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MX2010001189A - Derivados de naftiridina como modulares del canal de potasio. - Google Patents

Derivados de naftiridina como modulares del canal de potasio.

Info

Publication number
MX2010001189A
MX2010001189A MX2010001189A MX2010001189A MX2010001189A MX 2010001189 A MX2010001189 A MX 2010001189A MX 2010001189 A MX2010001189 A MX 2010001189A MX 2010001189 A MX2010001189 A MX 2010001189A MX 2010001189 A MX2010001189 A MX 2010001189A
Authority
MX
Mexico
Prior art keywords
formula
compound
potassium channel
channel modulators
pharmaceutically acceptable
Prior art date
Application number
MX2010001189A
Other languages
English (en)
Inventor
Jean-Michel Vernier
La Rosa Martha De
Original Assignee
Valeant Pharmaceuticals Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valeant Pharmaceuticals Int filed Critical Valeant Pharmaceuticals Int
Publication of MX2010001189A publication Critical patent/MX2010001189A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Liquid Crystal Substances (AREA)
  • Pyridine Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Esta invención proporciona compuestos de fórmula l (ver formula 1) en donde W y Z son independientemente CH o N yen donde otros sustituyentes se definen en la presente; tales compuestos son moduladores del canal de calcio; la invención también proporciona una composición que comprende un portador 6 excipiente farmacéuticamente aceptable y al menos uno, de los siguientes: una cantidad farmacéuticamente efectiva de un compuesto de fórmula l; una sal farmacéuticamente aceptable de un compuesto de fórmula l; un éster farmacéuticamente aceptable de un compuesto de fórmula l; la invención también proporciona un método para prevenir o tratar una enfermedad o trastorno que se ve afectado por las actividades de canales de potasio, que comprende administrar a un paciente que lo necesita una cantidad terapéuticamente efectiva de un compuesto de fórmula l o una sal o éster o solvato del mismo.
MX2010001189A 2007-08-01 2008-07-31 Derivados de naftiridina como modulares del canal de potasio. MX2010001189A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96286207P 2007-08-01 2007-08-01
US12/181,126 US8563566B2 (en) 2007-08-01 2008-07-28 Naphthyridine derivatives as potassium channel modulators
PCT/US2008/071803 WO2009018466A1 (en) 2007-08-01 2008-07-31 Naphthyridine derivatives as potassium channel modulators

Publications (1)

Publication Number Publication Date
MX2010001189A true MX2010001189A (es) 2010-08-10

Family

ID=39865205

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010001189A MX2010001189A (es) 2007-08-01 2008-07-31 Derivados de naftiridina como modulares del canal de potasio.

Country Status (15)

Country Link
US (1) US8563566B2 (es)
EP (2) EP2311836A1 (es)
JP (1) JP2010535244A (es)
KR (1) KR20100068373A (es)
CN (1) CN101778848A (es)
AT (1) ATE495175T1 (es)
AU (1) AU2008282118A1 (es)
BR (1) BRPI0814893A2 (es)
CA (1) CA2695196A1 (es)
DE (1) DE602008004555D1 (es)
MX (1) MX2010001189A (es)
PL (1) PL2183250T3 (es)
RU (1) RU2481347C2 (es)
TW (1) TW200922571A (es)
WO (1) WO2009018466A1 (es)

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Also Published As

Publication number Publication date
DE602008004555D1 (de) 2011-02-24
WO2009018466A1 (en) 2009-02-05
EP2183250A1 (en) 2010-05-12
CA2695196A1 (en) 2009-02-05
JP2010535244A (ja) 2010-11-18
TW200922571A (en) 2009-06-01
EP2311836A1 (en) 2011-04-20
RU2481347C2 (ru) 2013-05-10
US20090170885A1 (en) 2009-07-02
US8563566B2 (en) 2013-10-22
RU2010107284A (ru) 2011-09-10
EP2183250B1 (en) 2011-01-12
CN101778848A (zh) 2010-07-14
ATE495175T1 (de) 2011-01-15
BRPI0814893A2 (pt) 2015-09-15
PL2183250T3 (pl) 2011-06-30
AU2008282118A1 (en) 2009-02-05
KR20100068373A (ko) 2010-06-23

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