MX2013005008A - Derivados de carboxamida y urea heteroaromaticos sustituidos como ligandos del receptor vanilloide. - Google Patents
Derivados de carboxamida y urea heteroaromaticos sustituidos como ligandos del receptor vanilloide.Info
- Publication number
- MX2013005008A MX2013005008A MX2013005008A MX2013005008A MX2013005008A MX 2013005008 A MX2013005008 A MX 2013005008A MX 2013005008 A MX2013005008 A MX 2013005008A MX 2013005008 A MX2013005008 A MX 2013005008A MX 2013005008 A MX2013005008 A MX 2013005008A
- Authority
- MX
- Mexico
- Prior art keywords
- urea derivatives
- substituted heteroaromatic
- receptor ligands
- vanilloid receptor
- heteroaromatic carboxamide
- Prior art date
Links
- -1 heteroaromatic carboxamide Chemical class 0.000 title abstract 2
- 150000003672 ureas Chemical class 0.000 title abstract 2
- 102000011040 TRPV Cation Channels Human genes 0.000 title 1
- 108010062740 TRPV Cation Channels Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
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- Dermatology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Child & Adolescent Psychology (AREA)
Abstract
La invención se relaciona con derivados de carboxamida y urea heteroaromáticos sustituidos, con procesos para la preparación de los mismos, con composiciones farmacéuticas que comprenden esos compuestos y también con el uso de esos compuestos para preparar composiciones farmacéuticas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10014449 | 2010-11-10 | ||
| PCT/EP2011/005628 WO2012062462A1 (en) | 2010-11-10 | 2011-11-09 | Substituted heteroaromatic carboxamide and urea derivatives as vanilloid receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2013005008A true MX2013005008A (es) | 2013-08-01 |
Family
ID=43501425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013005008A MX2013005008A (es) | 2010-11-10 | 2011-11-09 | Derivados de carboxamida y urea heteroaromaticos sustituidos como ligandos del receptor vanilloide. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20120115903A1 (es) |
| EP (1) | EP2638034A1 (es) |
| JP (1) | JP2013545740A (es) |
| AR (1) | AR083817A1 (es) |
| AU (1) | AU2011328520A1 (es) |
| BR (1) | BR112013010768A2 (es) |
| CA (1) | CA2816769A1 (es) |
| MX (1) | MX2013005008A (es) |
| TW (1) | TW201305139A (es) |
| WO (1) | WO2012062462A1 (es) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| AU2013255441B2 (en) | 2012-05-02 | 2017-11-09 | Lupin Limited | Substituted pyrazole compounds as CRAC modulators |
| NZ702747A (en) | 2012-06-13 | 2017-03-31 | Incyte Holdings Corp | Substituted tricyclic compounds as fgfr inhibitors |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| WO2014122083A1 (de) | 2013-02-06 | 2014-08-14 | Bayer Cropscience Ag | Halogensubstituierte pyrazolderivate als schädlingsbekämpfungsmittel |
| LT2986610T (lt) | 2013-04-19 | 2018-04-10 | Incyte Holdings Corporation | Bicikliniai heterociklai, kaip fgfr inhibitoriai |
| CA2935646A1 (en) | 2014-01-03 | 2015-07-09 | Bayer Animal Health Gmbh | Novel pyrazolyl-heteroarylamides as pesticides |
| JP6466461B2 (ja) | 2014-02-03 | 2019-02-06 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | Rorガンマのジヒドロピロロピリジン阻害剤 |
| GB201401886D0 (en) | 2014-02-04 | 2014-03-19 | Lytix Biopharma As | Neurodegenerative therapies |
| HRP20221373T1 (hr) | 2014-03-07 | 2023-01-06 | Biocryst Pharmaceuticals, Inc. | Supstituirani pirazoli kao inhibitori kalikreina u ljudskoj plazmi |
| AU2015333610B2 (en) | 2014-10-14 | 2019-11-07 | Vitae Pharmaceuticals, Llc | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
| SG10201913036RA (en) | 2015-02-20 | 2020-02-27 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| ES2856931T3 (es) | 2015-08-05 | 2021-09-28 | Vitae Pharmaceuticals Llc | Moduladores de ROR-gamma |
| EP3130589A1 (en) * | 2015-08-13 | 2017-02-15 | Grünenthal GmbH | Heterocyclic aza compounds |
| EP3130590A1 (en) * | 2015-08-13 | 2017-02-15 | Grünenthal GmbH | Aromatic aza compounds as vr1/trpv1 ligands |
| BR112018010018A2 (pt) | 2015-11-20 | 2018-11-21 | Vitae Pharmaceuticals Inc | moduladores de ror-gama |
| TWI757266B (zh) | 2016-01-29 | 2022-03-11 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
| US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| MX2020000887A (es) | 2017-07-24 | 2020-07-22 | Vitae Pharmaceuticals Llc | Inhibidores de ror?. |
| EP3788046B1 (en) | 2018-05-04 | 2025-12-10 | Incyte Corporation | Salts of an fgfr inhibitor |
| EP4309737A3 (en) | 2018-05-04 | 2024-03-27 | Incyte Corporation | Solid forms of an fgfr inhibitor and processes for preparing the same |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CR20220169A (es) | 2019-10-14 | 2022-10-27 | Incyte Corp | Heterociclos bicíclicos como inhibidores de fgfr |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| KR20220131900A (ko) | 2019-12-04 | 2022-09-29 | 인사이트 코포레이션 | Fgfr 억제제의 유도체 |
| CN120965654A (zh) * | 2019-12-31 | 2025-11-18 | 诺华制药股份有限公司 | 用于治疗与sting活性有关的疾病的化合物和组合物 |
| JP2023509421A (ja) * | 2019-12-31 | 2023-03-08 | アイエフエム デュー インコーポレイテッド | Sting活性に関連する状態を治療するための化合物および組成物 |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| US12065494B2 (en) | 2021-04-12 | 2024-08-20 | Incyte Corporation | Combination therapy comprising an FGFR inhibitor and a Nectin-4 targeting agent |
| AR126101A1 (es) | 2021-06-09 | 2023-09-13 | Incyte Corp | Heterociclos tricíclicos como inhibidores de fgfr |
| AR126102A1 (es) | 2021-06-09 | 2023-09-13 | Incyte Corp | Heterociclos tricíclicos como inhibidores de fgfr |
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| EP1628661A2 (en) * | 2003-06-05 | 2006-03-01 | Vertex Pharmaceuticals Incorporated | Modulators of vr1 receptor |
| GB0322016D0 (en) * | 2003-09-19 | 2003-10-22 | Merck Sharp & Dohme | New compounds |
| AU2005313108B2 (en) * | 2004-12-10 | 2011-05-26 | Msd Italia S.R.L. | Heterocycle derivatives as histone deacetylase (HDAC) inhibitors |
| WO2007054480A1 (en) * | 2005-11-08 | 2007-05-18 | N.V. Organon | 2-(benzimidazol-1-yl)-acetamide biaryl derivatives and their use as inhibitors of the trpv1 receptor |
| US8957219B2 (en) * | 2008-10-17 | 2015-02-17 | Shionogi & Co., Ltd. | Acetic acid amide derivative having inhibitory activity on endothelial lipase |
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2011
- 2011-11-09 MX MX2013005008A patent/MX2013005008A/es not_active Application Discontinuation
- 2011-11-09 CA CA2816769A patent/CA2816769A1/en not_active Abandoned
- 2011-11-09 AU AU2011328520A patent/AU2011328520A1/en not_active Abandoned
- 2011-11-09 WO PCT/EP2011/005628 patent/WO2012062462A1/en not_active Ceased
- 2011-11-09 BR BR112013010768A patent/BR112013010768A2/pt not_active IP Right Cessation
- 2011-11-09 AR ARP110104185A patent/AR083817A1/es unknown
- 2011-11-09 US US13/292,785 patent/US20120115903A1/en not_active Abandoned
- 2011-11-09 JP JP2013538100A patent/JP2013545740A/ja active Pending
- 2011-11-09 TW TW100140876A patent/TW201305139A/zh unknown
- 2011-11-09 EP EP11791203.0A patent/EP2638034A1/en not_active Withdrawn
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| AU2011328520A1 (en) | 2013-05-02 |
| CA2816769A1 (en) | 2012-05-18 |
| US20120115903A1 (en) | 2012-05-10 |
| JP2013545740A (ja) | 2013-12-26 |
| WO2012062462A1 (en) | 2012-05-18 |
| AR083817A1 (es) | 2013-03-27 |
| EP2638034A1 (en) | 2013-09-18 |
| TW201305139A (zh) | 2013-02-01 |
| BR112013010768A2 (pt) | 2016-07-12 |
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