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MX2009004699A - Compuestos de piridinona. - Google Patents

Compuestos de piridinona.

Info

Publication number
MX2009004699A
MX2009004699A MX2009004699A MX2009004699A MX2009004699A MX 2009004699 A MX2009004699 A MX 2009004699A MX 2009004699 A MX2009004699 A MX 2009004699A MX 2009004699 A MX2009004699 A MX 2009004699A MX 2009004699 A MX2009004699 A MX 2009004699A
Authority
MX
Mexico
Prior art keywords
pyridinone compounds
compound
directed
pyridinone
cancer
Prior art date
Application number
MX2009004699A
Other languages
English (en)
Inventor
Gretchen M Schroeder
Zhen-Wei Cai
Robert M Borzilleri
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2009004699A publication Critical patent/MX2009004699A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La invención se dirige a compuestos de piridinona útiles para modular la cinasa Met que tiene la siguiente estructura: (ver fórmula (I)) y se dirige además a composiciones farmacéuticas que comprenden el compuesto; y métodos para tratar enfermedades proliferativas, tales como cáncer por la administración de este compuesto.
MX2009004699A 2006-11-08 2007-11-08 Compuestos de piridinona. MX2009004699A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85754006P 2006-11-08 2006-11-08
PCT/US2007/084047 WO2008058229A1 (en) 2006-11-08 2007-11-08 Pyridinone compounds

Publications (1)

Publication Number Publication Date
MX2009004699A true MX2009004699A (es) 2009-05-15

Family

ID=39048786

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004699A MX2009004699A (es) 2006-11-08 2007-11-08 Compuestos de piridinona.

Country Status (20)

Country Link
US (2) US7851489B2 (es)
EP (1) EP2089364B1 (es)
JP (1) JP5276005B2 (es)
KR (1) KR101390076B1 (es)
CN (1) CN101535264B (es)
AR (1) AR063628A1 (es)
AU (1) AU2007317296B2 (es)
CA (1) CA2669266C (es)
CL (1) CL2007003226A1 (es)
DK (1) DK2089364T3 (es)
ES (1) ES2424851T3 (es)
HR (1) HRP20130626T1 (es)
MX (1) MX2009004699A (es)
NO (1) NO342395B1 (es)
PE (1) PE20081490A1 (es)
PL (1) PL2089364T3 (es)
PT (1) PT2089364E (es)
SI (1) SI2089364T1 (es)
TW (1) TWI409259B (es)
WO (1) WO2008058229A1 (es)

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Also Published As

Publication number Publication date
KR101390076B1 (ko) 2014-04-29
HRP20130626T1 (en) 2013-08-31
WO2008058229A1 (en) 2008-05-15
PT2089364E (pt) 2013-08-26
CL2007003226A1 (es) 2008-02-08
TWI409259B (zh) 2013-09-21
HK1131608A1 (en) 2010-01-29
AR063628A1 (es) 2009-02-04
NO20091605L (no) 2009-05-27
CN101535264A (zh) 2009-09-16
PL2089364T3 (pl) 2013-11-29
US7851489B2 (en) 2010-12-14
JP2010509362A (ja) 2010-03-25
US20080114033A1 (en) 2008-05-15
PE20081490A1 (es) 2008-10-30
US20110052583A1 (en) 2011-03-03
EP2089364A1 (en) 2009-08-19
EP2089364B1 (en) 2013-06-12
NO342395B1 (no) 2018-05-14
ES2424851T3 (es) 2013-10-09
DK2089364T3 (da) 2013-09-02
AU2007317296A1 (en) 2008-05-15
CA2669266A1 (en) 2008-05-15
JP5276005B2 (ja) 2013-08-28
KR20090096423A (ko) 2009-09-10
AU2007317296B2 (en) 2012-07-05
US8536200B2 (en) 2013-09-17
SI2089364T1 (sl) 2013-10-30
TW200829564A (en) 2008-07-16
CA2669266C (en) 2014-04-29
CN101535264B (zh) 2012-11-28

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