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HK1249469A1 - 用RORγ抑制剂治疗癌症的方法 - Google Patents

用RORγ抑制剂治疗癌症的方法 Download PDF

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Publication number
HK1249469A1
HK1249469A1 HK18109103.5A HK18109103A HK1249469A1 HK 1249469 A1 HK1249469 A1 HK 1249469A1 HK 18109103 A HK18109103 A HK 18109103A HK 1249469 A1 HK1249469 A1 HK 1249469A1
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HK
Hong Kong
Prior art keywords
cancer
methods
inhibitors
rorgamma
treating cancer
Prior art date
Application number
HK18109103.5A
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English (en)
Inventor
Hongwu CHEN
June X. Zou
Junjian WANG
Original Assignee
The Regents Of The University Of California
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Publication of HK1249469A1 publication Critical patent/HK1249469A1/zh

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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HK18109103.5A 2015-03-12 2016-03-11 用RORγ抑制剂治疗癌症的方法 HK1249469A1 (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562132465P 2015-03-12 2015-03-12
US62/132,465 2015-03-12
US201662280081P 2016-01-18 2016-01-18
US62/280,081 2016-01-18
PCT/US2016/021983 WO2016145298A1 (en) 2015-03-12 2016-03-11 METHODS FOR TREATING CANCER WITH RORgamma INHIBITORS

Publications (1)

Publication Number Publication Date
HK1249469A1 true HK1249469A1 (zh) 2018-11-02

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HK18109103.5A HK1249469A1 (zh) 2015-03-12 2016-03-11 用RORγ抑制剂治疗癌症的方法

Country Status (6)

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US (1) US10959984B2 (zh)
EP (1) EP3268087A4 (zh)
JP (1) JP2018513123A (zh)
CN (1) CN107614062A (zh)
HK (1) HK1249469A1 (zh)
WO (1) WO2016145298A1 (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1249469A1 (zh) 2015-03-12 2018-11-02 The Regents Of The University Of California 用RORγ抑制剂治疗癌症的方法
IL266261B (en) * 2016-10-27 2022-07-01 Escalier Biosciences Bv Ror-gamma modulators
WO2019023651A2 (en) 2017-07-28 2019-01-31 Massachusetts Institute Of Technology MODULATORS OF THE SMALL MOLECULE ANDROGEN RECEPTOR
EP3849556A1 (en) * 2018-09-13 2021-07-21 Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) Modulation of trf1 for brain cancer treatment
WO2020061024A1 (en) * 2018-09-18 2020-03-26 Yale University Dermatologic topical applications of ror gamma and ror gamma-t inhibitors for the prevention of skin cancer development
WO2020065682A1 (en) * 2018-09-29 2020-04-02 Translational Health Science And Technology Institute Ror antagonists, their use and method of treatment comprising the said modulators
RU2679625C1 (ru) * 2018-11-08 2019-02-12 Ильясов Шамиль Сионович ПРИМЕНЕНИЕ 3-О-СУЛЬФАМОИЛОКСИ-6-ОКСА-7β-МЕТИЛ-D-ГОМО-8α-ЭСТРА-1,3,5(10)-ТРИЕН-17а-ОНА ДЛЯ ЛЕЧЕНИЯ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ, ВКЛЮЧАЯ ТРИЖДЫ-НЕГАТИВНУЮ ФОРМУ, И СПОСОБ ЕГО ПОЛУЧЕНИЯ
CN113710239A (zh) * 2019-02-20 2021-11-26 加利福尼亚大学董事会 视黄酸受体相关孤儿受体γ(RORγ)依赖性癌症的治疗
CN109879784B (zh) * 2019-03-18 2021-06-29 中国科学院广州生物医药与健康研究院 一种联苯胺类化合物及其应用
EP3946349A4 (en) 2019-04-03 2023-05-24 The Scripps Research Institute METHOD OF INHIBITION OF TREM-1
WO2021011493A1 (en) * 2019-07-12 2021-01-21 Duke University 3' utr crispr-dcas 13 engineering system and methods of using same
CN113912563B (zh) * 2020-07-10 2025-05-27 中国科学院广州生物医药与健康研究院 一种苯并五元氮杂环化合物及其应用
WO2022067185A1 (en) * 2020-09-27 2022-03-31 Veru Inc. Methods of treating prostate cancer with minimal side effects
WO2022122740A1 (en) * 2020-12-07 2022-06-16 Diaccurate Ror-gamma inhibitors for the treatment of ror-gamma-dependent cancer
WO2023281097A1 (en) 2021-07-09 2023-01-12 Immunic Ag Methods for treating cancer
CN116917306A (zh) * 2022-02-18 2023-10-20 上海醇健医药技术有限公司 17-吡啶基-10α-甲基-甾体衍生物及中间体化合物、其制备方法、其用途、以及其药物组合物

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4957735A (en) 1984-06-12 1990-09-18 The University Of Tennessee Research Corporation Target-sensitive immunoliposomes- preparation and characterization
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5004697A (en) 1987-08-17 1991-04-02 Univ. Of Ca Cationized antibodies for delivery through the blood-brain barrier
US5055303A (en) 1989-01-31 1991-10-08 Kv Pharmaceutical Company Solid controlled release bioadherent emulsions
US5271961A (en) 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5268164A (en) 1990-04-23 1993-12-07 Alkermes, Inc. Increasing blood-brain barrier permeability with permeabilizer peptides
US5254342A (en) 1991-09-30 1993-10-19 University Of Southern California Compositions and methods for enhanced transepithelial and transendothelial transport or active agents
ATE154240T1 (de) 1992-03-12 1997-06-15 Alkermes Inc Acth enthaltende mikrokugeln mit gesteuerter abgabe
US5534496A (en) 1992-07-07 1996-07-09 University Of Southern California Methods and compositions to enhance epithelial drug transport
US5514670A (en) 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
US5962318A (en) 1996-11-15 1999-10-05 St. Jude Children's Research Hospital Cytotoxic T lymphocyte-mediated immunotherapy
US7435596B2 (en) 2004-11-04 2008-10-14 St. Jude Children's Research Hospital, Inc. Modified cell line and method for expansion of NK cell
EP1771204A4 (en) * 2004-07-01 2008-08-13 Univ New York COMPOSITIONS AND METHOD FOR MODULATING ROR-GAMMA-T
WO2007103009A2 (en) 2006-03-01 2007-09-13 Janssen Pharmaceutica N.V. CANCER TREATMENT COMBINING LYMPHODEPLETING AGENT WITH CTLs AND CYTOKINES
WO2011115892A1 (en) * 2010-03-15 2011-09-22 Griffin Patrick R Modulators of the retinoic acid receptor-related orphan receptors
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
WO2012100734A1 (en) 2011-01-24 2012-08-02 Glaxo Group Limited Compounds useful as retinoid-related orphan receptor gamma modulators
EP2487159A1 (en) 2011-02-11 2012-08-15 MSD Oss B.V. RorgammaT inhibitors
EP2688594B1 (en) * 2011-03-22 2016-12-14 The Brigham and Women's Hospital, Inc. Compositions and their use in the treatment of cancer
WO2012158784A2 (en) * 2011-05-16 2012-11-22 Theodore Mark Kamenecka Modulators of the nuclear hormone receptor ror
EP2736330A4 (en) * 2011-07-29 2015-05-27 Tempero Pharmaceuticals Inc COMPOUNDS AND METHODS
US9156837B2 (en) * 2011-07-29 2015-10-13 Takeda Pharmaceutical Company Limited Heterocyclic compound
CN104379559B (zh) 2012-04-27 2016-11-09 葛兰素集团有限公司 化合物
WO2014008214A1 (en) 2012-07-02 2014-01-09 Biogen Idec Ma Inc. Biaryl-containing compounds as inverse agonists of ror-gamma receptors
WO2014008366A2 (en) 2012-07-05 2014-01-09 Nutramax Laboratories, Inc. Compositions comprising sulforaphane or a sulforaphane precursor and ursolic acid
WO2014026328A1 (en) 2012-08-15 2014-02-20 Merck Sharp & Dohme Corp. 3-cyclohexenyl substituted indole and indazole compounds as rorgammat inhibitors and uses thereof
WO2014026329A1 (en) 2012-08-15 2014-02-20 Merck Sharp & Dohme Corp. N-alkylated indole and indazole compounds as rorgammat inhibitors and uses thereof
WO2014026327A1 (en) 2012-08-15 2014-02-20 Merck Sharp & Dohme Corp. 4-heteroaryl substituted benzoic acid compounds as rorgammat inhibitors and uses thereof
WO2014026330A1 (en) 2012-08-15 2014-02-20 Merck Sharp & Dohme Corp. 3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
US20150307947A1 (en) * 2012-12-04 2015-10-29 Caris Mpi, Inc. Molecular profiling for cancer
WO2013171729A2 (en) 2013-01-08 2013-11-21 Glenmark Pharmaceuticals S.A. Aryl and heteroaryl amide compounds as rorgamat modulator
EP2991994B1 (en) * 2013-05-01 2018-08-15 Vitae Pharmaceuticals, Inc. Thiazolopyrrolidine inhibitors of ror-gamma
WO2015008234A1 (en) * 2013-07-17 2015-01-22 Glenmark Pharmaceuticals S.A. Bicyclic heterocyclic compounds as ror gamma modulators
CN105531274A (zh) 2013-09-11 2016-04-27 豪夫迈·罗氏有限公司 作为RORc调节剂的酮-咪唑并吡啶衍生物
EP3060553A4 (en) 2013-10-25 2017-03-29 Glaxosmithkline LLC Novel compounds
UA117941C2 (uk) 2013-12-05 2018-10-25 Лід Фарма Холдінг Б.В. МОДУЛЯТОРИ ROR-ГAMMA (RORγ)
WO2015083130A1 (en) 2013-12-06 2015-06-11 Aurigene Discovery Technologies Limited Fused pyridine and pyrimidine derivatives as ror gamma modulators
CN104530014B (zh) 2013-12-25 2018-03-20 中国科学院广州生物医药与健康研究院 2‑氧代‑1,2‑二氢苯并[cd]吲哚‑6‑磺酰胺类化合物及其组合物和应用
WO2015101928A1 (en) 2013-12-31 2015-07-09 Aurigene Discovery Technologies Limited Fused thiophene and thiazole derivatives as ror gamma modulators
JP6466461B2 (ja) 2014-02-03 2019-02-06 ヴァイティー ファーマシューティカルズ，インコーポレイテッド Ｒｏｒガンマのジヒドロピロロピリジン阻害剤
CN105272904B (zh) 2014-07-18 2019-04-09 中国科学院广州生物医药与健康研究院 N-苯基酰胺类化合物及其应用
HK1249469A1 (zh) 2015-03-12 2018-11-02 The Regents Of The University Of California 用RORγ抑制剂治疗癌症的方法
WO2017127442A1 (en) 2016-01-18 2017-07-27 The Regents Of The University Of California Methods for treating cancer with rorgamma inhibitors

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