B2 (es)
CA (1) CA2938311C (es)
CL (1) CL2016001947A1 (es)
DK (1) DK3102576T3 (es)
EA (1) EA031804B1 (es)
EC (1) ECSP16071151A (es)
ES (1) ES2735099T3 (es)
HU (1) HUE045511T2 (es)
IL (1) IL246902B (es)
LT (1) LT3102576T (es)
MX (1) MX371017B (es)
PE (1) PE20161372A1 (es)
PH (1) PH12016501457B1 (es)
PL (1) PL3102576T3 (es)
PT (1) PT3102576T (es)
RS (1) RS59007B1 (es)
SG (1) SG11201606080SA (es)
SI (1) SI3102576T1 (es)
TW (1) TWI658041B (es)
UA (1) UA121309C2 (es)
WO (1) WO2015116904A1 (es)

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JP6466461B2 (ja) * 2014-02-03 2019-02-06 ヴァイティー ファーマシューティカルズ，インコーポレイテッド Ｒｏｒガンマのジヒドロピロロピリジン阻害剤
EP3180349B1 (en) 2014-08-12 2025-03-12 Monash University Lymph directing prodrugs and therapeutic uses thereof
AU2015333610B2 (en) * 2014-10-14 2019-11-07 Vitae Pharmaceuticals, Llc Dihydropyrrolopyridine inhibitors of ROR-gamma
KR20250009586A (ko) 2014-10-29 2025-01-17 바이시클러드 리미티드 Mt1-mmp에 특이적인 바이사이클릭 펩타이드 리간드
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HK1249469A1 (zh) 2015-03-12 2018-11-02 The Regents Of The University Of California 用RORγ抑制剂治疗癌症的方法
PL3294713T3 (pl) 2015-05-15 2021-07-26 Aurigene Discovery Technologies Limited Podstawione związki tetrahydrochinolinonowe jako modulatory ror gamma
HUE047988T2 (hu) 2015-06-09 2020-05-28 Abbvie Inc Nukleáris receptor modulátorok (ROR) gyulladásos és autoimmun betegségek kezelésére
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CN108137482B (zh) 2015-09-08 2024-03-15 莫纳什大学 定向淋巴的前药
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BR112019000603A2 (pt) 2016-07-14 2019-04-30 Cadila Healthcare Limited composto, composição farmacêutica, método para o tratamento de doenças e uso do composto
TW201815388A (zh) 2016-07-14 2018-05-01 印度商卡迪拉保健有限公司 作為ＲＯＲγ調節劑之新穎化合物
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UY37507A (es) 2016-12-05 2018-06-29 Lead Pharma Holding Bv Moduladores de ror gamma (ror¿)
CN110603261A (zh) 2016-12-23 2019-12-20 拜斯科阿迪有限公司 具有新型键结构的肽衍生物
JP2020059651A (ja) * 2016-12-26 2020-04-16 科研製薬株式会社 ピラゾール誘導体及びそれを含有する医薬
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HC Change of company name or juridical status

Owner name: UCB BIOPHARMA SPRL

Owner name: STARBUCKS CORPORATION