[go: up one dir, main page]

MA26409A1 - Derives de pyrimidine a noyaux condenses heterocycliques, et compositions pharmaceutiques les contenant - Google Patents

Derives de pyrimidine a noyaux condenses heterocycliques, et compositions pharmaceutiques les contenant

Info

Publication number
MA26409A1
MA26409A1 MA24256A MA24256A MA26409A1 MA 26409 A1 MA26409 A1 MA 26409A1 MA 24256 A MA24256 A MA 24256A MA 24256 A MA24256 A MA 24256A MA 26409 A1 MA26409 A1 MA 26409A1
Authority
MA
Morocco
Prior art keywords
pharmaceutical compositions
compositions containing
pyrimidine derivatives
heterocyclic condensed
condensed cores
Prior art date
Application number
MA24256A
Other languages
English (en)
Inventor
Paul Moyer Mikel
Daniel Arnold Lee
Beth Sobolov-Jaynes Susan
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA26409A1 publication Critical patent/MA26409A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
MA24256A 1995-06-07 1996-06-03 Derives de pyrimidine a noyaux condenses heterocycliques, et compositions pharmaceutiques les contenant MA26409A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1995/007881 WO1996040142A1 (fr) 1995-06-07 1995-06-07 Derives de pyrimidine heterocycliques a noyaux condenses
HU9601559A HUP9601559A3 (en) 1995-06-07 1996-06-06 Heterocyclic ring-fused pyrimidine derivatives, pharmaceutical compositions containing the same and intermediates

Publications (1)

Publication Number Publication Date
MA26409A1 true MA26409A1 (fr) 2004-12-20

Family

ID=89994036

Family Applications (1)

Application Number Title Priority Date Filing Date
MA24256A MA26409A1 (fr) 1995-06-07 1996-06-03 Derives de pyrimidine a noyaux condenses heterocycliques, et compositions pharmaceutiques les contenant

Country Status (32)

Country Link
EP (1) EP0831829B1 (fr)
JP (1) JP3290666B2 (fr)
CN (1) CN1141298A (fr)
AP (1) AP637A (fr)
AR (1) AR002746A1 (fr)
AT (1) ATE247469T1 (fr)
AU (1) AU5479196A (fr)
BR (1) BR9602695A (fr)
CA (1) CA2223081C (fr)
CO (1) CO4440628A1 (fr)
CZ (1) CZ164196A3 (fr)
DE (1) DE69531558T2 (fr)
DK (1) DK0831829T3 (fr)
ES (1) ES2203642T3 (fr)
FI (1) FI974443A7 (fr)
HR (1) HRP960269A2 (fr)
HU (1) HUP9601559A3 (fr)
IL (1) IL118487A0 (fr)
MA (1) MA26409A1 (fr)
MX (1) MX9709867A (fr)
NO (1) NO962386L (fr)
NZ (1) NZ286755A (fr)
OA (1) OA10460A (fr)
PL (1) PL314641A1 (fr)
PT (1) PT831829E (fr)
RU (1) RU2136683C1 (fr)
SG (1) SG45483A1 (fr)
SI (1) SI9600184A (fr)
SK (1) SK72996A3 (fr)
TR (1) TR199600474A2 (fr)
WO (1) WO1996040142A1 (fr)
ZA (1) ZA964725B (fr)

Families Citing this family (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0682027T3 (da) * 1994-05-03 1998-05-04 Ciba Geigy Ag Pyrrolopyrimidinderivater med antiproliferativ virkning
TW321649B (fr) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
DE69609602T2 (de) * 1995-04-03 2001-04-12 Novartis Ag, Basel Pyrazolderivate und verfahren zu deren herstellung
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
US5932574A (en) * 1995-04-27 1999-08-03 Zeneca Limited Quinazoline derivatives
TR199800012T1 (xx) * 1995-07-06 1998-04-21 Novartis Ag Piroloprimidinler ve preparasyon i�in tatbikler.
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
JP4275733B2 (ja) * 1996-01-23 2009-06-10 ノバルティス アクチエンゲゼルシャフト ピロロピリミジンおよびその製造法
AU719434B2 (en) 1996-02-13 2000-05-11 Astrazeneca Ab Quinazoline derivatives as VEGF inhibitors
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
ES2169355T3 (es) 1996-03-05 2002-07-01 Astrazeneca Ab Derivados de 4-anilinoquinazolina.
DE69710712T3 (de) 1996-04-12 2010-12-23 Warner-Lambert Co. Llc Umkehrbare inhibitoren von tyrosin kinasen
GB9607729D0 (en) * 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
AU3176297A (en) * 1996-06-25 1998-01-14 Novartis Ag Substituted 7-amino-pyrrolo{3,2-d}pyrimidines and the use thereof
ATE384062T1 (de) 1996-08-23 2008-02-15 Novartis Pharma Gmbh Substituierte pyrrolopyrimidine und verfahren zu ihrer herstellung
EP0929553B1 (fr) 1996-10-02 2005-03-16 Novartis AG Derives de pyrimidine et procedes de preparation de ces derniers
US6225318B1 (en) 1996-10-17 2001-05-01 Pfizer Inc 4-aminoquinazolone derivatives
CA2272705C (fr) 1996-11-27 2003-03-18 Pfizer Inc. Derives de pyrimidines bicycliques fusionnes
JP2001514260A (ja) 1997-09-02 2001-09-11 デュポン ファーマシューティカルズ カンパニー Ｃｎｓおよびストレス関連疾患の治療に有用な、副腎皮質刺激ホルモン放出ホルモン拮抗剤としての、複素環基が置換した環縮合ピリジン類およびピリミジン類
CN1280580A (zh) 1997-11-11 2001-01-17 辉瑞产品公司 用作抗癌药的噻吩并嘧啶和噻吩并吡啶衍生物
JPH11236333A (ja) * 1997-12-30 1999-08-31 Pfizer Prod Inc 抗ガン剤として有用なイミダゾリン−４−オン誘導体
RS49779B (sr) 1998-01-12 2008-06-05 Glaxo Group Limited, Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
DE69943144D1 (de) 1998-03-31 2011-03-03 Kyowa Hakko Kirin Co Ltd Stickstoffenthaltende heterocyclische verbindungen
PA8474101A1 (es) * 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
HRP20000885B1 (hr) 1998-06-19 2007-03-31 Pfizer Products Inc. PIROLO[2,3-d]PIRIMIDINSKI SPOJEVI
WO2000023444A1 (fr) * 1998-10-21 2000-04-27 Abbott Laboratories Composes de 4-aminopyrido[2,3-d]pyrimidine a disubstitution 5,7
US6174903B1 (en) 1998-12-28 2001-01-16 Pfizer Inc. Imidazolidin-4-one derivatives useful as anticancer agents
JP3270834B2 (ja) 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
UA71945C2 (en) * 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
US6933299B1 (en) 1999-07-09 2005-08-23 Smithkline Beecham Corporation Anilinoquinazolines as protein tyrosine kinase inhibitors
JP2003504363A (ja) 1999-07-09 2003-02-04 グラクソ グループ リミテッド プロテインチロシンキナーゼ阻害剤としてのアニリノキナゾリン類
US6432979B1 (en) 1999-08-12 2002-08-13 American Cyanamid Company Method of treating or inhibiting colonic polyps and colorectal cancer
CN1373763A (zh) 1999-09-15 2002-10-09 沃尼尔·朗伯公司 作为激酶抑制剂的蝶啶酮
RU2264404C2 (ru) * 1999-10-21 2005-11-20 Ф.Хоффманн-Ля Рош Аг Алкиламинозамещенные бициклические азотсодержащие гетероциклы и фармацевтическая композиция на их основе
GB9925958D0 (en) * 1999-11-02 1999-12-29 Bundred Nigel J Therapeutic use
EP1676845B1 (fr) 1999-11-05 2008-06-11 AstraZeneca AB Nouveaux dérivés de type quinazoline
JP2001142235A (ja) 1999-11-17 2001-05-25 Fuji Denki Gazo Device Kk 電子写真用感光体
JP4078074B2 (ja) 1999-12-10 2008-04-23 ファイザー・プロダクツ・インク ピロロ［２，３−ｄ］ピリミジン化合物
DE60106022T2 (de) 2000-06-06 2006-03-09 Pfizer Products Inc., Groton Thiophenverbindungen zur verwendung als antikrebsmittel
CA2412560C (fr) 2000-06-26 2008-12-30 Pfizer Products Inc. Composes pyrrolo[2,3-d]pyrimidine en tant qu'agents immunosuppresseurs
HUP0302221A3 (en) 2000-09-20 2004-01-28 Merck Patent Gmbh 4-amino-quinazolines
DE60134679D1 (de) 2000-10-20 2008-08-14 Eisai R&D Man Co Ltd Stickstoff enthaltende aromatische Heterozyklen
ATE330956T1 (de) 2001-04-13 2006-07-15 Pfizer Prod Inc Bizyklisch substituierte 4- aminopyridopyrimidinderivate
AR035885A1 (es) * 2001-05-14 2004-07-21 Novartis Ag Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica
US7301023B2 (en) 2001-05-31 2007-11-27 Pfizer Inc. Chiral salt resolution
WO2003000194A2 (fr) 2001-06-21 2003-01-03 Pfizer Inc. Derives bicycliques de pyridine et de pyrimidine utiles en tant qu'agents anticancereux
CZ294535B6 (cs) * 2001-08-02 2005-01-12 Ústav Experimentální Botaniky Avčr Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
GB0121033D0 (en) * 2001-08-30 2001-10-24 Novartis Ag Organic compounds
US7829566B2 (en) 2001-09-17 2010-11-09 Werner Mederski 4-amino-quinazolines
GT200200234A (es) * 2001-12-06 2003-06-27 Compuestos cristalinos novedosos
RU2289583C2 (ru) * 2001-12-27 2006-12-20 Ф.Хоффманн-Ля Рош Аг Пиримидотриазины, способ их получения, фармацевтическая композиция на их основе и применение
AU2003202263A1 (en) 2002-01-10 2003-07-30 Bayer Healthcare Ag Roh-kinase inhibitors
EP1471910A2 (fr) 2002-01-17 2004-11-03 Neurogen Corporation Analogues de quinazoline-4-ylamine substitues comme modulateurs de receptors de la capsaicin
WO2003062225A1 (fr) 2002-01-23 2003-07-31 Bayer Pharmaceuticals Corporation Derives pyrimidine en tant qu'inhibiteurs de kinase rho
ES2298497T3 (es) 2002-01-23 2008-05-16 Bayer Pharmaceuticals Corporation Inhibidores de quinasa rho.
JP2003238561A (ja) 2002-02-13 2003-08-27 Fuji Denki Gazo Device Kk キノメタン化合物
JP2005527511A (ja) 2002-03-01 2005-09-15 ファイザー インコーポレイテッド 抗血管形成剤として有用なチエノピリジンのインドリル−尿素誘導体およびその使用法
MXPA04008592A (es) * 2002-03-07 2004-12-06 Hoffmann La Roche Inhibidores de piridina biciclica y pirimidina p38 cinasa.
UA77303C2 (en) 2002-06-14 2006-11-15 Pfizer Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
BR0316487A (pt) 2002-11-26 2005-10-11 Pfizer Prod Inc Método todo de tratamento da rejeição de transplantes
WO2004064736A2 (fr) 2003-01-17 2004-08-05 Threshold Pharmaceuticals, Inc. Traitement de l'hyperplasie benigne de la prostate au moyen d'agents energolytiques
FR2851248B1 (fr) * 2003-02-18 2005-04-08 Aventis Pharma Sa Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
AU2004240772B2 (en) 2003-05-22 2011-04-28 Nerviano Medical Sciences S.R.L. Pyrazolo-quinazoline derivatives,process for their preparation and their use as kinase inhibitors
MXPA06001758A (es) * 2003-08-15 2006-08-11 Irm Llc Anilino purinas sustituidas en la posicion 6 utiles como inhibidores de rtk.
US7338957B2 (en) * 2003-08-28 2008-03-04 Irm Llc Compounds and compositions as protein kinase inhibitors
ATE412655T1 (de) 2003-08-29 2008-11-15 Pfizer Als neue antiangiogene mittel geeignete thienopyridinphenylacetamide und derivate davon
US7419978B2 (en) 2003-10-22 2008-09-02 Bristol-Myers Squibb Company Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
JP4303726B2 (ja) 2003-11-11 2009-07-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 ウレア誘導体およびその製造方法
JP4503022B2 (ja) 2003-12-23 2010-07-14 ファイザー・インク 新規キノリン誘導体
WO2005095419A1 (fr) * 2004-04-01 2005-10-13 Takeda Pharmaceutial Company Limited Dérivé de thiazolopyrimidine
JP4842929B2 (ja) 2004-05-27 2011-12-21 ファイザー・プロダクツ・インク 癌治療に有用なピロロピリミジン誘導体
US7507740B2 (en) * 2004-06-02 2009-03-24 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
UA91508C2 (ru) * 2004-06-02 2010-08-10 Такеда Фармасьютикал Компани Лимитед Конденсированное гетероциклическое соединение
JP2007161585A (ja) * 2004-06-25 2007-06-28 Taisho Pharmaceut Co Ltd 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体
ES2322175T3 (es) 2004-09-17 2009-06-17 EISAI R&D MANAGEMENT CO., LTD. Composicion medicinal con estabilidad mejorada y gelificacion reducida.
US7947676B2 (en) * 2004-12-14 2011-05-24 Astrazeneca Ab Pyrazolo[3,4-d]pyrimidine compounds as antitumor agents
DE602006004844D1 (de) * 2005-02-03 2009-03-05 Vertex Pharma Pyrrolopyrimidine verwendbar als protein kinase inhibitoren
US7423043B2 (en) 2005-02-18 2008-09-09 Lexicon Pharmaceuticals, Inc. 4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine compounds
US20090111805A1 (en) * 2005-02-24 2009-04-30 Pfizer Inc. Bicyclic heteroaromatic derivatives useful as anticancer agents
ES2314933T3 (es) * 2005-06-17 2009-03-16 Janssen Pharmaceutica Nv Compuestos de naftiridina.
US9006240B2 (en) 2005-08-02 2015-04-14 Eisai R&D Management Co., Ltd. Method for assay on the effect of vascularization inhibitor
CN101384592A (zh) * 2005-12-21 2009-03-11 艾博特公司 抗病毒化合物
ATE475660T1 (de) 2005-12-21 2010-08-15 Abbott Lab Antivirale verbindungen
US7910595B2 (en) * 2005-12-21 2011-03-22 Abbott Laboratories Anti-viral compounds
WO2007081517A2 (fr) 2005-12-21 2007-07-19 Abbott Laboratories Composes anti-viraux
JP5255559B2 (ja) * 2006-03-31 2013-08-07 アボット・ラボラトリーズ インダゾール化合物
CA2909277A1 (fr) * 2006-04-04 2007-10-11 Kevan M. Shokat Antagonistes de la kinase
CA2652442C (fr) 2006-05-18 2014-12-09 Eisai R & D Management Co., Ltd. Agent antitumoral destine au cancer de la thyroide
EP1889847A1 (fr) * 2006-07-10 2008-02-20 DeveloGen Aktiengesellschaft Dérivés de pyrrolopyrimidine pour applications pharmaceutiques
EP2065372B1 (fr) 2006-08-28 2012-11-28 Eisai R&D Management Co., Ltd. Agent antitumoral pour cancer gastrique non différencié
CA2673097A1 (fr) * 2006-12-12 2008-06-19 Takeda Pharmaceutical Company Limited Compose heterocyclique condense
EP2094276A4 (fr) 2006-12-20 2011-01-05 Abbott Lab Composés antiviraux
JP5319306B2 (ja) 2007-01-29 2013-10-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 未分化型胃癌治療用組成物
CN101848895B (zh) 2007-11-09 2013-10-23 卫材R&D管理有限公司 血管新生抑制物质和抗肿瘤性铂络合物的组合使用
TW200944528A (en) 2008-03-12 2009-11-01 Takeda Pharmaceutical Fused heterocyclic compound
JP2011529920A (ja) 2008-07-31 2011-12-15 ジェネンテック， インコーポレイテッド ピリミジン化合物、組成物及び使用方法
BRPI0917459B1 (pt) 2008-08-20 2017-09-12 Zoetis Services Llc N-methyl-1- [trans-4- [methyl (7h-pyrrol [2,3-d] pyridol [2,3-d] pyrimidine compounds, use of these in therapy and crystalline a form of n-methyl- pyrimidin-4-yl) amino] cyclohexyl} methanosulphonamide
TW201014860A (en) * 2008-09-08 2010-04-16 Boehringer Ingelheim Int New chemical compounds
KR101126736B1 (ko) * 2008-11-27 2012-04-12 주식회사 레고켐 바이오사이언스 티로신 키나아제 저해 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염 및 이를 포함하는 약학적 조성물
KR20250123237A (ko) 2009-01-16 2025-08-14 엑셀리시스, 인코포레이티드 암의 치료를 위한 ｎ-（４-｛〔６，７-비스（메틸옥시）퀴놀린-4-일〕옥시｝페닐）-ｎ＇-（４-플루오로페닐）사이클로프로판-1,1-디카르복사미드의 말산염 및 그 결정형
DE102009005193A1 (de) * 2009-01-20 2010-07-22 Merck Patent Gmbh Neue heterocyclische Verbindungen als MetAP-2 Inhibitoren
CA2752265A1 (fr) * 2009-02-17 2010-08-26 Boehringer Ingelheim International Gmbh Derives pyrimido-[5,4-d]-pyrimidine pour l'inhibition des tyrosine-kinases
UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
AU2010285740C1 (en) 2009-08-19 2016-03-17 Eisai R&D Management Co., Ltd. Quinoline derivative-containing pharmaceutical composition
CA2778686C (fr) 2009-11-12 2015-07-21 F. Hoffmann-La Roche Ag Composes de purine n-9-substitues, compositions et procedes d'utilisation
WO2011058025A1 (fr) 2009-11-12 2011-05-19 F. Hoffmann-La Roche Ag Composés de pyrazolopyrimidine et de purine n-7-substitués, compositions et procédés d'utilisation correspondants
CN102822177A (zh) * 2010-02-05 2012-12-12 美国辉瑞有限公司 吡咯并[2,3-d]嘧啶脲化合物
ES2573515T3 (es) 2010-06-25 2016-06-08 Eisai R&D Management Co., Ltd. Agente antitumoral que emplea compuestos con efecto inhibitorio de cinasas combinados
AU2011295441B2 (en) * 2010-08-27 2015-04-09 Merck Patent Gmbh Furopyridine derivatives
CN103298816A (zh) 2010-12-17 2013-09-11 内尔维阿诺医学科学有限公司 作为激酶抑制剂的取代的吡唑并-喹唑啉衍生物
SG10201913982WA (en) 2011-03-04 2020-03-30 Newgen Therapeutics Inc Alkyne Substituted Quinazoline Compound And Methods Of Use
JP6021805B2 (ja) 2011-04-18 2016-11-09 エーザイ・アール・アンド・ディー・マネジメント株式会社 腫瘍治療剤
EP3444363B1 (fr) 2011-06-03 2020-11-25 Eisai R&D Management Co., Ltd. Biomarqueurs pour la prédiction et l'estimation de la sensibilité de sujets atteints d'un cancer de la thyroïde et du rein vis-à-vis de composés lenvatinib
ES2606638T3 (es) * 2012-02-21 2017-03-24 Merck Patent Gmbh Derivados de furopiridina
CN104837841A (zh) 2012-09-26 2015-08-12 拜耳制药股份公司 用于治疗过度增殖性疾病的取代的吲唑-吡咯并嘧啶
CA2885787A1 (fr) 2012-09-26 2014-04-03 Lars Wortmann Indazol-pyrrolopyrimidines substituees utiles dans le traitement de troubles hyperproliferatifs
BR112015009004A8 (pt) 2012-12-21 2021-07-20 Eisai R&D Man Co Ltd forma amorfa de derivado de quinolina e método de produção da mesma
HK1222173A1 (zh) * 2013-02-01 2017-06-23 Bayer Pharma Aktiengesellschaft 取代的吡唑并嘧啶基氨基-吲唑类
WO2014145576A2 (fr) * 2013-03-15 2014-09-18 Northwestern University Pyrrolo(2,3-d)pyrimidines substituées pour le traitement du cancer
US10517861B2 (en) 2013-05-14 2019-12-31 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
NZ729137A (en) 2014-08-04 2022-07-29 Nuevolution As Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases
JP6659554B2 (ja) 2014-08-28 2020-03-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 高純度キノリン誘導体およびその製造方法
LT3263106T (lt) 2015-02-25 2024-01-10 Eisai R&D Management Co., Ltd. Chinolino darinių kartumo sumažinimo būdas
AU2015384801B2 (en) 2015-03-04 2022-01-06 Eisai R&D Management Co., Ltd. Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer
AU2016279474B2 (en) 2015-06-16 2021-09-09 Eisai R&D Management Co., Ltd. Anticancer agent
SG11201801083UA (en) 2015-08-20 2018-03-28 Eisai R&D Man Co Ltd Tumor therapeutic agent
GB201520499D0 (en) * 2015-11-20 2016-01-06 Medical Res Council Technology Compounds
CN106831779B (zh) * 2015-11-28 2019-07-19 南昌弘益药业有限公司 一类jak激酶抑制剂的新化合物
CN110072528B (zh) 2017-02-08 2022-04-26 卫材R&D管理有限公司 治疗肿瘤的药物组合物
KR20200013644A (ko) 2017-05-16 2020-02-07 에자이 알앤드디 매니지먼트 가부시키가이샤 간세포 암종의 치료
NL2022471B1 (en) 2019-01-29 2020-08-18 Vationpharma B V Solid state forms of oclacitinib
CN111825674A (zh) * 2019-04-22 2020-10-27 上海仕谱生物科技有限公司 嘧啶并五元杂环类化合物及其作为突变型idh2抑制剂的用途
JP2021098692A (ja) 2019-12-20 2021-07-01 ヌエヴォリューション・アクティーゼルスカブＮｕｅｖｏｌｕｔｉｏｎ Ａ／Ｓ 核内受容体に対して活性の化合物
JP7746259B2 (ja) 2019-12-20 2025-09-30 ヌエヴォリューション・アクティーゼルスカブ 核内受容体に対して活性の化合物
US11780843B2 (en) 2020-03-31 2023-10-10 Nuevolution A/S Compounds active towards nuclear receptors
US11613532B2 (en) 2020-03-31 2023-03-28 Nuevolution A/S Compounds active towards nuclear receptors
WO2022221227A1 (fr) 2021-04-13 2022-10-20 Nuvalent, Inc. Hétérocycles amino-substitués pour le traitement de cancers avec des mutations egfr

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4012513A (en) * 1971-11-03 1977-03-15 Imperial Chemical Industries Limited Indole derivatives for providing analgesic and anti-inflammatory effects
JPS58126887A (ja) * 1981-09-26 1983-07-28 Takeda Chem Ind Ltd 新規７−デアザプリン誘導体
JPS58157790A (ja) * 1982-03-16 1983-09-19 Takeda Chem Ind Ltd ７−デアザプリン誘導体およびその製造法
JPS60233080A (ja) * 1984-05-02 1985-11-19 Takeda Chem Ind Ltd ７−デアザプリン誘導体
IE60433B1 (en) * 1986-08-26 1994-07-13 Warner Lambert Co Novel 9-deazaguanines
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
US5378700A (en) * 1989-10-11 1995-01-03 Teijin Limited Fused pyrimidine derivative, process for preparation of same and pharmaceutical preparation comprising same as active ingredient
US5320663A (en) * 1992-07-02 1994-06-14 E. I. Du Pont De Nemours And Company Method of obtaining lead and organolead from contaminated media using metal accumulating plants
PL176526B1 (pl) * 1992-12-17 1999-06-30 Pfizer Pirolopirymidyny jako związki o działaniu antagonistów czynnika uwalniającego kortykotropinę
WO1995001355A1 (fr) * 1993-06-30 1995-01-12 Biocryst Pharmaceuticals, Inc. Composes a base de 9-deazahypoxanthines utilises comme inhibiteurs de pnp

Also Published As

Publication number Publication date
JP3290666B2 (ja) 2002-06-10
CA2223081A1 (fr) 1996-12-19
ES2203642T3 (es) 2004-04-16
FI974443A0 (fi) 1997-12-05
WO1996040142A1 (fr) 1996-12-19
PL314641A1 (en) 1996-12-09
RU2136683C1 (ru) 1999-09-10
EP0831829A1 (fr) 1998-04-01
SI9600184A (en) 1997-04-30
HUP9601559A3 (en) 1997-07-28
AP637A (en) 1998-04-08
FI974443L (fi) 1997-12-05
NZ286755A (en) 1998-03-25
PT831829E (pt) 2003-12-31
CN1141298A (zh) 1997-01-29
EP0831829B1 (fr) 2003-08-20
FI974443A7 (fi) 1997-12-05
HU9601559D0 (en) 1996-08-28
AP9600805A0 (en) 1996-07-31
DE69531558T2 (de) 2004-03-18
CO4440628A1 (es) 1997-05-07
SG45483A1 (en) 1998-01-16
TR199600474A2 (tr) 1996-12-21
SK72996A3 (en) 1997-04-09
AU5479196A (en) 1996-12-19
JPH10508875A (ja) 1998-09-02
HUP9601559A2 (en) 1997-02-28
CZ164196A3 (en) 1996-12-11
DE69531558D1 (de) 2003-09-25
NO962386D0 (no) 1996-06-06
ATE247469T1 (de) 2003-09-15
NO962386L (no) 1996-12-09
DK0831829T3 (da) 2003-12-15
CA2223081C (fr) 2001-03-06
AR002746A1 (es) 1998-04-29
OA10460A (en) 2002-03-28
IL118487A0 (en) 1996-09-12
HRP960269A2 (en) 1997-08-31
BR9602695A (pt) 1998-10-06
ZA964725B (en) 1997-12-08
MX9709867A (es) 1998-03-31
EP0831829A4 (fr) 1998-11-25

Similar Documents

Publication Publication Date Title
MA26409A1 (fr) Derives de pyrimidine a noyaux condenses heterocycliques, et compositions pharmaceutiques les contenant
MA26537A1 (fr) Derives de 2-aminopyridine nouveaux et compositions pharmaceutiques les contenant.
DZ2086A1 (fr) Benzylaminopipéridines substituées et compositionspharmaceutiques les contenant.
BRPI9810519B1 (pt) derivados de 4''-substituìdo-9-desoxo-9a-aza-9a-homoeritromicina a e composição farmacêutica compreendendo os mesmos.
BG97198A (bg) Диалкокси-пиридинил-бензимидазолови производни, метод за получаването им и тяхното фармацевтично приложение
PT869126E (pt) Derivados de ditiolano, sua preparacao e seus efeitos terapeuticos
FI962589L (fi) 2,4-disulfofenyylibutyylinitroni, sen suolat ja niiden käyttö farmaseuttisina aineina
FI973148L (fi) Substituoituja heterosyklisiä yhdisteitä, menetelmä niiden valmistamiseksi ja niitä sisältäviä farmaseuttisia koostumuksia
ATE187063T1 (de) Arzneimittel
BR9611628A (pt) Derivados de pirido [2,3-d] pirimidina e composições medicinais dos mesmos
FI935887L (fi) Tiatzolidiinidionijohdannaiset, niiden valmistus ja käyttö
EE200000161A (et) Halogeenasendatud tetratsüklilise tetrahüdrofuraani derivaadid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon
FI945052L (fi) Anti-iskeeminen lääke
BR9600300A (pt) Artigo e composição aquosa
FR2681067B1 (fr) Derives heterocycliques n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
FI931011A7 (fi) Kondensoituneet heterosykliset ketonijohdannaiset, niiden valmistus ja käyttö
FR2731706B1 (fr) Composes heterocycliques aromatiques, compositions pharmaceutiques et cosmetiques les contenant et utilisations
FR2687401B1 (fr) Derives de la 1,4-dialkylpiperazine, procedes d'obtention et compositions pharmaceutiques les contenant.
EE03878B1 (et) 5-O-desosaminüül-6-O-metüülerütronoliid A derivaadid, nende valmistamismeetod ja kasutamine bioaktiivsete ühendite valmistamiseks
FR2662692B1 (fr) Derives heterocycliques doues d'activite anticonvulsivante, procede de preparation et composition pharmaceutique.
BR9808060B1 (pt) composição farmacêutica, e, uso da lamivudina ou um seu derivado farmaceuticamente aceitável.
FI935654A7 (fi) Kondensoituneet heterosykliset yhdisteet, niiden valmistus ja käyttö
BR9911178B1 (pt) Derivados de 3-(2-oxo-[1,3']bipirrolidinil-3-ilidenometil)-cefems, bem como preparação farmacêutica e uso dos mesmos
DE69619680D1 (de) Heterocyclisch kondensierte thiazol-derivate
IT1290447B1 (it) Derivati 1,3-ossatiolanici ad attivita' antivirale