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AU3176297A - Substituted 7-amino-pyrrolo{3,2-d}pyrimidines and the use thereof - Google Patents

Substituted 7-amino-pyrrolo{3,2-d}pyrimidines and the use thereof

Info

Publication number
AU3176297A
AU3176297A AU31762/97A AU3176297A AU3176297A AU 3176297 A AU3176297 A AU 3176297A AU 31762/97 A AU31762/97 A AU 31762/97A AU 3176297 A AU3176297 A AU 3176297A AU 3176297 A AU3176297 A AU 3176297A
Authority
AU
Australia
Prior art keywords
pyrimidines
pyrrolo
amino
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU31762/97A
Inventor
Eva Altmann
Jurgen Klaus Maibaum
Martin Missbach
Leo Widler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG, Novartis AG filed Critical Ciba Geigy AG
Publication of AU3176297A publication Critical patent/AU3176297A/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU31762/97A 1996-06-25 1997-06-16 Substituted 7-amino-pyrrolo{3,2-d}pyrimidines and the use thereof Abandoned AU3176297A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH159196 1996-06-25
CH1591/96 1996-06-25
PCT/EP1997/003115 WO1997049706A1 (en) 1996-06-25 1997-06-16 SUBSTITUTED 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES AND THE USE THEREOF

Publications (1)

Publication Number Publication Date
AU3176297A true AU3176297A (en) 1998-01-14

Family

ID=4214005

Family Applications (1)

Application Number Title Priority Date Filing Date
AU31762/97A Abandoned AU3176297A (en) 1996-06-25 1997-06-16 Substituted 7-amino-pyrrolo{3,2-d}pyrimidines and the use thereof

Country Status (2)

Country Link
AU (1) AU3176297A (en)
WO (1) WO1997049706A1 (en)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200001079T2 (en) 1997-10-20 2000-07-21 F.Hoffmann-La Roche Ag Bicyclic kinase inhibitors.
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
HRP20000885B1 (en) 1998-06-19 2007-03-31 Pfizer Products Inc. PIROLO [2,3-d] PYRIMIDINE COMPOUNDS
PA8474101A1 (en) 1998-06-19 2000-09-29 Pfizer Prod Inc PYROLEUM [2,3-D] PIRIMIDINE COMPOUNDS
US6713474B2 (en) 1998-09-18 2004-03-30 Abbott Gmbh & Co. Kg Pyrrolopyrimidines as therapeutic agents
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
US7071199B1 (en) * 1999-09-17 2006-07-04 Abbott Gmbh & Cco. Kg Kinase inhibitors as therapeutic agents
JP4078074B2 (en) 1999-12-10 2008-04-23 ファイザー・プロダクツ・インク Pyrrolo [2,3-d] pyrimidine compound
WO2001072751A1 (en) * 2000-03-29 2001-10-04 Knoll Gesellschaft Mit Beschraenkter Haftung Pyrrolopyrimidines as tyrosine kinase inhibitors
CA2412560C (en) 2000-06-26 2008-12-30 Pfizer Products Inc. Pyrrolo[2,3-d]pyrimidine compounds as immunosuppressive agents
US6515013B2 (en) 2000-07-13 2003-02-04 Abbott Laboratories 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
CA2415396C (en) * 2000-07-13 2011-03-08 Abbott Laboratories 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
AR035885A1 (en) 2001-05-14 2004-07-21 Novartis Ag DERIVATIVES OF 4-AMINO-5-FENIL-7-CYCLLOBUTILPIRROLO (2,3-D) PYRIMIDINE, A PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION AND THE USE OF SUCH DERIVATIVES FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION
US7301023B2 (en) 2001-05-31 2007-11-27 Pfizer Inc. Chiral salt resolution
CN1523991A (en) 2001-08-10 2004-08-25 ��˹��ŵ�� Use of a c-Src inhibitor alone or in combination with STI571 for the treatment of leukemia
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
ES2201899B1 (en) * 2002-04-01 2005-06-01 Almirall Prodesfarma, S.A. DERIVATIVES OF AZAINDOLILPIPERIDINE AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS.
BR0313078A (en) 2002-08-06 2005-07-12 Astrazeneca Ab A compound or a pharmaceutically acceptable salt thereof, a pharmaceutical composition, and use of the compound or a pharmaceutically acceptable salt thereof.
BR0316487A (en) 2002-11-26 2005-10-11 Pfizer Prod Inc Whole method of treating transplant rejection
ES2295816T3 (en) 2003-01-14 2008-04-16 Arena Pharmaceuticals, Inc. ARILO AND HETEROARILO 1,2,3-TRISUSTITUTED DERIVATIVES AS METABOLISM MODULATORS, AND PROFILAXIS AND TREATMENT OF DISORDERS RELATED TO THE SAME, SUCH AS DIABETES AND HYPERGLUCEMIA.
AR045047A1 (en) 2003-07-11 2005-10-12 Arena Pharm Inc ARILO AND HETEROARILO DERIVATIVES TRISUSTITUIDOS AS MODULATORS OF METABOLISM AND PROFILAXIS AND TREATMENT OF DISORDERS RELATED TO THEMSELVES
US7132426B2 (en) 2003-07-14 2006-11-07 Arena Pharmaceuticals, Inc. Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
JP4570566B2 (en) * 2003-08-26 2010-10-27 帝人ファーマ株式会社 Pyrrolopyrimidinone derivatives
US7557113B2 (en) 2003-08-26 2009-07-07 Teijin Pharma Limited Substituted pyrrolo[3,2-d]pyrimidine derivatives
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
US20120101114A1 (en) 2007-03-28 2012-04-26 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
BRPI0810086B1 (en) * 2007-03-28 2021-11-09 Pharmacyclics Llc BRUTON'S TYROSINE KINASE INHIBITOR COMPOUND, USE OF SUCH COMPOUND AND PHARMACEUTICAL COMPOSITION
UA103195C2 (en) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк PURCHASE DERIVATIVES FOR THE APPLICATION IN THE TREATMENT OF ALLERGIES, INFLAMMATORY AND INFECTIOUS DISEASES
BRPI0917459B1 (en) 2008-08-20 2017-09-12 Zoetis Services Llc N-METHYL-1- [TRANS-4- [METHYL (7H-PYRROL [2,3-D] PYRIDOL [2,3-D] PYRIMIDINE COMPOUNDS, USE OF THESE IN THERAPY AND CRYSTALLINE AS N-METHYL-PYRIMIDIN -4-YL) AMINO] CYCLOHEXYL} METHANOSULPHONAMIDE
KR20120093867A (en) 2009-09-10 2012-08-23 아이알엠 엘엘씨 Ether derivatives of bicyclic heteroaryls
KR101483215B1 (en) * 2010-01-29 2015-01-16 한미약품 주식회사 Bicyclic heteroaryl derivatives having inhibitory activity for protein kinases
EP2571361A4 (en) 2010-05-19 2013-11-13 Univ North Carolina PYRAZOLOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER
NZ702485A (en) 2010-06-03 2016-04-29 Pharmacyclics Llc The use of inhibitors of bruton’s tyrosine kinase (btk)
EP2582680A1 (en) 2010-06-17 2013-04-24 Novartis AG Biphenyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
JP2013532149A (en) 2010-06-17 2013-08-15 ノバルティス アーゲー Piperidinyl-substituted 1,3-dihydro-benzimidazol-2-ylideneamine derivatives
EP2619198A1 (en) 2010-09-22 2013-07-31 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
CN103328482A (en) * 2011-01-03 2013-09-25 韩美药品株式会社 New bicyclic compound for modulating G protein-coupled receptors
WO2012120469A1 (en) 2011-03-08 2012-09-13 Novartis Ag Fluorophenyl bicyclic heteroaryl compounds
US10952415B2 (en) 2011-03-09 2021-03-23 Richard G. Pestell Prostate cancer cell lines, gene signatures and uses thereof
CN103582643B (en) * 2011-04-04 2016-06-15 弗马塞斯有限公司 Kinases inhibitor
CA2760174A1 (en) * 2011-12-01 2013-06-01 Pharmascience Inc. Protein kinase inhibitors and uses thereof
KR20140048968A (en) 2011-07-13 2014-04-24 파마시클릭스, 인코포레이티드 Inhibitors of bruton's tyrosine kinase
BR112014001425A2 (en) 2011-07-22 2017-11-21 Glaxosmithkline Llc pharmaceutical dosage form, pharmaceutical composition, and compound (i) or pharmaceutically acceptable salt thereof
MX2014004086A (en) * 2011-10-03 2014-09-22 Univ North Carolina Pyrrolopyrimidine compounds for the treatment of cancer.
US8377946B1 (en) 2011-12-30 2013-02-19 Pharmacyclics, Inc. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
WO2013173312A1 (en) 2012-05-14 2013-11-21 Pestell Richard G Using modulators of ccr5 for treating cancer
WO2013177168A1 (en) 2012-05-22 2013-11-28 The University Of North Carolina At Chapel Hill Pyrimidine compounds for the treatment of cancer
BR112014030424A8 (en) 2012-06-04 2017-07-11 Pharmacyclics Inc CRYSTALLINE FORMS OF A BRUTON TYROSINE KINASE INHIBITOR
MX2015001081A (en) 2012-07-24 2015-10-14 Pharmacyclics Inc Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk).
MY175676A (en) 2012-08-24 2020-07-06 Glaxosmithkline Llc Pyrazolopyrimidine compounds
US9562047B2 (en) 2012-10-17 2017-02-07 The University Of North Carolina At Chapel Hill Pyrazolopyrimidine compounds for the treatment of cancer
EA201590855A1 (en) 2012-11-15 2015-11-30 Фармасайкликс, Инк. COMPOUNDS OF PYRROPOLYMIDININE AS KINAZ INHIBITORS
PL2922549T3 (en) 2012-11-20 2017-11-30 Glaxosmithkline Llc Novel compounds
AU2013348217B2 (en) * 2012-11-20 2016-10-06 Glaxosmithkline Llc Novel compounds
JP6216386B2 (en) * 2012-11-20 2017-10-18 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC New compounds
WO2014085225A1 (en) 2012-11-27 2014-06-05 The University Of North Carolina At Chapel Hill Pyrimidine compounds for the treatment of cancer
JP2016531941A (en) 2013-09-30 2016-10-13 ファーマサイクリックス エルエルシー Inhibitor of breton-type tyrosine kinase
US20210317140A1 (en) * 2013-10-18 2021-10-14 Medivation Technologies, Inc. Heterocyclic Compounds and Methods of Use
CA2833701A1 (en) * 2013-11-19 2015-05-19 Pharmascience Inc. Protein kinase inhibitors
EP3119910A4 (en) 2014-03-20 2018-02-21 Pharmacyclics LLC Phospholipase c gamma 2 and resistance associated mutations
WO2015157127A1 (en) 2014-04-11 2015-10-15 The University Of North Carolina At Chapel Hill Therapuetic uses of selected pyrimidine compounds with anti-mer tyrosine kinase activity
CN108064274A (en) 2014-07-30 2018-05-22 耶达研究及发展有限公司 For cultivating the culture medium of multipotential stem cell
SG11201700849XA (en) 2014-08-07 2017-03-30 Pharmacyclics Llc Novel formulations of a bruton's tyrosine kinase inhibitor
PL3242666T3 (en) 2015-01-06 2025-02-17 Arena Pharmaceuticals, Inc. Compound for use in treating conditions related to the s1p1 receptor
IL315294A (en) 2015-03-03 2024-10-01 Pharmacyclics Llc Pharmaceutical formulations of proton tyrosine kinase inhibitor
JP6838744B2 (en) 2015-06-22 2021-03-03 アリーナ ファーマシューティカルズ, インコーポレイテッド (R) -2- (7- (4-cyclopentyl-3- (trifluoromethyl) benzyloxy) -1,2,3,4-tetrahydrocyclopenta [b] indole-for use in S1P1 receptor-related disorders Crystalline L-arginine salt of 3-yl) acetic acid (Compound 1)
US10709708B2 (en) 2016-03-17 2020-07-14 The University Of North Carolina At Chapel Hill Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor
CN112585147B (en) * 2017-10-13 2023-12-05 帝国理工学院创新有限公司 MAP4K4 inhibitors
EP3730483B1 (en) 2017-12-21 2023-08-30 Hefei Institutes of Physical Science, Chinese Academy of Sciences Class of pyrimidine derivative kinase inhibitors
KR102859841B1 (en) 2018-06-06 2025-09-12 아레나 파마슈티칼스, 인크. Treatment of conditions associated with the S1P1 receptor
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
GB201819839D0 (en) * 2018-12-05 2019-01-23 Imperial Innovations Ltd MAP4K4 inhibitors
EP3914698B1 (en) 2019-01-23 2024-12-11 Yeda Research and Development Co. Ltd Culture media for pluripotent stem cells
NL2022471B1 (en) 2019-01-29 2020-08-18 Vationpharma B V Solid state forms of oclacitinib
US20220395553A1 (en) 2019-11-14 2022-12-15 Cohbar, Inc. Cxcr4 antagonist peptides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1046731C (en) * 1994-09-29 1999-11-24 诺瓦蒂斯有限公司 Pyrrolo[2,3-d]pyrimidine compounds and their applications
DK0831829T3 (en) * 1995-06-07 2003-12-15 Pfizer Heterocyclic, ring-condensed pyrimidine derivatives

Also Published As

Publication number Publication date
WO1997049706A1 (en) 1997-12-31

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