[go: up one dir, main page]

WO2007035629A3 - Inhibiteurs de dipeptidylpeptidase - Google Patents

Inhibiteurs de dipeptidylpeptidase Download PDF

Info

Publication number
WO2007035629A3
WO2007035629A3 PCT/US2006/036276 US2006036276W WO2007035629A3 WO 2007035629 A3 WO2007035629 A3 WO 2007035629A3 US 2006036276 W US2006036276 W US 2006036276W WO 2007035629 A3 WO2007035629 A3 WO 2007035629A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
pyrimidinedione derivatives
pyrimidinedione
methods
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/036276
Other languages
English (en)
Other versions
WO2007035629A2 (fr
Inventor
Jun Feng
Stephen L Gwaltney
Jeffrey A Stafford
Zhiyuan Zhang
Bruce J Elder
Paul K Isbester
Grant J Palmer
Jonathon S Salsbury
Luckner Ulysse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Priority to US12/066,769 priority Critical patent/US8222411B2/en
Priority to JP2008531408A priority patent/JP5122462B2/ja
Priority to CA2622642A priority patent/CA2622642C/fr
Priority to EP06814853A priority patent/EP1924567B1/fr
Priority to KR1020087007951A priority patent/KR101368988B1/ko
Publication of WO2007035629A2 publication Critical patent/WO2007035629A2/fr
Publication of WO2007035629A3 publication Critical patent/WO2007035629A3/fr
Priority to IL190135A priority patent/IL190135A/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)

Abstract

La présente invention porte sur des méthodes de synthèse de composés de formule (I) où les variables sont telles que définis dans la présente invention. La présente invention porte également sur des méthodes de synthèse de composés pouvant être employés pour inhiber la dipeptidylpeptidase.
PCT/US2006/036276 2005-09-16 2006-09-15 Inhibiteurs de dipeptidylpeptidase Ceased WO2007035629A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US12/066,769 US8222411B2 (en) 2005-09-16 2006-09-15 Dipeptidyl peptidase inhibitors
JP2008531408A JP5122462B2 (ja) 2005-09-16 2006-09-15 ジペプチジルペプチダーゼ阻害剤
CA2622642A CA2622642C (fr) 2005-09-16 2006-09-15 Inhibiteurs de dipeptidylpeptidase
EP06814853A EP1924567B1 (fr) 2005-09-16 2006-09-15 Inhibiteurs de dipeptidylpeptidase
KR1020087007951A KR101368988B1 (ko) 2005-09-16 2006-09-15 디펩티딜 펩티다제 억제제
IL190135A IL190135A (en) 2005-09-16 2008-03-12 A process for preparing pyrimidindione derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71808405P 2005-09-16 2005-09-16
US60/718,084 2005-09-16

Publications (2)

Publication Number Publication Date
WO2007035629A2 WO2007035629A2 (fr) 2007-03-29
WO2007035629A3 true WO2007035629A3 (fr) 2007-06-14

Family

ID=37889413

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/036276 Ceased WO2007035629A2 (fr) 2005-09-16 2006-09-15 Inhibiteurs de dipeptidylpeptidase

Country Status (8)

Country Link
US (1) US8222411B2 (fr)
EP (1) EP1924567B1 (fr)
JP (1) JP5122462B2 (fr)
KR (1) KR101368988B1 (fr)
CN (2) CN102675221A (fr)
CA (1) CA2622642C (fr)
IL (1) IL190135A (fr)
WO (1) WO2007035629A2 (fr)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200838536A (en) * 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
CL2008002427A1 (es) 2007-08-16 2009-09-11 Boehringer Ingelheim Int Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2.
WO2009099172A1 (fr) * 2008-02-07 2009-08-13 Takeda Pharmaceutical Company Limited Produit pharmaceutique
WO2009099171A1 (fr) * 2008-02-07 2009-08-13 Takeda Pharmaceutical Company Limited Produit pharmaceutique
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
ES2764251T3 (es) 2008-08-15 2020-06-02 Boehringer Ingelheim Int Inhibidores de DPP-4 para uso en el tratamiento de curación de heridas en pacientes diabéticos
WO2010072680A1 (fr) 2008-12-23 2010-07-01 Sandoz Ag Forme cristalline d'un composé organique
TW201036975A (en) 2009-01-07 2010-10-16 Boehringer Ingelheim Int Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
TWI466672B (zh) 2009-01-29 2015-01-01 Boehringer Ingelheim Int 小兒科病人糖尿病之治療
WO2010092163A2 (fr) 2009-02-13 2010-08-19 Boehringer Ingelheim International Gmbh Médicaments antidiabétiques
UY32441A (es) 2009-02-13 2010-09-30 Boehringer Ingelheim Int Composicion farmaceutica, metodos de tratamiento y sus usos
EP2410855B1 (fr) * 2009-03-26 2016-06-01 Mapi Pharma Limited Procédé de préparation d'alogliptine
BR112012012641A2 (pt) 2009-11-27 2020-08-11 Boehringer Ingelheim International Gmbh TRATAMENTO DE PACIENTES DIABÉTICOS GENOTIPADOS COM INIBIDORES DE DPP-lVTAL COMO LINAGLIPTINA
WO2011079778A1 (fr) 2009-12-30 2011-07-07 China Shanghai Fochon Pharmaceutical Co Ltd Dérivés de 3-(3-aminopipéridin-1-yl)-5-oxo-1,2,4-triazine à titre d'inhibiteurs de dipeptidyl peptidase iv (dpp-iv)
US20130109703A1 (en) 2010-03-18 2013-05-02 Boehringer Ingelheim International Gmbh Combination of a GPR119 Agonist and the DPP-IV Inhibitor Linagliptin for Use in the Treatment of Diabetes and Related Conditions
NZ602921A (en) 2010-05-05 2016-01-29 Boehringer Ingelheim Int Combination therapy comprising the administration of a glp-1 receptor agonist and a ddp-4 inhibitor
KR20190050871A (ko) 2010-06-24 2019-05-13 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
WO2012118945A2 (fr) 2011-03-03 2012-09-07 Merck Sharp & Dohme Corp. Hétérocycles bicycliques fondus, utilisés comme inhibiteurs de la dipeptidylpeptidase-4
WO2013046229A1 (fr) * 2011-09-26 2013-04-04 Hetero Research Foundation Nouveaux sels de l'alogliptine
WO2013174767A1 (fr) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh Dérivé de xanthine en tant qu'inhibiteur de la dpp-4 à utiliser dans la modification de l'apport alimentaire et dans la régulation des préférences alimentaires
CN104519874B (zh) 2012-06-05 2018-08-03 武田药品工业株式会社 固体制剂
CN103524483B (zh) * 2012-07-02 2016-01-20 苏州朗科生物技术有限公司 一种苯甲酸阿格列汀的制备方法
CN104003975A (zh) * 2013-02-22 2014-08-27 四川海思科制药有限公司 曲格列汀新的固态形式及其制备方法和用途
CN103193762B (zh) * 2013-03-29 2015-07-29 山东罗欣药业集团股份有限公司 苯甲酸阿格列汀的制备方法
WO2014188334A2 (fr) * 2013-05-24 2014-11-27 Glenmark Pharmaceuticals Limited; Glenmark Generics Limited Procédé de préparation d'alogliptine
CN104592195A (zh) * 2013-10-31 2015-05-06 江苏万邦生化医药股份有限公司 一种苯甲酸阿格列汀的制备方法
CN104672210B (zh) * 2013-11-29 2018-05-11 北大方正集团有限公司 阿格列汀和苯甲酸阿格列汀的制备方法
WO2015092805A1 (fr) * 2013-12-18 2015-06-25 Harman Finochem Limited Procédé de préparation de succinate de trélagliptine
WO2015092739A1 (fr) * 2013-12-19 2015-06-25 Mylan Laboratories Ltd. Procédé de préparation d'alogliptine
WO2015092807A1 (fr) * 2013-12-20 2015-06-25 Finochem Limited Harman Nouveau procédé de préparation de benzoate d'alogliptine
CN104725350A (zh) * 2013-12-23 2015-06-24 湖北华世通生物医药科技有限公司 阿格列汀盐酸盐的多晶b型晶体、其制备方法及生产用途
CN104725349A (zh) * 2013-12-23 2015-06-24 湖北华世通生物医药科技有限公司 阿格列汀盐酸盐多晶a型晶体、其制备方法及生产用途
CN104803971B (zh) * 2014-01-24 2021-11-30 深圳信立泰药业股份有限公司 化合物A单苯甲酸盐的晶型α及其制备方法和含有该晶型的药物组合物
CA2942631A1 (fr) 2014-03-14 2015-09-17 Takeda Pharmaceutical Company Limited Procede de production d'un compose heterocyclique
CN105228988B (zh) * 2014-04-01 2017-06-27 杭州普晒医药科技有限公司 曲格列汀半琥珀酸盐的晶体及其制备方法和药物组合物
CN105017213B (zh) * 2014-04-30 2017-11-14 成都苑东生物制药股份有限公司 尿嘧啶衍生物
CN105085475B (zh) * 2014-05-09 2019-05-21 上海科胜药物研发有限公司 一种合成阿格列汀中间体的方法
CN103980249B (zh) * 2014-05-30 2016-01-20 安徽省新星药物开发有限责任公司 一种苯甲酸阿格列汀的精制方法
CN105315256B (zh) * 2014-07-07 2018-02-06 广州朗圣药业有限公司 一种适合工业化的高纯度琥珀酸曲格列汀的制备方法
WO2016024224A1 (fr) * 2014-08-11 2016-02-18 Sun Pharmaceutical Industries Limited Procédé de préparation de 4-fluoro-2-méthylbenzonitrile
CN105384724A (zh) * 2014-09-01 2016-03-09 广东东阳光药业有限公司 一种氟代物的晶型及其制备方法
CN105418580A (zh) * 2014-09-11 2016-03-23 上海医药工业研究院 制备曲格列汀的新工艺
CN104311535A (zh) * 2014-09-16 2015-01-28 广东东阳光药业有限公司 一种制备dpp-iv抑制剂的方法
CN105524041A (zh) * 2014-09-30 2016-04-27 四川海思科制药有限公司 曲格列汀新晶型及其制备方法和用途
CN105524042B (zh) * 2014-10-22 2019-09-13 重庆医药工业研究院有限责任公司 一种制备曲格列汀的方法
CN104402832A (zh) * 2014-11-04 2015-03-11 广东东阳光药业有限公司 一种二氢嘧啶衍生物的制备方法
CN105646446B (zh) * 2014-11-14 2018-09-28 瀚晖制药有限公司 一种纯化阿格列汀的方法
CN111440145A (zh) * 2014-11-25 2020-07-24 上海医药工业研究院 高纯度曲格列汀的新晶型及其制备
CN104829590B (zh) * 2015-04-08 2020-04-24 重庆医药工业研究院有限责任公司 一种纯化曲格列汀的方法
EP3292112B1 (fr) * 2015-05-04 2019-08-14 Indoco Remedies Limited Procédé pour la préparation d' alogliptine
CN105622575A (zh) * 2015-06-16 2016-06-01 上海元智生物医药科技有限公司 曲格列汀的制备方法
CN104961726A (zh) * 2015-06-19 2015-10-07 浙江永宁药业股份有限公司 一种曲格列汀的制备方法
CN105017161A (zh) * 2015-06-26 2015-11-04 南京百迪尔生物医药有限公司 化合物及其制备方法和用途
RU2766579C2 (ru) 2015-07-02 2022-03-15 ХОРАЙЗОН ОРФАН ЭлЭлСи Цистеаминдиоксигеназа-резистентные аналоги цистеамина и их применение
CN105418581A (zh) * 2015-10-26 2016-03-23 杭州华东医药集团新药研究院有限公司 琥珀酸曲格列汀的制备方法
CN106608853B (zh) * 2015-10-27 2019-10-25 北京福元医药股份有限公司 二肽基肽酶ⅳ抑制剂的制备方法
CN105646447A (zh) * 2015-12-25 2016-06-08 北京康立生医药技术开发有限公司 一种二肽基肽酶抑制剂的合成方法
CN105541793B (zh) * 2016-01-04 2018-08-10 河北国龙制药有限公司 曲格列汀的合成方法
CN105669645B (zh) * 2016-02-18 2019-12-31 南京正大天晴制药有限公司 曲格列汀及其琥珀酸盐的制备方法
CN107337664A (zh) * 2016-05-03 2017-11-10 上海现代制药股份有限公司 一种曲格列汀的制备方法
CN107434800A (zh) * 2016-05-27 2017-12-05 威海迪素制药有限公司 一种琥珀酸曲格列汀晶型a的制备方法
CN105968093B (zh) * 2016-06-29 2018-09-28 郑州明泽医药科技有限公司 琥珀酸曲格列汀的制备方法
CN106279104B (zh) * 2016-08-16 2019-04-26 杭州新博思生物医药有限公司 一种制备琥珀酸曲格列汀的工艺改进方法
CN106749175A (zh) * 2016-12-08 2017-05-31 郑州明泽医药科技有限公司 一种曲格列汀的纯化方法
CN106946851B (zh) * 2017-03-14 2019-11-12 牡丹江医学院 一种用于预防和治疗肾结石的药物
CN107698560A (zh) * 2017-11-17 2018-02-16 石家庄度恩医药科技有限公司 一种曲格列汀的制备方法
CN109970706A (zh) * 2017-12-27 2019-07-05 徐州万邦金桥制药有限公司 一种琥珀酸曲格列汀a晶型的制备和精制方法
CN108017614A (zh) * 2018-01-25 2018-05-11 中国科学院海洋研究所 Dpp-4抑制剂及其在制备治疗2型糖尿病药物中的应用
CN111349075A (zh) * 2018-12-21 2020-06-30 浙江万晟药业有限公司 一种琥珀酸曲格列汀的制备方法
CN109705089B (zh) * 2019-02-27 2020-04-10 浙江华贝药业有限责任公司 化合物的纯化方法
CN113307777B (zh) * 2020-02-27 2023-01-17 石药集团欧意药业有限公司 一种苯甲酸阿格列汀中间体及苯甲酸阿格列汀的制备方法
CN114057685A (zh) * 2020-07-31 2022-02-18 西安新通药物研究有限公司 一种高收率苯甲酸阿格列汀的制备方法
CN112500356A (zh) * 2020-12-08 2021-03-16 湖南千金湘江药业股份有限公司 一种3,4-二氢嘧啶苯甲腈衍生物及其制备方法与应用
CN112480013A (zh) * 2020-12-08 2021-03-12 湖南千金湘江药业股份有限公司 一种3,4-二氢嘧啶苯甲腈衍生物及其制备方法与应用
CN112480074A (zh) * 2020-12-08 2021-03-12 湖南千金湘江药业股份有限公司 3,4-二氢嘧啶苯甲腈衍生物及其制备方法与应用
TR202022144A1 (tr) 2020-12-29 2022-07-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Alogli̇pti̇n i̇çeren farmasöti̇k kompozi̇syonlar
TR202022612A2 (tr) 2020-12-31 2022-07-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Alogli̇pti̇ni̇n farmasöti̇k kapsül kompozi̇syonlari
MX2022014458A (es) * 2021-04-14 2023-02-27 Shionogi & Co Derivados de triazina que tienen actividad inhibidora de la replicacion del virus y composicion farmaceutica que constituye el mismo.
CN114105889B (zh) * 2021-12-16 2023-06-13 山东创新药物研发有限公司 一种dpp-iv抑制剂关键中间体的制备方法及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0748800A2 (fr) * 1995-06-09 1996-12-18 F. Hoffmann-La Roche Ag Dérivés de pyrimidine dione, pyrimidine trione, triazine dione, tetrahydroquinazoline dione comme antagonistes des récepteurs alpha-1-adrénergiques
WO2001055119A2 (fr) * 2000-01-25 2001-08-02 Neurocrine Biosciences, Inc. Antagonistes du recepteur de la gonadoliberine et methodes associees
WO2005095381A1 (fr) * 2004-03-15 2005-10-13 Takeda Pharmaceutical Company Limited Inhibiteurs de la dipeptidyle peptidase

Family Cites Families (414)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB699812A (en) 1950-11-29 1953-11-18 British Ind Solvents Ltd Manufacture of substituted pyrimidones
GB1053063A (fr) 1963-05-18
DE1670912C3 (de) 1967-08-18 1981-06-11 Bayer Ag, 5090 Leverkusen Herbizide Mittel auf Basis von 1,2,4-Triazin-5-onen
GB1377642A (en) 1971-01-14 1974-12-18 Koninklijke Gist Spiritus Penicillanic and cephalosporanic acid derivatives
US3960949A (en) 1971-04-02 1976-06-01 Schering Aktiengesellschaft 1,2-Biguanides
DE2150686A1 (de) 1971-10-12 1973-04-19 Basf Ag 6-amino-uracil-5-carbonsaeurethioamide
BE792206A (fr) 1971-12-02 1973-06-01 Byk Gulden Lomberg Chem Fab
AU5996573A (en) 1972-09-11 1975-03-06 Commonwealth Scientific And Industrial Research Organisation Pyridinium salts
US3823135A (en) 1972-12-26 1974-07-09 Shell Oil Co Pyrimidone herbicides
GB1464248A (en) 1973-11-01 1977-02-09 Ici Ltd Substituted triazinediones their preparation and use as herbicides
DE2361551A1 (de) 1973-12-11 1975-06-19 Basf Ag Wasserloesliche azofarbstoffe
DE2500024A1 (de) 1975-01-02 1976-07-08 Basf Ag Wasserloesliche azofarbstoffe
DE2720085A1 (de) 1977-05-05 1978-11-16 Hoechst Ag Pyrimido(6,1-a)isochinolin-2-on- derivate
US4494978A (en) 1976-12-30 1985-01-22 Chevron Research Company Herbicidal N-(N'-hydrocarbyloxycarbamylalkyl)-2,6-dialkyl-alpha-haloacetanilides
CH657851A5 (de) 1983-06-28 1986-09-30 Ciba Geigy Ag Chromogene chinazolonverbindungen.
AR240698A1 (es) 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
DE3856378T2 (de) 1987-09-04 2000-05-11 Beecham Group P.L.C., Brentford Substituierte Thiazolidindionderivate
US4935493A (en) 1987-10-06 1990-06-19 E. I. Du Pont De Nemours And Company Protease inhibitors
WO1989010701A1 (fr) 1988-05-05 1989-11-16 Basf Aktiengesellschaft Produits a base de derives d'uracil pour stimuler la croissance et reduire la graisse chez les animaux
JPH0251150A (ja) 1988-08-12 1990-02-21 Konica Corp 新規なシアンカプラーを含有するハロゲン化銀写真感光材料
IL92915A0 (en) 1989-01-05 1990-09-17 Ciba Geigy Ag Certain pyrrolylphenyl-substituted hydroxamic acid derivatives
GB8900382D0 (en) 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
US5433955A (en) 1989-01-23 1995-07-18 Akzo N.V. Site specific in vivo activation of therapeutic drugs
IE63502B1 (en) 1989-04-21 1995-05-03 Zeneca Ltd Aminopyrimidine derivatives useful for treating cardiovascular disorders
ES2113879T3 (es) 1990-01-24 1998-05-16 Douglas I Buckley Analogos de glp-1 utiles para el tratamiento de diabetes.
CA2075627A1 (fr) 1990-02-13 1991-08-14 William J. Greenlee Antagonistes de l'angiotensine ii incorporant un element benzyle substitue
US5366862A (en) 1990-02-14 1994-11-22 Receptor Laboratories, Inc. Method for generating and screening useful peptides
US5814460A (en) 1990-02-14 1998-09-29 Diatide, Inc. Method for generating and screening useful peptides
DE69129998T2 (de) 1990-02-15 1998-12-24 Takeda Chemical Industries, Ltd., Osaka Pyrimidindionderivate, deren Herstellung und Verwendung
US5462928A (en) 1990-04-14 1995-10-31 New England Medical Center Hospitals, Inc. Inhibitors of dipeptidyl-aminopeptidase type IV
DE4110019C2 (de) 1991-03-27 2000-04-13 Merck Patent Gmbh Imidazopyridine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
US5387512A (en) 1991-06-07 1995-02-07 Merck & Co. Inc. Preparation of 3-[z-benzoxazol-2-yl)ethyl]-5-(1-hydroxyethyl)-6-methyl-2-(1H)-pyridinone by biotransformation
ATE349461T1 (de) 1991-10-22 2007-01-15 New England Medical Center Inc Inhibitoren der dipeptidyl-aminopeptidase vom typ iv
US6825169B1 (en) 1991-10-22 2004-11-30 Trustees Of Tufts College Inhibitors of dipeptidyl-aminopeptidase type IV
ES2107557T3 (es) 1991-12-10 1997-12-01 Shionogi & Co Derivado de acido hidroxamico a base de sulfonamida aromatica.
US5350752A (en) 1991-12-16 1994-09-27 E. R. Squibb & Sons, Inc. Dihydropyrimidine derivatives
DE4141788A1 (de) 1991-12-18 1993-06-24 Merck Patent Gmbh Imidazopyridine
US5602102A (en) 1992-05-29 1997-02-11 Board Of Regents, The Univ. Of Tx System Dipeptidyl peptidase-I inhibitors and uses thereof
DE4305602A1 (de) 1992-06-17 1993-12-23 Merck Patent Gmbh Imidazopyridine
WO1994003055A1 (fr) 1992-07-31 1994-02-17 The Government Of The United States Of America, Asrepresented By The Secretary Of The Department Of Health And Human Services Production de quantites elevees de cellules hematopoietiques par administration d'inhibiteurs de la dipeptidyle peptidase iv
IL106877A (en) 1992-09-10 1998-03-10 Lilly Co Eli Rhodanine derivatives for use as medicaments for the treatment of alzheimer's disease
IL106998A0 (en) 1992-09-17 1993-12-28 Univ Florida Brain-enhanced delivery of neuroactive peptides by sequential metabolism
US5811281A (en) 1993-07-12 1998-09-22 Cornell Research Foundation, Inc. Immortalized intestinal epithelial cell lines
IL111785A0 (en) 1993-12-03 1995-01-24 Ferring Bv Dp-iv inhibitors and pharmaceutical compositions containing them
DE4341453A1 (de) 1993-12-06 1995-06-08 Merck Patent Gmbh Imidazopyridine
DE69521500T2 (de) 1994-03-08 2001-12-13 Otsuka Pharmaceutical Factory, Inc. Phosphorsäurediester-derivate
US5580979A (en) 1994-03-15 1996-12-03 Trustees Of Tufts University Phosphotyrosine peptidomimetics for inhibiting SH2 domain interactions
US5543396A (en) 1994-04-28 1996-08-06 Georgia Tech Research Corp. Proline phosphonate derivatives
WO1995034538A2 (fr) 1994-06-10 1995-12-21 Universitaire Instelling Antwerpen Purification de proteases serines, et leurs inhibiteurs synthetiques
CA2194014C (fr) 1994-06-17 2009-10-06 Benjamin John Reed Lutte biologique contre les insectes
US5601986A (en) 1994-07-14 1997-02-11 Amgen Inc. Assays and devices for the detection of extrahepatic biliary atresia
DE4432860A1 (de) 1994-09-15 1996-03-21 Merck Patent Gmbh Imidazopyridine
US5512549A (en) 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
CA2190973C (fr) 1995-04-13 2001-06-19 Yasuo Konno Nouveaux derives 4,6-diarylpyrimidine et leurs sels
US5614379A (en) 1995-04-26 1997-03-25 Eli Lilly And Company Process for preparing anti-obesity protein
US6325989B1 (en) 1995-06-01 2001-12-04 Dana-Farber Cancer Institute, Inc. Form of dipeptidylpeptidase IV (CD26) found in human serum
US6265551B1 (en) 1995-06-01 2001-07-24 Dana-Farber Cancer Institute, Inc. Form of dipeptidylpeptidase IV (CD26) found in human serum, antibodies thereto, and uses thereof
JPH0928376A (ja) 1995-07-21 1997-02-04 Ajinomoto Co Inc 新規ジペプチジルペプチダーゼｉｖとその製造方法
JP2000504723A (ja) 1996-02-13 2000-04-18 ジー．ディー．サール アンド カンパニー シクロオキシゲナーゼ―２阻害剤および５―リポキシゲナーゼ阻害剤投与の免疫抑制効果
DE122010000020I1 (de) 1996-04-25 2010-07-08 Prosidion Ltd Verfahren zur Senkung des Blutglukosespiegels in Säugern
US20020006899A1 (en) 1998-10-06 2002-01-17 Pospisilik Andrew J. Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals
US5965532A (en) 1996-06-28 1999-10-12 Trustees Of Tufts College Multivalent compounds for crosslinking receptors and uses thereof
CZ298812B6 (cs) 1996-07-01 2008-02-13 Dr. Reddy's Laboratories Limited Azolidindionové deriváty, způsob jejich přípravy, farmaceutické kompozice s jejich obsahem a jejich použití v léčbě diabetu a příbuzných nemocí
US5885997A (en) 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6006753A (en) 1996-08-30 1999-12-28 Eli Lilly And Company Use of GLP-1 or analogs to abolish catabolic changes after surgery
US7235627B2 (en) 1996-08-30 2007-06-26 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6458924B2 (en) 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6174905B1 (en) 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
AU4721897A (en) 1996-10-25 1998-05-22 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline derivatives
US6011155A (en) 1996-11-07 2000-01-04 Novartis Ag N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
TW492957B (en) 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
IL130181A0 (en) 1996-12-05 2000-06-01 Amgen Inc Substituted pyrimidone and pyridone compounds and methods of use
GB9702701D0 (en) 1997-02-01 1997-04-02 Univ Newcastle Ventures Ltd Quinazolinone compounds
US20030060434A1 (en) 1997-02-18 2003-03-27 Loretta Nielsen Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
US6100234A (en) 1997-05-07 2000-08-08 Tufts University Treatment of HIV
DK0981630T3 (da) 1997-05-16 2009-03-09 Novozymes Inc Polypeptider med prolyldipeptidylaminopeptidaseaktivitet og nukleinsyrer, der koder for samme
EP0897012A1 (fr) 1997-07-05 1999-02-17 Societe Des Produits Nestle S.A. Clonage de la prolyl-dipeptidyl-peptidase d'Aspergillus oryzae
US6235493B1 (en) 1997-08-06 2001-05-22 The Regents Of The University Of California Amino acid substituted-cresyl violet, synthetic fluorogenic substrates for the analysis of agents in individual in vivo cells or tissue
IL125950A0 (en) 1997-09-05 1999-04-11 Pfizer Prod Inc Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy
IL135068A (en) 1997-09-29 2004-03-28 Point Therapeutics Inc Stimulation of hematopoietic cells in vitro
AU9602198A (en) 1997-10-06 1999-04-27 Trustees Of Tufts College Cytoplasmic dipeptidylpeptidase iv from human t-cells
US6485955B1 (en) 1997-10-06 2002-11-26 The Trustees Of Tufts University Quiescent cell dipeptidyl peptidase: a novel cytoplasmic serine protease
US6342611B1 (en) 1997-10-10 2002-01-29 Cytovia, Inc. Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof
CN1281346A (zh) 1997-10-10 2001-01-24 西托维亚公司 新型荧光报道分子及其应用,包括对胱天肽酶的测定
WO1999025719A1 (fr) 1997-11-18 1999-05-27 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Substance physiologiquement active, la sulphostine, procede de fabrication et utilisation
FR2771004B1 (fr) 1997-11-19 2000-02-18 Inst Curie Utilisation de derives de benzhydryl sulfinyle pour la fabrication de medicaments ayant un effet eveillant dans des situations de troubles de la vigilance d'origine medicamenteuse
AU1616499A (en) 1997-12-01 1999-06-16 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Chemokine variants and methods of use
BR9813608B1 (pt) 1997-12-16 2011-11-01 célula hospedeira de bacillus transgênica, e, processo para produzir um polipeptìdeo tendo atividade aminopeptidase.
US6380357B2 (en) 1997-12-16 2002-04-30 Eli Lilly And Company Glucagon-like peptide-1 crystals
EP2574336A1 (fr) 1998-02-02 2013-04-03 Trustees Of Tufts College Utilisation dýinhibiteurs de dipeptidylpeptidase pour réguler le métabolisme du glucose
AU3034299A (en) 1998-03-09 1999-09-27 Fondatech Benelux N.V. Serine peptidase modulators
US20020061839A1 (en) 1998-03-09 2002-05-23 Scharpe Simon Lodewijk Serine peptidase modulators
EP1054871A2 (fr) 1998-04-01 2000-11-29 Du Pont Pharmaceuticals Company Antagonistes de l'integrine
FR2777283B1 (fr) 1998-04-10 2000-11-24 Adir Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE19823831A1 (de) 1998-05-28 1999-12-02 Probiodrug Ges Fuer Arzneim Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
JP2002517401A (ja) 1998-06-05 2002-06-18 ポイント セラピューティクス， インコーポレイテッド 環状ボロプロリン化合物
DE19828113A1 (de) 1998-06-24 2000-01-05 Probiodrug Ges Fuer Arzneim Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
DE19828114A1 (de) 1998-06-24 2000-01-27 Probiodrug Ges Fuer Arzneim Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV
US6129911A (en) 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
DE19834591A1 (de) 1998-07-31 2000-02-03 Probiodrug Ges Fuer Arzneim Verfahren zur Steigerung des Blutglukosespiegels in Säugern
EP1100530B1 (fr) 1998-07-31 2003-10-08 Novo Nordisk A/S In vitro stimulation de la proliferation des cellules de langerhans beta pancreatique
JP4624558B2 (ja) 1998-08-10 2011-02-02 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ， アズ レプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ ＧＬＰ−１またはＥｘｅｎｄｉｎ−４による、非インスリン産生細胞のインスリン産生細胞への分化、およびその使用
JP2002523365A (ja) 1998-08-21 2002-07-30 ポイント セラピューティクス， インコーポレイテッド 基質の活性の調節
AU6044699A (en) 1998-09-17 2000-04-03 Akesis Pharmaceuticals, Inc. Compositions and methods for treatment of glucose metabolism disorders
DE19845153A1 (de) 1998-10-01 2000-04-06 Merck Patent Gmbh Imidazo[4,5]-pyridin-4-on-derivate
US20030176357A1 (en) 1998-10-06 2003-09-18 Pospisilik Andrew J. Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
CO5150173A1 (es) 1998-12-10 2002-04-29 Novartis Ag Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
DE19900471A1 (de) 1999-01-08 2000-07-13 Merck Patent Gmbh Imidazo[4,5c]-pyridin-4-on-derivate
BR0007656A (pt) 1999-01-22 2001-10-30 Kirin Brewery Composto,composição farmacêutica, uso docomposto, e, métodos para tratar uma doençaselecionada do grupo que consiste de tumor,retinopatia diabética, reumatismo crÈnico,psorìase, aterosclerose, e sarcoma de kaposi epara inibir a angiogênese de vasossanguineos-alvo
IL144703A (en) 1999-02-10 2010-04-15 Curis Inc Use of peptide yy for the preparation of a pharmaceutical composition for enhancing pancreatic cell differentiation
AU3960400A (en) 1999-03-05 2000-09-28 Molteni L. E C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A. Use of metformin in the preparation of pharmaceutical compositions capable of inhibiting the enzyme dipeptidyl peptidase iv
GB9906715D0 (en) 1999-03-23 1999-05-19 Ferring Bv Compositions for promoting growth
GB9906714D0 (en) 1999-03-23 1999-05-19 Ferring Bv Compositions for improving fertility
AU4031500A (en) 1999-03-26 2000-10-16 Akesis Pharmaceuticals, Inc. Edible solids for treatment of glucose metabolism disorders
US6548529B1 (en) 1999-04-05 2003-04-15 Bristol-Myers Squibb Company Heterocyclic containing biphenyl aP2 inhibitors and method
JP2002542246A (ja) 1999-04-20 2002-12-10 ノボ ノルディスク アクティーゼルスカブ 新規な化合物、それらの製造及び使用
EP1180121B9 (fr) 1999-05-17 2004-09-08 Conjuchem, Inc. Peptides insulinotropes a longue duree d'action
DE19926233C1 (de) 1999-06-10 2000-10-19 Probiodrug Ges Fuer Arzneim Verfahren zur Herstellung von Thiazolidin
US6107317A (en) 1999-06-24 2000-08-22 Novartis Ag N-(substituted glycyl)-thiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
US6110949A (en) 1999-06-24 2000-08-29 Novartis Ag N-(substituted glycyl)-4-cyanothiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
US6172081B1 (en) 1999-06-24 2001-01-09 Novartis Ag Tetrahydroisoquinoline 3-carboxamide derivatives
US6528486B1 (en) 1999-07-12 2003-03-04 Zealand Pharma A/S Peptide agonists of GLP-1 activity
US6617340B1 (en) 1999-07-29 2003-09-09 Novartis Ag N-(substituted glycyl)-pyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
DE19940130A1 (de) 1999-08-24 2001-03-01 Probiodrug Ges Fuer Arzneim Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung
CA2384135A1 (fr) 1999-09-10 2001-03-22 Catherine Anne Abbott Dipeptidyl peptidases
US6559188B1 (en) 1999-09-17 2003-05-06 Novartis Ag Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes
US6414002B1 (en) 1999-09-22 2002-07-02 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
KR20020047185A (ko) 1999-09-28 2002-06-21 플레믹 크리스티안 퀴나졸리논
US6251391B1 (en) 1999-10-01 2001-06-26 Klaire Laboratories, Inc. Compositions containing dipepitidyl peptidase IV and tyrosinase or phenylalaninase for reducing opioid-related symptons
US6447772B1 (en) 1999-10-01 2002-09-10 Klaire Laboratories, Inc. Compositions and methods relating to reduction of symptoms of autism
WO2001027090A1 (fr) 1999-10-08 2001-04-19 Meiji Seika Kaisha, Ltd. DERIVES D'ACIDE BENZOIQUE A SUBSTITUTION m PRESENTANT UN ANTAGONISME CONTRE L'INTEGRINE αvβ¿3?
US6261794B1 (en) 1999-10-14 2001-07-17 Saint Louis University Methods for identifying inhibitors of methionine aminopeptidases
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US20040152745A1 (en) 1999-11-12 2004-08-05 Guilford Pharmaceuticals, Inc. Dipeptidyl peptidase IV inhibitors and methods of making and using dipeptidyl peptidase IV inhibitors
JP2003535034A (ja) 1999-11-12 2003-11-25 ギルフォード ファーマシューティカルズ インコーポレイテッド ジペプチジルペプチダーゼｉｖ阻害剤並びにジペプチジルペプチダーゼｉｖ阻害剤の製造及び使用法
GB9928330D0 (en) 1999-11-30 2000-01-26 Ferring Bv Novel antidiabetic agents
WO2001041779A2 (fr) 1999-12-08 2001-06-14 1149336 Ontario Inc. Traitement relatif a la chimiotherapie
US6380398B2 (en) 2000-01-04 2002-04-30 Novo Nordisk A/S Therapeutically active and selective heterocyclic compounds that are inhibitors of the enzyme DPP-IV
ES2275654T5 (es) 2000-01-21 2012-06-07 Novartis Ag Combinaciones que contienen inhibidores de la dipeptidilpeptidasa-IV y agentes antidiabéticos
WO2001055105A1 (fr) 2000-01-24 2001-08-02 Novo Nordisk A/S 2-cyanopyroles et -pyrrolines a substitution n inhibant l'enzyme dpp-iv
BR0107837A (pt) 2000-01-27 2003-01-14 Lilly Co Eli Processo para solubilização de compostos peptìdeo 1 semelhantes a glucagon
US6569901B2 (en) 2000-01-28 2003-05-27 Novo Nordisk A/S Alkynyl-substituted propionic acid derivatives, their preparation and use
US7217722B2 (en) 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
EP1259246A2 (fr) 2000-02-25 2002-11-27 Novo Nordisk A/S Inhibition de la degenerescence des cellules beta
US6448045B1 (en) 2000-03-10 2002-09-10 The Regents Of The University Of California Inducing insulin gene expression in pancreas cells expressing recombinant PDX-1
US6395767B2 (en) 2000-03-10 2002-05-28 Bristol-Myers Squibb Company Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
US6608038B2 (en) 2000-03-15 2003-08-19 Novartis Ag Methods and compositions for treatment of diabetes and related conditions via gene therapy
EP1136482A1 (fr) 2000-03-23 2001-09-26 Sanofi-Synthelabo Dérivés de 2-amino-3-(alkyl)-pyrimidone comme inhibiteurs de GSK3bêta
EP1280764B1 (fr) 2000-03-24 2010-11-24 Methylgene, Inc. Inhibiteurs d'histone desacetylase
US6555519B2 (en) 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
BR0109553A (pt) 2000-03-31 2003-06-03 Probiodrug Ag Método para o melhoramento de sinalização de ilhota em diabetes melito e para sua prevenção
US6573096B1 (en) 2000-04-01 2003-06-03 The Research Foundation At State University Of New York Compositions and methods for inhibition of cancer invasion and angiogenesis
US6545170B2 (en) 2000-04-13 2003-04-08 Pharmacia Corporation 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
EP1288216A1 (fr) 2000-04-18 2003-03-05 Sumitomo Pharmaceuticals Company, Limited Quinazolinediones tricycliques
EP2223922B1 (fr) 2000-04-25 2016-03-02 ICOS Corporation Inhibiteurs delta de phosphatidyl-inositol 3-kinase humaine
GB0010188D0 (en) 2000-04-26 2000-06-14 Ferring Bv Inhibitors of dipeptidyl peptidase IV
GB0010183D0 (en) 2000-04-26 2000-06-14 Ferring Bv Inhibitors of dipeptidyl peptidase IV
DE10025464A1 (de) 2000-05-23 2001-12-06 Inst Medizintechnologie Magdeb Kombinierte Verwendung von Enzyminhibitoren zur Therapie von Autoimmunerkrankungen, bei Transplantationen und Tumorerkrankungen sowie Kombinationen von Enzyminhibitoren umfassende pharmazeutische Zubereitungen
US6783757B2 (en) 2000-06-01 2004-08-31 Kirkman Group, Inc. Composition and method for increasing exorphin catabolism to treat autism
WO2001094597A1 (fr) 2000-06-09 2001-12-13 Prozymex A/S Proenzyme purifiee de dipeptidyl peptidase i (pro-dppi)
TW583185B (en) 2000-06-13 2004-04-11 Novartis Ag N-(substituted glycyl)-2-cyanopyrrolidines and pharmaceutical composition for inhibiting dipeptidyl peptidase-IV (DPP-IV) or for the prevention or treatment of diseases or conditions associated with elevated levels of DPP-IV comprising the same
US6432969B1 (en) 2000-06-13 2002-08-13 Novartis Ag N-(substituted glycyl)-2 cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
US6627636B2 (en) 2000-06-15 2003-09-30 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US6620821B2 (en) 2000-06-15 2003-09-16 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7078397B2 (en) 2000-06-19 2006-07-18 Smithkline Beecham Corporation Combinations of dipeptidyl peptidase IV inhibitors and other antidiabetic agents for the treatment of diabetes mellitus
GB0014969D0 (en) 2000-06-19 2000-08-09 Smithkline Beecham Plc Novel method of treatment
WO2002002560A2 (fr) 2000-07-04 2002-01-10 Novo Nordisk A/S Composes heterocycliques inhibiteurs de l'enzyme dpp-iv
AU2001269123A1 (en) 2000-07-10 2002-01-21 Bayer Aktiengesellschaft Regulation of human dipeptidyl-peptidase iv-like enzyme
TW535080B (en) 2000-07-24 2003-06-01 Ten Square Co Ltd Method and apparatus for optimal fitting activities into customer idle time
JP2002042960A (ja) 2000-07-25 2002-02-08 Yazaki Corp コネクタ支持機構
US6518269B1 (en) 2000-07-28 2003-02-11 University Of Arizona Foundation Cancer treatment
WO2002010139A1 (fr) 2000-08-01 2002-02-07 Pharmacia Corporation Derives d'acide hexahydro-7-1h-azepine-2-yl-hexanoique comme inhibiteurs d'oxyde nitrique synthase inductible
ES2311532T3 (es) 2000-08-04 2009-02-16 Warner-Lambert Company Llc 2-(4-pirdil)amino-6-dialcoxifenil-pirido(2.3-d)pirimidin-7-onas.
US7074794B2 (en) 2000-08-10 2006-07-11 Mitsubishi Pharma Corporation Proline derivatives and the use thereof as drugs
US20020165237A1 (en) 2000-08-11 2002-11-07 Fryburg David Albert Treatment of the insulin resistance syndrome
US20020037829A1 (en) 2000-08-23 2002-03-28 Aronson Peter S. Use of DPPIV inhibitors as diuretic and anti-hypertensive agents
US6900226B2 (en) 2000-09-06 2005-05-31 Hoffman-La Roche Inc. Neuropeptide Y antagonists
ATE378411T1 (de) 2000-09-08 2007-11-15 Prozymex As Ratten-spezifische cathepsin, dipeptidyl peptidase i (dppi): kristallstruktur, hemmstoffe und deren anwendungen
PE20020453A1 (es) 2000-09-27 2002-06-06 Merck & Co Inc Derivados del acido benzopirancarboxilico para el tratamiento de la diabetes y los trastornos de lipidos
US20020064736A1 (en) 2000-09-27 2002-05-30 Fuji Photo Film Co., Ltd. Dye-forming coupler, silver halide photographic light-sensitive material, and method for producing an azomethine dye
GB0023983D0 (en) 2000-09-29 2000-11-15 Prolifix Ltd Therapeutic compounds
SE0003599D0 (sv) 2000-10-05 2000-10-05 Thomas Johansson Anordning för fuktabsorption
CN1257891C (zh) 2000-10-06 2006-05-31 田边制药株式会社 含氮五员环化合物
JP2004528812A (ja) 2000-10-12 2004-09-24 フェリング ベスローテン フェンノートシャップ Ｄｐｐｉｖに関連する新規セリンプロテアーゼ遺伝子
AUPR107800A0 (en) 2000-10-27 2000-11-23 University Of Sydney, The Peptide and nucleic acid molecule ii
DE60134563D1 (de) 2000-10-27 2008-08-07 Probiodrug Ag Behandlung von neurologischen und neuropsychologischen störungen
BR0115055A (pt) 2000-10-30 2003-12-30 Ortho Mcneil Pharm Inc Terapia de combinação compreendendo agentes anticonvulsantes e antidiabéticos
AU2002246568A1 (en) 2000-10-31 2002-08-06 Vanderbilt University Biological markers and diagnostic tests for angiotensin converting enzyme inhibitor- and vasopeptidase inhibitor-associated angioedema
JP4350946B2 (ja) 2000-10-31 2009-10-28 メルク エンド カムパニー インコーポレーテッド 糖尿病及び脂質異常症の治療のためのベンゾピランカルボン酸誘導体
AU2002225954A1 (en) 2000-11-08 2002-05-21 The University Of Georgia Research Foundation, Inc. Dipeptidylpeptidases and methods of use
TWI243162B (en) 2000-11-10 2005-11-11 Taisho Pharmaceutical Co Ltd Cyanopyrrolidine derivatives
US20030055052A1 (en) 2000-11-10 2003-03-20 Stefan Peters FAP-activated anti-tumor compounds
US20020155565A1 (en) 2000-11-10 2002-10-24 Pilar Garin-Chesa FAP-activated anti-tumor compounds
US20030203946A1 (en) 2000-11-17 2003-10-30 Carsten Behrens Glucagon antagonists/inverse agonists
EP1343763A1 (fr) 2000-11-20 2003-09-17 Bristol-Myers Squibb Company Derives de pyridones utilises en tant qu'inhibiteurs ap2
WO2002083143A1 (fr) 2000-12-11 2002-10-24 Tularik Inc. Antagonistes de cxcr3
WO2002051836A1 (fr) 2000-12-27 2002-07-04 Kyowa Hakko Kogyo Co., Ltd. Inhibiteur de dipeptidyl peptidase iv
CA2436724C (fr) 2001-01-02 2010-03-16 Siegfried Ansorge Utilisation combinee d'inhibiteurs enzymatiques et de preparations pharmaceutiques constituees de ces inhibiteurs pour le traitement et la prophylaxie de l'arteriosclerose, pour le traitement et la prevention de reactions allergiques de type i selon la classification de gell et coombs et pour le traitement et la prevention
DE10100053A1 (de) 2001-01-02 2002-08-22 Keyneurotek Ag I G Verwendung von Enzyminhibitoren der Dipeptidylpeptidase IV sowie der Aminopeptidase N und pharmazeutischen Zubereitungen daraus zur Prävention und/oder Therapie Ischämie-bedingter akuter und chronischer neurodegenerativer Prozesse und Erkrankungen
WO2002059301A1 (fr) 2001-01-27 2002-08-01 K.U. Leuven Research And Development Chemokines
CN1500080A (zh) 2001-02-02 2004-05-26 ����ҩƷ��ҵ��ʽ���� 稠合杂环化合物
TWI255817B (en) 2001-02-14 2006-06-01 Kissei Pharmaceutical Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof
WO2002066627A1 (fr) 2001-02-16 2002-08-29 Bayer Aktiengesellschaft Regulation de la dipeptidyle peptidase 8 humaine
SK288003B6 (sk) 2001-02-24 2012-10-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthin derivatives, method for the preparation thereof, pharmaceutical composition containing thereof and their use
US6337069B1 (en) 2001-02-28 2002-01-08 B.M.R.A. Corporation B.V. Method of treating rhinitis or sinusitis by intranasally administering a peptidase
JP4178816B2 (ja) 2001-03-15 2008-11-12 田辺三菱製薬株式会社 医薬組成物
EP1372650B1 (fr) 2001-03-19 2008-11-19 Novartis AG Combinaisons comprenant un agent anti-diarrheique et une epothilone ou un derive d'epothilone
ATE395912T1 (de) 2001-03-27 2008-06-15 Merck & Co Inc Dipeptidylpeptidase-hemmer für die behandlung oder prävention von diabetes
FR2822826B1 (fr) 2001-03-28 2003-05-09 Servier Lab Nouveaux derives sulfonyles d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE10115921A1 (de) 2001-03-30 2002-10-02 Boehringer Ingelheim Pharma Verfahren zur Herstellung von 4,6-Diaminopyrimido[5,4-d]pyrimidinen
US6890905B2 (en) 2001-04-02 2005-05-10 Prosidion Limited Methods for improving islet signaling in diabetes mellitus and for its prevention
GB0109146D0 (en) 2001-04-11 2001-05-30 Ferring Bv Treatment of type 2 diabetes
US6573287B2 (en) 2001-04-12 2003-06-03 Bristo-Myers Squibb Company 2,1-oxazoline and 1,2-pyrazoline-based inhibitors of dipeptidyl peptidase IV and method
PE20021080A1 (es) 2001-04-12 2003-02-12 Boehringer Ingelheim Int Un anticuerpo especifico fapo bibh1 en el tratamiento del cancer
CN101172158A (zh) 2001-05-11 2008-05-07 得克萨斯州立大学董事会 抗cd26单克隆抗体作为对与表达cd26的细胞相关疾病的治疗
FR2824825B1 (fr) 2001-05-15 2005-05-06 Servier Lab Nouveaux derives d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20030060494A1 (en) 2001-05-18 2003-03-27 Nobuyuki Yasuda Pharmaceutical use of N-carbamoylazole derivatives
IL143366A0 (en) 2001-05-24 2002-04-21 Harasit Medical Res Services & Treatment of renal fibrosis
US7105556B2 (en) 2001-05-30 2006-09-12 Bristol-Myers Squibb Company Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
US6794379B2 (en) 2001-06-06 2004-09-21 Tularik Inc. CXCR3 antagonists
EP1406622B1 (fr) 2001-06-20 2006-02-22 Merck & Co., Inc. Inhibiteurs de dipeptidyl peptidase utilises dans le traitement du diabete
JP2004535433A (ja) 2001-06-20 2004-11-25 メルク　エンド　カムパニー　インコーポレーテッド 糖尿病治療用のジペプチジルペプチダーゼ阻害薬
GB0115517D0 (en) 2001-06-25 2001-08-15 Ferring Bv Novel antidiabetic agents
DE10150203A1 (de) 2001-10-12 2003-04-17 Probiodrug Ag Peptidylketone als Inhibitoren der DPIV
US7368421B2 (en) 2001-06-27 2008-05-06 Probiodrug Ag Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
WO2003002596A2 (fr) 2001-06-27 2003-01-09 Probiodrug Ag Nouvelle utilisation d'inhibiteurs de la dipeptidyl peptidase iv
DE10154689A1 (de) 2001-11-09 2003-05-22 Probiodrug Ag Substituierte Aminoketonverbindungen
US20030135023A1 (en) 2001-06-27 2003-07-17 Hans-Ulrich Demuth Peptide structures useful for competitive modulation of dipeptidyl peptidase IV catalysis
US20030130199A1 (en) 2001-06-27 2003-07-10 Von Hoersten Stephan Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
EP1399420B1 (fr) 2001-06-27 2007-12-05 SmithKline Beecham Corporation Pyrrolidines servant d'inhibiteurs de dipeptidyl peptidase
WO2003002553A2 (fr) 2001-06-27 2003-01-09 Smithkline Beecham Corporation Fluoropyrrolidines inhibitrices de la dipeptidyl peptidase
CA2450722A1 (fr) 2001-06-27 2003-01-09 Smithkline Beecham Corporation Fluoropyrrolidines inhibitrices de la dipeptidyl peptidase
US6869947B2 (en) 2001-07-03 2005-03-22 Novo Nordisk A/S Heterocyclic compounds that are inhibitors of the enzyme DPP-IV
EP1404675B1 (fr) 2001-07-03 2008-03-12 Novo Nordisk A/S Derives de purine inhibiteurs de dpp-iv pour le traitement du diabete
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
AU2002322585A1 (en) 2001-07-20 2003-03-03 Adipogenix, Inc. Fat accumulation-modulating compounds
AU2002330672A1 (en) 2001-07-25 2003-02-17 Genset S.A. Gmg-1 polynucleotides and polypeptides and uses thereof
CA2453653A1 (fr) 2001-07-26 2003-02-06 Genset S.A. Polynucleotides et polypeptides gmg-2 et leurs utilisations
WO2003011814A1 (fr) 2001-07-30 2003-02-13 Novo Nordisk A/S Nouveaux derives de vinyl n-(2-benzoylphenyl)-l-tyrosine et leur utilisation en tant qu'agents antidiabetiques, etc.
CN1537093A (zh) 2001-07-30 2004-10-13 ŵ��Ų�ڿ˹�˾ 新乙烯基羧酸衍生物以及它们作为抗糖尿病等药物的用途
JP2005501058A (ja) 2001-07-31 2005-01-13 ザ ガバメント オブ ザ ユナイテッドステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ ザ ナショナル インステ Ｇｌｐ−１、ｅｘｅｎｄｉｎ−４、そのペプチド・アナログ及びその使用
JP2005509409A (ja) 2001-08-08 2005-04-14 ジェンザイム・コーポレーション 糖尿病および他の血糖疾患の治療方法
WO2003016335A2 (fr) 2001-08-13 2003-02-27 Probiodrug Ag Inhibiteurs irreversibles de la cysteine protease de la legumaine
EP1285922A1 (fr) 2001-08-13 2003-02-26 Warner-Lambert Company 1-alkyl ou 1-cycloalkyltriazolo[4,3-a]quinazolin-5-ones comme inhibiteurs de phosphodiestérase
JP2003128551A (ja) 2001-08-15 2003-05-08 Sankyo Co Ltd 新規抗糖尿病医薬組成物
DE10143840A1 (de) 2001-09-06 2003-03-27 Probiodrug Ag Neue Inhibitoren der Dipeptidylpeptidase I
US6844316B2 (en) 2001-09-06 2005-01-18 Probiodrug Ag Inhibitors of dipeptidyl peptidase I
US20030186963A1 (en) 2001-09-14 2003-10-02 Dorwald Florencio Zaragoza Substituted piperidines
US6673829B2 (en) 2001-09-14 2004-01-06 Novo Nordisk A/S Aminoazetidine,-pyrrolidine and -piperidine derivatives
US20040259883A1 (en) 2001-09-14 2004-12-23 Hiroshi Sakashita Thiazolidine derivative and medicinal use thereof
EP1463727A2 (fr) 2001-09-19 2004-10-06 Novo Nordisk A/S Composes heterocycliques constituant des inhibiteurs de l'enzyme dpp-iv
AR036604A1 (es) 2001-09-21 2004-09-22 Mitsubishi Pharma Corp Derivados de 4-pirimidona 3-sustituida
ME00090B (fr) 2001-09-21 2010-10-10 Bristol Myers Squibb Holdings Ireland Composes contenant du lactame et leurs derives en tant qu'inhibiteurs du facteur xa
BR0212892A (pt) 2001-09-21 2004-08-03 Mitsubishi Pharma Corp Derivados de 4-pirimidona-3-substituìdo
US7019010B2 (en) 2001-09-27 2006-03-28 Novertis Ag Combinations
JP4394442B2 (ja) 2001-10-01 2010-01-06 ブリストル−マイヤーズ スクイブ カンパニー 抗炎症剤として有用なスピロ−ヒダントイン化合物
WO2003030946A1 (fr) 2001-10-09 2003-04-17 Novartis Ag Regulation de la production d'insuline
US7064135B2 (en) 2001-10-12 2006-06-20 Novo Nordisk Inc. Substituted piperidines
YU31004A (sh) 2001-10-18 2006-08-17 Bristol-Myers Squibb Company Mimetici humanog glukagonu sličnog peptida-1 i njihova upotreba u lečenju dijabetesa i srodnih stanja
TWI301834B (en) 2001-10-22 2008-10-11 Eisai R&D Man Co Ltd Pyrimidone compound and pharmaceutical composition including the same
GB0125445D0 (en) 2001-10-23 2001-12-12 Ferring Bv Protease Inhibitors
GB0125446D0 (en) 2001-10-23 2001-12-12 Ferring Bv Novel anti-diabetic agents
US6861440B2 (en) 2001-10-26 2005-03-01 Hoffmann-La Roche Inc. DPP IV inhibitors
BR0213958A (pt) 2001-10-31 2004-09-08 Novartis Ag Métodos para tratar diabete e condições relacionadas com base em polimorfismos no gene tcf1
EP1442028A4 (fr) 2001-11-06 2009-11-04 Bristol Myers Squibb Co Derives d'acides substitues en tant qu'agents de lutte contre le diabete et contre l'obesite, et procede associe
US20030125304A1 (en) 2001-11-09 2003-07-03 Hans-Ulrich Demuth Substituted amino ketone compounds
US20030089935A1 (en) 2001-11-13 2003-05-15 Macronix International Co., Ltd. Non-volatile semiconductor memory device with multi-layer gate insulating structure
JP2005511636A (ja) 2001-11-26 2005-04-28 トラスティーズ オブ タフツ カレッジ 自己免疫疾患の治療方法及びそれに関する試薬
MXPA04004956A (es) 2001-11-26 2004-08-11 Schering Corp Antagonistas de la hormona concentradora de melanina basados en la piperidina para tratamiento de la obesidad y de trastornos del sistema nervioso central.
WO2003045977A2 (fr) 2001-11-26 2003-06-05 Trustees Of Tufts College Inhibiteurs peptidomimetiques d'enzymes de clivage post-proline
WO2003048081A2 (fr) 2001-12-04 2003-06-12 Bristol-Myers Squibb Company Glycinamides en tant qu'inhibiteurs du facteur xa
GB0129988D0 (en) 2001-12-14 2002-02-06 Ferring Bv Imidazolidineacetic acid derivatives
EP1458374A2 (fr) 2001-12-14 2004-09-22 Novo Nordisk A/S Composes ralentissant l'activite de la lipase hormono-sensible
SE0104340D0 (sv) 2001-12-20 2001-12-20 Astrazeneca Ab New compounds
IL162620A0 (en) 2001-12-21 2005-11-20 Novo Nordisk As Amide derivatives as gk activators
TW200301698A (en) 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
WO2003057144A2 (fr) 2001-12-26 2003-07-17 Guilford Pharmaceuticals Changement d'inhibiteurs de la dipeptidyl peptidase iv
US6727261B2 (en) 2001-12-27 2004-04-27 Hoffman-La Roche Inc. Pyrido[2,1-A]Isoquinoline derivatives
EP1790353A1 (fr) 2001-12-29 2007-05-30 Novo Nordisk A/S Utilisation combinée d'un composé GLP-1 et d'un modulateur de complications diabétiques tardives
DE60323823D1 (de) 2002-01-11 2008-11-13 Novo Nordisk As Verfahren und zusammensetzung zur behandlung von diabetes, hypertonie, chronischer herzinsuffizienz und mit flüssigkeitsretention einhergehenden zuständen
AU2003218969A1 (en) 2002-02-01 2003-09-02 Probiodrug Ag Modulation of t lymphocytes using dp iv inhibitors
US7101898B2 (en) 2002-02-01 2006-09-05 Novo Nordisk A/S Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes
CA2474168A1 (fr) 2002-02-01 2003-08-14 Merck & Co., Inc. Inhibiteurs de la 11-beta-hydroxysteroide deshydrogenase 1 utiles pour le traitement du diabete, de l'obesite et de la dyslipidemie
PL371678A1 (en) 2002-02-13 2005-06-27 F.Hoffmann-La Roche Ag Novel pyridin- and pyrimidin-derivatives
JP4216197B2 (ja) 2002-02-13 2009-01-28 エフ．ホフマン−ラ ロシュ アーゲー 新規ピリジン及びキノリン誘導体
ES2246481T3 (es) 2002-02-27 2006-02-16 Pfizer Products Inc. Inhibidores de la acc.
CN1622941A (zh) 2002-02-28 2005-06-01 普罗西迪恩有限公司 基于谷氨酰胺酰基的dpiv抑制剂
HUP0200849A2 (hu) 2002-03-06 2004-08-30 Sanofi-Synthelabo N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
DE60336901D1 (de) 2002-03-07 2011-06-09 X Ceptor Therapeutics Inc Chinazolinon modulatoren von nukleinrezeptoren
CN1274668C (zh) 2002-03-11 2006-09-13 诺瓦提斯公司 那格列奈的盐
KR20040099324A (ko) 2002-03-13 2004-11-26 유로-셀티큐 에스.에이. 아릴 치환된 피리미딘 및 이것의 용도
DE10211555A1 (de) 2002-03-15 2003-10-02 Imtm Inst Fuer Medizintechnolo Verwendung der Inhibitoren von Enzymen mit Aktivitäten der Aminopeptidase N und/oder der Dipeptidylpeptidase IV und pharmazeutischen Zubereitungen daraus zur Therapie und Prävention dermatologischer Erkrankungen mit sebozytärer Hyperproliferation und veränderten Differenzierungszuständen
TW200305415A (en) 2002-03-22 2003-11-01 Novartis Ag Combination of organic compounds
US7348318B2 (en) 2002-03-25 2008-03-25 Nippon Kayaku Kabushiki Kaisha α-Amino-N-(diaminophosphinyl)lactam derivatives
JP2005526811A (ja) 2002-03-25 2005-09-08 メルク　エンド　カムパニー　インコーポレーテッド 糖尿病の治療または予防用β−アミノ複素環式ジペプチジルペプチダーゼ阻害剤
US20030232761A1 (en) 2002-03-28 2003-12-18 Hinke Simon A. Novel analogues of glucose-dependent insulinotropic polypeptide
TW200918046A (en) 2002-04-03 2009-05-01 Novartis Ag Indolylmaleimide derivatives
US20040106802A1 (en) 2002-04-08 2004-06-03 Torrent Pharmaceuticals Ltd. Novel compounds and therapeutic uses thereof
CN1633420A (zh) 2002-04-08 2005-06-29 托伦脱药品有限公司 噻唑烷－4－腈和类似物以及它们作为二肽基－肽酶抑制剂的用途
JP2005531540A (ja) 2002-04-30 2005-10-20 トラスティーズ・オブ・タフツ・カレッジ セリンプロテアーゼ阻害剤のスマートプロドラッグ
TW200307667A (en) 2002-05-06 2003-12-16 Bristol Myers Squibb Co Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
US7057046B2 (en) 2002-05-20 2006-06-06 Bristol-Myers Squibb Company Lactam glycogen phosphorylase inhibitors and method of use
TW200407143A (en) 2002-05-21 2004-05-16 Bristol Myers Squibb Co Pyrrolotriazinone compounds and their use to treat diseases
ATE478867T1 (de) 2002-05-23 2010-09-15 Novartis Vaccines & Diagnostic Substituierte quinazolinone verbindungen
GB0212412D0 (en) 2002-05-29 2002-07-10 Novartis Ag Combination of organic compounds
AU2003233010A1 (en) 2002-06-04 2003-12-19 Pfizer Products Inc. Process for the preparation of 3,3,4,4-tetrafluoropyrrolidine and derivatives thereof
US6710040B1 (en) 2002-06-04 2004-03-23 Pfizer Inc. Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors
JP2005533771A (ja) 2002-06-04 2005-11-10 ファイザー・プロダクツ・インク ジペプチジルペプチダーゼｉｖ阻害剤としてのフッ素化環式アミド
TWI273104B (en) 2002-06-06 2007-02-11 Eisai Co Ltd Novel fused imidazole derivative
AR040241A1 (es) 2002-06-10 2005-03-23 Merck & Co Inc Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia
HUP0202001A2 (hu) 2002-06-14 2005-08-29 Sanofi-Aventis DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok
US20040009972A1 (en) 2002-06-17 2004-01-15 Ding Charles Z. Benzodiazepine inhibitors of mitochondial F1F0 ATP hydrolase and methods of inhibiting F1F0 ATP hydrolase
AU2003276125B2 (en) 2002-06-17 2007-05-17 Smithkline Beecham Corporation Chemical process
SE0201976D0 (sv) 2002-06-24 2002-06-24 Astrazeneca Ab Novel compounds
US20040006004A1 (en) 2002-06-27 2004-01-08 Markku Koulu Method for prevention and treatment of diseases or disorders related to excessive formation of vascular tissue or blood vessels
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
US20040054171A1 (en) 2002-07-04 2004-03-18 Jensen Anette Frost Polymorphic forms of a 4H-thieno[3,2-E]-1,2,4-thiadiazine 1,1-dioxide derivative
CA2490972C (fr) 2002-07-09 2012-05-29 Bristol-Myers Squibb Company Derives heterocycliques substitues utiles comme agents antidiabetique et anti-obesite et procede correspondant
JP4579681B2 (ja) 2002-07-09 2010-11-10 ブリストル−マイヤーズ スクイブ カンパニー 抗糖尿病薬および抗肥満薬として有用な置換ヘテロシクロ誘導体および方法
EP1578434A2 (fr) 2002-07-09 2005-09-28 Point Therapeutics, Inc. Procedes et compositions ayant trait a des composes d'isoleucine boroproline
JP2004099600A (ja) 2002-07-19 2004-04-02 Sankyo Co Ltd 二環性アミノ基置換化合物を含有する医薬組成物
WO2004014860A2 (fr) 2002-08-08 2004-02-19 Takeda Pharmaceutical Company Limited Composes heterocycliques fusionnes
ATE394118T1 (de) 2002-08-09 2008-05-15 Prosidion Ltd Dipeptidyl peptidase iv inhibitoren zur senkung der chronische gewichtszunahme
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
BR122012026540B8 (pt) 2002-08-21 2021-05-25 Boehringer Ingelheim Pharma 8-[3-amino-piperidin-1-il]-xantinas, seus sais farmacêuticamente aceitáveis, seu uso e seu processo de preparação, bem como medicamento e seu processo de preparação
DE10238477A1 (de) 2002-08-22 2004-03-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Purinderivate, deren Herstellung und deren Verwendung als Arzneimittel
US7495005B2 (en) 2002-08-22 2009-02-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, their preparation and their use in pharmaceutical compositions
DE10238470A1 (de) 2002-08-22 2004-03-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel
NZ538956A (en) 2002-08-29 2006-08-31 Taisho Pharmaceutical Co Ltd Benzenesulfonate salt of 4-fluoro-2-cyanopyrrolidine derivative used to inhibit dipeptidyl peptidase IV (DPPIV)
US6998502B1 (en) 2002-09-05 2006-02-14 Sabinsa Corporation Convenient process of manufacture for difluoromethylornithine and related compounds
EP1398032A1 (fr) 2002-09-10 2004-03-17 PheneX Pharmaceuticals AG 4-oxoquinazolines se liant au récepteur nucléair LXR
JP2004123738A (ja) 2002-09-11 2004-04-22 Takeda Chem Ind Ltd 徐放性製剤
WO2004024184A1 (fr) 2002-09-11 2004-03-25 Takeda Pharmaceutical Company Limited Preparation a liberation prolongee
US20040058876A1 (en) 2002-09-18 2004-03-25 Torsten Hoffmann Secondary binding site of dipeptidyl peptidase IV (DP IV)
AU2003293311A1 (en) 2002-09-18 2004-04-23 Prosidion Ltd. Secondary binding site of dipeptidyl peptidase iv (dp iv)
US7262207B2 (en) 2002-09-19 2007-08-28 Abbott Laboratories Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
CA2768674A1 (fr) 2002-09-19 2004-04-01 Abbott Laboratories Compositions pharmaceutiques utiles comme inhibiteurs de la peptidase-iv dipeptidyl (dpp-iv)
NZ538936A (en) 2002-09-26 2006-12-22 Eisai Co Ltd Combination drug comprising a combination of a dipeptidyl peptidase IV (DPPIV) inhibitor with biguanide
US6869966B2 (en) 2002-09-30 2005-03-22 Banyu Pharmaceutical Co., Ltd. N-substituted-2-oxodihydropyridine derivatives
ES2291680T3 (es) 2002-10-07 2008-03-01 MERCK & CO., INC. Antidiabeticos beta-amino heterociclicos inhibidores de la dipeptidil peptidasa.
WO2004033455A2 (fr) 2002-10-08 2004-04-22 Novo Nordisk A/S Sels succiniques d'inhibiteurs heterocycliques de dpp-iv
WO2004032861A2 (fr) 2002-10-11 2004-04-22 Bristol-Myers Squibb Company Composes hexahydro-benzimidazolones utiles en tant qu'agents anti-inflammatoires
BR0315381A (pt) 2002-10-18 2005-08-23 Merck & Co Inc Composto ou um sal farmaceuticamente aceitável deste, composição farmacêutica, e, métodos para inibir a atividade da enzima dipeptidil peptidase-iv em um mamìfero em necessidade disto, para tratar diabetes em um mamìfero em necessidade disto, para tratar diabete não dependente de insulina (tipo 2) em um mamìfero em necessidade disto, para tratar hiperglicemia em um mamìfero em necessidade disto, para tratar a obesidade em um mamìfero em necessidade disto, para tratar um ou mais distúrbios de lipìdios selecionados do grupo de dislipidemia, hiperlipidemia, hipertrigliceridemia, hipercolesterolemia, hdl baixo e ldl alto em um mamìfero em necessidade disto, e para tratar em um mamìfero em necessidade disto uma ou mais condições
EP1553947A4 (fr) 2002-10-21 2006-11-29 Bristol Myers Squibb Co Quinazolinones et derives de celles-ci comme inhibiteurs du facteur xa
EP1553937B1 (fr) 2002-10-23 2010-06-02 Bristol-Myers Squibb Company Inhibiteurs de dipeptidyl peptidase iv a base de glycinenitrile
WO2004041795A1 (fr) 2002-10-30 2004-05-21 Guilford Pharmaceuticals Inc. Nouveaux inhibiteurs de dipeptidyl peptidase iv
CA2504735C (fr) 2002-11-07 2009-06-23 Merck & Co., Inc. Derives de phenylalanine utilises comme inhibiteurs de la dipeptidyl peptidase dans le traitement ou la prevention du diabete
US7482337B2 (en) 2002-11-08 2009-01-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
JP2006508975A (ja) 2002-11-18 2006-03-16 ファイザー・プロダクツ・インク ジペプチジルペプチダーゼｉｖを阻害するフッ素化環状アミド
DE10254304A1 (de) 2002-11-21 2004-06-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel
AU2002952946A0 (en) 2002-11-27 2002-12-12 Fujisawa Pharmaceutical Co., Ltd. Dpp-iv inhibitor
US7109192B2 (en) 2002-12-03 2006-09-19 Boehringer Ingelheim Pharma Gmbh & Co Kg Substituted imidazo-pyridinones and imidazo-pyridazinones, the preparation thereof and their use as pharmaceutical compositions
UY28103A1 (es) 2002-12-03 2004-06-30 Boehringer Ingelheim Pharma Nuevas imidazo-piridinonas sustituidas, su preparación y su empleo como medicacmentos
JP2006510630A (ja) 2002-12-04 2006-03-30 メルク　エンド　カムパニー　インコーポレーテッド 糖尿病を治療又は予防するためのジペプチジルペプチダーゼ阻害剤としてのフェニルアラニン誘導体
US7524847B2 (en) 2002-12-04 2009-04-28 Eisai R&D Management Co., Ltd. Fused 1,3-dihydro-imidazole ring compounds
US7420079B2 (en) 2002-12-09 2008-09-02 Bristol-Myers Squibb Company Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof
WO2004058266A1 (fr) 2002-12-20 2004-07-15 Merck & Co., Inc. Derives de 3-amino-4-phenylbutanoique acide utilises en tant qu'inhibiteurs de dipeptidyl peptidase pour le traitement ou la prevention du diabete
WO2004062613A2 (fr) 2003-01-13 2004-07-29 Bristol-Myers Squibb Company Inhibiteurs d'integrase hiv
WO2004064778A2 (fr) 2003-01-17 2004-08-05 Merck & Co. Inc. Derives d'acide 3-amino-4-phenylbutanoique utilises comme inhibiteurs de la dipeptidyl peptidase pour le traitement ou la prevention du diabete
KR100998796B1 (ko) 2003-01-31 2010-12-06 가부시키가이샤산와카가쿠켄큐쇼 디펩티딜 펩티다아제 ｉｖ를 저해하는 화합물
JP2006516573A (ja) 2003-01-31 2006-07-06 メルク　エンド　カムパニー　インコーポレーテッド 糖尿病の治療および予防のためのジペプチジルペプチダーゼ阻害薬としての３−アミノ−４−フェニルブタン酸誘導体
WO2004071454A2 (fr) 2003-02-13 2004-08-26 Guilford Pharmaceuticals Inc. Composes d'azetidine substitues servant d'inhibiteurs de dipeptidyl peptidase iv
DE10308351A1 (de) 2003-02-27 2004-11-25 Aventis Pharma Deutschland Gmbh 1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10308353A1 (de) 2003-02-27 2004-12-02 Aventis Pharma Deutschland Gmbh Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10308356A1 (de) 2003-02-27 2004-09-09 Aventis Pharma Deutschland Gmbh Cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
US7148246B2 (en) 2003-02-27 2006-12-12 Sanofi-Aventis Deutschland Gmbh Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals
AU2003207881A1 (en) 2003-02-28 2004-09-17 Aic Dipeptidyl peptidase inhibitors
WO2004076434A1 (fr) 2003-02-28 2004-09-10 Aic Inhibiteurs de dipeptidyl peptidases
WO2004078777A2 (fr) 2003-03-04 2004-09-16 Biorexis Pharmaceutical Corporation Proteines protegees contre la dipeptidylpeptidase
AR043443A1 (es) 2003-03-07 2005-07-27 Merck & Co Inc Procedimiento de preparacion de tetrahidrotriazolopirazinas y productos intermedios
US20050014732A1 (en) 2003-03-14 2005-01-20 Pharmacia Corporation Combination of an aldosterone receptor antagonist and an anti-diabetic agent
AR043505A1 (es) 2003-03-18 2005-08-03 Merck & Co Inc Preparacion de beta-cetoamidas e intermediarios de reaccion
WO2004085661A2 (fr) 2003-03-24 2004-10-07 Merck & Co., Inc Procede de synthese de derives d'acides amines beta chiraux
KR20050122220A (ko) 2003-03-25 2005-12-28 다케다 샌디에고, 인코포레이티드 디펩티딜 펩티다제 억제제
JP2006521400A (ja) 2003-03-26 2006-09-21 バイエル・フアーマシユーチカルズ・コーポレーシヨン 糖尿病及び関連障害の処置のための化合物及びそれらの使用
TWI357408B (en) 2003-03-26 2012-02-01 Mitsubishi Tanabe Pharma Corp 3-substituted-4-pyrimidone derivatives
WO2004087650A2 (fr) 2003-03-27 2004-10-14 Merck & Co. Inc. Procede et intermediaires pour la preparation d'inhibiteurs d'amide d'acide beta-amino de dipeptidyle peptidase-iv
WO2004089362A1 (fr) 2003-04-11 2004-10-21 Novo Nordisk A/S 2-cyanopyrroles et leurs analogues en tant qu'inhibiteurs de dipeptidylpeptidase-iv (dp-iv)
WO2004096806A1 (fr) 2003-04-30 2004-11-11 Sumitomo Pharmaceuticals Co. Ltd. Derive d'imidazole condense
EP1622870A2 (fr) 2003-05-05 2006-02-08 Prosidion Ltd. Inhibiteurs de la dp iv a base de glutaminyle
DE602004026289D1 (de) 2003-05-05 2010-05-12 Probiodrug Ag Glutaminylcyclase-hemmer
EA009291B1 (ru) 2003-05-05 2007-12-28 Пробиодруг Аг Применение эффекторов глутаминил- и глутаматциклаз
NZ572274A (en) 2003-05-05 2009-06-26 Probiodrug Ag Use of effectors of glutaminyl and glutamate cyclases
AU2003902260A0 (en) 2003-05-09 2003-05-29 Fujisawa Pharmaceutical Co., Ltd. Dpp-iv inhibitor
WO2004103993A1 (fr) 2003-05-14 2004-12-02 Syrrx, Inc. Inhibiteurs de dipeptidyl peptidase
ATE447574T1 (de) 2003-05-14 2009-11-15 Merck & Co Inc 3-amino-4-phenylbutansäurederivate als dipeptidylpeptidase-hemmer zur behandlung oder vorbeugung von diabetes
AU2004238719A1 (en) 2003-05-15 2004-11-25 Taisho Pharmaceutical Co., Ltd. Cyanofluoropyrrolidine derivative
EP1631680A2 (fr) 2003-05-21 2006-03-08 Bayer HealthCare AG Diagnostics et agents therapeutiques destines a des maladies liees a une dipeptidylpeptidase iv (dpp4)
WO2004104215A2 (fr) 2003-05-21 2004-12-02 Bayer Healthcare Ag Approches diagnostiques et therapeutiques des maladies associees a la dipeptidylpeptidase 7 (dpp7)
CA2526770A1 (fr) 2003-06-06 2004-12-23 Merck & Co., Inc. Indoles fusionnes en tant qu'inhibiteurs de dipeptidyle peptidase destines au traitement ou a la prevention des diabetes
AU2003902946A0 (en) 2003-06-12 2003-06-26 Fujisawa Pharmaceutical Co., Ltd. Dpp-iv inhibitor
EP1638950A4 (fr) 2003-06-17 2010-06-30 Merck Sharp & Dohme Derives de cyclohexylglycine servant d'inhibiteurs de la dipeptidyl peptidase pour le traitement ou la prevention du diabete
DE10327439A1 (de) 2003-06-18 2005-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Imidazopyridazinon- und Imidazopyridonderivate, deren Herstellung und deren Verwendung als Arzneimittel
US7566707B2 (en) 2003-06-18 2009-07-28 Boehringer Ingelheim International Gmbh Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions
KR100744893B1 (ko) 2003-06-20 2007-08-01 에프. 호프만-라 로슈 아게 Ｄｐｐ-ｉｖ 저해제로서 헥사하이드로피리도아이소퀴놀린
BRPI0411713B8 (pt) 2003-06-20 2021-05-25 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas que compreendem os mesmos, método para tratamento e/ou profilaxia de enfermidades que estão associadas com dpp-iv e sua utilização
JO2625B1 (en) 2003-06-24 2011-11-01 ميرك شارب اند دوم كوربوريشن Phosphoric acid salts of dipeptidyl betidase inhibitor 4
DE10330842A1 (de) 2003-07-08 2005-02-10 Institut für Medizintechnologie Magdeburg GmbH, IMTM Verwendung der Inhibitoren von Enzymen mit Aktivitäten der Aminopeptidase N und/oder der Dipeptidylpeptidase IV und pharmazeutischen Zubereitungen daraus zur Therapie und Prävention dermatologischer Erkrankungen mit Hyperproliferation und veränderten Differenzierungszuständen von Fibroblasten
CA2533893A1 (fr) 2003-07-31 2005-02-10 Merck & Co., Inc. Hexahydrodiazepinones utilises en tant qu'inhibiteurs de la dipeptidyl peptidase iv pour le traitement ou la prevention du diabete
US6995183B2 (en) 2003-08-01 2006-02-07 Bristol Myers Squibb Company Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
KR20060041309A (ko) 2003-08-13 2006-05-11 다케다 야쿠힌 고교 가부시키가이샤 ４-피리미돈 유도체 및 펩티딜 펩티다제 저해제로서의 그의용도
WO2005019168A2 (fr) 2003-08-20 2005-03-03 Pfizer Products Inc. Derives fluores de lysine en tant qu'inhibiteurs de la dipeptidylpeptidase iv
US20050065144A1 (en) 2003-09-08 2005-03-24 Syrrx, Inc. Dipeptidyl peptidase inhibitors
JP2007505121A (ja) 2003-09-08 2007-03-08 武田薬品工業株式会社 ジペプチジルぺプチダーゼ阻害剤
EP1532980A1 (fr) 2003-11-24 2005-05-25 Novo Nordisk A/S Carboxamides d'indole n-heteroarylé et leurs analogues, utiles comme des activateurs de glucokinase pour le traitement de diabetes
BRPI0507485A (pt) 2004-02-05 2007-07-10 Probiodrug Ag inibidores novos de glutaminil ciclase
CN1926128A (zh) * 2004-03-15 2007-03-07 武田药品工业株式会社 二肽基肽酶抑制剂
EP1828192B1 (fr) 2004-12-21 2014-12-03 Takeda Pharmaceutical Company Limited Inhibiteurs de dipeptidyle peptidase
MY147393A (en) 2005-09-14 2012-11-30 Takeda Pharmaceutical Administration of dipeptidyl peptidase inhibitors
PE20070622A1 (es) 2005-09-14 2007-08-22 Takeda Pharmaceutical Administracion de inhibidores de dipeptidil peptidasa
PT1931350E (pt) 2005-09-14 2014-02-12 Takeda Pharmaceutical Administração de inibidores de dipeptidil peptidase
TW200745079A (en) 2005-09-16 2007-12-16 Takeda Pharmaceuticals Co Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0748800A2 (fr) * 1995-06-09 1996-12-18 F. Hoffmann-La Roche Ag Dérivés de pyrimidine dione, pyrimidine trione, triazine dione, tetrahydroquinazoline dione comme antagonistes des récepteurs alpha-1-adrénergiques
WO2001055119A2 (fr) * 2000-01-25 2001-08-02 Neurocrine Biosciences, Inc. Antagonistes du recepteur de la gonadoliberine et methodes associees
WO2005095381A1 (fr) * 2004-03-15 2005-10-13 Takeda Pharmaceutical Company Limited Inhibiteurs de la dipeptidyle peptidase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KOTANI T ET AL: "HIGHLY SELECTIVE ALDOSE REDUCTASE INHIBITORS. 3. STRUCTURAL DIVERSITY OF 3-(ARYLMETHYL)-2,4,5-TRIOXOIMIDAZOLIDINE-1-ACETIC ACIDS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 40, no. 5, 1997, pages 684 - 694, XP000652330, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
KR20080045262A (ko) 2008-05-22
IL190135A0 (en) 2008-08-07
IL190135A (en) 2014-02-27
EP1924567B1 (fr) 2012-08-22
EP1924567A2 (fr) 2008-05-28
CN102675221A (zh) 2012-09-19
US20090275750A1 (en) 2009-11-05
CA2622642A1 (fr) 2007-03-29
CA2622642C (fr) 2013-12-31
JP2009508873A (ja) 2009-03-05
JP5122462B2 (ja) 2013-01-16
US8222411B2 (en) 2012-07-17
CN101360723A (zh) 2009-02-04
KR101368988B1 (ko) 2014-02-28
WO2007035629A2 (fr) 2007-03-29

Similar Documents

Publication Publication Date Title
WO2007035629A3 (fr) Inhibiteurs de dipeptidylpeptidase
WO2007085895A3 (fr) Inhibiteurs fap
WO2009079008A8 (fr) Benzopyranes et analogues utilisés comme inhibiteurs de la rho kinase
WO2009122436A3 (fr) Procédé perfectionné pour la préparation d'analogues de morphinane
WO2007015017A3 (fr) Nouveaux derives de polyquinoleines et leur utilisation therapeutique
WO2008084223A3 (fr) Composés chimiques 637
WO2007143434A3 (fr) Activateurs de glucokinase
WO2008079787A3 (fr) Activateurs de glucokinase
WO2007028135A3 (fr) Composes a base d'imidazopyridine
WO2007104034A3 (fr) Activateurs de la glucokinase
WO2007061923A3 (fr) Activateurs de la glucokinase
WO2009108383A3 (fr) Dérivés de xanthine substitués
WO2010063700A3 (fr) Nouveaux microbiocides
NO20076371L (no) Fremgangsmate for fremstilling av fenoliske 4-bifenylylazetidin-2-oner
WO2008116107A3 (fr) Activateurs de glucokinase
WO2006007532A3 (fr) Composes heteroaryles substitues en 2
CL2012000560A1 (es) Procedimiento de preparacion del compuesto intermediario acido 3-oxo-tetrahidrotiofeno-2-carboxilico, utiles en la preparacion de dihidrotienopirimidinas (divisional de la solicitud 3095-08).
WO2006127893A3 (fr) Procedes de production d'acides 4-(biphenylyl)azetidin-2-one phosphoniques
WO2008053334A3 (fr) Procédé amélioré de préparation de rosuvastatine calcique
WO2008061108A3 (fr) Dérivés de phtalazine
WO2007057768A3 (fr) Derives de sulfonyle
WO2009127718A3 (fr) Nouveaux microbiocides
WO2008075205A3 (fr) Procédé amélioré de préparation de la voriconazole
WO2006127287A3 (fr) Inhibiteurs a base de pyrrolopyridine, pour inhiber la dipeptidyl peptidase iv, et procedes correspondants
WO2005121078A3 (fr) Composes cyclopentene substitues

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200680042863.9

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: 190135

Country of ref document: IL

ENP Entry into the national phase

Ref document number: 2622642

Country of ref document: CA

Ref document number: 2008531408

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2006814853

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 1263/KOLNP/2008

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 1020087007951

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 12066769

Country of ref document: US