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BRPI9810519B1 - derivados de 4''-substituìdo-9-desoxo-9a-aza-9a-homoeritromicina a e composição farmacêutica compreendendo os mesmos. - Google Patents

derivados de 4''-substituìdo-9-desoxo-9a-aza-9a-homoeritromicina a e composição farmacêutica compreendendo os mesmos.

Info

Publication number
BRPI9810519B1
BRPI9810519B1 BRPI9810519-1A BRPI9810519A BRPI9810519B1 BR PI9810519 B1 BRPI9810519 B1 BR PI9810519B1 BR PI9810519 A BRPI9810519 A BR PI9810519A BR PI9810519 B1 BRPI9810519 B1 BR PI9810519B1
Authority
BR
Brazil
Prior art keywords
homoerythromycin
deoxo
aza
derivatives
substituted
Prior art date
Application number
BRPI9810519-1A
Other languages
English (en)
Inventor
Brian Scott Bronk
Michael Anthony Letavic
Takushi Kaneko
Bingwei Vera Yang
Edward Alan Glazer
Hengmiao Cheng
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI9810519(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BRPI9810519A publication Critical patent/BRPI9810519A/pt
Publication of BRPI9810519B1 publication Critical patent/BRPI9810519B1/pt
Publication of BRPI9810519B8 publication Critical patent/BRPI9810519B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI9810519A 1997-06-11 1998-05-29 derivados de 4''-substituído-9-desoxo-9a-aza-9a-homoeritromicina a e composição farmacêutica compreendendo os mesmos. BRPI9810519B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11
PCT/IB1998/000839 WO1998056802A1 (en) 1997-06-11 1998-05-29 4'-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Publications (3)

Publication Number Publication Date
BRPI9810519A BRPI9810519A (pt) 2000-09-19
BRPI9810519B1 true BRPI9810519B1 (pt) 2012-02-22
BRPI9810519B8 BRPI9810519B8 (pt) 2022-11-16

Family

ID=21959336

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9810519A BRPI9810519B8 (pt) 1997-06-11 1998-05-29 derivados de 4''-substituído-9-desoxo-9a-aza-9a-homoeritromicina a e composição farmacêutica compreendendo os mesmos.

Country Status (49)

Country Link
US (4) US6420536B1 (pt)
EP (1) EP0988310B9 (pt)
JP (2) JP3315704B2 (pt)
KR (1) KR100396168B1 (pt)
CN (4) CN1172947C (pt)
AP (1) AP1231A (pt)
AR (1) AR013086A1 (pt)
AT (1) ATE251173T1 (pt)
AU (1) AU749816B2 (pt)
BG (1) BG64391B1 (pt)
BR (1) BRPI9810519B8 (pt)
CA (1) CA2293823C (pt)
CO (1) CO4950611A1 (pt)
CZ (1) CZ298556B6 (pt)
DE (2) DE122004000018I2 (pt)
DK (1) DK0988310T3 (pt)
DZ (1) DZ2514A1 (pt)
EA (1) EA002441B1 (pt)
EG (1) EG24081A (pt)
ES (1) ES2205487T3 (pt)
FR (1) FR04C0013I2 (pt)
GT (1) GT199800077A (pt)
HN (1) HN1998000086A (pt)
HR (1) HRP980314B1 (pt)
HU (2) HU228005B1 (pt)
ID (1) ID22992A (pt)
IL (1) IL132809A0 (pt)
IS (1) IS1998B (pt)
LU (1) LU91076I9 (pt)
MA (1) MA24564A1 (pt)
ME (1) ME00876B (pt)
MY (1) MY123354A (pt)
NL (1) NL300150I2 (pt)
NO (1) NO316911B1 (pt)
NZ (2) NZ514871A (pt)
OA (1) OA11224A (pt)
PA (1) PA8452201A1 (pt)
PE (1) PE79699A1 (pt)
PL (1) PL191601B1 (pt)
PT (1) PT988310E (pt)
RS (1) RS49675B (pt)
SI (1) SI0988310T1 (pt)
SK (1) SK284171B6 (pt)
TN (1) TNSN98082A1 (pt)
TW (1) TW472060B (pt)
UA (1) UA67744C2 (pt)
UY (1) UY25040A1 (pt)
WO (1) WO1998056802A1 (pt)
ZA (1) ZA985017B (pt)

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EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
ATE353014T1 (de) * 1997-09-10 2007-02-15 Merial Ltd Verwendung von 9a-azaliden als antimikrobielle mittel für tiere
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
CA2411293A1 (en) * 1999-01-28 2000-07-28 Pfizer Products Inc. Novel azalides and methods of making same
EA003417B1 (ru) * 1999-05-18 2003-04-24 Пфайзер Продактс Инк. Новые кристаллические формы макролидного антибиотика
CN1351608A (zh) * 1999-05-24 2002-05-29 辉瑞产品公司 13－甲基红霉素衍生物
US6465437B1 (en) 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
ATE315042T1 (de) * 1999-08-24 2006-02-15 Abbott Lab 9a-azalide mit antibakterieller wirkung
US6608033B1 (en) * 1999-08-27 2003-08-19 Pfizer Inc. Treatment or prevention of coccidiosis
DE60003586T2 (de) * 2000-01-27 2004-01-08 Pfizer Products Inc., Groton Antibiotische azalid-zusammensetzungen
OA12257A (en) * 2000-04-27 2003-11-06 Pfizer Prod Inc the use of azalide antibiotic compositions for treating or preventing a bacterial or protozoal infection in mammals.
CA2445306C (en) * 2001-04-27 2008-02-12 Pfizer Products Inc. Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
WO2003011266A2 (en) * 2001-08-01 2003-02-13 Pfizer Products Inc. Azalide antibiotic compositions
WO2004080391A2 (en) 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
WO2005030227A1 (en) 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
EP1689434A1 (en) * 2003-11-21 2006-08-16 Pfizer Products Inc. The use of anti biotics as vaccine adjuvants
DK1730131T3 (da) * 2004-03-16 2012-08-13 Boehringer Ingelheim Int Glucopyranosyl-substituerede benzol-derivater, lægemiddel indeholdende disse forbindelser, deres anvendelse og fremgangsmåder til deres fremstilling
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
ATE429921T1 (de) * 2005-01-14 2009-05-15 Glaxosmithkline Zagreb 9a-carbamoyl- und thiocarbamoylazalide mit antimalariawirkung
US9453042B2 (en) * 2007-10-25 2016-09-27 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
CN102245195B (zh) 2008-10-24 2016-01-13 森普拉制药公司 使用含三唑的大环内酯的生物防御
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN102724874B (zh) 2009-09-10 2018-06-01 森普拉制药公司 治疗疟疾、结核病和mac疾病的方法
PL2550286T3 (pl) 2010-03-22 2016-07-29 Cempra Pharmaceuticals Inc Krystaliczne postaci makrolidu i ich zastosowanie
CA2799937A1 (en) 2010-05-20 2011-11-24 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
US8940880B2 (en) * 2010-09-20 2015-01-27 Novartis Ag Process for the preparation of 9-deoxo-9a-homoerythromycin A, modified in the C-4″ of the cladinose ring by an epoxide group
WO2012051126A2 (en) * 2010-10-10 2012-04-19 Synovo Gmbh Anti-inflammatory macrolides
CN102993250B (zh) * 2011-07-06 2016-02-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
WO2013013834A1 (en) 2011-07-27 2013-01-31 Farma Grs, D.O.O. New crystalline forms of tulathromycin
SG11201405895UA (en) 2012-03-27 2014-10-30 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
RU2015138796A (ru) 2013-03-14 2017-04-19 Семпра Фармасьютикалс, Инк. Способы и составы для лечения респираторных заболеваний
HK1218864A1 (zh) 2013-03-15 2017-03-17 森普拉制药公司 用於制备大环内酯抗菌剂的收敛方法
WO2015014907A1 (en) * 2013-07-31 2015-02-05 Farma Grs, D.O.O. Process for preparation of tulathromycin
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普（天津）生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) * 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) * 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

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UA70972C2 (uk) 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків

Also Published As

Publication number Publication date
HK1068893A1 (en) 2005-07-29
OA11224A (en) 2003-07-16
FR04C0013I2 (pt) 2005-10-21
EP0988310B9 (en) 2006-03-08
UY25040A1 (es) 2000-09-29
CN1566129A (zh) 2005-01-19
HN1998000086A (es) 1999-03-08
NO316911B1 (no) 2004-06-21
AU7347598A (en) 1998-12-30
IL132809A0 (en) 2001-03-19
TW472060B (en) 2002-01-11
KR20010013632A (ko) 2001-02-26
CN101691390A (zh) 2010-04-07
US6777393B2 (en) 2004-08-17
ES2205487T3 (es) 2004-05-01
BRPI9810519B8 (pt) 2022-11-16
ID22992A (id) 1999-12-23
ME00876B (me) 2012-06-20
DE122004000018I2 (de) 2011-01-13
US20040180842A1 (en) 2004-09-16
HRP980314A2 (en) 1999-04-30
DE122004000018I1 (de) 2004-09-30
NO996106L (no) 2000-02-10
UA67744C2 (uk) 2004-07-15
PA8452201A1 (es) 2000-05-24
JP2000514098A (ja) 2000-10-24
NO996106D0 (no) 1999-12-10
ZA985017B (en) 1999-12-17
AP9801255A0 (en) 1998-06-30
CA2293823C (en) 2004-02-17
US6936592B2 (en) 2005-08-30
BRPI9810519A (pt) 2000-09-19
PL191601B1 (pl) 2006-06-30
MA24564A1 (fr) 1998-12-31
CO4950611A1 (es) 2000-09-01
NL300150I1 (nl) 2004-08-02
EG24081A (en) 2008-05-11
HK1028048A1 (en) 2001-02-02
FR04C0013I1 (pt) 2004-06-11
EA199901015A1 (ru) 2000-06-26
EP0988310B1 (en) 2003-10-01
LU91076I9 (en) 2018-07-02
DE69818665T2 (de) 2004-04-29
DZ2514A1 (fr) 2003-02-01
IS5252A (is) 1999-11-16
GT199800077A (es) 1999-12-02
CN1259136A (zh) 2000-07-05
NZ514871A (en) 2003-08-29
HUS1200028I1 (hu) 2016-08-29
US6420536B1 (en) 2002-07-16
IS1998B (is) 2005-03-15
TNSN98082A1 (fr) 2005-03-15
NZ500660A (en) 2002-03-01
CN1243766C (zh) 2006-03-01
PT988310E (pt) 2003-12-31
CZ442199A3 (cs) 2000-07-12
SI0988310T1 (en) 2004-02-29
KR100396168B1 (ko) 2003-08-27
JP2002316933A (ja) 2002-10-31
HUP0002209A2 (hu) 2000-12-28
CA2293823A1 (en) 1998-12-17
CN1793155A (zh) 2006-06-28
AR013086A1 (es) 2000-12-13
RS49675B (sr) 2007-11-15
SK168399A3 (en) 2000-11-07
AU749816B2 (en) 2002-07-04
ATE251173T1 (de) 2003-10-15
WO1998056802A1 (en) 1998-12-17
HUP0002209A3 (en) 2003-05-28
CZ298556B6 (cs) 2007-11-07
LU91076I2 (fr) 2004-07-05
EP0988310A1 (en) 2000-03-29
DK0988310T3 (da) 2003-12-15
HRP980314B1 (en) 2004-04-30
YU58699A (pt) 2002-08-12
MY123354A (en) 2006-05-31
JP3315704B2 (ja) 2002-08-19
HU228005B1 (en) 2012-08-28
SK284171B6 (sk) 2004-10-05
NL300150I2 (nl) 2004-09-01
HK1088014A1 (zh) 2006-10-27
BG64391B1 (bg) 2004-12-30
EA002441B1 (ru) 2002-04-25
CN1793155B (zh) 2010-05-12
US20040023896A1 (en) 2004-02-05
AP1231A (en) 2003-12-11
PL337505A1 (en) 2000-08-28
BG103945A (en) 2000-07-31
PE79699A1 (es) 1999-08-25
DE69818665D1 (de) 2003-11-06
US20020061858A1 (en) 2002-05-23
CN1172947C (zh) 2004-10-27

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